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1. 发明申请

WO2011142813A1 DYNAMIC MIXING AND ELECTROPORATION CHAMBER AND SYSTEM 审中-公开
标题翻译：动力混合动力室和系统
公开(公告)号：WO2011142813A1
公开(公告)日：2011-11-17
申请号：PCT/US2011000827
申请日：2011-05-11
申请人： CELLECTIS SA , KING ALAN D , WALTERS ROBERT J , DEITZ STEPHEN B , RODIS DONALD J , WALTERS DERIN C
发明人： KING ALAN D , DEITZ STEPHEN B , RODIS DONALD J , WALTERS DERIN C , WALTERS RICHARD E
IPC分类号： C07K1/26 , G01N27/26
CPC分类号： C12N13/00 , C12M35/02
摘要： The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules. It further provides a chamber that can be used to electroporate the contents of the chamber after mixing. In accordance with the invention, cell suspensions that may be contaminated with degrading enzymes are stored separately from water-based liquids that contain the exogenous material. Contact of the two water-based liquids (cell suspension and exogenous material) first occurs within the chamber. The chamber of the present invention has two or more inlet ports to allow separate entrance of water-based liquids. Two other ports are vent and exit ports. The inside of the chamber allows flow of all water-based liquids down the same side of the chamber and curved comers for redirecting flow direction and gently mixing water- based liquids. The chamber also includes electrodes as chamber walls for electroporation of chamber contents.
摘要翻译：本发明涉及一种用于混合细胞和外源材料的装置，用于以保持细胞存活力和外源性材料的完整性的方式使用电穿孔将外源材料递送到细胞中。外源物质可以是多核苷酸，肽，蛋白质或其它药物分子。它进一步提供一个室，可以用于混合后电化室的内容物。根据本发明，可能被降解酶污染的细胞悬浮液与含有外源性物质的水基液体分离储存。首先在室内发生两种水性液体（细胞悬浮液和外源性物质）的接触。本发明的腔室具有两个或更多个入口端口，以允许单独进入水基液体。另外两个端口是排气口和出口。室内部允许所有水基液体在腔室的同一侧流动并弯曲，用于重新定向流动方向，并轻轻混合水基液体。该室还包括电极作为用于室内容物电穿孔的室壁。

2. 发明申请

WO2007002149A2 METHODS AND COMPOSITIONS RELATING TO A VACCINE AGAINST PROSTATE CANCER 审中-公开
标题翻译：与疫苗相关的方法和组合物对前列腺癌
公开(公告)号：WO2007002149A2
公开(公告)日：2007-01-04
申请号：PCT/US2006024076
申请日：2006-06-21
申请人： CYTO PULSE SCIENCES INC , LEDER CHRISTOPHER , KING ALAN D , PAVLENKO MAXIM , PISA PAVEL
发明人： LEDER CHRISTOPHER , KING ALAN D , PAVLENKO MAXIM , PISA PAVEL
IPC分类号： A61K39/00 , G01N33/574
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/53
摘要： An object of the invention is to provide methods and compositions relating to a vaccine against prostate cancer which includes a non- human -primate PSA for administration to humans to provide an immune response against human PSA. More generally, an object of the invention is to provide methods and compositions relating to using a non-human primate xenogeneic antigen (e. g. protein) in a human, wherein, with respect to the non-human primate xenogeneic antigen that is used, there are relatively few interspecies differences between the non-human primate xenogeneic antigen and the human self antigen in order to induce an optimal immune response in the human to its native self antigen.
摘要翻译：本发明的一个目的是提供涉及针对前列腺癌的疫苗的方法和组合物，其包括用于向人施用以提供针对人PSA的免疫应答的非人 - 先合PSA。更一般地，本发明的目的是提供涉及在人中使用非人灵长类异种抗原（例如蛋白质）的方法和组合物，其中就所用的非人灵长类异种抗原而言，存在非人灵长类异种抗原和人自身抗原之间相对较少的种间差异，以诱导人体对其天然自身抗原的最佳免疫应答。

3. 发明申请

WO2004083379A3 LARGE VOLUME EX VIVO ELECTROPORATION METHOD 审中-公开
标题翻译：大容量电视电子方法
公开(公告)号：WO2004083379A3
公开(公告)日：2006-03-02
申请号：PCT/US2004005237
申请日：2004-03-15
申请人： WALTERS RICHARD E , KING ALAN D
发明人： WALTERS RICHARD E , KING ALAN D
IPC分类号： A61K9/00 , A61N1/30 , C12M1/42 , C12N20060101 , C12N13/00 , C12M1/00 , C12M3/00
CPC分类号： C12N13/00 , A61K9/0009 , C12M1/42 , C12M3/00 , C12M3/006 , C12M3/02 , C12M35/02 , C12M45/07 , C12N15/87
摘要： An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into the vesicles which includes the steps of: a. retaining a suspension of the vesicles and the exogenous material in a treatment volume in a chamber which includes electrodes, wherein the chamber has a geometric factor (cm
摘要翻译：本发明的目的是提供一种用外源材料处理囊泡的电穿孔方法，用于将外源材料插入囊泡中，其包括以下步骤：a。将囊泡和外源材料的悬浮液保持在包括电极的室中的处理体积中，其中所述室具有几何因子（cm

4. 发明申请

WO2007018824A3 NEEDLE GUARD MECHANISMS 审中-公开
标题翻译：针防守机制
公开(公告)号：WO2007018824A3
公开(公告)日：2007-11-01
申请号：PCT/US2006025530
申请日：2006-06-28
申请人： SMITHS MEDICAL ASD INC , BIALECKI DENNIS M , SUTTON THOMAS K , ALBERT SEAN J , GORAL DAVID J , LILLEY THOMAS F JR , KING ALAN D
发明人： BIALECKI DENNIS M , SUTTON THOMAS K , ALBERT SEAN J , GORAL DAVID J , LILLEY THOMAS F JR , KING ALAN D
IPC分类号： A61M5/32 , A61M25/06
CPC分类号： A61M25/0606 , A61M5/3273 , A61M25/0618 , A61M2005/3247 , A61M2005/325
摘要： A needle guard (10) includes a clip (12) with a canting wall (16) to grip the needle shaft (56) and a distal wall (20) to block the tip (58) thereof, wherein the canting and distal walls may be interconnected by an angled strut (24), a spring member (14), such as a leaf spring, may have a portion extending past an edge (27) of the strut to bias the clip to grip the needle shaft, and the distal wall may be or include a stylus (38) and have an L-shape to define a lip (36) to help block the needle tip. The clip may have a depending heel (34) to help pivot the clip about a ledge (72) to grip the needle shaft. A needle support (80) may be provided to limit flexure of the needle which might otherwise allow the needle to come loose from the clip. Arrangements (300, 302) for limiting rotation of the needle hub and needle guard housing are provided, as is a protective shroud (320) to reduce the risk of inadvertent activation of the needle guard. Further, the needle guard may be used with a catheter assembly (200). Also provided is an improved duckbill release mechanism (260, 268).
摘要翻译：护针器（10）包括具有用于夹持针轴（56）的倾斜壁（16）的夹子（12）和用于阻挡其的尖端（58）的远端壁（20），其中倾斜壁和远端壁可以通过成角度的支柱（24）相互连接，诸如片簧的弹簧构件（14）可以具有延伸超过支柱的边缘（27）的部分以偏压夹以夹持针轴，并且远端壁可以是或包括触针（38）并且具有L形以限定唇部（36）以帮助阻挡针尖。夹子可具有悬垂的脚跟（34）以帮助围绕凸缘（72）枢转夹子以夹持针轴。可以设置针支撑件（80）以限制针的弯曲，否则可能会使针从夹子上松脱。提供了用于限制针座和针头罩壳体的旋转的装置（300,302），如同保护罩（320）一样，以减少无意中启动针头罩的风险。此外，护针器可以与导管组件（200）一起使用。还提供了改进的鸭嘴形释放机构（260,268）。

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