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1. 发明申请

WO2011094170A1 PULSATILE PERI-CORNEAL DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2011094170A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022310
申请日：2011-01-25
申请人： ALCON RESEARCH, LTD. , WEINER, Alan L. , KABRA, Bhagwati P.
发明人： WEINER, Alan L. , KABRA, Bhagwati P.
IPC分类号： A61F9/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61N1/30
摘要： The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.
摘要翻译：本发明涉及脉动眼用角膜周围药物递送装置。该装置包括环形体和用于在延长的时间段内释放多个单独和不同剂量的治疗组合物的机构。

2. 发明申请

WO2008094989A2 PUNCTAL PLUGS AND METHODS OF DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：管状插管和递送治疗药物的方法
公开(公告)号：WO2008094989A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052439
申请日：2008-01-30
申请人： ALCON RESEARCH, LTD. , RODSTROM, Theron, R. , SMITH, II, Larry , TIAN, Youqin , MARSH, David, Allen , WEINER, Alan, L. , BAKSHI, Shivalik
发明人： RODSTROM, Theron, R. , SMITH, II, Larry , TIAN, Youqin , MARSH, David, Allen , WEINER, Alan, L. , BAKSHI, Shivalik
IPC分类号： A61K9/16
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/00781
摘要： The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.
摘要翻译：本发明涉及用于向眼睛持续释放药物的可植入眼部装置以及用于制造和使用这些装置的方法。在一个实施方案中，本发明提供了一种装置，其包括：（a）包含前列腺素和硅氧烷的基质的主体; （b）主体外表面上的聚对二甲苯涂层; 和（c）从聚对二甲苯涂层的外表面延伸到主体的外表面的一个或多个孔。

3. 发明申请

WO2007076454A1 PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKI) COMPOUNDS TO THE EYE 审中-公开
标题翻译：用于将受体酪氨酸激酶抑制（RTKI）化合物输送到眼睛的药物制剂
公开(公告)号：WO2007076454A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/062518
申请日：2006-12-21
申请人： ALCON, INC. , WEINER, Alan, L. , GHOSH, Malay , HAN, Wesley, Wehsin
发明人： WEINER, Alan, L. , GHOSH, Malay , HAN, Wesley, Wehsin
IPC分类号： A61K9/00 , A61K9/127 , A61K31/00 , A61K31/56 , A61K31/58 , A61K45/00 , A61K48/00
CPC分类号： A61K9/1271 , A61K9/0014 , A61K9/0048 , A61K9/08 , A61K9/127 , A61K31/00 , A61K31/192 , A61K31/375 , A61K31/416 , A61K31/56 , A61K31/565 , A61K31/573 , A61K31/58
摘要： The present invention relates to development of efficacious ophthalmic pharmaceutical compositions for treating ocular neovascularization comprising an active compound in a therapeutically effective amount encapsulated or solubilized in phospholipid vesicles.
摘要翻译：本发明涉及开发用于治疗眼新生血管形成的有效眼用药物组合物，其包含以包封或溶解于磷脂囊泡中的治疗有效量的活性化合物。

4. 发明申请

WO2007024369A2 OPHTHALMIC INJECTOR 审中-公开
公开(公告)号：WO2007024369A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/027955
申请日：2006-07-19
申请人： ALCON MANUFACTURING, LTD. , MARSH, David A. , RODSTROM, Theron R. , WEINER, Alan L.
发明人： MARSH, David A. , RODSTROM, Theron R. , WEINER, Alan L.
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F9/0017 , A61F9/007 , A61F9/00781 , A61M5/445 , A61M2205/3653 , A61M2210/0612
摘要： An ophthalmic injector having a nose cone with a heating chamber, a heater assembly, and a needle that provide improved drug delivery.
摘要翻译：一种具有具有加热室的鼻锥体，加热器组件和提供改善的药物递送的针的眼科注射器。

5. 发明申请

WO2010101758A1 PERI-CORNEAL DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2010101758A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025335
申请日：2010-02-25
申请人： ALCON RESEARCH, LTD. , RODSTROM, Theron R. , MARSH, David A. , WEINER, Alan L. , SMITH II, Larry , WAX, Martin B.
发明人： RODSTROM, Theron R. , MARSH, David A. , WEINER, Alan L. , SMITH II, Larry , WAX, Martin B.
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： The present invention is directed to an ophthalmic peri-corneal drug delivery device. The device includes a core of matrix material and therapeutic agent and a coating over the core. One or more opening[s] extend through the coating to provide for release of the drug to the eye. Moreover, the device is designed to lay atop the external surface of the eye.
摘要翻译：本发明涉及眼用角膜周围药物递送装置。该装置包括基质材料和治疗剂的核心以及核心上的涂层。一个或多个开口延伸穿过涂层以提供药物释放到眼睛。此外，该设备被设计成放置在眼睛的外表面上方。

6. 发明申请

WO2009086097A1 INTRAOCULAR IRRIGATING SOLUTIONS COMPRISING HISTIDINE AND METHODS FOR TREATING CORNEAL EDEMA 审中-公开
标题翻译：包括病史的肠内灌注解决方案和治疗脊髓损伤的方法
公开(公告)号：WO2009086097A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087670
申请日：2008-12-19
申请人： ALCON RESEARCH, LTD. , SHAH, Mandar, V. , BULLOCK, Joseph, Paul , WEINER, Alan, L. , DOLLINGER, Harli
发明人： SHAH, Mandar, V. , BULLOCK, Joseph, Paul , WEINER, Alan, L. , DOLLINGER, Harli
IPC分类号： A61K31/4172 , A61P27/02 , A61K9/00
CPC分类号： A61K9/0048 , A61K31/4172
摘要： One aspect of the present invention relates to methods of treating corneal edema comprising contacting a cornea with an ophthalmic irrigating composition comprising histidine. In certain embodiments, the ophthalmic irrigating compositions contact the corneal endothelium. Another aspect of the present invention relates to ophthalmic irrigating compositions for treating corneal edema comprising histidine and optionally, calcium glycerophosphate and/or glutathione disulfide.
摘要翻译：本发明的一个方面涉及治疗角膜水肿的方法，包括使角膜与包含组氨酸的眼用冲洗组合物接触。在某些实施方案中，眼用冲洗组合物接触角膜内皮。本发明的另一方面涉及用于治疗角膜水肿的眼用冲洗组合物，其包含组氨酸和任选的甘油磷酸钙和/或二硫化谷胱甘肽。

7. 发明申请

WO2009086073A1 STABILIZED GLYCEROPHOSPHATE-CONTAINING SURGICAL IRRIGATING SOLUTION 审中-公开
标题翻译：稳定的含有糖苷酸盐的手术灌注溶液
公开(公告)号：WO2009086073A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087631
申请日：2008-12-19
申请人： ALCON RESEARCH, LTD. , SHAH, Mandar, V. , BULLOCK, Joseph, Paul , WEINER, Alan, L. , DOLLINGER, Harli , PATEL, Simaben B.
发明人： SHAH, Mandar, V. , BULLOCK, Joseph, Paul , WEINER, Alan, L. , DOLLINGER, Harli , PATEL, Simaben B.
IPC分类号： A61K9/00 , A61K9/08 , A61K31/19 , A61K47/02 , A61K47/12 , A61K47/24
CPC分类号： A61K31/19 , A61K9/0048 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/24
摘要： One aspect of the present invention relates to stabilized irrigating compositions comprising sodium glycerophosphate and/or calcium glycerophosphate, and a bicarbonate salt. Another aspect of the present invention relates to methods of irrigating ocular tissues during a surgical procedure comprising bathing the intraocular tissues with an irrigating composition comprising sodium glycerophosphate and/or calcium glycerophosphate, and a bicarbonate salt.
摘要翻译：本发明的一个方面涉及包含甘油磷酸钠和/或甘油磷酸钙和碳酸氢盐的稳定的冲洗组合物。本发明的另一方面涉及在手术过程中冲洗眼组织的方法，包括用包含磷酸甘油钠和/或甘油磷酸钙和碳酸氢盐的冲洗组合物洗涤眼内组织。

8. 发明申请

WO2006058109A1 TRIPLE NATURAL POLYMER VISCOELASTIC COMPOSITION 审中-公开
标题翻译：三重自由聚合物粘弹性组合物
公开(公告)号：WO2006058109A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/042523
申请日：2005-11-22
申请人： ALCON, INC. , JAFARI, Masoud, R. , MARKWARDT, Kerry, L. , WEINER, Alan, L.
发明人： JAFARI, Masoud, R. , MARKWARDT, Kerry, L. , WEINER, Alan, L.
IPC分类号： A61K9/08 , A61K31/728 , A61K31/726 , A61K47/36
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K31/7008 , A61K31/728 , A61K31/737 , A61L24/0031 , A61L24/043 , A61L2430/16 , C08L5/08
摘要： A triple natural polymer viscoelastic composition is disclosed. By combining glucosamine sulfate ("GS"), sodium hyaluronate ("HA") and chondroitin sulfate ("CS"), the triple natural polymer viscoelastic compositions of this invention can provide a viscoelastic agent at a surgical site that not only serves as a protective agent to ocular tissues, but that can also act as an agent to alleviate pain and inflammation associated with ocular surgery. Embodiments of this invention can comprise GS combined with existing HA/CS viscoelastic agents. Embodiments of this invention can also comprise GS and CS in combination with an irrigation solution. Further, to enhance retention time at the site of an intra-articulate application of an embodiment of this invention, the following biodegradable polymers may also be included in an embodiment of the compositions of the present invention: cellulose derivatives (e.g., hydroxypropylmethylcellulose, ethylcellulose, caboxymethylcellulose, etc.), carbopol, citosan, and collagen.
摘要翻译：公开了一种三重天然聚合物粘弹性组合物。通过结合葡糖胺硫酸盐（“GS”），透明质酸钠（“HA”）和硫酸软骨素（“CS”），本发明的三重天然聚合物粘弹性组合物可以在手术部位提供粘弹性剂，其不仅用作保护剂可用于眼组织，但也可作为缓解与眼部手术相关的疼痛和炎症的药剂。本发明的实施方案可以包含GS与现有HA / CS粘弹剂的组合。本发明的实施方案还可以包括与灌洗溶液组合的GS和CS。此外，为了增强在本发明的实施方式的关节内应用的部位的保留时间，以下生物可降解聚合物也可以包括在本发明组合物的一个实施方案中：纤维素衍生物（例如羟丙基甲基纤维素，乙基纤维素，甲氧基甲基纤维素等），卡波朋酚，柠檬酸和胶原蛋白。

9. 发明申请

WO9501764A3 OCULAR INSERT WITH ANCHORING PROTRUSIONS 审中-公开
标题翻译：具有锚定推理的OCULAR插入
公开(公告)号：WO9501764A3
公开(公告)日：1995-03-02
申请号：PCT/US9407136
申请日：1994-06-20
申请人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
发明人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. As shown in Figure 7, the device (70) with ribbed configuration has circular cylindrical walls (72) with domed end portions (74). A series of arcuate shaped ribs (76), of circular, toroidal cross section, are provided at intervals along the length of the device (70).

10. 发明申请

WO2010078063A1 IN-SITU REFILLABLE OPHTHALMIC IMPLANT 审中-公开
公开(公告)号：WO2010078063A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/068613
申请日：2009-12-18
申请人： ALCON RESEARCH, LTD. , WEINER, Alan L.
发明人： WEINER, Alan L.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： The present invention is directed to an in-situ refillable ophthalmic implant (10) having a refill port (28) in communication with a reservoir (14) and a release control mechanism (24). The present invention also relates to methods of forming and using the ophthalmic implant. Preferably, the control release mechanism include opening [s] (50) providing for passive passage of pharmaceutical ophthalmic composition, particularly therapeutic agent, out of the reservoir, through the opening [s] and into the eye.
摘要翻译：本发明涉及一种具有与储液器（14）和释放控制机构（24）连通的再填充口（28）的原位可再充注眼科植入物（10）。本发明还涉及形成和使用眼科植入物的方法。优选地，控制释放机构包括提供药物眼用组合物，特别是治疗剂从储存器中通过开口被静脉通过并进入眼睛的开口（50）。

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