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1. 发明申请

WO2012129115A3 MATERIALS AND METHODS FOR PROFILING MICRORNAS 审中-公开
标题翻译：用于分析MICRORNAS的材料和方法
公开(公告)号：WO2012129115A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029522
申请日：2012-03-16
申请人： UNIV SOUTH FLORIDA , MOHAPATRA SHYAM S , WANG JIA-WANG
发明人： MOHAPATRA SHYAM S , WANG JIA-WANG
IPC分类号： C12Q1/68 , C12N15/11 , C12Q1/48
CPC分类号： C12Q1/6851 , C12Q1/6876 , C12Q2525/161 , C12Q2525/173 , C12Q2525/207
摘要： The present invention provides materials and methods for detecting, quantifying, and/or high-throughput -profiling microRNAs. Advantageously, the present invention is more sensitive and specific than other currently-available miRNA qPCR assays. In addition, the present invention is convenient, easy-to-perform, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of all miRNAs, a universal reverse primer for PGR amplification reaction, and universal probes. In another embodiment, the present invention provides assays that allow simultaneous detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction.
摘要翻译：本发明提供了用于检测，量化和/或高通量 - 形成微RNA的材料和方法。有利地，本发明比其他目前可用的miRNA qPCR测定更灵敏和特异。另外，本发明方便，易于执行并且成本有效。在一个实施方案中，本发明提供了用于所有miRNA的逆转录的通用引物，用于PGR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供了允许使用单一逆转录反应同时检测和/或定量多个靶miRNA的测定。

2. 发明申请

WO2008157790A3 PULSED LASERS IN FREQUENCY DOMAIN DIFFUSE OPTICAL TOMOGRAPHY AND SPECTROSCOPY 审中-公开
标题翻译：频率范围内的脉冲激光光学光学和光谱学
公开(公告)号：WO2008157790A3
公开(公告)日：2009-02-26
申请号：PCT/US2008067741
申请日：2008-06-20
申请人： DARTMOUTH COLLEGE , JIANG SHUDONG , POGUE BRIAN WILLIAM , WANG JIA , PAULSEN KEITH D
发明人： JIANG SHUDONG , POGUE BRIAN WILLIAM , WANG JIA , PAULSEN KEITH D
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0073
摘要： A diffuse optical tomography system incorporating a a mode- locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.
摘要翻译：包含锁模可调激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

3. 发明申请

WO2008147974A1 MICRO-RNAS MODULATING IMMUNITY AND INFLAMMATION 审中-公开
标题翻译： MICRO-RNAS调节免疫和炎症
公开(公告)号：WO2008147974A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064678
申请日：2008-05-23
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam S. , WANG, Jia-wang
发明人： MOHAPATRA, Shyam S. , WANG, Jia-wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/7105 , C12N15/113 , C12N2310/113 , C12Q1/6809 , C12Q2600/136 , C12Q2600/178 , C12Q2525/107
摘要： MicroRNAs are shown to be up- and/or down-regulated in inflammation and immune cells using a mouse model of asthma and regulatory T cells as source of RNA, respectively. Modulating the expression of these microRNAs can be effective in redirecting inflammation and immunity and hence, may be beneficial as biomarkers or as therapeutic agents against diverse human immunologic and inflammatory diseases.
摘要翻译： MicroRNA分别在哮喘和调节性T细胞的小鼠模型中分别在炎症和免疫细胞中上调和/或下调。调节这些微小RNA的表达可以有效地重定向炎症和免疫，因此可能作为生物标志物或作为治疗剂对多种人类免疫学和炎性疾病有益。

4. 发明申请

WO2008100498A3 TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL STEM CELLS 审中-公开
标题翻译：使用普通干细胞治疗炎症性疾病
公开(公告)号：WO2008100498A3
公开(公告)日：2008-10-30
申请号：PCT/US2008001831
申请日：2008-02-12
申请人： ANTHROGENESIS CORP , EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , FALECK HERBERT
发明人： EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , FALECK HERBERT
IPC分类号： A61K35/44 , A61K35/50 , A61K35/64 , A61K38/21 , A61P37/06 , C12N5/073
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译：本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。

5. 发明申请

WO2007092598A3 NOVEL NEUROLOGICAL FUNCTION OF MPKCI 审中-公开
标题翻译： MPKCI的新神经功能
公开(公告)号：WO2007092598A3
公开(公告)日：2008-10-30
申请号：PCT/US2007003497
申请日：2007-02-09
申请人： UNIV MARYLAND , WANG JIA BEI , BARBIER ELISABETH
发明人： WANG JIA BEI , BARBIER ELISABETH
IPC分类号： A61K49/00 , A01K67/00 , A61K38/00 , C12N15/63
CPC分类号： A61K38/16 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K31/485
摘要： Wildtype and mice lacking the gene encoding PKCI/HINT 1 (PKC -/- ) were used to assess the involvement of PKCI/HINT1 in regulating basal locomotor activity and the behavioral activating effects of the psychostimulant, amphetamine. PKCl -/- mice displayed low level of spontaneous locomotion relative to WT littermates. Acute administration of amphetamine significantly increased locomotor activity in WT mice; an effect that was enhanced in PKCl -/- mice. Microdialysis studies revealed no alteration in basal DA dynamics in the striatum and nucleus accumbens of KO mice. Similarly, the ability of acute amphetamine to increase DA levels in these brain regions was unaltered. However, a dopamine receptor agonist, apomorphine (10mg/kg), was able to induce a significantly higher locomotor activity in PKCI -/- mice as compared with WT, suggesting there may be a dopaminergic functional change at the postsynaptic site. Our results also revealed that PKCI KO mice showed a less depression and anxiety trait than their litter mate controls (WT), which indicate that PKCI could also play a role in regulating the emotion states of brain. Together, these results indicated that PKCI/HINT1 may have a suppressive role in normal DA neurotransmission, and may also play an important role for the action of psychostimulants in schizophrenia.
摘要翻译：使用缺乏编码PKCI / HINT1（PKC - / - ）的基因的野生型和小鼠来评估PKCI / HINT1参与调节基础运动活性和精神兴奋剂苯丙胺的行为活化作用。小鼠相对于WT同窝出生者显示出低水平的自发运动。安非他明的急性给药显着增加WT小鼠的运动活性; 在PKC1 小鼠中增强的作用。微透析研究显示KO小鼠的纹状体和伏隔核中的基础DA动力学没有改变。类似地，急性苯丙胺胺在这些脑区域中增加DA水平的能力是未改变的。然而，与WT相比，多巴胺受体激动剂阿朴吗啡（10mg / kg）能够诱导PKC1 - / - 小鼠的运动活性显着更高，这表明可能存在多巴胺能功能变化突触后位点。我们的研究结果还表明，PKCI KO小鼠的凋亡抑制和焦虑特征比其凋零物质控制（WT）低，这表明PKCI也可以在调节脑的情绪状态方面发挥作用。这些结果一起表明，PKCI / HINT1可能在正常DA神经传递中具有抑制作用，并且也可能对精神分裂症患者精神分裂症的作用起重要作用。

6. 发明申请

WO2008051568A9 METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS 审中-公开
公开(公告)号：WO2008051568A9
公开(公告)日：2008-09-12
申请号：PCT/US2007022545
申请日：2007-10-23
申请人： ANTHROGENESIS CORP , EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
发明人： EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
IPC分类号： A61F2/28 , A61K35/50 , A61L27/38 , A61P19/00 , C12N5/073 , C12N5/074 , C12N5/077
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.

7. 发明申请

WO2007079183A3 PLACENTAL STEM CELL POPULATIONS 审中-公开
标题翻译：单位干细胞群体
公开(公告)号：WO2007079183A3
公开(公告)日：2007-11-15
申请号：PCT/US2006049491
申请日：2006-12-28
申请人： ANTHROGENESIS CORP , ABRAMSON SASCHA DAWN , EDINGER JAMES W , FALECK HERBERT , HARIRI ROBERT J , LABAZZO KRISTEN S , PERIERA MARIAN , WANG JIA-LUN , YE QIAN
发明人： ABRAMSON SASCHA DAWN , EDINGER JAMES W , FALECK HERBERT , HARIRI ROBERT J , LABAZZO KRISTEN S , PERIERA MARIAN , WANG JIA-LUN , YE QIAN
IPC分类号： C12N5/073 , C12N5/0735 , C12N5/074
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
摘要翻译：本发明提供胎盘干细胞和胎盘干细胞群体，以及培养，增殖和扩增胎盘干细胞的方法。本发明还提供了分离胎盘干细胞的方法。本发明还提供了在测定和移植中使用胎盘干细胞的方法。

8. 发明申请

WO2007092598A9 NOVEL NEUROLOGICAL FUNCTION OF MPKCI 审中-公开
标题翻译： MPKCI的新型神经功能
公开(公告)号：WO2007092598A9
公开(公告)日：2007-11-01
申请号：PCT/US2007003497
申请日：2007-02-09
申请人： UNIV MARYLAND , WANG JIA BEI , BARBIER ELISABETH
发明人： WANG JIA BEI , BARBIER ELISABETH
IPC分类号： A61K31/485
CPC分类号： A61K38/16 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K31/485
摘要： Wildtype and mice lacking the gene encoding PKCI/HINT 1 (PKC -/- ) were used to assess the involvement of PKCI/HINT1 in regulating basal locomotor activity and the behavioral activating effects of the psychostimulant, amphetamine. PKCl -/- mice displayed low level of spontaneous locomotion relative to WT littermates. Acute administration of amphetamine significantly increased locomotor activity in WT mice; an effect that was enhanced in PKCl -/- mice. Microdialysis studies revealed no alteration in basal DA dynamics in the striatum and nucleus accumbens of KO mice. Similarly, the ability of acute amphetamine to increase DA levels in these brain regions was unaltered. However, a dopamine receptor agonist, apomorphine (10mg/kg), was able to induce a significantly higher locomotor activity in PKCI -/- mice as compared with WT, suggesting there may be a dopaminergic functional change at the postsynaptic site. Our results also revealed that PKCI KO mice showed a less depression and anxiety trait than their litter mate controls (WT), which indicate that PKCI could also play a role in regulating the emotion states of brain. Together, these results indicated that PKCI/HINT1 may have a suppressive role in normal DA neurotransmission, and may also play an important role for the action of psychostimulants in schizophrenia.
摘要翻译：野生型和缺乏编码PKCI / HINT1（PKC ）基因的小鼠用于评估PKCI / HINT1参与调节基础运动活性和精神兴奋剂苯丙胺的行为激活作用。 PKCl - / - 小鼠显示相对于WT同窝动物的低水平的自发运动。急性施用苯丙胺显着增加WT小鼠的运动活性; 这种作用在PKC1 - / - 小鼠中增强。微透析研究显示KO小鼠的纹状体和伏隔核中的基础DA动力学没有改变。同样，急性苯丙胺增加这些大脑区域DA水平的能力没有改变。然而，与WT相比，多巴胺受体激动剂阿扑吗啡（10mg / kg）能够在PKCI - / - 小鼠中诱导显着更高的运动活性，表明在小鼠中可能存在多巴胺能功能改变突触后部位。我们的结果还表明PKCI KO小鼠表现出比其伴侣对照（WT）更少的抑郁和焦虑特征，这表明PKCI也可以在调节大脑的情绪状态中起作用。总之，这些结果表明PKCI / HINT1可能在正常DA神经传递中具有抑制作用，并且也可能在精神兴奋剂在精神分裂症中的作用中起重要作用。

9. 发明申请

WO2007079184A3 CO-CULTURE OF PLACENTAL STEM CELLS AND STEM CELLS FROM A SECOND SOURCE 审中-公开
标题翻译：来自第二个来源的细胞干细胞和干细胞的共培养
公开(公告)号：WO2007079184A3
公开(公告)日：2007-10-18
申请号：PCT/US2006049492
申请日：2006-12-28
申请人： ANTHROGENESIS CORP , HEIDARAN MOHAMAD , WANG JIA-LUN , YE QIAN , ZEITLIN ANDREW
发明人： HEIDARAN MOHAMAD , WANG JIA-LUN , YE QIAN , ZEITLIN ANDREW
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N2502/02 , C12N2502/025 , G01N33/56966
摘要： The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to placental stem cells or stem cells from a second source, alone. The combination is referred to as a combined stem cell population. The invention also provides in vitro and in vivo methods for identifying and producing combined stem cell populations, and models of engraftment. In accordance with the present invention, the placental stem cells may be combined with, e.g., umbilical cord blood-derived stem or progenitor cells, fetal or neonatal stem cells or progenitor cells, adult stem cells or progenitor cells, hematopoietic stem cells or progenitor cells, stem or progenitor cells derived from bone marrow, etc.
摘要翻译：本发明涉及胎盘干细胞和衍生自第二来源的干细胞或祖细胞的组合，其中与来自第二来源的胎盘干细胞或干细胞相比，该组合显示出改善的植入。该组合被称为组合干细胞群体。本发明还提供用于鉴定和产生组合的干细胞群体和植入模型的体外和体内方法。根据本发明，胎盘干细胞可与例如脐带血衍生的干细胞或祖细胞，胎儿或新生儿干细胞或祖细胞，成体干细胞或祖细胞，造血干细胞或祖细胞，源自骨髓的干细胞或祖细胞等

10. 发明申请

WO2003106466A2 N-HALAMINE SILOXANES FOR USE IN BIOCIDAL COATINGS AND MATERIALS 审中-公开
标题翻译：用于生物涂料和材料的N-山梨糖醇硅氧烷
公开(公告)号：WO2003106466A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018883
申请日：2003-06-12
申请人： AUBURN UNIVERSITY , VANSON HALOSOURCE, INC. , WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
发明人： WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
IPC分类号： C07F7/18
CPC分类号： C07F7/1836 , Y10T428/31663
摘要： Heterocyclic and acyclic silane monomers and siloxane polymers, and their halogenated derivatives, are provided for the purpose of functionalizing surfaces or materials so as to render them biocidal upon exposure to oxidative halogen solutions.The biocidal function can be imparted either before or after bonding or adhesion to the surface or material. The biocidal surfaces and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. Examples of surfaces and materials which can be rendered biocidal in this invention include, but are not limited to, cellulose, chitin, chitosan, synthetic fibers, glass, ceramics, plastics, rubber, cement grout, latex caulk, porcelain, acrylic films, vinyl, polyurethanes, silicon tubing, marble, metals, metal oxides, and silica.
摘要翻译：提供杂环和非环状硅烷单体和硅氧烷聚合物及其卤化衍生物用于官能化表面或材料的目的，以便在暴露于氧化卤素溶液时使其成为杀生物剂。杀生物功能可以在粘合或粘附之前或之后赋予到表面或材料。然后杀生物表面和材料可用于灭活病原微生物如细菌，真菌和酵母，以及可能引起传染病的病毒颗粒，以及引起有害气味和不愉快着色如霉菌的微生物。在本发明中可呈现杀生物剂的表面和材料的实例包括但不限于纤维素，壳多糖，壳聚糖，合成纤维，玻璃，陶瓷，塑料，橡胶，水泥浆，乳胶填料，瓷，丙烯酸膜，乙烯基，聚氨酯，硅管，大理石，金属，金属氧化物和二氧化硅。

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