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1. 发明申请

WO2019143685A1 METHODS AND COMPOSITIONS FOR TREATING PRE-ECLAMPSIA 审中-公开
公开(公告)号：WO2019143685A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/013800
申请日：2019-01-16
申请人： WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： SHARMA, Surendra
IPC分类号： A61K31/7016 , A61K31/7024
摘要： Methods and compositions using trehalose or a derivative or prodrug thereof for treating pre-eclampsia in a subject are disclosed.

2. 发明申请

WO2014036263A1 AN ACCURATE ANALYSIS TOOL AND METHOD FOR THE QUANTITATIVE ACOUSTIC ASSESSMENT OF INFANT CRY 审中-公开
标题翻译：婴儿CRY定量声学评估的精确分析工具及方法
公开(公告)号：WO2014036263A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057295
申请日：2013-08-29
申请人： BROWN UNIVERSITY , WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： SHEINKOPF, Stephen J. , LESTER, Barry M. , SILVERMAN, Harvey F.
IPC分类号： G06F17/00 , G06F17/14
CPC分类号： A61B5/4803 , A61B5/121 , A61B5/16 , A61B5/4076 , A61B5/7257 , A61B5/7275 , G10L17/26 , G10L25/18 , G10L25/66 , G10L25/78 , G10L25/90 , G10L2025/906
摘要： An automated infant cry analyzer with high accuracy to detect important acoustic features of cry is provided. The system's accuracy was rigorously tested and was compared to ground truth manual coding. The resulting methods and systems are applied to infant developmental disorders.
摘要翻译：提供了一种具有高精度的自动婴儿呼吸分析仪，用于检测呼吸的重要声学特征。系统的准确性进行了严格的测试，并与实地手工编码进行了比较。所产生的方法和系统适用于婴儿发育障碍。

3. 发明申请

WO2013032960A3 VITAMIN D RECEPTOR - COREGULATOR INHIBITORS 审中-公开
标题翻译：维生素D受体 - 调节剂抑制剂
公开(公告)号：WO2013032960A3
公开(公告)日：2013-09-12
申请号：PCT/US2012052416
申请日：2012-08-26
申请人： UWM RES FOUNDATION INC , SIDHU PREETPAL SINGH , NANDHIKONDA PREMCHENDAR , ARNOLD ALEXANDER E , SINGH RAKESH K , WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： SIDHU PREETPAL SINGH , NANDHIKONDA PREMCHENDAR , ARNOLD ALEXANDER E , SINGH RAKESH K
IPC分类号： C07D209/16 , A61K31/404 , A61P35/00 , C07D401/12 , C07D407/12
CPC分类号： C07D401/12 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , C07D209/16 , C07D407/12 , A61K2300/00
摘要： Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
摘要翻译：本文描述了用于抑制维生素D受体靶基因表达，抑制维生素D受体与至少一种维生素D受体共激活剂之间的相互作用，用于治疗受试者中的癌症以及用于抑制维生素D受体靶向基因中的血管生成的化合物，药物组合物和方法学科。

4. 发明申请

WO2007070494A3 HETEROCYCLES AND DERIVATIVES THEREOF AND METHODS OF MANUFACTURE AND THERAPEUTIC USE 审中-公开
公开(公告)号：WO2007070494A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/047320
申请日：2006-12-12
申请人： WOMEN & INFANTS HOSPITAL OF RHODE ISLAND , BRARD, Laurent , KALKUNTE, Satyan , SINGH, Rakesh, Kumar
发明人： BRARD, Laurent , KALKUNTE, Satyan , SINGH, Rakesh, Kumar
IPC分类号： A01N45/00 , A61K31/59
摘要： This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.

5. 发明申请

WO2022155322A1 METHODS FOR THE DETECTION AND TREATMENT OF PROTEINOPATHIES 审中-公开
公开(公告)号：WO2022155322A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012296
申请日：2022-01-13
申请人： WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： SHARMA, Surendra
IPC分类号： A61K31/00 , A61P25/00 , G01N33/68 , A61P25/14 , A61P25/28
摘要： The present disclosure relates in part to a blood-based method for the detection of a proteinopathy in a subject including, but not limited to, Alzheimer's disease (AD), mild cognitive impairment (MCI), and preeclampsia (PE), utilizing autophagy-deficient trophoblast (ADT) cells to sequester protein aggregates from the serum of said subject, and permit detection thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a proteinopathy in a subject by the administration of trehalose, a salt, solvate, stereoisomer, derivative, prodrug and or any mixture thereof.

6. 发明申请

WO2014070645A1 DETECTION AND TREATMENT OF PREGNANCY COMPLICATIONS 审中-公开
标题翻译：孕产妇的检测与治疗
公开(公告)号：WO2014070645A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067032
申请日：2013-10-28
申请人： BROWN UNIVERSITY , WOMEN & INFANTS' HOSPITAL OF RHODE ISLAND
发明人： SHARMA, Surendra , KALKUNTE, Satyan , JESCHKE, Udo
IPC分类号： G01N33/74
CPC分类号： G01N33/76 , A61K38/24 , G01N33/689 , G01N2400/10 , G01N2440/38 , G01N2800/368
摘要： Disclosed herein is a method of of identifying and/or addressing incipient preeclampsia in a patient-subject by the steps of by the steps of (a) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a said patient- subject at about 25 weeks of pregnancy or earlier; (b) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a pregnant non- preeclampsia one or more subjects at about 30 weeks of pregnancy or later, wherein said at least one sialyl Lewis antigen assay is for a sialyl Lewis antigen assayed in step (a) is and if more than one subject is assayed, averaging said results; and (c) managing said patient-subject for preeclampsia, if said level of at least one sialyl Lewis antigen of step (a) is at or greater than about 20% above the level of such silalyl Lewis antigen assayed in step (b).
摘要翻译：本文公开了一种通过以下步骤来鉴定和/或解决患者主体中初始先兆子痫的方法：（a）进行生物测定以确定所述患者受试者中至少一种唾液酸路易斯抗原的水平怀孕约25周或更早; （b）进行生物测定，以在妊娠非先兆子痫一个或多个受试者中怀孕或之后约30周确定至少一种唾液酸路易斯抗原的水平，其中所述至少一种唾液酸路易斯抗原测定法用于唾液酸路易斯在步骤（a）中测定的抗原是如果测定多于一个受试者，则对所述结果求平均值; 如果步骤（a）的至少一种唾液酸路易斯抗原的水平高于或高于步骤（b）中测定的这样的硅烷基路易斯抗原水平的约20％，则（c）管理所述患者受试者的先兆子痫。

7. 发明申请

WO2014039987A2 TREATMENT OF DISEASE USING INTER-ALPHA INHIBITOR PROTEINS 审中-公开
标题翻译：用ALPHA抑制蛋白治疗疾病
公开(公告)号：WO2014039987A2
公开(公告)日：2014-03-13
申请号：PCT/US2013058791
申请日：2013-09-09
申请人： PROTHERA BIOLOG INC , WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： LIM YOW-PIN , STONESTREET BARBARA
IPC分类号： A61K38/17
CPC分类号： A61K38/57
摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.
摘要翻译：本发明涉及治疗哺乳动物（例如人）中的医学病症（例如疾病和损伤）的方法，例如缺氧/缺血，烧伤和病毒感染（例如，流感，西尼罗病毒和登革热），在成人和儿童（如新生儿）中，通过施用包含IAIP的组合物。

8. 发明申请

WO2014039987A3 TREATMENT OF DISEASE USING INTER-ALPHA INHIBITOR PROTEINS 审中-公开
公开(公告)号：WO2014039987A3
公开(公告)日：2014-03-13
申请号：PCT/US2013/058791
申请日：2013-09-09
申请人： PROTHERA BIOLOGICS, INC. , WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： LIM, Yow-pin , STONESTREET, Barbara
IPC分类号： A61K38/57
摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

9. 发明申请

WO2013032960A2 VITAMIN D RECEPTOR - COREGULATOR INHIBITORS 审中-公开
标题翻译：维生素D受体 - 调理剂抑制剂
公开(公告)号：WO2013032960A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/052416
申请日：2012-08-26
申请人： UWM RESEARCH FOUNDATION, INC. , SIDHU, Preetpal, Singh , NANDHIKONDA, Premchendar , ARNOLD, Alexander, E. , SINGH, Rakesh, K. , WOMEN & INFANTS HOSPITAL OF RHODE ISLAND
发明人： SIDHU, Preetpal, Singh , NANDHIKONDA, Premchendar , ARNOLD, Alexander, E. , SINGH, Rakesh, K.
IPC分类号： C07D209/16 , C07D401/12 , C07D407/12 , A61K31/404 , A61P35/00
CPC分类号： C07D401/12 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , C07D209/16 , C07D407/12 , A61K2300/00
摘要： Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
摘要翻译：本文描述了用于抑制维生素D受体靶基因表达的化合物，药物组合物和方法，抑制维生素D受体和至少一种维生素D受体共激活因子之间的相互作用，用于治疗受试者中的癌症，以及用于抑制受试者中的血管生成学科。

10. 发明申请

WO2012170513A2 HE4 BASED THERAPY FOR MALIGNANT DISEASE 审中-公开
标题翻译： HE4基于恶性疾病的治疗方法
公开(公告)号：WO2012170513A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041080
申请日：2012-06-06
申请人： WOMEN & INFANTS' HOSPITAL OF RHODE ISLAND , MOORE, Richard, G. , SINGH, Rakesh, K.
发明人： MOORE, Richard, G. , SINGH, Rakesh, K.
IPC分类号： A61K38/17 , A61K38/22 , A61K39/395 , A61P35/00
CPC分类号： A61K33/24 , A61K31/337 , A61K31/4745 , A61K31/568 , A61K31/592 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K38/17 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K16/18 , C12N15/113 , G01N33/57484 , G01N33/57496 , G01N2333/811 , G01N2800/52 , A61K2300/00
摘要： The invention provides compositions and methods for utilizing human epididymal secretory protein E4 (HE4) in the prevention and treatment of cancer and other human diseases.
摘要翻译：本发明提供了利用人附睾分泌蛋白E4（HE4）预防和治疗癌症等人类疾病的组合物和方法。

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