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1. 发明申请

WO2012129115A3 MATERIALS AND METHODS FOR PROFILING MICRORNAS 审中-公开
标题翻译：用于分析MICRORNAS的材料和方法
公开(公告)号：WO2012129115A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029522
申请日：2012-03-16
申请人： UNIV SOUTH FLORIDA , MOHAPATRA SHYAM S , WANG JIA-WANG
发明人： MOHAPATRA SHYAM S , WANG JIA-WANG
IPC分类号： C12Q1/68 , C12N15/11 , C12Q1/48
CPC分类号： C12Q1/6851 , C12Q1/6876 , C12Q2525/161 , C12Q2525/173 , C12Q2525/207
摘要： The present invention provides materials and methods for detecting, quantifying, and/or high-throughput -profiling microRNAs. Advantageously, the present invention is more sensitive and specific than other currently-available miRNA qPCR assays. In addition, the present invention is convenient, easy-to-perform, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of all miRNAs, a universal reverse primer for PGR amplification reaction, and universal probes. In another embodiment, the present invention provides assays that allow simultaneous detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction.
摘要翻译：本发明提供了用于检测，量化和/或高通量 - 形成微RNA的材料和方法。有利地，本发明比其他目前可用的miRNA qPCR测定更灵敏和特异。另外，本发明方便，易于执行并且成本有效。在一个实施方案中，本发明提供了用于所有miRNA的逆转录的通用引物，用于PGR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供了允许使用单一逆转录反应同时检测和/或定量多个靶miRNA的测定。

2. 发明申请

WO2008147974A1 MICRO-RNAS MODULATING IMMUNITY AND INFLAMMATION 审中-公开
标题翻译： MICRO-RNAS调节免疫和炎症
公开(公告)号：WO2008147974A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064678
申请日：2008-05-23
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam S. , WANG, Jia-wang
发明人： MOHAPATRA, Shyam S. , WANG, Jia-wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/7105 , C12N15/113 , C12N2310/113 , C12Q1/6809 , C12Q2600/136 , C12Q2600/178 , C12Q2525/107
摘要： MicroRNAs are shown to be up- and/or down-regulated in inflammation and immune cells using a mouse model of asthma and regulatory T cells as source of RNA, respectively. Modulating the expression of these microRNAs can be effective in redirecting inflammation and immunity and hence, may be beneficial as biomarkers or as therapeutic agents against diverse human immunologic and inflammatory diseases.
摘要翻译： MicroRNA分别在哮喘和调节性T细胞的小鼠模型中分别在炎症和免疫细胞中上调和/或下调。调节这些微小RNA的表达可以有效地重定向炎症和免疫，因此可能作为生物标志物或作为治疗剂对多种人类免疫学和炎性疾病有益。

3. 发明申请

WO2003106466A2 N-HALAMINE SILOXANES FOR USE IN BIOCIDAL COATINGS AND MATERIALS 审中-公开
标题翻译：用于生物涂料和材料的N-山梨糖醇硅氧烷
公开(公告)号：WO2003106466A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018883
申请日：2003-06-12
申请人： AUBURN UNIVERSITY , VANSON HALOSOURCE, INC. , WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
发明人： WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
IPC分类号： C07F7/18
CPC分类号： C07F7/1836 , Y10T428/31663
摘要： Heterocyclic and acyclic silane monomers and siloxane polymers, and their halogenated derivatives, are provided for the purpose of functionalizing surfaces or materials so as to render them biocidal upon exposure to oxidative halogen solutions.The biocidal function can be imparted either before or after bonding or adhesion to the surface or material. The biocidal surfaces and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. Examples of surfaces and materials which can be rendered biocidal in this invention include, but are not limited to, cellulose, chitin, chitosan, synthetic fibers, glass, ceramics, plastics, rubber, cement grout, latex caulk, porcelain, acrylic films, vinyl, polyurethanes, silicon tubing, marble, metals, metal oxides, and silica.
摘要翻译：提供杂环和非环状硅烷单体和硅氧烷聚合物及其卤化衍生物用于官能化表面或材料的目的，以便在暴露于氧化卤素溶液时使其成为杀生物剂。杀生物功能可以在粘合或粘附之前或之后赋予到表面或材料。然后杀生物表面和材料可用于灭活病原微生物如细菌，真菌和酵母，以及可能引起传染病的病毒颗粒，以及引起有害气味和不愉快着色如霉菌的微生物。在本发明中可呈现杀生物剂的表面和材料的实例包括但不限于纤维素，壳多糖，壳聚糖，合成纤维，玻璃，陶瓷，塑料，橡胶，水泥浆，乳胶填料，瓷，丙烯酸膜，乙烯基，聚氨酯，硅管，大理石，金属，金属氧化物和二氧化硅。

4. 发明申请

WO02078614A3 LPS-RESPONSIVE CHS1/BEIGE-LIKE ANCHOR GENE AND THERAPEUTIC APPLICATIONS THEREOF 审中-公开
标题翻译： LPS-RESPONSIVE CHS1 / BEIGE-like锚定基因及其治疗应用
公开(公告)号：WO02078614A3
公开(公告)日：2003-03-20
申请号：PCT/US0210350
申请日：2002-04-02
申请人： UNIV SOUTH FLORIDA , KERR WILLIAM G , WANG JIA-WANG
发明人： KERR WILLIAM G , WANG JIA-WANG
IPC分类号： A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： C07K14/47
摘要： The present invention relates to a novel LPS-responsive and Beige-like Anchor gene (lrba), variants of the lrba gene, fragments of the lrba gene, and polypeptides encoded thereby. The subject invention also pertains to lrba interfering RNA, and uses thereof. In another aspect, the present invention also includes methods of inhibiting tumor growth in a patient by suppressing lrba function.
摘要翻译：本发明涉及一种新的LPS-响应和米色样锚定基因（lrba），lrba基因的变体，lrba基因的片段，以及由此编码的多肽。本发明还涉及lrba干扰RNA及其用途。另一方面，本发明还包括通过抑制lba蛋白功能来抑制患者肿瘤生长的方法。

5. 发明申请

WO2012129115A2 MATERIALS AND METHODS FOR PROFILING MICRORNAS 审中-公开
标题翻译：材料和方法简介微阵列
公开(公告)号：WO2012129115A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/029522
申请日：2012-03-16
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , WANG, Jia-Wang
发明人： MOHAPATRA, Shyam, S. , WANG, Jia-Wang
IPC分类号： C12Q1/68 , C12Q1/48 , C12N15/11
CPC分类号： C12Q1/6851 , C12Q1/6876 , C12Q2525/161 , C12Q2525/173 , C12Q2525/207
摘要： The present invention provides materials and methods for detecting, quantifying, and/or high-throughput -profiling microRNAs. Advantageously, the present invention is more sensitive and specific than other currently-available miRNA qPCR assays. In addition, the present invention is convenient, easy-to-perform, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of all miRNAs, a universal reverse primer for PGR amplification reaction, and universal probes. In another embodiment, the present invention provides assays that allow simultaneous detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction.
摘要翻译：本发明提供用于检测，定量和/或高通量提供微小RNA的材料和方法。有利地，本发明比其他目前可用的miRNA qPCR测定更灵敏和特异。此外，本发明方便，易于使用，性价比高。在一个实施方案中，本发明提供了用于所有miRNA逆转录的通用引物，用于PGR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供允许使用单次逆转录反应同时检测和/或定量多个靶miRNA的测定。

6. 发明申请

WO2011103502A3 MATERIALS AND METHODS FOR PROFILING MICRORNAS 审中-公开
标题翻译：材料和方法简介微阵列
公开(公告)号：WO2011103502A3
公开(公告)日：2012-01-12
申请号：PCT/US2011025532
申请日：2011-02-18
申请人： UNIV SOUTH FLORIDA , MOHAPATRA SHYAM S , WANG JIA-WANG
发明人： MOHAPATRA SHYAM S , WANG JIA-WANG
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6851 , C12N2310/141 , C12N2320/10 , C12Q2525/301 , C12Q2525/173 , C12Q2521/107
摘要： The present invention provides materials and methods for detecting, quantifying, and/or profiling microRNAs. Advantageously, the present invention is sensitive, specific, convenient, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of miRNAs, a universal reverse primer for PCR amplification reaction, and a universal probe. In another embodiment, the present invention provides assays that allow the detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction and a single qPCR reaction.
摘要翻译：本发明提供用于检测，定量和/或分析微小RNA的材料和方法。有利地，本发明是敏感的，具体的，方便的和具有成本效益的。在一个实施方案中，本发明提供了用于miRNA逆转录的通用引物，用于PCR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供允许使用单次逆转录反应和单次qPCR反应来检测和/或定量多个靶miRNA的测定。

7. 发明申请

WO2011103502A2 MATERIALS AND METHODS FOR PROFILING MICRORNAS 审中-公开
标题翻译：材料和方法简介微阵列
公开(公告)号：WO2011103502A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025532
申请日：2011-02-18
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , WANG, Jia-Wang
发明人： MOHAPATRA, Shyam, S. , WANG, Jia-Wang
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6851 , C12N2310/141 , C12N2320/10 , C12Q2525/301 , C12Q2525/173 , C12Q2521/107
摘要： The present invention provides materials and methods for detecting, quantifying, and/or profiling microRNAs. Advantageously, the present invention is sensitive, specific, convenient, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of miRNAs, a universal reverse primer for PCR amplification reaction, and a universal probe. In another embodiment, the present invention provides assays that allow the detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction and a single qPCR reaction.
摘要翻译：本发明提供用于检测，定量和/或分析微小RNA的材料和方法。有利地，本发明是敏感的，具体的，方便的和具有成本效益的。在一个实施方案中，本发明提供了用于miRNA逆转录的通用引物，用于PCR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供允许使用单次逆转录反应和单次qPCR反应来检测和/或定量多个靶miRNA的测定。

8. 发明申请

WO2006099567A3 BIOCIDAL N-HALAMINE EPOXIDES 审中-公开
标题翻译：生物碱N-硫酸环氧化物
公开(公告)号：WO2006099567A3
公开(公告)日：2007-09-13
申请号：PCT/US2006009628
申请日：2006-03-10
申请人： UNIV AUBURN , WORLEY S D , LIANG JIE , CHEN YONGJUN , BROUGHTON ROYALL M , WANG JIA-WANG , WU RONG , CHO UNCHIN , LEE JAEWOONG , BARNES KEVIN
发明人： WORLEY S D , LIANG JIE , CHEN YONGJUN , BROUGHTON ROYALL M , WANG JIA-WANG , WU RONG , CHO UNCHIN , LEE JAEWOONG , BARNES KEVIN
IPC分类号： C07D233/00 , C07D235/00 , C08G63/44
CPC分类号： A01N65/00 , A01N35/02 , A01N43/50 , A01N43/90 , A01N59/00 , A61Q17/005 , C09D5/14 , C09D5/16 , A01N25/10 , A01N25/34
摘要： N-halaminehydantoinyl epoxide compounds which can be used for the construction of coatings and materials which can be rendered biocidal by exposure to halogen solutions either before or after curing the coating or material are disclosed. The biocidal coatings and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. The coatings are compatible with a variety of substrates including, but not limited to, cellulose, chitin, chitosan, synthetic fibers, cement grout, latex caulk, acrylic films, polyurethanes, plastics and paints.
摘要翻译：公开了可用于构建涂层和材料的N-卤代乙酰乙酰基环氧化合物，其可以在固化涂层或材料之前或之后通过暴露于卤素溶液而变成杀生物剂。然后可以使用杀生物涂料和材料来灭活病原微生物如细菌，真菌和酵母，以及可能引起传染病的病毒颗粒，以及引起有害气味和令人不快的着色如霉菌的微生物。这些涂层与各种基材相容，包括但不限于纤维素，壳多糖，壳聚糖，合成纤维，水泥浆，乳胶填缝剂，丙烯酸膜，聚氨酯，塑料和油漆。

9. 发明申请

WO2003106466A3 HETEROCYCLIC HALAMINE-SUBSTITUTED SILOXANES FOR USE IN BIOCIDAL COATINGS AND MATERIALS 审中-公开
公开(公告)号：WO2003106466A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018883
申请日：2003-06-12
申请人： AUBURN UNIVERSITY , VANSON HALOSOURCE, INC. , WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
发明人： WORLEY, Shelby, D. , CHEN, Yongjun , WANG, Jia-Wang , WU, Rong , LI, Yanjun
IPC分类号： C07F7/18
摘要： Siloxane monomers and polymers functionalized by certain N-halogenated heterocyclic moieties are provided for the purpose of functionalizing surfaces or materials so as to render them biocidal upon exposure to oxidative halogen solutions. The biocidal function can be imparted either before or after bonding or adhesion to the surface or material. The biocidal surfaces and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. Examples of surfaces and materials which can be rendered biocidal in this invention include, but are not limited to, cellulose, chitin, chitosan, synthetic fibers, glass, ceramics, plastics, rubber, cement grout, latex caulk, porcelain, acrylic films, vinyl, polyurethanes, silicon tubing, marble, metals, metal oxides, and silica.

10. 发明申请

WO2006099567A2 BIOCIDAL N-HALAMINE EPOXIDES 审中-公开
标题翻译：生物碱N-硫杂环氧化物
公开(公告)号：WO2006099567A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009628
申请日：2006-03-10
申请人： AUBURN UNIVERSITY , WORLEY, S.D. , LIANG, Jie , CHEN, Yongjun , BROUGHTON, Royall, M. , WANG, Jia-wang , WU, Rong , CHO, Unchin , LEE, Jaewoong , BARNES, Kevin
发明人： WORLEY, S.D. , LIANG, Jie , CHEN, Yongjun , BROUGHTON, Royall, M. , WANG, Jia-wang , WU, Rong , CHO, Unchin , LEE, Jaewoong , BARNES, Kevin
IPC分类号： C11D7/26
CPC分类号： A01N65/00 , A01N35/02 , A01N43/50 , A01N43/90 , A01N59/00 , A61Q17/005 , C09D5/14 , C09D5/16 , A01N25/10 , A01N25/34
摘要： N-halaminehydantoinyl epoxide compounds which can be used for the construction of coatings and materials which can be rendered biocidal by exposure to halogen solutions either before or after curing the coating or material are disclosed. The biocidal coatings and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. The coatings are compatible with a variety of substrates including, but not limited to, cellulose, chitin, chitosan, synthetic fibers, cement grout, latex caulk, acrylic films, polyurethanes, plastics and paints.
摘要翻译：公开了可用于构建涂料和材料的N-卤代乙酰乙酰基环氧化合物，其可以在固化涂层或材料之前或之后通过暴露于卤素溶液而具有杀菌作用。然后可以使用杀生物涂层和材料来灭活病原微生物，例如细菌，真菌和酵母，以及可能引起传染病的病毒颗粒，以及引起有害气味和不愉快着色如微生物的微生物。涂层与各种基材相容，包括但不限于纤维素，壳多糖，壳聚糖，合成纤维，水泥浆，乳胶填缝剂，丙烯酸膜，聚氨酯，塑料和油漆。

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