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1. 发明申请

WO2013159005A3 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译：改善（LIGNO）纤维素材料分离中纤维素酶酶混合物活性的方法
公开(公告)号：WO2013159005A3
公开(公告)日：2014-01-16
申请号：PCT/US2013037390
申请日：2013-04-19
申请人： DYADIC INTERNAT USA LTD , EMALFARB MARK , SINITSYN ARKADY , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN
发明人： EMALFARB MARK , SINITSYN ARKADY , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN
IPC分类号： C12N1/15
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
摘要翻译：本发明涉及关于将复合碳水化合物转化为纤维素材料的简单糖的改进的活性谱的改良的丝状真菌生物，包括属于选自以下的属的真菌生物：Chrysosporium，Thielavia，Talaromyces，Thermomyces，嗜热链球菌，丝状芽孢杆菌，白喉菌，丝状菌属，丝状芽孢杆菌属，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其变形和远视。通过各种诱变方法修饰参与生产纤维二糖内酯，纤维二糖酸，葡萄糖酸内酯，葡萄糖酸和相关产品的酶的基因，得到具有改善的活性谱的丝状真菌生物，得到核苷酸取代，插入和缺失，增加从改性生物获得的酶混合物中的糖化水平。

2. 发明申请

WO2013159005A2 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译：改善（LIGNO）纤维素材料分离中纤维素酶酶混合物活性的方法
公开(公告)号：WO2013159005A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/037390
申请日：2013-04-19
申请人： DYADIC INTERNATIONAL (USA) LTD. , EMALFARB, Mark , SINITSYN, Arkady , JUNDZIL, Richard , WERY, Jan , VISSER, Jacob , JOOSTEN, Rob , KOETSIER, Martijn
发明人： EMALFARB, Mark , SINITSYN, Arkady , JUNDZIL, Richard , WERY, Jan , VISSER, Jacob , JOOSTEN, Rob , KOETSIER, Martijn
IPC分类号： C12N9/24 , C12N15/80 , C12P19/14
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
摘要翻译：本发明涉及关于将复合碳水化合物转化为纤维素材料的简单糖的改进的活性谱的改良的丝状真菌生物，包括属于选自以下的属的真菌生物：Chrysosporium，Thielavia，Talaromyces，Thermomyces，嗜热链球菌，丝状芽孢杆菌，白喉菌，丝状菌属，丝状芽孢杆菌属，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其变形和远视。通过各种诱变方法修饰参与生产纤维二糖内酯，纤维二糖酸，葡萄糖酸内酯，葡萄糖酸和相关产品的酶的基因，得到具有改善的活性谱的丝状真菌生物，得到核苷酸取代，插入和缺失，增加从改性生物获得的酶混合物中的糖化水平。

3. 发明申请

WO2012078741A3 NOVEL FUNGAL ESTERASES 审中-公开
公开(公告)号：WO2012078741A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063716
申请日：2011-12-07
申请人： DYADIC INTERNATIONAL (USA) INC. , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
发明人： VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
IPC分类号： C12N15/55 , C12N15/62 , C07K19/00 , C12N9/16 , C12N15/63
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve the digestability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.

4. 发明申请

WO2012021883A2 NOVEL FUNGAL ENZYMES 审中-公开
标题翻译：新型真菌酶
公开(公告)号：WO2012021883A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/047734
申请日：2011-08-15
申请人： DYADIC INTERNATIONAL, INC. , EMALFARB, Mark , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn
发明人： EMALFARB, Mark , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn
IPC分类号： A01H5/00
CPC分类号： C12N9/2402
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及各种真菌酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及将木质纤维素生物质转化为可发酵糖的方法，该酶用于降解木质纤维素材料和酶的新组合，包括提供来自植物生物质的糖的协同释放的酶。本发明还涉及通过细胞壁降解释放细胞内容物的方法。本发明还涉及在各种其它方法中使用新型酶和这些酶的组合物的方法，包括洗涤衣物，洗涤剂方法，生物精制，纸和纸浆的脱墨和生物漂白以及废物流的处理。

5. 发明申请

WO2012018691A2 NOVEL FUNGAL ENZYMES 审中-公开
标题翻译：新型真菌酶
公开(公告)号：WO2012018691A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/045949
申请日：2011-07-29
申请人： DYADIC INTERNATIONAL, INC. , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
发明人： VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
IPC分类号： C12P7/06
CPC分类号： C12P19/02 , A23K10/14 , A23K20/189 , A23L29/06 , C11D3/386 , C11D3/38636 , C11D3/38645 , C12N9/2402 , C12P7/10 , C12P2203/00 , C12Y302/01055 , D06L1/14 , D06L4/40 , D06M16/003 , D06P1/228 , D06P5/13 , D06P5/137 , D06P5/15 , D06P5/158 , D21C5/005 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve digestability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefming, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及各种真菌酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及将木质纤维素生物质转化为可发酵糖的方法，其中酶可降解木质纤维素材料和酶的新组合，包括提供来自植物生物质的糖的协同释放的酶。本发明还涉及通过细胞壁降解释放细胞内容物的方法。本发明还涉及使用新型酶和这些酶的组合物来提高动物饲料的消化能力和各种其他方法的方法，包括食品和饮料加工，烘烤，衣服洗涤，洗涤剂方法，生物修复，脱墨和生物漂白的纸和纸浆，以及废物流的处理。

6. 发明申请

WO2011059329A2 NOVEL PENTOSE TRANSPORTERS AND USES THEREOF 审中-公开
标题翻译：新款PENTOSE TRANSPORTERS及其用途
公开(公告)号：WO2011059329A2
公开(公告)日：2011-05-19
申请号：PCT/NL2010/050755
申请日：2010-11-12
申请人： UNIVERSITEIT UTRECHT HOLDING B.V. , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG , STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , UNIVERSITEIT LEIDEN , VANKUYK, Patricia, Ann , DE VRIES, Ronald, Peter , VISSER, Jacob , RAM, Arthur, Franciscus, Johannes , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes , BATTAGLIA, Evy , VIVAS DUARTE, Diana, Alexandra
发明人： VANKUYK, Patricia, Ann , DE VRIES, Ronald, Peter , VISSER, Jacob , RAM, Arthur, Franciscus, Johannes , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes , BATTAGLIA, Evy , VIVAS DUARTE, Diana, Alexandra
IPC分类号： C07K14/38
CPC分类号： C07K14/38 , Y02E50/16
摘要： The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.
摘要翻译：本发明涉及从粗碳源生产生物燃料，蛋白质，肽和其他增值化合物。发明人确定了编码新戊糖转运蛋白的基因，特别是L-阿拉伯糖和/或D-木糖的转运蛋白。通过xlnR和araR调节黑曲霉基因有助于鉴定这些基因及其底物特异性。提供新的戊糖转运体及其编码核酸。还提供了表达转运蛋白的宿主细胞（以上）及其工业应用，例如在生物燃料生产中。

7. 发明申请

WO9713853A3 PROTEIN DETECTION 审中-公开
标题翻译：蛋白质检测
公开(公告)号：WO9713853A3
公开(公告)日：1997-06-19
申请号：PCT/EP9604510
申请日：1996-10-14
申请人： GIST BROCADES BV , DEN BROECK HENRIETTE CATHARINA , GRAAFF LEENDERT HENDRIK DE , VISSER JACOB , OOYEN ALBERT JOHANNES JOSEPH V
发明人： VAN DEN BROECK HENRIETTE CATHA , DE GRAAFF LEENDERT HENDRIK , VISSER JACOB , VAN OOYEN ALBERT JOHANNES JOSE
IPC分类号： C12N15/09 , C07K14/38 , C07K14/39 , C12N1/21 , C12N9/24 , C12N9/42 , C12N15/00 , C12N15/10 , C12N15/56 , C12N15/70 , C12R1/19 , C12R1/66
CPC分类号： C12N15/1086 , C12N9/2437 , C12N9/248 , C12Y302/01004 , C12Y302/01008 , C12Y302/01032 , C12Y302/01055
摘要： The present invention provides a method for identifying a DNA fragment encoding a protein of interest, wherein a cDNA library in the form of bacterial host cells transformed with DNA obtainable from an eukaryotic organism capable of producing said protein is screened for expression of said protein using a test which is indicative for its presence, characterised in that screening of the host cells is performed after the transforming DNA has become part of a plasmid. The cDNA library is preferably from an eukaryotic organism. The eukaryotic organism is preferably a fungus or a yeast cell, more preferably an Aspergillus species, most preferred is a member of the Aspergillus niger group. The enzymes screened for are preferably enzymes which show cellulase, endoxylanase or arabinoxylan degrading activity.

8. 发明申请

WO1996041882A1 HYDROPHOBINS FROM EDIBLE FUNGI, GENES, NUCLEOTIDE SEQUENCES AND DNA-FRAGMENTS ENCODING FOR SAID HYDROPHOBINS, AND EXPRESSION THEREOF 审中-公开
标题翻译：从食用真菌，基因，核苷酸序列和编码用于表达该亲水基因的DNA片段的HYDROPHOBIN及其表达
公开(公告)号：WO1996041882A1
公开(公告)日：1996-12-27
申请号：PCT/NL1996000234
申请日：1996-06-11
申请人： PROEFSTATION VOOR DE CHAMPIGNONCULTUUR , RIJKSLANDBOUWUNIVERSITEIT WAGENINGEN , VAN GRIENSVEN, Leonardus, Johannes, Lambertus, Donatus , DE GROOT, Petrus, Wilhelmus, Johannes , SCHAAP, Petrus, Johannes , VISSER, Jacob
发明人： PROEFSTATION VOOR DE CHAMPIGNONCULTUUR , RIJKSLANDBOUWUNIVERSITEIT WAGENINGEN
IPC分类号： C12N15/31
CPC分类号： C07K14/375
摘要： The present invention relates to a hydrophobin, or a protein or polypeptide essentially corresponding thereto, derived from an edible fungus, preferably with GRAS status, more preferably from the genus Agaricus, such as Agaricus bisporus. The invention further relates to genes, nucleotide sequences or DNA fragments encoding a ripening form of such a hydropobin, as well as recombinant DNA material containing said gene, nucleotide sequence or DNA fragment. The invention further relates to a process for producing a ripening form of a hydrophobin, a protein or a polypeptide essentially corresponding thereto, derived from an edible fungus, comprising expression of such a gene, gene sequence or DNA fragment, for instance by culturing a cell containing this genetic material. In a further aspect, the invention relates to a regulatory region of a hydrophobin gene from an edible fungus, recombinant DNA material containing said region, as well as to a method for expressing genes in a fungus, preferably an edible fungus, in which said genes are brought to controlled expression under the control of said regulatory region. This method is preferably carried out using the genus Agaricus, especially the fruit bodies thereof.
摘要翻译：本发明涉及一种衍生自食用真菌，优选具有GRAS状态的疏水蛋白或基本相应于其的蛋白质或多肽，更优选来自姬松茸，例如双孢蘑菇。本发明还涉及编码这种水蛭素成熟形式的基因，核苷酸序列或DNA片段，以及含有该基因，核苷酸序列或DNA片段的重组DNA材料。本发明还涉及一种生产来源于食用真菌的疏水蛋白，基本上与其对应的蛋白质或多肽的成熟形式的方法，包括表达这种基因，基因序列或DNA片段，例如通过培养细胞含有这种遗传物质。在另一方面，本发明涉及来自食用真菌的疏水蛋白基因的调节区，含有所述区的重组DNA材料，以及用于在真菌（优选食用真菌）中表达基因的方法，其中所述基因在所述调节区域的控制下被带到受控表达。该方法优选使用姬松科，特别是其果实体进行。

9. 发明申请

WO2012027374A3 NOVEL FUNGAL CARBOHYDRATE HYDROLASES 审中-公开
标题翻译：新型FUNGAL CARBOHYDRATE HYDROLASES
公开(公告)号：WO2012027374A3
公开(公告)日：2012-08-16
申请号：PCT/US2011048817
申请日：2011-08-23
申请人： DYADIC INTERNAT USA INC , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
发明人： VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
IPC分类号： C12N15/56 , A23K1/165 , C11D3/386 , C12N9/24 , C12P7/06
CPC分类号： C11D3/38636 , A21D8/042 , A23K20/189 , C12N9/2402 , C12N9/2434 , C12Y302/01055 , Y02E50/17
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve digestability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及各种真菌酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及将木质纤维素生物质转化为可发酵糖的方法，该酶用于降解木质纤维素材料和酶的新组合，包括提供来自植物生物质的糖的协同释放的酶。本发明还涉及通过细胞壁降解释放细胞内容物的方法。本发明还涉及使用新型酶和这些酶的组合物来改善动物饲料的消化能力和各种其它方法的方法，包括食品和饮料加工，烘烤，衣服洗涤，洗涤剂方法，生物精炼，脱墨和生物漂白的纸和纸浆，以及废物流的处理。

10. 发明申请

WO2012018691A3 NOVEL FUNGAL ENZYMES 审中-公开
标题翻译：新型真菌酶
公开(公告)号：WO2012018691A3
公开(公告)日：2012-05-03
申请号：PCT/US2011045949
申请日：2011-07-29
申请人： DYADIC INTERNATIONAL INC , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
发明人： VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
IPC分类号： C07H21/04 , C12N9/30 , C12N9/58
CPC分类号： C12P19/02 , A23K10/14 , A23K20/189 , A23L29/06 , C11D3/386 , C11D3/38636 , C11D3/38645 , C12N9/2402 , C12P7/10 , C12P2203/00 , C12Y302/01055 , D06L1/14 , D06L4/40 , D06M16/003 , D06P1/228 , D06P5/13 , D06P5/137 , D06P5/15 , D06P5/158 , D21C5/005 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： This invention relates to novel fungal enzymes, nucleic acid molecules encoding such enzymes, and methods for producing the same. The invention further relates to a method to convert lignocellulosic biomass to fermentable sugars with the enzymes, novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass, release of cellular content by degradation of cell walls, improve digestability of animal feed, and use of the enzymes in food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新型真菌酶，编码这些酶的核酸分子及其制备方法。本发明进一步涉及一种将木质纤维素生物质转化为酶的可发酵糖的方法，酶的新型组合，包括提供植物生物质协同释放糖，通过细胞壁降解释放细胞含量，提高动物消化能力食品和饮料加工中的酶的进料和使用，烘焙，洗涤衣物，洗涤剂方法，生物精炼，纸和纸浆的脱墨和生物漂白以及废物流的处理。

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