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1. 发明申请

WO2011142813A4 DYNAMIC MIXING AND ELECTROPORATION CHAMBER AND SYSTEM 审中-公开
公开(公告)号：WO2011142813A4
公开(公告)日：2011-11-17
申请号：PCT/US2011/000827
申请日：2011-05-11
申请人： CELLECTIS SA , KING, Alan, D. , WALTERS, Robert, J. , DEITZ, Stephen, B. , RODIS, Donald, J. , WALTERS, Derin, C.
发明人： KING, Alan, D. , DEITZ, Stephen, B. , RODIS, Donald, J. , WALTERS, Derin, C.
IPC分类号： C07K1/26 , G01N27/26
摘要： The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules. It further provides a chamber that can be used to electroporate the contents of the chamber after mixing. In accordance with the invention, cell suspensions that may be contaminated with degrading enzymes are stored separately from water-based liquids that contain the exogenous material. Contact of the two water-based liquids (cell suspension and exogenous material) first occurs within the chamber. The chamber of the present invention has two or more inlet ports to allow separate entrance of water-based liquids. Two other ports are vent and exit ports. The inside of the chamber allows flow of all water-based liquids down the same side of the chamber and curved comers for redirecting flow direction and gently mixing water- based liquids. The chamber also includes electrodes as chamber walls for electroporation of chamber contents.

2. 发明申请

WO2011142813A1 DYNAMIC MIXING AND ELECTROPORATION CHAMBER AND SYSTEM 审中-公开
标题翻译：动力混合动力室和系统
公开(公告)号：WO2011142813A1
公开(公告)日：2011-11-17
申请号：PCT/US2011000827
申请日：2011-05-11
申请人： CELLECTIS SA , KING ALAN D , WALTERS ROBERT J , DEITZ STEPHEN B , RODIS DONALD J , WALTERS DERIN C
发明人： KING ALAN D , DEITZ STEPHEN B , RODIS DONALD J , WALTERS DERIN C , WALTERS RICHARD E
IPC分类号： C07K1/26 , G01N27/26
CPC分类号： C12N13/00 , C12M35/02
摘要： The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules. It further provides a chamber that can be used to electroporate the contents of the chamber after mixing. In accordance with the invention, cell suspensions that may be contaminated with degrading enzymes are stored separately from water-based liquids that contain the exogenous material. Contact of the two water-based liquids (cell suspension and exogenous material) first occurs within the chamber. The chamber of the present invention has two or more inlet ports to allow separate entrance of water-based liquids. Two other ports are vent and exit ports. The inside of the chamber allows flow of all water-based liquids down the same side of the chamber and curved comers for redirecting flow direction and gently mixing water- based liquids. The chamber also includes electrodes as chamber walls for electroporation of chamber contents.
摘要翻译：本发明涉及一种用于混合细胞和外源材料的装置，用于以保持细胞存活力和外源性材料的完整性的方式使用电穿孔将外源材料递送到细胞中。外源物质可以是多核苷酸，肽，蛋白质或其它药物分子。它进一步提供一个室，可以用于混合后电化室的内容物。根据本发明，可能被降解酶污染的细胞悬浮液与含有外源性物质的水基液体分离储存。首先在室内发生两种水性液体（细胞悬浮液和外源性物质）的接触。本发明的腔室具有两个或更多个入口端口，以允许单独进入水基液体。另外两个端口是排气口和出口。室内部允许所有水基液体在腔室的同一侧流动并弯曲，用于重新定向流动方向，并轻轻混合水基液体。该室还包括电极作为用于室内容物电穿孔的室壁。

3. 发明申请

WO2005101516A3 SEQUENTIALLY CHARGED NANOCRYSTAL LIGHT EMITTING DEVICE 审中-公开
公开(公告)号：WO2005101516A3
公开(公告)日：2005-10-27
申请号：PCT/US2005/011640
申请日：2005-04-06
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , ATWATER, Harry, A. , WALTERS, Robert, J.
发明人： ATWATER, Harry, A. , WALTERS, Robert, J.
IPC分类号： H01L29/788
摘要： A light emitting device including a transistor structure formed on a semiconductor substrate. The transistor structure having a source region, a drain region, a channel region between the source and drain regions, and a gate oxide on the channel region. The light emitting device including a plurality of nanocrystals embedded in the gate oxide, and a gate contact made of semitransparent or transparent material formed on the gate oxide. The nanocrystals are adapted to be first charged with first type charge carriers, and then provided second type charge carriers, such that the first and second type charge carriers form excitons used to emit light.

4. 发明申请

WO2015042617A1 ULTRA LOW POWER SOLID STATE SPECTRAL RADIOMETER 审中-公开
标题翻译：超低功率固态光谱仪
公开(公告)号：WO2015042617A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/063910
申请日：2014-11-04
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY , HOHEISEL, Raymond , SCHEIMAN, David, A. , LORENTZEN, Justin, R. , JENKINS, Phillip, P. , WALTERS, Robert, J.
发明人： HOHEISEL, Raymond , SCHEIMAN, David, A. , LORENTZEN, Justin, R. , JENKINS, Phillip, P. , WALTERS, Robert, J.
IPC分类号： G01J5/22 , G01J1/42
CPC分类号： G01J3/32 , G01J3/0264 , G01J3/0291 , G01J3/2803 , G01J3/36 , G01J5/30 , G01J5/46
摘要： A spectral radiometer system, measures incoming light intensity and spectral distribution in different wavelength -bands. An additional data storage device allows recording of the measured data. The inclusive sensor system yields very high sensitivity to incoming light. Furthermore, outstanding linearity of the detector response over several orders of magnitude of incoming light is achieved. Additional benefits are ultra low power consumption and minimum size. The sensor system can be used in remote solar radiation monitoring applications like mobile solar power units as well as in long-term environmental monitoring systems where high precision and low power consumption is a necessity.
摘要翻译：光谱辐射计系统测量不同波段的入射光强度和光谱分布。附加数据存储设备允许记录测量数据。包含的传感器系统对入射光产生非常高的灵敏度。此外，实现了在几个数量级的入射光下的检测器响应的出色的线性度。额外的优点是超低功耗和最小尺寸。传感器系统可用于远程太阳辐射监测应用，如移动太阳能发电机组以及需要高精度和低功耗的长期环境监测系统。

5. 发明申请

WO2005101516A2 SEQUENTIALLY CHARGED NANOCRYSTAL LIGHT EMITTING DEVICE 审中-公开
标题翻译：按顺序充电的纳米级发光器件
公开(公告)号：WO2005101516A2
公开(公告)日：2005-10-27
申请号：PCT/US2005011640
申请日：2005-04-06
申请人： CALIFORNIA INST OF TECHN , ATWATER HARRY A , WALTERS ROBERT J
发明人： ATWATER HARRY A , WALTERS ROBERT J
IPC分类号： H01L29/06 , H01L33/00 , H01L33/08 , H01L33/16
CPC分类号： H01L33/16 , B82Y20/00 , H01L33/0004 , H01L33/0041 , H01L33/08 , Y10S977/95
摘要： A light emitting device including a transistor structure formed on a semiconductor substrate. The transistor structure having a source region, a drain region, a channel region between the source and drain regions, and a gate oxide on the channel region. The light emitting device including a plurality of nanocrystals embedded in the gate oxide, and a gate contact made of semitransparent or transparent material formed on the gate oxide. The nanocrystals are adapted to be first charged with first type charge carriers, and then provided second type charge carriers, such that the first and second type charge carriers form excitons used to emit light.
摘要翻译：一种发光器件，包括形成在半导体衬底上的晶体管结构。晶体管结构具有源极区，漏极区，源区和漏区之间的沟道区以及沟道区上的栅极氧化物。该发光器件包括嵌入栅极氧化物中的多个纳米晶体，以及由栅极氧化物上形成的半透明或透明材料制成的栅极接触。纳米晶体适于首先带有第一类型的电荷载体，然后提供第二类型的载流子，使得第一和第二类型的载流子形成用于发光的激子。

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