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1. 发明申请

WO9501764A3 OCULAR INSERT WITH ANCHORING PROTRUSIONS 审中-公开
标题翻译：具有锚定推理的OCULAR插入
公开(公告)号：WO9501764A3
公开(公告)日：1995-03-02
申请号：PCT/US9407136
申请日：1994-06-20
申请人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
发明人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. As shown in Figure 7, the device (70) with ribbed configuration has circular cylindrical walls (72) with domed end portions (74). A series of arcuate shaped ribs (76), of circular, toroidal cross section, are provided at intervals along the length of the device (70).

2. 发明申请

WO2008094989A3 PUNCTAL PLUGS AND METHODS OF DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：管状插管和递送治疗药物的方法
公开(公告)号：WO2008094989A3
公开(公告)日：2009-04-30
申请号：PCT/US2008052439
申请日：2008-01-30
申请人： ALCON RES LTD , RODSTROM THERON R , SMITH II LARRY , TIAN YOUQIN , MARSH DAVID ALLEN , WEINER ALAN L , BAKSHI SHIVALIK
发明人： RODSTROM THERON R , SMITH II LARRY , TIAN YOUQIN , MARSH DAVID ALLEN , WEINER ALAN L , BAKSHI SHIVALIK
IPC分类号： A61P27/06
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/00781
摘要： The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.
摘要翻译：本发明涉及用于向眼睛持续释放药物的可植入眼部装置以及用于制造和使用这些装置的方法。在一个实施方案中，本发明提供了一种装置，其包括：（a）包含前列腺素和硅氧烷的基质的主体; （b）主体外表面上的聚对二甲苯涂层; 和（c）从聚对二甲苯涂层的外表面延伸到主体的外表面的一个或多个孔。

3. 发明申请

WO0018316A3 SUSTAINED RELEASE, AND COMFORTABLE OPHTHALMIC COMPOSITION AND METHOD FOR OCULAR THERAPY 审中-公开
标题翻译：可持续发布和易于使用的眼科组合物和方法进行眼科治疗
公开(公告)号：WO0018316A3
公开(公告)日：2000-11-16
申请号：PCT/US9921957
申请日：1999-09-22
申请人： ALCON LAB INC , CASTILLO ERNESTO J , SARKAR RUMA , SINGH ONKAR N , WEINER ALAN L , YARBOROUGH CODY
发明人： CASTILLO ERNESTO J , SARKAR RUMA , SINGH ONKAR N , WEINER ALAN L , YARBOROUGH CODY
IPC分类号： A61K47/30 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/138 , A61K31/5575 , A61K45/00 , A61K47/04 , A61K47/10 , A61K47/18 , A61P27/02 , A61K31/78
CPC分类号： A61K9/0048 , Y10S514/912
摘要： Disclosed are reduced stinging, sustained release ophthalmic formulations. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when in need thereof.
摘要翻译：公开了减少刺激性持续释放的眼用制剂。还公开了治疗方法，包括当需要时将这些制剂局部施用于眼睛。

4. 发明申请

WO2007024369A3 OPHTHALMIC INJECTOR 审中-公开
公开(公告)号：WO2007024369A3
公开(公告)日：2009-01-15
申请号：PCT/US2006027955
申请日：2006-07-19
申请人： ALCON RES LTD , MARSH DAVID A , RODSTROM THERON R , WEINER ALAN L
发明人： MARSH DAVID A , RODSTROM THERON R , WEINER ALAN L
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F9/0017 , A61F9/007 , A61F9/00781 , A61M5/445 , A61M2205/3653 , A61M2210/0612
摘要： An ophthalmic injector having a nose cone with a heating chamber, a heater assembly, and a needle that provide improved drug delivery.
摘要翻译：一种具有具有加热室的鼻锥体，加热器组件和提供改善的药物递送的针的眼科注射器。

5. 发明申请

WO2007047744A2 METHOD FOR TREATING PRIMARY AND SECONDARY FORMS OF GLAUCOMA 审中-公开
标题翻译：用于处理GLAUCOMA的主要和次要形式的方法
公开(公告)号：WO2007047744A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040683
申请日：2006-10-13
申请人： ALCON INC , ROBIN ALAN L , WEINER ALAN L , MARSH DAVID ALLEN
发明人： ROBIN ALAN L , WEINER ALAN L , MARSH DAVID ALLEN
CPC分类号： A61K9/0051 , A61K9/0048 , A61K9/10 , A61K9/5005 , A61K31/542 , A61K31/5575 , A61K31/57 , A61K31/573
摘要： Methods and compositions for controlling ocular hypertension associated with (i) primary open angle glaucoma (POAG), (ii) other forms of glaucoma, or (iii) glucocorticoid therapy are disclosed. The methods involve administration of angiostatic agents and other IOP-lowering agents via local injections in the anterior segment of the eye. The most preferred IOP-lowering agents are angiostatic steroids, particularly anecortave acetate, and the most preferred route of administration is an anterior juxtascleral injection or implant. The invention is based in part on the discovery that anterior juxtascleral injections of anecortave acetate are capable of controlling intraocular pressure for sustained periods of from one to several months or more. This result is believed to be attributable to facilitation of access of the anecortave acetate to the trabecular meshwork via the anterior juxtascleral route of administration. This route of administration is also believed to be advantageous for other types of IOP-lowering agents, particularly molecules that cannot readily penetrate the cornea due to size or other physical properties.
摘要翻译：公开了用于控制与（i）原发性开角型青光眼（POAG），（ii）其他形式的青光眼或（iii）糖皮质激素治疗）相关的高眼压症的方法和组合物。该方法包括通过局部注射在眼前段施用血管抑制剂和其它降低IOP的药剂。最优选的降低IOP的药物是血管抑制类固醇，特别是醋酸醋酸酯，并且最优选的给药途径是前交联注射或植入物。本发明部分基于以下发现：醋酸前列腺素的前交联注射能够在一至几个月或更长时间内控制眼内压。据认为，这一结果可归因于通过前交替施用途径来促进醋酸阿那替托通入小梁网。也认为这种给药途径对于其它类型的降低IOP的药剂是有利的，特别是由于大小或其它物理性质而不能容易地渗入角膜的分子。

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