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1. 发明申请

WO0173134A2 GENE PROFILING ARRAYS 审中-公开
标题翻译：基因分布阵列
公开(公告)号：WO0173134A2
公开(公告)日：2001-10-04
申请号：PCT/US0109993
申请日：2001-03-28
申请人： US HEALTH , WANG ENA , MARINCOLA FRANCESCO M , MILLER LANCE D
发明人： WANG ENA , MARINCOLA FRANCESCO M , MILLER LANCE D
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/513
摘要： Ordered arrays of mixtures of nucleic acid molecules are provided, which mixtures reflect the expression profile of one or more specimens, such as different cells or tissues. In particular embodiments, complete mRNA mixtures from specimens are separately arrayed on a substrate. Specimens from which such mixtures of nucleic acid molecules are produced can be taken from any source, including animal, plant and/or microbial cells, and can be assembled in any collection desired. The collections can, for instance, include different cell types, different phenotypes, cells grown under different conditions, cells of different ages or developmental stages, and so forth. The nucleic acid arrays are provided in both macro- and microarray formats, and are suitable for gene profiling in which relative quantitative expression from a single source or multiple sources may be determined. Techniques are also disclosed for producing high-fidelity, amplified mixtures of nucleic acid molecules using a combination of anti-sense RNA amplification and template-switching synthesis. Amplified mixtures produced using this method can, for instance, be applied to the disclosed arrays. The disclosed arrays allow high throughput analysis of differential gene expression in a specimen (such as a tumor) or a variety of specimens (such as a variety of tumors), and are suitable for automated preparation and analysis.
摘要翻译：提供了核酸分子混合物的有序阵列，其混合物反映了一个或多个样品（例如不同细胞或组织）的表达谱。在具体实施方案中，将来自样品的完整mRNA混合物分别排列在基底上。产生核酸分子的这种混合物的样品可以从任何来源（包括动物，植物和/或微生物细胞）获取，并且可以以任何所需的收集物组装。例如，这些集合可以包括不同的细胞类型，不同的表型，在不同条件下生长的细胞，不同年龄或发育阶段的细胞等等。核酸阵列以宏阵列和微阵列格式提供，并且适用于可以确定来自单个来源或多个来源的相对定量表达的基因分析。还公开了使用反义RNA扩增和模板切换合成的组合产生高保真，扩增的核酸分子混合物的技术。使用该方法制备的扩增混合物可以例如应用于所公开的阵列。所公开的阵列允许在样品（例如肿瘤）或多种标本（例如多种肿瘤））中差异基因表达的高通量分析，并且适用于自动化制备和分析。

2. 发明申请

WO2012129488A3 GENE SIGNATURES ASSOCIATED WITH REJECTION OR RECURRENCE OF CANCER 审中-公开
标题翻译：与癌症排斥或复发相关的基因标记
公开(公告)号：WO2012129488A3
公开(公告)日：2012-12-27
申请号：PCT/US2012030312
申请日：2012-03-23
申请人： UNIV VIRGINIA COMMONWEALTH , MANJILI MASOUD H , KMIECIAK MACIEJ , TOOR AMIR A , IDOWU MICHAEL O , BEAR HARRY D , PAYNE KYLE K , MARINCOLA FRANCESCO M , WANG ENA
发明人： MANJILI MASOUD H , KMIECIAK MACIEJ , TOOR AMIR A , IDOWU MICHAEL O , BEAR HARRY D , PAYNE KYLE K , MARINCOLA FRANCESCO M , WANG ENA
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N2800/54
摘要： Methods and tools for assessing the prognosis for patients following treatment of primary tumors are provided. The methods involve identifying immune- or cancer-related genetic markers whose differential expression patterns at tumor lesions are indicative of either tumor recurrence or recurrence-free survival. The methods and tools of the invention assist physicians by providing objective decision-making tools for planning patient treatment protocols.
摘要翻译：提供了评估原发肿瘤治疗后患者预后的方法和工具。该方法涉及鉴定免疫或癌症相关的遗传标记，其在肿瘤损伤处的差异表达模式指示肿瘤复发或无复发存活。本发明的方法和工具通过提供用于规划患者治疗方案的客观决策工具来帮助医师。

3. 发明申请

WO2001073134A3 GENE PROFILING ARRAYS 审中-公开
公开(公告)号：WO2001073134A3
公开(公告)日：2001-10-04
申请号：PCT/US2001/009993
申请日：2001-03-28
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH , WANG, Ena , MARINCOLA, Francesco, M. , MILLER, Lance, D.
发明人： WANG, Ena , MARINCOLA, Francesco, M. , MILLER, Lance, D.
IPC分类号： C12Q1/68
摘要： Ordered arrays of mixtures of nucleic acid molecules are provided, which mixtures reflect the expression profile of one or more specimens, such as different cells or tissues. In particular embodiments, complete mRNA mixtures from specimens are separately arrayed on a substrate. Specimens from which such mixtures of nucleic acid molecules are produced can be taken from any source, including animal, plant and/or microbial cells, and can be assembled in any collection desired. The collections can, for instance, include different cell types, different phenotypes, cells grown under different conditions, cells of different ages or developmental stages, and so forth. The nucleic acid arrays are provided in both macro- and microarray formats, and are suitable for gene profiling in which relative quantitative expression from a single source or multiple sources may be determined. Techniques are also disclosed for producing high-fidelity, amplified mixtures of nucleic acid molecules using a combination of anti-sense RNA amplification and template-switching synthesis. Amplified mixtures produced using this method can, for instance, be applied to the disclosed arrays. The disclosed arrays allow high throughput analysis of differential gene expression in a specimen (such as a tumor) or a variety of specimens (such as a variety of tumors), and are suitable for automated preparation and analysis.

4. 发明申请

WO2012129488A2 GENE SIGNATURES ASSOCIATED WITH REJECTION OR RECURRENCE OF CANCER 审中-公开
标题翻译：与癌症的抑制或复发相关的基因标志
公开(公告)号：WO2012129488A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/030312
申请日：2012-03-23
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , MANJILI, Masoud, H. , KMIECIAK, Maciej , TOOR, Amir, A. , IDOWU, Michael, O. , BEAR, Harry, D. , PAYNE, Kyle, K. , MARINCOLA, Francesco, M. , WANG, Ena
发明人： MANJILI, Masoud, H. , KMIECIAK, Maciej , TOOR, Amir, A. , IDOWU, Michael, O. , BEAR, Harry, D. , PAYNE, Kyle, K. , MARINCOLA, Francesco, M. , WANG, Ena
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N2800/54
摘要： Methods and tools for assessing the prognosis for patients following treatment of primary tumors are provided. The methods involve identifying immune- or cancer-related genetic markers whose differential expression patterns at tumor lesions are indicative of either tumor recurrence or recurrence-free survival. The methods and tools of the invention assist physicians by providing objective decision-making tools for planning patient treatment protocols.
摘要翻译：提供了评估原发性肿瘤治疗后患者预后的方法和工具。该方法涉及确定免疫或癌症相关的遗传标记，其肿瘤损伤上的差异表达模式指示肿瘤复发或无复发存活。本发明的方法和工具通过提供用于规划患者治疗方案的客观决策工具来协助医生。

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