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1. 发明申请

WO2003102135A3 CONTROL SEQUENCES OF THE HUMAN CORIN GENE 审中-公开
公开(公告)号：WO2003102135A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/016741
申请日：2003-05-28
申请人： SCHERING AKTIENGESELLSCHAFT , PAN, Junliang , WU, Qingyu
发明人： PAN, Junliang , WU, Qingyu
IPC分类号： C07H21/02
摘要： This invention provides a novel expression control region isolated form mammalian corin genes. This control region preferentially activates transcription in cardiac cells. Methods and compositions are provided to employ this control region for identification of agents capable of modulating corin expression and for treatment of cardiac diseases.

2. 发明申请

WO2006094536A1 TARGETED PLASMINOGEN ACTIVATOR FUSION PROTEINS AS THROMBOLYTIC AGENTS 审中-公开
标题翻译：靶向PLASMINOGEN激活剂融合蛋白作为血栓形成剂
公开(公告)号：WO2006094536A1
公开(公告)日：2006-09-14
申请号：PCT/EP2005/009553
申请日：2005-09-06
申请人： PAION DEUTSCHLAND GMBH , PAN, Junliang , WU, Qingyu , SCHÜTTLER, Achim
发明人： PAN, Junliang , WU, Qingyu , SCHÜTTLER, Achim
IPC分类号： C12N9/72 , C07K19/00 , A61K38/16 , A61P9/10
CPC分类号： C12N9/6456 , A61K38/00 , A61K47/6849 , C07K2319/33
摘要： This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen activator DSPAalphal, or analogs, fragments, derivatives, or variants thereof, which are useful as thrombolytic agents. Pharmaceutical compositions containing these fusion proteins, methods of using these fusion proteins as thrombolytic agents, and processes for synthesizing these fusion proteins are also described herein.
摘要翻译：本发明涉及新型融合蛋白，其包含靶向蛋白和纤溶酶原激活剂，优选结合P-选择素的抗体，其可操作地连接于纤溶酶原激活物DSPAα或其类似物，片段，衍生物或变体，其可用作溶栓剂。包含这些融合蛋白的药物组合物，使用这些融合蛋白作为溶栓剂的方法，以及合成这些融合蛋白的方法也在本文中描述。

3. 发明申请

WO2004033630A2 MODIFIED HEPSIN MOLECULES HAVING A SUBSTITUTE ACTIVATION SEQUENCE AND USES THEREOF 审中-公开
标题翻译：具有替代激活序列的修饰的HEPSIN分子及其用途
公开(公告)号：WO2004033630A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031219
申请日：2003-10-02
申请人： SCHERING AKTIENGESELLSCHAFT , PARRY, Gordon , VOGEL, David , WHITLOW, Marc , WU, Qingyu
发明人： PARRY, Gordon , VOGEL, David , WHITLOW, Marc , WU, Qingyu
IPC分类号： C12N
CPC分类号： C07K16/3069 , C07K16/30 , C07K16/40 , C07K2317/92 , C12N9/6424
摘要： The present invention provides modified hepsin molecules, or fragments or derivatives thereof, including those having a substitute activation sequence. The modified hepsin molecules are cleaved at the substitute activation sequence, thereby generating activated modified hepsin molecule, or fragments or derivatives thereof, that exhibit the functional activity of naturally-occurring, wild-type hepsin molecules.
摘要翻译：本发明提供了修饰的高频蛋白酶分子或其片段或衍生物，包括具有替代激活序列的那些。修饰的高分子蛋白酶分子在替代活化序列处被切割，从而产生表现出天然存在的野生型热敏蛋白酶分子的功能活性的活化的修饰的高解磷蛋白酶分子或其片段或衍生物。

4. 发明申请

WO2010081335A1 A method of producing biofuel using sugarcane as feedstock 审中-公开
标题翻译：以甘蔗为原料生产生物燃料的方法
公开(公告)号：WO2010081335A1
公开(公告)日：2010-07-22
申请号：PCT/CN2009/074298
申请日：2009-09-28
申请人： TSINGHUA UNIVERSITY , WU, Qingyu , CHENG, Yun
发明人： WU, Qingyu , CHENG, Yun
IPC分类号： C10G3/00 , C12P5/00 , C10L1/02
CPC分类号： C10L1/026 , C12P7/649 , Y02E50/13 , Y02P30/20
摘要： The subject invention provides methods for producing biofuel from microorganism metabolite by using sugarcane as feedstock. In a preferred embodiment, alga was cultivated by using sugarcane- originated carbon 5 source as feedstock, resulting algal oil accumulation in algal cells at high content. And biodiesel was produced from said algal oil by transesterification.
摘要翻译：本发明提供了通过使用甘蔗作为原料从微生物代谢物生产生物燃料的方法。在优选的实施方案中，通过使用以甘蔗为原料的碳源5作为原料培养藻类，从而以高含量在藻类细胞中积累藻油。并且通过酯交换从所述藻油生产生物柴油。

5. 发明申请

WO2003102135A2 CONTROL SEQUENCES OF THE HUMAN CORIN GENE 审中-公开
标题翻译：人类角蛋白基因的控制序列
公开(公告)号：WO2003102135A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/016741
申请日：2003-05-28
申请人： SCHERING AKTIENGESELLSCHAFT , PAN, Junliang , WU, Qingyu
发明人： PAN, Junliang , WU, Qingyu
IPC分类号： C12N
CPC分类号： C12N9/6424 , A61K38/00 , A61K48/00 , C12N2799/021 , C12N2830/008 , C12Q1/6883 , C12Q2600/158
摘要： This invention provides a novel expression control region isolated form mammalian corin genes. This control region preferentially activates transcription in cardiac cells. Methods and compositions are provided to employ this control region for identification of agents capable of modulating corin expression and for treatment of cardiac diseases.
摘要翻译：本发明提供从哺乳动物corin基因分离的新型表达控制区。该控制区优先激活心脏细胞中的转录。提供方法和组合物以使用该控制区域来鉴定能够调节corin表达和治疗心脏病的药剂。

6. 发明申请

WO2003080564A1 MENTHOL SUBSTITUTED ANTITHROMBOTIC PAI-1 INHIBITORS 审中-公开
标题翻译： MENTHOL替代抗生素PAI-1抑制剂
公开(公告)号：WO2003080564A1
公开(公告)日：2003-10-02
申请号：PCT/US2003/007506
申请日：2003-03-12
申请人： SCHERING AKTIENGESELLSCHAFT , BAUER, Shawn , MOHAN, Raju , SHAW, Kenneth, J. , WU, Qingyu , YE, Bin , BUCKMAN, Brad, O. , GHANNAM, Ameen , GRIEDEL, Brian, D. , KHIM, Seock-kyu , ZHAO, Zuchun
发明人： BAUER, Shawn , MOHAN, Raju , SHAW, Kenneth, J. , WU, Qingyu , YE, Bin , BUCKMAN, Brad, O. , GHANNAM, Ameen , GRIEDEL, Brian, D. , KHIM, Seock-kyu , ZHAO, Zuchun
IPC分类号： C07C235/06
CPC分类号： C07D213/74 , C07C235/10 , C07C235/16 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/79 , C07D213/80 , C07D235/26 , C07D241/04 , C07D257/04 , C07D319/08 , C07D401/04
摘要： This invention is directed to menthol-substituted compounds and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention relates to pharmaceutical compositions and their pharmaceutically acceptable salts, containing the menthol substituted compounds, derivatives of the menthol substituted compounds, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译：本发明涉及通过抑制纤溶酶原激活物抑制剂-1（PAI-1）可用作抗血栓形成剂的薄荷醇取代的化合物及其药学上可接受的盐。此外，本发明涉及含有薄荷醇取代的化合物，薄荷醇取代的化合物的衍生物的药物组合物及其药学上可接受的盐，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。

7. 发明申请

WO2004033630A3 MODIFIED HEPSIN MOLECULES HAVING A SUBSTITUTE ACTIVATION SEQUENCE AND USES THEREOF 审中-公开
标题翻译：具有替代激活序列的修饰的HEPSIN分子及其用途
公开(公告)号：WO2004033630A3
公开(公告)日：2005-02-10
申请号：PCT/US0331219
申请日：2003-10-02
申请人： SCHERING AG , PARRY GORDON , VOGEL DAVID , WHITLOW MARC , WU QINGYU
发明人： PARRY GORDON , VOGEL DAVID , WHITLOW MARC , WU QINGYU
IPC分类号： C07K16/30 , C07K16/40 , C12N9/64 , C12N9/50 , A61K38/48 , C12Q1/37
CPC分类号： C07K16/3069 , C07K16/30 , C07K16/40 , C07K2317/92 , C12N9/6424
摘要： The present invention provides modified hepsin molecules, or fragments or derivatives thereof, including those having a substitute activation sequence. The modified hepsin molecules are cleaved at the substitute activation sequence, thereby generating activated modified hepsin molecule, or fragments or derivatives thereof, that exhibit the functional activity of naturally-occurring, wild-type hepsin molecules.
摘要翻译：本发明提供了修饰的高频蛋白酶分子或其片段或衍生物，包括具有替代激活序列的那些。修饰的高分子蛋白酶分子在替代活化序列处被切割，从而产生表现出天然存在的野生型热敏蛋白酶分子的功能活性的活化的修饰的高解磷蛋白酶分子或其片段或衍生物。

8. 发明申请

WO2004111225A1 NOVEL MODIFIED CORIN MOLECULES HAVING SUBSTITUTE ACTIVATION SEQUENCES AND USES THEREOF 审中-公开
标题翻译：具有替代激活序列的新型改性的CORIN分子及其用途
公开(公告)号：WO2004111225A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/018669
申请日：2004-06-09
申请人： SCHERING AKITENGESELLSCHAFT , WU, Qingyu
发明人： WU, Qingyu
IPC分类号： C12N9/64
CPC分类号： C12N9/6424 , Y10S435/975
摘要： This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.
摘要翻译：本发明涉及包含替代活化序列的新型修饰的corin分子或其片段或衍生物。修饰的corin分子在替代活化序列处被切割，从而产生表现出天然存在的野生型corin分子的功能活性的活化的corin分子或其片段或衍生物。修饰的corin分子可用于治疗各种疾病或病症，包括充血性心力衰竭和急性心肌梗塞。

9. 发明申请

WO2010096658A1 CORIN AS A MARKER FOR HEART FAILURE 审中-公开
标题翻译： CORIN作为心脏失败的标记
公开(公告)号：WO2010096658A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024744
申请日：2010-02-19
申请人： THE CLEVELAND CLINIC FOUNDATION , WU, Qingyu , CHEN, Shenghan , PLOW, Edward , DONG, Ningzheng , RUAN, Changgeng
发明人： WU, Qingyu , CHEN, Shenghan , PLOW, Edward , DONG, Ningzheng , RUAN, Changgeng
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/325 , G01N2800/56
摘要： The invention is a method of assessing whether an individual is afflicted with congestive heart failure (CHF) comprising comparing the level of corin or portion thereof in the individual to the level of corin or portion thereof in a control, wherein a decrease in the level of corin or portion thereof in the individual compared to the level of corin or portion thereof in the control indicates that the individual is afflicted with CHF. The methods described herein can be also be used to determine the severity of CHF in an individual, whether an individual's treatment for CHF is effective and whether an individual is at risk of developing CHF.
摘要翻译：本发明是一种评估个体是否患有充血性心力衰竭（CHF）的方法，其包括将个体中的corin或其部分的水平与对照中的corin或其部分的水平进行比较，其中，与对照中的角质层或其部分相比，个体中的corin或其部分表明个体患有CHF。本文所述的方法也可用于确定个体中CHF的严重性，个体对CHF的治疗是否有效以及个体是否处于发展CHF的风险中。

10. 发明申请

WO2009120760A1 CORIN FOR TREATING OBESITY AND DIABETES 审中-公开
标题翻译：用于治疗肥胖和糖尿病的角质
公开(公告)号：WO2009120760A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038216
申请日：2009-03-25
申请人： THE CLEVELAND CLINIC FOUNDATION , WU, Qingyu , JIANG, Jingjing , WANG, Wei
发明人： WU, Qingyu , JIANG, Jingjing , WANG, Wei
IPC分类号： A61K38/48 , A61P3/10 , A61P3/04
CPC分类号： A61K38/482
摘要： Provided herein are methods of inhibiting agouti or agouti-related protein (AGRP) in a cell or in an individual in need thereof, comprising administering to the cell or the individual an effective amount of an agent that induces corin expression, activity or a combination thereof in the cell or individual. The invention also provides a method of treating obesity in an individual in need thereof comprising administering to the individual an effective amount of an agent that enhances corin expression, activity or a combination thereof in the individual. Further provided is a method of treating diabetes type II in an individual in need thereof comprising administering to the individual an effective amount of an agent that enhances corin expression, activity or a combination thereof in the individual.
摘要翻译：本文提供了抑制细胞或有需要的个体中的agouti或agouti相关蛋白（AGRP）的方法，包括向细胞或个体施用有效量的诱导corin表达，活性或其组合的药剂在细胞或个体。本发明还提供了治疗有需要的个体中的肥胖症的方法，其包括向个体施用有效量的增强个体中的Corin表达，活性或其组合的药剂。进一步提供了一种在有需要的个体中治疗II型糖尿病的方法，其包括向个体施用有效量的在个体中增强corin表达，活性或其组合的药剂。

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