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1. 发明申请

WO2018213489A1 SYSTEMS, METHODS, AND DEVICES FOR ASSISTING OR PERFORMING GUIDED INTERVENTIONAL PROCEDURES USING INERTIAL MEASUREMENT UNITS AND MAGNETOMETER SENSORS 审中-公开
公开(公告)号：WO2018213489A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033025
申请日：2018-05-16
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTEMENT OF HEALTH & HUMAN SERVICES , XU, Sheng , WOOD, Bradford, J., Ph.D. , TSE, Tsz Ho
发明人： XU, Sheng , WOOD, Bradford, J., Ph.D. , TSE, Tsz Ho
IPC分类号： G01C21/16 , A61B17/17 , A61B17/34 , A61B90/11
摘要： An instrument tracker includes a case having an interior and exterior with a plurality of instrument seats, an inertial measurement unit (IMU), and a controller. The IMU and controller are arranged within the interior of the case and the controller is disposed in communication with the IMU and is responsive to instructions recorded on a memory to receive position information from the IMU, determine at least one of position and orientation of an instrument fixed relative to the case by the plurality of instrument seats using the position information received from the IMU, and transmit the at least one of position and orientation to a display device for displaying position and orientation of the instrument relative to a predetermined insertion path through a subject between an entry point on the surface of the subject and a region of interest within the interior of the subject. Instrument tracking systems and methods tracking position of instruments are also described.

2. 发明申请

WO2014152488A2 IMAGEABLE EMBOLIC MICROSPHERE 审中-公开
标题翻译：可塑胶囊微胶囊
公开(公告)号：WO2014152488A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/027395
申请日：2014-03-14
申请人： DREHER, Matthew, R. , WOOD, Bradford, J. , NEGUSSIE, Ayele, H. , LEWIS, Andrew, Leonard , TANG, Yiqing
发明人： DREHER, Matthew, R. , WOOD, Bradford, J. , NEGUSSIE, Ayele, H. , LEWIS, Andrew, Leonard , TANG, Yiqing
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead, The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with cheraotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译：本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。珠粒包含共价掺入到预先形成的水凝胶珠粒的聚合物网络中的含碘化合物。珠粒通过将预形成的氢键珠活化成亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备。不透射线的珠粒可以加载治疗剂，并用于栓塞增生组织或实体肿瘤的方法。

3. 发明申请

WO2009153723A1 METHOD AND SYSTEM FOR PERFORMING BIOPSIES 审中-公开
标题翻译：用于生物生产的方法和系统
公开(公告)号：WO2009153723A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052519
申请日：2009-06-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , XU, Sheng , KRUECKER, Jochen , SHECHTER, Guy , FARMER, Ian , CHOYKE, Peter, Lyle , PINTO, Peter , WOOD, Bradford, J.
发明人： XU, Sheng , KRUECKER, Jochen , SHECHTER, Guy , FARMER, Ian , CHOYKE, Peter, Lyle , PINTO, Peter , WOOD, Bradford, J.
IPC分类号： A61B19/00
CPC分类号： A61B8/4254 , A61B10/0233 , A61B34/20 , A61B2034/2051 , A61B2090/364 , A61B2090/374 , A61B2090/378
摘要： A method and system for performing biopsies can include an imaging system (190) for obtaining diagnostic images of a target region (200); a tracking system (100); a probe (75) having a deployable biopsy needle for performing a biopsy procedure where the tracking system generates tracking information for at least one of the probe and the biopsy needle; an ultrasound imaging system (50) for obtaining ultrasound imaging of the target region; and a computer (150) in communication with the tracking system, the imaging system and the ultrasound imaging system. The computer can register the tracking system with the imaging system. The computer transfers a marking (500) of a biopsy site associated with the biopsy procedure from the ultrasound imaging to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.
摘要翻译：用于进行活组织检查的方法和系统可以包括用于获得目标区域（200）的诊断图像的成像系统（190）; 跟踪系统（100）; 具有用于执行活检程序的可展开活检针的探针（75），其中所述跟踪系统生成所述探针和所述活检针中的至少一个的跟踪信息; 用于获得所述目标区域的超声成像的超声成像系统（50）以及与跟踪系统，成像系统和超声成像系统通信的计算机（150）。计算机可以使用成像系统注册跟踪系统。计算机根据跟踪信息和跟踪系统与诊断图像的配准，将与活检程序相关联的活检部位的标记（500）从超声成像传送到诊断图像。

4. 发明申请

WO0203873A3 RADIOFREQUENCY PROBES FOR TISSUE TREATMENT AND METHODS OF USE 审中-公开
标题翻译：用于组织治疗的无线电探测和使用方法
公开(公告)号：WO0203873A3
公开(公告)日：2002-05-10
申请号：PCT/US0120632
申请日：2001-06-28
申请人： US HEALTH , WOOD BRADFORD J
发明人： WOOD BRADFORD J
IPC分类号： A61B18/14 , A61B19/00
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61B2090/3925
摘要： A device and method for radiofrequency treatment of tissue is disclosed. The device includes an introducer, a plurality of RF electrodes positionable in a nondeployed state within the introducer, and an electrode advancement element. In the nondeployed state, the RF electrodes are contained within the introducer, and separated from the subject's tissue by a plug which substantially occludes the distal end of the introducer. In the method for RF tissue treatment, the introducer is introduced into the tissue of a subject. The RF electrodes are then positioned in the deployed state when the electrode advancement element advances the RF electrodes through the distal end of the introducer, thereby displacing the plug. The electrode advancement element may be a spring-loaded element, and may be actuated by a triggering device on the introducer. The introducer and the RF electrodes may be scored to enhance their visibility in medical imaging studies such as ultrasound, thereby helping to ensure optimal placement of the introducer and the RF electrodes.
摘要翻译：公开了一种用于组织射频治疗的装置和方法。该装置包括导引器，可在导引器内以非部署状态定位的多个RF电极和电极前进元件。在非部署状态下，RF电极被包含在导引器内，并且通过基本上封闭导引器的远端的插塞与被检者的组织分离。在用于RF组织处理的方法中，引入器被引入到受试者的组织中。然后当电极前进元件使RF电极通过引导器的远端前进时，RF电极被定位在展开状态，从而移位插头。电极推进元件可以是弹簧加载元件，并且可以由导引器上的触发装置来致动。可以对导引器和RF电极进行刻痕以增强其在诸如超声的医学成像研究中的可见性，从而有助于确保导引器和RF电极的最佳放置。

5. 发明申请

WO2014152488A3 IMAGEABLE EMBOLIC MICROSPHERE 审中-公开
标题翻译：可塑胶囊微胶囊
公开(公告)号：WO2014152488A3
公开(公告)日：2015-03-05
申请号：PCT/US2014027395
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译：本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。珠子通过将预形成的氢键珠活化成亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备。不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。

6. 发明申请

WO2014152488A8 IMAGEABLE EMBOLIC MICROSPHERE 审中-公开
标题翻译：可塑胶囊微胶囊
公开(公告)号：WO2014152488A8
公开(公告)日：2014-12-04
申请号：PCT/US2014027395
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译：本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。珠子通过将预形成的氢键珠活化成亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备。不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。

7. 发明申请

WO2004016155A3 APPARATUS FOR MULTIFOCAL DEPOSITION AND ANALYSIS AND METHODS FOR ITS USE 审中-公开
标题翻译：多功能沉积装置及其分析及其使用方法
公开(公告)号：WO2004016155A3
公开(公告)日：2004-08-12
申请号：PCT/US0325575
申请日：2003-08-14
申请人： GOVERNMENT OF US SECRETARY OF , BETH ISRAEL HOSPITAL , WOOD BRADFORD J , GORBACH ALEXANDER M , PERELMAN LEV T , HVIZDA JULIE , NEEMAN ZIV
发明人： WOOD BRADFORD J , GORBACH ALEXANDER M , PERELMAN LEV T , HVIZDA JULIE , NEEMAN ZIV
IPC分类号： A61B20060101 , A61B1/018 , A61B5/00 , A61B6/00 , A61B18/22 , A61B18/24
CPC分类号： A61B18/24 , A61B1/00167 , A61B1/018 , A61B5/0075 , A61B5/0084 , A61B2018/2211
摘要： An multifocal apparatus for delivering an agent to and/or gathering information about a biological tissue. The apparatus includes a catheter (24) having a catheter lumen extending longitudinally at least partially therethrough and a deployment port within the distal portion of the catheter. A plurality of extendable-retractable needles (15) are housed within the catheter lumen and, when deployed, extend through the deployment port. A needle may be solid or hollow and may deliver an agent to the tissue, include a mechanism for gathering information about the tissue, or both.
摘要翻译：一种用于将药剂递送到和/或收集有关生物组织的信息的多焦点装置。该装置包括导管（24），其具有至少部分地穿过其纵向延伸的导管内腔和在导管的远端部分内的展开口。多个可伸缩针（15）容纳在导管内腔内，并且当展开时延伸穿过展开口。针可以是固体或中空的并且可以将药剂递送到组织，包括用于收集关于组织的信息的机构，或两者。

8. 发明申请

WO2004016155A2 APPARATUS FOR MULTIFOCAL DEPOSITION AND ANALYSIS AND METHODS FOR ITS USE 审中-公开
标题翻译：多功能沉积装置及其分析及其使用方法
公开(公告)号：WO2004016155A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025575
申请日：2003-08-14
申请人： THE GOVERNMENT OF UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , BETH ISRAEL DEACONESS MEDICAL CENTER , WOOD, Bradford, J. , GORBACH, Alexander, M. , PERELMAN, Lev, T. , HVIZDA, Julie , NEEMAN, Ziv
发明人： WOOD, Bradford, J. , GORBACH, Alexander, M. , PERELMAN, Lev, T. , HVIZDA, Julie , NEEMAN, Ziv
IPC分类号： A61B
CPC分类号： A61B18/24 , A61B1/00167 , A61B1/018 , A61B5/0075 , A61B5/0084 , A61B2018/2211
摘要： An multifocal apparatus for delivering an agent to and/or gathering information about a biological tissue. The apparatus includes a catheter having a catheter lumen extending longitudinally at least partially therethrough and a deployment port within the distal portion of the catheter. A plurality of extendable-retractable needles are housed within the catheter lumen and, when deployed, extend through the deployment port. A needle may be solid or hollow and may deliver an agent to the tissue, include a mechanism for gathering information about the tissue, or both.
摘要翻译：一种用于将药剂递送到和/或收集有关生物组织的信息的多焦点装置。该装置包括导管，其具有至少部分地穿过其纵向延伸的导管内腔和在导管的远端部分内的展开口。多个可伸缩的针头容纳在导管内腔内，并且在展开时延伸穿过展开口。针可以是固体或中空的并且可以将药剂递送到组织，包括用于收集关于组织的信息的机构，或两者。

9. 发明申请

WO2010096806A1 METHODS FOR LOADING CONTRAST AGENTS INTO A LIPOSOME 审中-公开
标题翻译：将对比剂加载到脂质体中的方法
公开(公告)号：WO2010096806A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/025049
申请日：2010-02-23
申请人： DUKE UNIVERSITY , THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , DEWHIRST, Mark, W. , YARMOLENKO, Pavel , WOOD, Bradford, J. , DREHER, Matthew, R. , NEGUSSIE, Ayele, H.
发明人： DEWHIRST, Mark, W. , YARMOLENKO, Pavel , WOOD, Bradford, J. , DREHER, Matthew, R. , NEGUSSIE, Ayele, H.
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K49/1812
摘要： The invention comprises compositions and methods for loading both magnetic resonance contrast agents and therapeutic agents into liposomes, such as low temperature sensitive liposomes (LTSLs). In certain embodiments, a passive technique is used to load the liposomes. In other embodiments, an active technique is used to load the liposomes. In further embodiments, a magnetic resonance contrast agent and Doxorubicin are loaded into the liposomes. The liposome compositions have higher contrast-agent loadings and are more stable, than those known in the art.
摘要翻译：本发明包括将磁共振造影剂和治疗剂加载到脂质体如低温敏感性脂质体（LTSL）中的组合物和方法。在某些实施方案中，使用无源技术来加载脂质体。在其它实施方案中，使用活性技术来加载脂质体。在另外的实施方案中，将磁共振造影剂和多柔比星加载到脂质体中。脂质体组合物具有比本领域已知的更高的造影剂载量并且更稳定。

10. 发明申请

WO2010064154A1 FEEDBACK SYSTEM FOR INTEGRATING INTERVENTIONAL PLANNING AND NAVIGATION 审中-公开
标题翻译：用于整合传统规划和导航的反馈系统
公开(公告)号：WO2010064154A1
公开(公告)日：2010-06-10
申请号：PCT/IB2009/054923
申请日：2009-11-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , THE UNITED STATES OF AMERICA, as represented by the Secretary, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KRUECKER, Jochen , DALAL, Sandeep , XU, Sheng , WOOD, Bradford J.
发明人： KRUECKER, Jochen , DALAL, Sandeep , XU, Sheng , WOOD, Bradford J.
IPC分类号： A61B18/12 , A61B18/18 , A61N7/02 , A61B18/02
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1477 , A61B18/1815 , A61B34/20 , A61B2018/1425 , A61B2034/104 , A61B2034/107 , A61B2034/2051 , A61B2090/378 , A61N7/02
摘要： A therapy planning and image guidance and navigation for an interventional procedure are combined in one system. The system includes: a radiofrequency ablation therapy planning component (1) capable of creating an initial treatment plan, adjusting the treatment plan to take into account data received during a procedure and transferring a treatment plan to a navigation component, a navigation system component (2) to guide an ablation probe (6) and a feedback sub-system (3) for determining actual ablation probe positions/orientations and actual ablation size/shape via imaging (4) and/or tracking (5) systems, and enabling exchange of information between the planning component and the navigation component. By combining and integrating procedure planning and navigation, and by providing feedback from the navigation component back to the planning component about actual electrode position and orientation and ablation volume, complex procedures can be carried out more accurately, efficiently, and potentially with better clinical outcomes.
摘要翻译：介入程序的治疗计划和图像引导和导航结合在一个系统中。该系统包括：能够创建初始治疗计划的射频消融治疗计划组件（1），调整治疗计划以考虑在手术期间接收的数据并将治疗计划转移到导航部件，导航系统部件（2 以引导消融探针（6）和反馈子系统（3），用于通过成像（4）和/或跟踪（5）系统确定实际的消融探针位置/取向和实际消融尺寸/形状，并且使得能够交换计划组件与导航组件之间的信息。通过结合和整合程序规划和导航，并通过向导航组件提供关于实际电极位置和取向和消融量的规划组件的反馈，可以更准确，高效地，潜在地实现更好的临床结果。

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