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1. 发明申请

WO2010008736A3 CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS 审中-公开
标题翻译：基于针对GLOBO H及其片段的抗体水平的癌症诊断
公开(公告)号：WO2010008736A3
公开(公告)日：2010-03-11
申请号：PCT/US2009047532
申请日：2009-06-16
申请人： ACADEMIA SINICA , WONG CHI-HUEY , WU CHUNG-YI , WANG CHENG-CHI
发明人： WONG CHI-HUEY , WU CHUNG-YI , WANG CHENG-CHI
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/57488 , G01N33/57415
摘要： A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.
摘要翻译：使用含有Gb5和Globo H，Bb2，Bb3和/或Bb4的聚糖阵列的癌症诊断方法。

2. 发明申请

WO2010009271A2 GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS 审中-公开
标题翻译： GLYCAN阵列在PTFE类铝合金玻璃滑块及相关方法上
公开(公告)号：WO2010009271A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050754
申请日：2009-07-15
申请人： Academia Sinica , WONG, Chi-Huey , WU, Chung-Yi , TSENG, Susan Y.
发明人： WONG, Chi-Huey , WU, Chung-Yi , TSENG, Susan Y.
IPC分类号： G01N33/50 , G01N33/66 , G01N33/68
CPC分类号： G01N33/553 , C40B40/12 , C40B50/14 , G01N33/582 , G01N2333/942 , G01N2400/10 , H01J49/40
摘要： Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
摘要翻译：镀铝玻璃片提供了一种新的聚糖阵列平台。具体来说，铝涂层玻璃片增加了基于荧光的测定方法的灵敏度。另外，铝涂层玻璃载玻片允许碳水化合物的质谱分析，并提供一个检查纤维素酶活性的平台。 ACG载玻片的独特性质包括：1）表面上的金属氧化物层可以活化，用于接枝有机化合物如改性寡糖; 2）表面保持导电，并且接枝的寡糖可以通过质谱法和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明玻片更敏感。

3. 发明申请

WO2010005598A1 GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS 审中-公开
标题翻译： GLOBO H和相关的抗癌药物与新型甘露醇辅剂
公开(公告)号：WO2010005598A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/004519
申请日：2009-08-06
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , YU, Alice , YU, John
发明人： WONG, Chi-Huey , WU, Chung-Yi , YU, Alice , YU, John
IPC分类号： A61K39/00 , A61K39/385
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CDId on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM 197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM 197.
摘要翻译：提供免疫原性组合物，癌症疫苗和治疗癌症的方法。组合物，其包含：（a）聚糖如Globo H或其免疫原性片段，其中所述聚糖通过诸如对硝基苯基之类的接头与载体蛋白缀合; 和（b）包含能够结合树突细胞上的CD1d的糖脂的佐剂，例如α-半乳糖基 - 神经酰胺衍生物，其中所述免疫原性组合物诱导与IgM同种型相比诱导更高相对水平的IgG同种型抗体的免疫应答抗体。提供了包含载体蛋白质白喉毒素交叉反应材料197（DT-CRM 197）和佐剂C34的免疫原性组合物。由本文公开的免疫原性组合物产生的抗体进一步中和至少一种抗原Globo H，阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4）。包括含有与DT-CRM 197结合的Globo H，SSEA-3或SSEA-4的免疫原性组合物的乳腺癌干细胞的治疗剂。

4. 发明申请

WO2018089407A1 RECOMBINANT VIRUS, COMPOSITION COMPRISING THE SAME, AND USES THEREOF 审中-公开
标题翻译：重组病毒，包含其的组合物及其用途
公开(公告)号：WO2018089407A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060510
申请日：2017-11-08
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi
发明人： WONG, Chi-Huey , WU, Chung-Yi
IPC分类号： C12N7/00 , C07K14/005 , C12N9/24 , A61K39/145 , A61K39/00
摘要： Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
摘要翻译：包含血凝素（HA）变体和/或神经氨酸酶（NA）变体（其可以包含在甲型流感病毒中）的免疫原性组合物，以及其用于引发针对甲型流感病毒的免疫应答的免疫原性组合物。

5. 发明申请

WO2010008736A2 CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS 审中-公开
标题翻译：基于抗体抗GLOBO H及其片段的癌症诊断
公开(公告)号：WO2010008736A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/047532
申请日：2009-06-16
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , WANG, Cheng-Chi
发明人： WONG, Chi-Huey , WU, Chung-Yi , WANG, Cheng-Chi
CPC分类号： G01N33/57488 , G01N33/57415
摘要： A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.
摘要翻译：使用含有Gb5和Globo H，Bb2，Bb3和/或Bb4的聚糖阵列的癌症诊断方法。

6. 发明申请

WO2014210397A1 RM2 ANTIGENS AND USE THEREOF 审中-公开
标题翻译： RM2抗生素及其用途
公开(公告)号：WO2014210397A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044465
申请日：2014-06-26
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , CHUANG, Hong-Yang , REN, Chien-Tai
发明人： WONG, Chi-Huey , WU, Chung-Yi , CHUANG, Hong-Yang , REN, Chien-Tai
IPC分类号： A61K39/385 , C07K14/33
CPC分类号： A61K39/0011 , A61K31/7028 , A61K39/385 , A61K49/00 , A61K2039/575 , A61K2039/585 , A61K2039/6037 , A61K2039/627 , C07H15/04 , C07H15/10 , C07H15/14 , C07K14/4748
摘要： Described herein are synthetic glycan conjugates, immmunogenic compositions thereof, vaccines thereof, and kits thereof. The present invention further provides methods of using the synthetic glycan conjugates, immunogenic compositions, or vaccines thereof to treat and/or prevent and/or diagnose proliferative diseases such as cancer. The provided glycan conjugate comprises a carrier and a glycan moiety of Formula (1-i) or Formula (1-ii): (structurally represented).
摘要翻译：本文描述的是合成聚糖缀合物，其免疫原性组合物，其疫苗及其试剂盒。本发明还提供了使用合成聚糖缀合物，免疫原性组合物或其疫苗来治疗和/或预防和/或诊断增殖性疾病如癌症的方法。所提供的聚糖缀合物包含式（1-i）或式（1-ii）的载体和聚糖部分：（结构上表示）。

7. 发明申请

WO2011130332A1 GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES 审中-公开
公开(公告)号：WO2011130332A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032192
申请日：2011-04-12
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , LIANG, Chi-Hui , YANG, An-Suei
发明人： WONG, Chi-Huey , WU, Chung-Yi , LIANG, Chi-Hui , YANG, An-Suei
IPC分类号： C12Q1/70 , C07K16/08
CPC分类号： G01N33/56983 , G01N33/53 , G01N33/54346 , G01N2333/11 , G01N2400/00 , G01N2400/38 , G01N2458/00
摘要： Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.
摘要翻译：提供了可以检测和区分各种亚型和流感病毒株的糖阵列。公开了使用纳米颗粒扩增技术的测定法使用聚糖阵列的方法。提供使用与包含用于使用单个反应检测多种血清型的流感病毒特异性抗体的噬菌体颗粒缀合的金纳米颗粒的三明治测定。针对流感病毒的特定目标HA的多种聚糖包括阵列。公开了包含与（a）噬菌体缀合的贵金属的检测分子，其显示表达针对血凝素的抗体的颗粒和（b）神经氨酸酶结合剂。

8. 发明申请

WO2010009271A3 GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS 审中-公开
标题翻译：类聚四氟乙烯涂层玻璃载玻片上的甘氨酸阵列及相关方法
公开(公告)号：WO2010009271A3
公开(公告)日：2010-04-22
申请号：PCT/US2009050754
申请日：2009-07-15
申请人： ACADEMIA SINICA , WONG CHI-HUEY , WU CHUNG-YI , TSENG SUSAN Y
发明人： WONG CHI-HUEY , WU CHUNG-YI , TSENG SUSAN Y
IPC分类号： G01N33/50 , G01N33/66 , G01N33/68
CPC分类号： G01N33/553 , C40B40/12 , C40B50/14 , G01N33/582 , G01N2333/942 , G01N2400/10 , H01J49/40
摘要： Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
摘要翻译：镀铝玻璃载玻片提供了一种新型聚糖阵列平台。具体而言，镀铝玻璃载玻片增加了基于荧光的测定方法的灵敏度。此外，镀铝玻璃载玻片允许对碳水化合物进行质谱分析，并为检查纤维素酶的活性提供平台。 ACG玻片的独特性能包括：1）表面的金属氧化物层可以被活化以接枝有机化合物，如修饰的低聚糖; 2）表面保持导电性，并且接枝的低聚糖可以通过质谱和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明载玻片更敏感。

9. 发明申请

WO2015026484A1 ANTIBODY-MEDIATED ANTI-TUMOR ACTIVITY INDUCED BY REISHI MUSHROOM POLYSACCHARIDES 审中-公开
标题翻译： REISHI蘑菇多糖诱导的抗体介导的抗肿瘤活性
公开(公告)号：WO2015026484A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/048325
申请日：2014-08-13
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , HSU, Hsien-Yeh , LIAO, Shih-Fen , LIANG, Chi-Hui
发明人： WONG, Chi-Huey , WU, Chung-Yi , HSU, Hsien-Yeh , LIAO, Shih-Fen , LIANG, Chi-Hui
IPC分类号： A61K31/715 , A61K31/736 , A61K36/074
CPC分类号： A61K39/0002 , A61K36/074 , A61K39/0011 , A61K2039/55572 , A61K2039/575
摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW = ~35kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-a-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain. Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.
摘要翻译：提供了包含FMS（来自ReishiF3的富含岩藻糖的多糖部分）的免疫原性组合物，癌症疫苗和用于治疗癌症的方法。组合物包含富含岩藻糖的灵芝多糖组分（FMS）MW =〜35kDa，其中FMS通过来自ReishiF3的尺寸排阻色谱分离，并且FMS包含主要具有选自1,4-甘露聚糖和1,6-己二醇骨架的多糖 -α-半乳聚糖，其中骨架连接到含末端岩藻糖的侧链上。提供了包含糖脂佐剂的免疫原性组合物。由本文公开的免疫原性组合物产生的抗体在细胞表面结合包含抗原Globo H，Globo H，Gb3，Gb4，Gb5（SSEA-3）和SSEA-4的癌细胞。

10. 发明申请

WO2014210564A1 GLYCAN CONJUGATES AND USE THEREOF 审中-公开
标题翻译： GLYCAN联合使用及其使用
公开(公告)号：WO2014210564A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044740
申请日：2014-06-27
申请人： ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , WANG, Chia-Hung , LI, Shiou-Ting
发明人： WONG, Chi-Huey , WU, Chung-Yi , WANG, Chia-Hung , LI, Shiou-Ting
IPC分类号： A61K31/70 , C07H1/00
CPC分类号： A61K39/095 , A61K31/715 , A61K39/385 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , A61K2039/55577 , A61K2039/6037 , A61K2039/627 , C07H1/00 , C07H15/04 , C07H15/18 , C08B37/006
摘要： Described herein are synthetic glycan conjugates comprising a carrier and a glycan moiety derived from Neisseria meningitidis, wherein the glycan moiety is covalently linked to the carrier through a linker. Also provided herein are a mixture of the glycan conjugates thereof, immmunogenic compositions thereof, and kits thereof. The invention further provides methods of using the synthetic glycan conjugates and immunogenic compositions thereof to treat and/or reduce the risk of infectious diseases such as bacterial infections.
摘要翻译：本文描述的是包含载体和衍生自脑膜炎奈瑟氏球菌的聚糖部分的合成聚糖缀合物，其中所述聚糖部分通过连接体共价连接至所述载体。本文还提供了其聚糖缀合物，其免疫原性组合物及其试剂盒的混合物。本发明还提供使用合成聚糖缀合物及其免疫原性组合物治疗和/或降低感染性疾病如细菌感染的风险的方法。

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