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1. 发明申请

WO2008109603A2 VITAL SIGN MONITOR FOR CUFFLESSLY MEASURING BLOOD PRESSURE WITHOUT USING AN EXTERNAL CALIBRATION 审中-公开
标题翻译：无需使用外部校准即可测量血压的VITAL SIGN MONITOR
公开(公告)号：WO2008109603A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/055803
申请日：2008-03-04
申请人： TRIAGE WIRELESS, INC. , ZHOU, Zhou , DHILLON, Marshall, Singh , VISSER, Henk , TERRY, Andrew, Stanley , BANET, Matthew
发明人： ZHOU, Zhou , DHILLON, Marshall, Singh , VISSER, Henk , TERRY, Andrew, Stanley , BANET, Matthew
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/02125 , A61B5/0261 , A61B5/0402 , A61B5/6824 , A61B5/7239
摘要： The invention provides a method for measuring a patient's blood pressure featuring the following steps: 1) measuring a first time-dependent optical signal with a first optical sensor; 2) measuring a second time-dependent optical signal with a second optical sensor; 3) measuring a time-dependent electrical signal with an electrical sensor; 4) estimating the patient's arterial properties using either the first or second time-dependent optical signal; 5) determining a pulse transit time (PTT) from the time-dependent electrical signal and at least one of the first and second time-dependent optical signals; and 6) calculating a blood pressure value using a mathematical model that includes the PTT and the patient's arterial properties.
摘要翻译：本发明提供了一种用于测量患者血压的方法，其特征在于以下步骤：1）用第一光学传感器测量第一时间相关的光信号; 2）用第二光学传感器测量第二时间相关光信号; 3）用电传感器测量与时间有关的电信号; 4）使用第一或第二时间依赖光信号估计患者的动脉特性; 5）根据时间相关电信号和第一和第二时间依赖光信号中的至少一个确定脉冲传播时间（PTT）; 以及6）使用包括PTT和患者动脉特性的数学模型来计算血压值。

2. 发明申请

WO2007040975A3 INTERNET-BASED PATIENT-MONITORING SYSTEM FEATURING INTERACTIVE MESSAGING ENGINE 审中-公开
公开(公告)号：WO2007040975A3
公开(公告)日：2007-04-12
申请号：PCT/US2006/036311
申请日：2006-09-18
申请人： BERKELEY HEARTLAB, INC. , HALL, Christopher , LANIER, Vance, Whitson, Jr. , BANET, Matthew , SCHULTZ, Randon , DHILLON, Marshal , FLEMING, Adam , VISSER, Henk
发明人： HALL, Christopher , LANIER, Vance, Whitson, Jr. , BANET, Matthew , SCHULTZ, Randon , DHILLON, Marshal , FLEMING, Adam , VISSER, Henk
IPC分类号： A61B5/00
摘要： The invention provides: 1) a monitoring device featuring systems that monitor the patient's vital sign and exercise information; 2) an Internet-based system configured to receive, store, and display vital sign and exercise from the monitoring device, and blood test information from an external blood test; and 3) a messaging system configured to process the vital sign, exercise, and blood test information, and in response send a personalized message to the patient.

3. 发明申请

WO2007040971A2 INTERNET-BASED HEALTH MANAGEMENT SYSTEM FOR IDENTIFYING AND MINIMIZING RISK FACTORS CONTRIBUTING TO METABOLIC SYNDROME 审中-公开
标题翻译：基于因特网的健康管理系统识别和最小化代谢综合症的风险因素
公开(公告)号：WO2007040971A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/036301
申请日：2006-09-18
申请人： BERKELEY HEARTLAB , HALL, Christopher , LANIER, Vance , SHEWMAKE, David , RUDERMAN, Frank , BANET, Matthew , SCHULTZ, Randon , DHILLON, Marshal , FLEMING, Adam , VISSER, Henk
发明人： HALL, Christopher , LANIER, Vance , SHEWMAKE, David , RUDERMAN, Frank , BANET, Matthew , SCHULTZ, Randon , DHILLON, Marshal , FLEMING, Adam , VISSER, Henk
IPC分类号： G01N33/92
CPC分类号： A61B5/0022 , A61B5/021 , A61B5/024 , A61B5/145 , A61B5/14532 , G06F19/00 , G06F19/3481 , G06Q50/22 , G16H10/20 , G16H10/60 , G16H15/00
摘要： The invention provides a system that determines if a patient has Metabolic Syndrome, and in response provides a disease-management program that helps reduce medical risks associated with this malady. The system features a device configured to collect glucose information and blood pressure information, and then transmit this information to a central computer system. The system also includes a database configured to receive triglyceride information and cholesterol information from an external blood test, and a central computer system featuring: 1) a communication interface configured to communicate with the device to receive glucose and blood pressure information and with the database to receive triglyceride and cholesterol information; 2) a user interface configured to accept patient information; and 3) a processor configured to operate an algorithm that processes the glucose, blood pressure, triglyceride, cholesterol, and patient information to determine if the patient has Metabolic Syndrome.
摘要翻译：本发明提供了一种确定患者是否患有代谢综合征并且作为响应提供疾病管理程序以帮助降低与这种疾病相关的医疗风险的系统。该系统具有一个配置为收集葡萄糖信息和血压信息的设备，然后将该信息传输到中央计算机系统。该系统还包括配置成从外部血液测试接收甘油三酯信息和胆固醇信息的数据库，以及中央计算机系统，其特征在于：1）通信接口，被配置为与设备通信以接收葡萄糖和血压信息，并且与数据库接收甘油三酯和胆固醇信息; 2）配置成接受患者信息的用户界面; 以及3）配置成操作处理葡萄糖，血压，甘油三酯，胆固醇和患者信息以确定患者是否患有代谢综合征的算法的处理器。

4. 发明申请

WO2006018818A1 MINIMIZING POWER CONSUMPTION IN HIGH FREQUENCY DIGITAL CIRCUITS 审中-公开
标题翻译：在高频数字电路中最大限度地降低功耗
公开(公告)号：WO2006018818A1
公开(公告)日：2006-02-23
申请号：PCT/IB2005/052715
申请日：2005-08-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , VISSER, Henk , VAUCHER, Cicero
发明人： VISSER, Henk , VAUCHER, Cicero
IPC分类号： H03K3/0233
CPC分类号： H03L7/06 , H03K3/012 , H03K3/2885 , H03K3/289
摘要： A circuit comprises a frequency divider connected to receive respective Igate and hatch DC-biasing currents. Such frequency divider will self-resonate at some frequency that depends, in part, on these DC-biasing currents. Corresponding current sources provide programmable magnitudes for each of these DC-biasing currents, and can therefore affect the self-resonant frequency and overall power consumption. During calibration, the frequency divider is allowed to self-oscillate, and the DC-biasing currents are manipulated to cause the self-resonant frequency to approximate some target frequency. The DC-biasing currents can be opportunistically lowered and still maintain reliable operation when the selfresonant frequency of the frequency divider is tuned to the target operational frequency. Such calibration is repeated as needed during the service life of the device.
摘要翻译：电路包括分频器，其连接以接收相应的Igate和阴影直流偏置电流。这种分频器在某些频率下将自谐振，该频率部分取决于这些直流偏置电流。相应的电流源为这些直流偏置电流中的每一个提供可编程的幅度，因此可以影响自谐振频率和总功耗。在校准期间，分频器被允许自振荡，并且操纵DC偏置电流以使自谐振频率接近某些目标频率。当分频器的自谐振频率调谐到目标工作频率时，直流偏置电流可以机会地降低，并保持可靠的运行。在设备的使用寿命期间根据需要重复这种校准。

5. 发明申请

WO2007092380A2 APOLIPOPROTEIN E GENOTYPING AND ACCOMPANYING INTERNET-BASED HEALTH MANAGEMENT SYSTEM 审中-公开
标题翻译： APOLIPOPROTEIN E基因分析和相关互联网卫生管理系统
公开(公告)号：WO2007092380A2
公开(公告)日：2007-08-16
申请号：PCT/US2007003034
申请日：2007-02-06
申请人： BERKELEY HEARTLAB INC , BANET MATTHEW , SCHULTZ RANDON , DHILLON MARSHAL , FLEMING ADAM , VISSER HENK , HALL CHRISTOPHER , LANIER VANCE JR
发明人： BANET MATTHEW , SCHULTZ RANDON , DHILLON MARSHAL , FLEMING ADAM , VISSER HENK , HALL CHRISTOPHER , LANIER VANCE JR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , G06F19/18 , G06F19/3418 , G06F19/3475 , G06F19/3481
摘要： The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient
摘要翻译：本发明提供一种用于监测患者的系统，其包括：1）测量来自患者的Apo E基因型或其衍生物的血液检测以产生Apo E信息; 2）接收并存储患者Apo E信息的数据库; 以及3）连接到数据库并基于因特网的系统，其被配置为使用算法来处理Apo E信息，所述算法作为响应，为患者产生饮食和治疗计划

6. 发明申请

WO2008109603A3 VITAL SIGN MONITOR FOR CUFFLESSLY MEASURING BLOOD PRESSURE WITHOUT USING AN EXTERNAL CALIBRATION 审中-公开
标题翻译：无需使用外部校准即可测量血压的VITAL SIGN监视器
公开(公告)号：WO2008109603A3
公开(公告)日：2009-12-30
申请号：PCT/US2008055803
申请日：2008-03-04
申请人： TRIAGE WIRELESS INC , ZHOU ZHOU , DHILLON MARSHALL SINGH , VISSER HENK , TERRY ANDREW STANLEY , BANET MATTHEW
发明人： ZHOU ZHOU , DHILLON MARSHALL SINGH , VISSER HENK , TERRY ANDREW STANLEY , BANET MATTHEW
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/02125 , A61B5/0261 , A61B5/0402 , A61B5/6824 , A61B5/7239
摘要： The invention provides a method for measuring a patient's blood pressure featuring the following steps: 1) measuring a first time-dependent optical signal with a first optical sensor; 2) measuring a second time-dependent optical signal with a second optical sensor; 3) measuring a time-dependent electrical signal with an electrical sensor; 4) estimating the patient's arterial properties using either the first or second time-dependent optical signal; 5) determining a pulse transit time (PTT) from the time-dependent electrical signal and at least one of the first and second time-dependent optical signals; and 6) calculating a blood pressure value using a mathematical model that includes the PTT and the patient's arterial properties.
摘要翻译：本发明提供了一种用于测量患者血压的方法，其特征在于以下步骤：1）用第一光学传感器测量第一时间相关的光信号; 2）用第二光学传感器测量第二时间相关光信号; 3）用电传感器测量与时间有关的电信号; 4）使用第一或第二时间依赖光信号估计患者的动脉特性; 5）根据时间相关电信号和第一和第二时间依赖光信号中的至少一个确定脉冲传输时间（PTT）; 以及6）使用包括PTT和患者动脉特性的数学模型来计算血压值。

7. 发明申请

WO2008109604A3 MONITOR FOR MEASURING VITAL SIGNS AND RENDERING VIDEO IMAGES 审中-公开
标题翻译：用于测量重要标志和呈现视频图像的监视器
公开(公告)号：WO2008109604A3
公开(公告)日：2008-11-06
申请号：PCT/US2008055804
申请日：2008-03-04
申请人： TRIAGE DATA NETWORKS , ZHOU ZHOU , DHILLON MARSHALL SINGH , VISSER HENK , TERRY ANDREW STANLEY , BANET MATTHEW , HUNT KENNETH ROBERT , FLEMING ADAM MICHAEL
发明人： ZHOU ZHOU , DHILLON MARSHALL SINGH , VISSER HENK , TERRY ANDREW STANLEY , BANET MATTHEW , HUNT KENNETH ROBERT , FLEMING ADAM MICHAEL
IPC分类号： A61B5/00
CPC分类号： A61B5/02141 , A61B5/002 , A61B5/0022 , A61B5/021 , A61B5/02125 , A61B5/0261
摘要： The invention features a vital sign monitor that includes: (1) a sensor component that attaches to the patient and features an optical sensor and an electrical sensor that measure, respectively a first and second signal: and (2) a control component. The control component features: (1) an analog-to-digital converter configured to convert the first signal and second signal into, respectively, a first digital signal and a second digital signal; (2) a CPU configured to operate an algorithm that generates a blood pressure value by processing with an algorithm the first digital signal and second digital signal; (3) a display element; (4) a graphical user interface generated by computer code operating on the CPU and configured to render on the display element the blood pressure value; and (5) a software component that renders video images on the display element. To capture video and audio information, the device further includes both a digital camera and a microphone.
摘要翻译：本发明的特征在于一种生命体征监视器，其包括：（1）传感器组件，其附着到患者并且具有分别测量第一和第二信号的光学传感器和电气传感器;以及（2）控制组件。控制部件的特征在于：（1）模数转换器，被配置为将第一信号和第二信号分别转换为第一数字信号和第二数字信号; （2）CPU，被配置为操作通过用算法处理第一数字信号和第二数字信号来生成血压值的算法; （3）显示元件; （4）由在CPU上运行的计算机代码生成的图形用户界面，并且该图形用户界面被配置为在显示元件上呈现血压值; 和（5）在显示元件上呈现视频图像的软件组件。为了捕捉视频和音频信息，该设备还包括数码相机和麦克风。

8. 发明申请

WO2009009761A1 DEVICE FOR DETERMINING RESPIRATORY RATE AND OTHER VITAL SIGNS 审中-公开
标题翻译：用于确定呼吸率和其他身体信号的装置
公开(公告)号：WO2009009761A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069862
申请日：2008-07-11
申请人： TRIAGE WIRELESS, INC. , BANET, Matthew, J. , ZHOU, Zhou , KOPOTIC, Robert, J. , DHILLON, Marshall, Singh , TERRY, Andrew, Stanley , VISSER, Henk, II
发明人： BANET, Matthew, J. , ZHOU, Zhou , KOPOTIC, Robert, J. , DHILLON, Marshall, Singh , TERRY, Andrew, Stanley , VISSER, Henk, II
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/002 , A61B5/0022 , A61B5/02055 , A61B5/022 , A61B5/0408 , A61B5/0823 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B7/04 , A61B2560/0412 , A61B2560/0462 , A61B2560/0468 , G06F19/00 , G16H40/67
摘要： A body-worn sensor that measures respiratory rate and other vital signs using an acoustic sensor (e.g., a small-scale sensor). The body-worn sensor features a chest-worn patch sensor that combines both the acoustic sensor and an ECG electrode into a single adhesive patch. To measure blood pressure, the device additionally performs a 'composite' PTT-based measurement that features both pressure- dependent and pressure-free measurements. The acoustic sensor measures respiration rate by recording sounds related to the patient's inspiration and expiration. The acoustic sensor is typically placed near the patient's trachea, but can also be placed on the middle right and left side of the chest, and the middle right and left side of the back.
摘要翻译：使用声传感器（例如小型传感器）测量呼吸频率和其他生命体征的身体磨损传感器。身体磨损的传感器具有胸部贴片传感器，其将声学传感器和ECG电极组合成单个粘合剂贴片。为了测量血压，该装置还执行基于PTT的“复合”测量，其具有压力依赖性和无压力测量。声学传感器通过记录与患者的吸气和呼气相关的声音来测量呼吸率。声学传感器通常放置在病人的气管附近，但也可以放置在胸部的中间右侧和左侧以及背部的中间右侧和左侧。

9. 发明申请

WO2007040971A3 INTERNET-BASED HEALTH MANAGEMENT SYSTEM FOR IDENTIFYING AND MINIMIZING RISK FACTORS CONTRIBUTING TO METABOLIC SYNDROME 审中-公开
标题翻译：基于互联网的卫生管理系统，用于识别和最小化风险因素对代谢综合征的贡献
公开(公告)号：WO2007040971A3
公开(公告)日：2007-10-11
申请号：PCT/US2006036301
申请日：2006-09-18
申请人： BERKELEY HEARTLAB , HALL CHRISTOPHER , LANIER VANCE , SHEWMAKE DAVID , RUDERMAN FRANK , BANET MATTHEW , SCHULTZ RANDON , DHILLON MARSHAL , FLEMING ADAM , VISSER HENK
发明人： HALL CHRISTOPHER , LANIER VANCE , SHEWMAKE DAVID , RUDERMAN FRANK , BANET MATTHEW , SCHULTZ RANDON , DHILLON MARSHAL , FLEMING ADAM , VISSER HENK
IPC分类号： G06F19/00
CPC分类号： A61B5/0022 , A61B5/021 , A61B5/024 , A61B5/145 , A61B5/14532 , G06F19/3481 , G06Q50/22 , G16H10/20 , G16H10/60 , G16H15/00
摘要： The invention provides a system that determines if a patient has Metabolic Syndrome, and in response provides a disease-management program that helps reduce medical risks associated with this malady. The system features a device configured to collect glucose information and blood pressure information, and then transmit this information to a central computer system. The system also includes a database configured to receive triglyceride information and cholesterol information from an external blood test, and a central computer system featuring: 1) a communication interface configured to communicate with the device to receive glucose and blood pressure information and with the database to receive triglyceride and cholesterol information; 2) a user interface configured to accept patient information; and 3) a processor configured to operate an algorithm that processes the glucose, blood pressure, triglyceride, cholesterol, and patient information to determine if the patient has Metabolic Syndrome.
摘要翻译：本发明提供了一种确定患者是否具有代谢综合征的系统，并且作为响应提供了有助于减少与该疾病相关的医疗风险的疾病管理程序。该系统具有被配置为收集葡萄糖信息和血压信息的装置，然后将该信息发送到中央计算机系统。该系统还包括配置为从外部血液测试中接收甘油三酯信息和胆固醇信息的数据库，以及中央计算机系统，其特征在于：1）通信接口，被配置为与设备通信以接收葡萄糖和血压信息，并且与数据库接受甘油三酯和胆固醇信息; 2）被配置为接收患者信息的用户界面; 以及3）处理器，其被配置为操作处理葡萄糖，血压，甘油三酯，胆固醇和患者信息以确定患者是否具有代谢综合征的算法。

10. 发明申请

WO2011034881A1 BODY-WORN VITAL SIGN MONITOR 审中-公开
标题翻译：身体健康监视器
公开(公告)号：WO2011034881A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/048866
申请日：2010-09-15
申请人： SOTERA WIRELESS, INC. , MOON, Jim , VISSER, Henk , HUNT, Robert , MCCOMBIE, Devin , DHILLON, Marshal , BANET, Matt
发明人： MOON, Jim , VISSER, Henk , HUNT, Robert , MCCOMBIE, Devin , DHILLON, Marshal , BANET, Matt
IPC分类号： A61B5/00
CPC分类号： A61B5/1116 , A61B5/0006 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/02225 , A61B5/0476 , A61B5/0809 , A61B5/0816 , A61B5/1118 , A61B5/14551 , A61B5/681 , A61B5/6823 , A61B5/6824 , A61B5/6826 , A61B2560/0209 , A61B2562/0219 , A61B2562/043 , G06F19/00
摘要： The invention provides a body- worn monitor featuring a processing system that receives a digital data stream from an ECG system. A cable houses the ECG system at one terminal end, and plugs into the processing system, which is worn on the patient's wrist like a conventional wristwatch. The ECG system features: i) a connecting portion connected to multiple electrodes worn by the patient; ii) a differential amplifier that receives electrical signals from each electrode and process them to generate an analog ECG waveform; iii) an analog-to-digital converter that converts the analog ECG waveform into a digital ECG waveform; and iv) a transceiver that transmits a digital data stream representing the digital ECG waveform (or information calculated from the waveform) through the cable and to the processing system. Different ECG systems, typically featuring three, five, or twelve electrodes, can be interchanged with one another.
摘要翻译：本发明提供了一种身体穿戴式监视器，其特征在于从ECG系统接收数字数据流的处理系统。电缆在一个终端安装ECG系统，并插入到像传统手表一样佩戴在患者手腕上的处理系统中。 ECG系统的特征在于：i）与患者佩戴的多个电极连接的连接部分; ii）差分放大器，其从每个电极接收电信号并处理它们以产生模拟ECG波形; iii）模拟 - 数字转换器，将模拟ECG波形转换为数字ECG波形; 以及iv）收发器，其通过电缆和处理系统发送表示数字ECG波形（或从波形计算的信息）的数字数据流。通常具有三个，五个或十二个电极的ECG系统可以彼此互换。

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