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1. 发明申请

WO0015809A3 URACIL PERMEASE FROM ARABIDOPSIS AS HERBICIDAL TARGET GENE 审中-公开
标题翻译：作为除草目标基因的阿拉伯半乳糖的尿素
公开(公告)号：WO0015809A3
公开(公告)日：2000-06-29
申请号：PCT/EP9906766
申请日：1999-09-13
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , LEVIN JOSHUA ZVI , POTTER SHARON LEE , BUDZISZEWSKI GREGORY JOSEPH , WARD ERIC RUSSELL , BERNASCONI PAUL
发明人： LEVIN JOSHUA ZVI , POTTER SHARON LEE , BUDZISZEWSKI GREGORY JOSEPH , WARD ERIC RUSSELL , BERNASCONI PAUL
IPC分类号： A01H5/00 , A01N63/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12Q1/02 , C12Q1/25 , C12Q1/68 , C12R1/91 , C12N15/82
CPC分类号： C12N9/00 , C12Q1/6895
摘要： The invention relates to a gene isolated from Arabidopsis that codes for a protein essential for seedling growth. The invention also includes the methods of using this protein to discover new herbicides, based on the essentiality of the gene for normal growth and development. The invention can also be used in a screening assay to identify inhibitors that are potential herbicides. The invention is also applied to the development of herbicide tolerant plants, plant tissues, plant seeds, and plant cells.
摘要翻译：本发明涉及从拟南芥分离的基因，其编码对于幼苗生长必需的蛋白质。本发明还包括基于用于正常生长和发育的基因的必需性使用该蛋白质发现新的除草剂的方法。本发明还可用于筛选测定以鉴定潜在除草剂的抑制剂。本发明还适用于除草剂耐受性植物，植物组织，植物种子和植物细胞的开发。

2. 发明申请

WO1998003536A1 CHEMICALLY-INDUCIBLE ARABIDOPSIS PR-1 PROMOTER 审中-公开
标题翻译：化学诱导性ARABIDOPSIS PR-1 PROMOTER
公开(公告)号：WO1998003536A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012626
申请日：1997-07-18
申请人： NOVARTIS CORPORATION , LEBEL, Edouard, Guillaume , RYALS, John, Andrew , THORNE, Leigh , UKNES, Scott, Joseph , WARD, Eric, Russell
发明人： NOVARTIS CORPORATION
IPC分类号： C07H21/04
CPC分类号： C12N15/8238 , C07K14/415
摘要： The nucleic acid sequence of the full-length, chemically inducible Arabidopsis PR-1 promoter has been discovered and is disclosed herein. Furthermore, cis-acting regulatory elements in the Arabidopsis PR-1 promoter involved in chemical induction have been characterized using deletion and linker-scanning mutagenesis and in vivo footprinting. It has been discovered that at least a portion of the region of promoter between positions -698 and -621 (relative to the transcription start site of the PR-1 gene) is required for induction of gene expression by chemicals. Two 10-bp linker-scanning mutations centered at 640-bp and 610-bp upstream from the transcription start site abolish the inducibility of the promoter while another 10-bp mutation centered at -670 bp results in average induced expression levels 4-fold higher than the unmutated promoter. Additionally, inducible in vivo footprints are located at positions -629 and -628 and at position -604 on the coding strand and at position -641 on the non-coding strand. The use of chemically inducible Arabidopsis PR-1 promoter fragments to regulate gene expression in plants in the presence of inducing chemicals such as SA, INA, and BTH is disclosed, as well as the use of these elements for the isolation of transcriptional regulatory proteins involved in the promoter regulation and for the construction of inducible hybrid promoters.
摘要翻译：已经发现了全长化学诱导型拟南芥PR-1启动子的核酸序列，并在此公开。此外，参与化学诱导的拟南芥PR-1启动子中的顺式作用调节元件已经使用缺失和连接物扫描诱变和体内足迹进行表征。已经发现，通过化学物质诱导基因表达需要至少部分-698和-621位点之间的启动子区域（相对于PR-1基因的转录起始位点）。以转录起始位点上游640-bp和610-bp为中心的两个10-bp接头扫描突变消除了启动子的诱导性，而另一个以-670bp为中心的10-bp突变导致平均诱导的表达水平高4倍比未突变的启动子。此外，可诱导的体内足迹位于编码链上的位置-629和-628，位置-604位于非编码链上-641位。公开了使用化学诱导型拟南芥PR-1启动子片段在诱导化学物质如SA，INA和BTH存在下调节植物中的基因表达，以及这些元件用于分离涉及转录调节蛋白的用途在启动子调节和诱导型杂合启动子的构建中。

3. 发明申请

WO1995034659A1 MANIPULATION OF PROTOPORPHYRINOGEN OXIDASE ENZYME ACTIVITY IN EUKARYOTIC ORGANISMS 审中-公开
标题翻译：原核生物有机体中原生质体氧化酶酶活性的操作
公开(公告)号：WO1995034659A1
公开(公告)日：1995-12-21
申请号：PCT/IB1995000452
申请日：1995-06-08
申请人： CIBA-GEIGY AG , WARD, Eric, Russell , VOLRATH, Sandra
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/53
CPC分类号： C12Y103/03004 , C12N5/04 , C12N9/001 , C12N15/8274 , C12Q1/6895
摘要： The present invention provides novel eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant. Plants having altered protox activity which confers tolerance to herbicides are also provided. These plants may be bred or engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or through increased levels of expression of the native protox gene, or they may be transformed with modified eukaryotic or prokaryotic protox coding sequences or wild type prokaryotic protox sequences which are herbicide tolerant. Diagnostic and other uses for the novel eukaryotic protox sequence are also described. Plant genes encoding wild-type and altered protox, purified plant protox, methods of isolating protox from plants, and methods of using protox-encoding genes are also disclosed.
摘要翻译：本发明提供编码天然原卟啉原氧化酶（protox）或耐除草剂的酶的修饰形式的新型真核DNA序列。还提供了赋予除草剂耐受性的具有改变的排毒活性的植物。这些植物可以通过将天然protox基因突变为抗性形式或通过增加天然protox基因的表达水平培育或设计用于抵抗前毒素抑制剂，或者可以用经修饰的真核或原核protox编码序列或野生型类型的原核生殖毒素序列是耐除草剂。还描述了用于新型真核毒素序列的诊断和其它用途。还公开了编码野生型和改变的protox的植物基因，纯化的植物protox，从植物中分离protox的方法，以及使用protox编码基因的方法。

4. 发明申请

WO9967402A3 METHODS TO SCREEN HERBICIDAL COMPOUNDS UTILIZING AIR SYNTHETASE FROM ARABIDOPSIS THALIANA 审中-公开
标题翻译：筛选利用沙门氏菌的空气合成酶的除草化合物的方法
公开(公告)号：WO9967402A3
公开(公告)日：2000-03-09
申请号：PCT/EP9904309
申请日：1999-06-22
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , WARD ERIC RUSSELL , GUYER CHARLES DAVID , POTTER SHARON LEE , SUBRAMANIAN VENKITESWARAN , WALTERS ERIC
发明人： WARD ERIC RUSSELL , GUYER CHARLES DAVID , POTTER SHARON LEE , SUBRAMANIAN VENKITESWARAN , WALTERS ERIC
IPC分类号： A01H5/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N15/09 , C12N15/52 , C12N15/82 , C12Q1/02 , C12Q1/25 , G01N33/15 , G01N33/50
CPC分类号： C12N9/93 , C12N15/52 , C12N15/8274
摘要： The present invention discloses methods to screen chemicals for herbicidal activity using recombinantly produced enzymes having AIR synthetase activity, and the use thereby to identify herbicidal chemicals to suppress the growth of undesired vegetation. Furthermore, the present invention provides methods for the development of herbicide tolerance in plants, plant tissues, plant seeds, and plant cells using genes encoding enzymes having AIR synthetase activity, and methods of using such transgenic plants to selectively suppress weed growth in crop fields.
摘要翻译：本发明公开了使用具有AIR合成酶活性的重组产生的酶来筛选化学物质除草活性的方法，以及由此鉴定除草化学物质以抑制不需要的植物生长的方法。此外，本发明提供了使用编码具有AIR合成酶活性的酶的基因的植物，植物组织，植物种子和植物细胞中除草剂耐受性发展的方法，以及使用这些转基因植物选择性抑制作物田中杂草生长的方法。

5. 发明申请

WO9938986A3 RIBOFLAVIN BIOSYNTHESIS GENES FROM PLANTS AND USES THEREOF 审中-公开
标题翻译： RIBOFLAVIN植物的生物合成基因及其用途
公开(公告)号：WO9938986A3
公开(公告)日：1999-09-23
申请号：PCT/EP9900556
申请日：1999-01-28
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , GUYER CHARLES DAVID , JOHNSON MARIE ANN , VOLRATH SANDRA LYNN , BRUNN SANDRA ALICE , WARD ERIC RUSSELL
发明人： GUYER CHARLES DAVID , JOHNSON MARIE ANN , VOLRATH SANDRA LYNN , BRUNN SANDRA ALICE , WARD ERIC RUSSELL
IPC分类号： A01H5/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/14 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/1085 , C12N9/14 , C12N15/8243 , C12N15/8274
摘要： The present invention provides plant riboflavin biosynthesis genes, including a gene that encodes the beta subunit of the plant riboflavin synthase enzyme complex (lumazine synthase) and a gene that encodes the bifunctional enzyme GTP cyclohydrolase II/DHBP synthase. Also disclosed are the recombinant production of these plant riboflavin biosynthesis enzymes in heterologous hosts, screening chemicals for herbicidal activity using these recombinantly produced enzymes, and the use of thereby identified herbicidal chemicals to suppress the growth of undesired vegetation. Furthermore, the present invention provides methods for the development of herbicide tolerance in plants, plant tissues, plant seeds and plant cells using the riboflavin biosynthesis genes of the invention.
摘要翻译：本发明提供植物核黄素生物合成基因，其包括编码植物核黄素合酶酶复合物（lumazine synthase）的β亚基的基因和编码双功能酶GTP环化水解酶II / DHBP合酶的基因。还公开了在异源宿主中重组生产这些植物核黄素生物合成酶，使用这些重组产生的酶筛选化学物质除草活性，以及使用由此鉴定的除草化学物质来抑制不需要的植物的生长。此外，本发明提供使用本发明的核黄素生物合成基因在植物，植物组织，植物种子和植物细胞中发展除草剂耐受性的方法。

6. 发明申请

WO1996018739A1 PLANT ADENYLOSUCCINATE LYASE AND DNA CODING THEREFOR 审中-公开
标题翻译：植物腺苷酸和其编码的DNA
公开(公告)号：WO1996018739A1
公开(公告)日：1996-06-20
申请号：PCT/EP1995004796
申请日：1995-12-06
申请人： CIBA-GEIGY AG , GUYER, Charles, David , WARD, Eric, Russell
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/60
CPC分类号： C12N9/88 , C12N15/8274
摘要： The present invention provides novel plant DNA sequences coding for native adenylosuccinate lyase (ADSL). Methods for using the complete or partial ADSL coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of transformed host cells capable of expressing ADSL is also taught. Methods of using the transformed host cells are taught, including methods for recombinant production of ADSL enzymes. A method for using the plant ADSL enzyme to screen for inhibitors of ADSL activity is also provided.
摘要翻译：本发明提供编码天然腺淀粉琥珀酸裂合酶（ADSL）的新型植物DNA序列。教导了使用完整或部分ADSL编码序列作为诊断，绘图和其他目的探针的方法。还教导了能够表达ADSL的转化的宿主细胞的产生。教导使用转化的宿主细胞的方法，包括重组生产ADSL酶的方法。还提供了使用植物ADSL酶筛选ADSL活性抑制剂的方法。

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