专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011031482A3 TREATMENT OF 'IQ MOTIF CONTAINING GTPASE ACTIVATING PROTEIN' (IQGAP) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IQGAP 审中-公开
标题翻译：通过抑制自然抗原转录到IQGAP来治疗“含有GTPASE激活蛋白”（IQGAP）相关疾病的IQ MOTIF
公开(公告)号：WO2011031482A3
公开(公告)日：2011-08-04
申请号：PCT/US2010046642
申请日：2010-08-25
申请人： OPKO CURNA LLC , COLLARD JOSEPH , KHORKOVA SHERMAN OLGA , COITO CARLOS
发明人： COLLARD JOSEPH , KHORKOVA SHERMAN OLGA , COITO CARLOS
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N15/52 , C12N15/63
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of 'IQ motif containing GTPase activating protein' (IQGAP), in particular, by targeting natural antisense polynucleotides of 'IQ motif containing GTPase activating protein' (IQGAP). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IQGAP.
摘要翻译：本发明涉及通过靶向含有GTP酶激活蛋白的IQ基因（IQGAP）的天然反义多核苷酸来调节“含有GTP酶活化蛋白”的IQ基序（IQGAP）的表达和/或功能的反义寡核苷酸。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与IQGAP表达相关的疾病和病症中的用途。

2. 发明申请

WO2011031482A2 TREATMENT OF 'IQ MOTIF CONTAINING GTPASE ACTIVATING PROTEIN' (IQGAP) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IQGAP 审中-公开
标题翻译：通过抑制IQGAP的天然反义转录物来治疗'含有GTP酶活化蛋白'（IQGAP）相关疾病的IQ MOTIF
公开(公告)号：WO2011031482A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/046642
申请日：2010-08-25
申请人： CURNA, INC. , COLLARD, Joseph , KHORKOVA SHERMAN, Olga , COITO, Carlos
发明人： COLLARD, Joseph , KHORKOVA SHERMAN, Olga , COITO, Carlos
IPC分类号： C12N15/113 , A61K48/00 , A61K31/7088 , C12N15/63 , C12N15/52
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of 'IQ motif containing GTPase activating protein' (IQGAP), in particular, by targeting natural antisense polynucleotides of 'IQ motif containing GTPase activating protein' (IQGAP). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IQGAP.
摘要翻译：本发明涉及调节'含有GTP酶活化蛋白的IQ基序'（IQGAP）的表达和/或功能的反义寡核苷酸，特别是通过靶向'IQ基序的天然反义多核苷酸 GTPase激活蛋白'（IQGAP）。本发明还涉及鉴定这些反义寡核苷酸及其在治疗与IQGAP表达相关的疾病和病症中的用途。

3. 发明申请

WO2011019815A2 TREATMENT OF ADIPONECTIN (ADIPOQ) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN ADIPONECTIN (ADIPOQ) 审中-公开
标题翻译：通过抑制ADIPONECTIN（ADIPOQ）自然抗原转录物治疗ADIPONECTIN（ADIPOQ）相关疾病
公开(公告)号：WO2011019815A2
公开(公告)日：2011-02-17
申请号：PCT/US2010/045168
申请日：2010-08-11
申请人： CURNA, INC. , COLLARD, Joseph , KHORKOVA SHERMAN, Olga
发明人： COLLARD, Joseph , KHORKOVA SHERMAN, Olga
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7088 , C12N15/1136 , C12N2310/113 , C12N2310/14 , C12N2310/31 , C12N2310/312 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2320/30 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/178
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Adiponectin (ADIPOQ), in particular, by targeting natural antisense polynucleotides of an Adiponectin (ADIPOQ). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Adiponectins (ADIPOQ)s.
摘要翻译：本发明涉及调节脂联素（ADIPOQ）的表达和/或功能的反义寡核苷酸，特别是通过靶向脂联素（ADIPOQ）的天然反义多核苷酸。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与脂联素（ADIPOQ）表达相关的疾病和病症中的用途。

4. 发明申请

WO2010053435A3 COMPOUNDS AND METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE CNS 审中-公开
标题翻译：化合物和方法用于治疗CNS的炎性疾病
公开(公告)号：WO2010053435A3
公开(公告)日：2010-07-08
申请号：PCT/SE2009051247
申请日：2009-11-04
申请人： INDEX PHARMACEUTICALS AB , BANDHOLTZ LISA CHARLOTTA , GIELEN ALEXANDER , ZARGARI AREZOU , VON STEIN OLIVER , AXELSSON LARS-GOERAN
发明人： BANDHOLTZ LISA CHARLOTTA , GIELEN ALEXANDER , ZARGARI AREZOU , VON STEIN OLIVER , AXELSSON LARS-GOERAN
IPC分类号： C12N15/117 , A61K31/7088 , A61P25/28
CPC分类号： C12N15/11 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/313 , C12N2310/315
摘要： Inflammatory diseases in the CNS can be treated or alleviated by the administration of an oligonucleotide in an amount sufficient to reduce the influx of mononuclear cells to the central nervous system by down-regulating the expression of at least one cell surface marker. For example multiple sclerosis can be treated or at least alleviated, by the administration of an oligonucleotide in a dose effective to inhibit or reduce the influx of mononuclear and/or autoaggressive cells to the central nervous system. The oligonucleotide can be used alone, or in combination with other treatment strategies.
摘要翻译：通过下调至少一种细胞表面标志物的表达，可以通过施用足以减少单核细胞向中枢神经系统的流入量的寡核苷酸来治疗或缓解CNS中的炎性疾病。例如，通过施用有效抑制或减少单核和/或自体突触细胞向中枢神经系统的流入的剂量的寡核苷酸，可以治疗或至少减轻多发性硬化症。寡核苷酸可以单独使用，或与其他治疗策略组合使用。

5. 发明申请

WO2010053433A1 INCREASED EXPRESSION OF SPECIFIC ANTIGENS 审中-公开
标题翻译：增加特异性抗原的表达
公开(公告)号：WO2010053433A1
公开(公告)日：2010-05-14
申请号：PCT/SE2009/051244
申请日：2009-11-03
申请人： INDEX PHARMACEUTICALS AB , KARLSSON, Åsa , BANDHOLTZ, Lisa, Charlotta , KOUZNETSOV, Nikolai , VON STEIN, Oliver , VON STEIN, Petra , ZARGARI, Arezou
发明人： KARLSSON, Åsa , BANDHOLTZ, Lisa, Charlotta , KOUZNETSOV, Nikolai , VON STEIN, Oliver , VON STEIN, Petra , ZARGARI, Arezou
IPC分类号： C12N15/117 , A61K31/7125 , A61P35/00 , A61P37/02 , A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： A61K45/06 , A61K31/7125 , A61K39/3955 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/313 , C12N2310/315 , A61K2300/00
摘要： The response of immunotherapy in the treatment of cancer is enhanced by use of an oligonucleotide in a dose effective to induce at least one of endogenous production of cytokines, and the regulation of the expression of one or more of the cell surface antigens (Figure 1).
摘要翻译：通过使用有效诱导细胞因子的内源性产生中的至少一种的剂量的寡核苷酸和调节一种或多种细胞表面抗原的表达来增强免疫治疗在癌症治疗中的应答（图1）。

6. 发明申请

WO2004097049A1 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA 审中-公开
标题翻译：用于清除RNA的寡核苷酸和核糖核酸
公开(公告)号：WO2004097049A1
公开(公告)日：2004-11-11
申请号：PCT/US2003/009808
申请日：2003-03-31
申请人： ISIS PHARMACEUTICALS, INC. , CROOKE, Stanley, T.
发明人： CROOKE, Stanley, T.
IPC分类号： C12Q1/68
CPC分类号： C12N15/1135 , C07H21/02 , C07H21/04 , C12N9/22 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/311 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/318 , C12N2310/321 , C12N2310/323 , C12N2310/3233 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuran-osyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulat-ing the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such a ribonuclease is referred to herein as a dsRNase, wherein "ds" indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.
摘要翻译：提供了包含寡核糖核苷酸和寡核糖核苷的寡聚化合物，其具有激活dsRNase的2'-戊酮呋喃 - 甲硅烷基核苷的亚序列。寡核糖核苷酸和寡核糖核苷可以包括用于增加对互补核酸链的结合亲和力的取代基以及用于增加核酸酶抗性的取代基。寡聚化合物可用于诊断和其他研究目的，用于调节生物体中蛋白质的表达，以及用于诊断，检测和治疗对寡核苷酸治疗敏感的其他病症。本发明还包括哺乳动物核糖核酸酶，即降解RNA的酶和这种核糖核酸酶的底物。这样的核糖核酸酶在本文中称为dsRNase，其中“ds”表示RNase对某些双链RNA底物的特异性。本文所述的dsR酶的人造底物可用于制备用于纯化哺乳动物核糖核酸酶以及非降解性RNA结合蛋白的亲和基质。

7. 发明申请

WO2004016805A9 IMMUNOSTIMULATORY NUCLEIC ACIDS 审中-公开
标题翻译：免疫球蛋白
公开(公告)号：WO2004016805A9
公开(公告)日：2004-08-19
申请号：PCT/US0325935
申请日：2003-08-19
申请人： COLEY PHARM GROUP INC , COLEY PHARM GMBH
发明人： KRIEG ARTHUR M , SAMULOWITZ ULRIKE , VOLLMER JOERG , UHLMANN EUGEN , JURK MARION , LIPFORD GRAYSON , RANKIN ROBERT
IPC分类号： A61K31/70 , A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/117 , C12Q1/00 , C12Q1/68 , C12Q
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译：本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。

8. 发明申请

WO2004044134A2 PHOSPHOROUS-LINKED OLIGOMERIC COMPOUNDS AND THEIR USE IN GENE MODULATION 审中-公开
标题翻译：磷酸二酯化合物及其在基因调控中的应用
公开(公告)号：WO2004044134A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035067
申请日：2003-11-04
申请人： ISIS PHARMACEUTICALS, INC. , BAKER, Brenda, F. , ELDRUP, Ann, B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanley, T. , PRAKASH, Thazha, P.
发明人： BAKER, Brenda, F. , ELDRUP, Ann, B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanley, T. , PRAKASH, Thazha, P.
IPC分类号： C12N
CPC分类号： C12N15/1135 , C07H21/02 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/311 , C12N2310/312 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/319 , C12N2310/321 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3517 , C12N2310/53 , C12N2310/3525 , C12N2310/3521
摘要： Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.
摘要翻译：提供了包含第一和第二寡核苷酸的寡核苷酸组合物，其中至少一部分第一寡核苷酸能够与至少一部分第二寡核苷酸杂交，第一寡核苷酸的至少一部分与选定的靶核酸，并且第一或第二寡核苷酸中的至少一个包含至少一个具有修饰的含磷核苷间键的核苷酸。还提供了寡核苷酸/蛋白质组合物，其包含与选定的靶核酸互补并且能够与选定的靶核酸杂交的寡核苷酸和至少一种包含至少一部分RNA诱导的沉默复合物（RISC）的蛋白质，其中至少一个核苷酸寡核苷酸具有修饰的含磷核苷键。

9. 发明申请

WO00024404A1 THIO-MODIFIED APTAMER SYNTHETIC METHODS AND COMPOSITIONS 审中-公开
标题翻译： THIO改性APTAMER合成方法和组合物
公开(公告)号：WO00024404A1
公开(公告)日：2000-05-04
申请号：PCT/US1999/024058
申请日：1999-10-26
IPC分类号： A61K38/00 , C07B61/00 , C07H21/00 , C12N15/10 , C12N15/115 , C12Q1/68 , A61K31/70 , B01D15/04 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12N15/115 , A61K38/00 , C07H21/00 , C12N15/1048 , C12N2310/313 , C12N2310/315 , C40B40/00
摘要： The present invention provides a method for concurrent achiral nucleotide modification and amplification using PCR. Provided by this method are NF-kB specific thioaptamers of novel sequence. This invention further provides methods of post-selection aptamer modification wherein one or more selected nucleotides of aptamers of known sequence are substituted with modified achiral nucleotides, particularly achiral thiophosphate nucleotides, wherein the substitution results in increased nuclease resistance while retaining binding efficiency and selectivity. Thiosubstitution of post-selection aptamers with specificity for the nuclear factor, NF- kappa B, produced in accordance with this method have increased binding affinity and specificity in addition to nuclease resistance. Also provided are methods for fractionating oligonucleotides depending on their degree of thiosubstitution by anion exchange chromatography.
摘要翻译：本发明提供了使用PCR进行同时进行的手性核苷酸修饰和扩增的方法。通过这种方法提供的是新型序列的NF-kB特异性硫胺素。本发明还提供了后选择适体修饰的方法，其中已知序列的适配体的一个或多个选定的核苷酸被修饰的非手性核苷酸，特别是非手性硫代磷酸核苷酸取代，其中取代导致增加的核酸酶抗性同时保持结合效率和选择性。根据该方法产生的对核因子NF-κB特异性的选择后适配子的硫取代取决于除核酸酶抗性之外还具有增加的结合亲和力和特异性。还提供了根据其通过阴离子交换色谱法进行硫代替换的程度来分级寡核苷酸的方法。

10. 发明申请

WO1998020168A1 ANTISENSE OLIGONUCLEOTIDES 审中-公开
标题翻译：反义寡核苷酸
公开(公告)号：WO1998020168A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020910
申请日：1997-11-03
申请人： DUKE UNIVERSITY
发明人： DUKE UNIVERSITY , MARKS, Jeffrey, R. , VAUGHN, James, P. , INGLEHART, James, D.
IPC分类号： C12Q01/68
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/313 , C12N2310/315 , C12Q1/6886
摘要： Oligonucleotides consisting of the nucleotide sequence US-3 [GGT GCT CAC TGC GGC (SEQ ID NO:2)] or UT-1 [TGC GGC TCC GGC CCC (SEQ ID NO:5)]. The oligonucleotides are useful as antisense oligonucleotides for inhibiting the expression of the ERBB2 tyrosine kinase receptor in a cell, in vitro or in vivo.
摘要翻译：由核苷酸序列US-3 [GGT GCT CAC TGC GGC（SEQ ID NO：2）]或UT-1 [TGC GGC TCC GGC CCC（SEQ ID NO：5）]组成的寡核苷酸。寡核苷酸可用作体外或体内抑制细胞中ERBB2酪氨酸激酶受体表达的反义寡核苷酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式