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1. 发明申请

WO2021038541A1 VIBRATION MOTOR 审中-公开
公开(公告)号：WO2021038541A1
公开(公告)日：2021-03-04
申请号：PCT/IB2020/058127
申请日：2020-09-01
申请人： VIBRANT LTD.
发明人： MOLNAR, Shai
IPC分类号： H02K7/06 , H02K1/34 , B06B1/04
摘要： A vibration motor, including a shell defining a cavity therein, an axis disposed entirely within the cavity, a first magnet which is rotationally movable relative to the shell and which includes at least two sections having alternating poles, and a second magnet including at least two sections having alternating poles. A first extension tab is attached to the first magnet and extends out of the shell via a slot. An unbalanced rotor is disposed between the first and the second magnets and is rotatable relative to the axis. The first extension tab is movable within the slot, such that moving the tab causes movement of the first magnet and changes a rotational position of the first magnet relative to the second magnet, thereby to change the efficiency of operation of the motor.

2. 发明申请

WO2019197964A1 VIBRATING CAPSULE FOR ENHANCING ABSORPTION OF INGESTED MEDICAMENTS 审中-公开
公开(公告)号：WO2019197964A1
公开(公告)日：2019-10-17
申请号：PCT/IB2019/052866
申请日：2019-04-08
申请人： VIBRANT LTD.
发明人： BEN-TSUR, Lior
IPC分类号： A61H23/00 , A61H23/02 , A61B17/22 , A61H21/00
摘要： A system and a method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament. The vibrating gastrointestinal capsule may include a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.

3. 发明申请

WO2013121276A1 GASTROINTESTINAL CAPSULE 审中-公开
标题翻译：胃肠胶囊
公开(公告)号：WO2013121276A1
公开(公告)日：2013-08-22
申请号：PCT/IB2013/000203
申请日：2013-02-17
申请人： VIBRANT LTD
发明人： SHABBAT, Ronny
IPC分类号： A61B1/00 , A61H21/00 , A61H23/02
CPC分类号： A61H23/02 , A61B1/00156 , A61H21/00 , A61H23/0254 , A61H23/0263 , A61H2201/1207 , A61H2201/149 , A61H2205/083
摘要： According to the teachings of the present invention there is provided a gastrointestinal capsule and treatment methods utilizing such a capsule, the capsule including: (a) a capsule housing having a longitudinal axis; (b) at least one thrusting mechanism, disposed within the housing, the thrusting mechanism adapted to exert radial forces on the housing, in a radial direction with respect to the axis, such that, when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in an active mode, the gastrointestinal capsule exerts forces against, or in a direction of, the walls of the tract; and (c) a power supply adapted to power the mechanism, wherein a ratio of the radial forces to axial forces exerted in an axial direction with respect to the axis, on the housing, by the thrusting mechanism, is at least 1:1.
摘要翻译：根据本发明的教导，提供了一种胃肠胶囊和利用这种胶囊的治疗方法，所述胶囊包括：（a）具有纵向轴线的胶囊壳体; （b）设置在所述壳体内的至少一个推压机构，所述推压机构适于相对于所述轴线在径向方向上在所述壳体上施加径向力，使得当所述胶囊设置在所述壳体的胃肠道内时使用者，并且所述机构处于主动模式，所述胃肠胶囊对所述管道的壁施加力或抵抗所述管道的壁的方向; 以及（c）适于对所述机构供电的电源，其中所述径向力与通过所述推压机构相对于所述轴线在所述壳体上的轴向方向上施加的轴向力之比至少为1:1。

4. 发明申请

WO2008035329A3 GASTROINTESTINAL CAPSULE 审中-公开
标题翻译：胃肠胶囊
公开(公告)号：WO2008035329A3
公开(公告)日：2009-05-07
申请号：PCT/IL2007001139
申请日：2007-09-17
申请人： VIBRANT LTD , SHOHAT SHAUL , BELENKY ALEXANDER , SHABAT RONI
发明人： SHOHAT SHAUL , BELENKY ALEXANDER , SHABAT RONI
IPC分类号： A61H1/00 , A61H23/02
CPC分类号： A61H23/0263 , A61H23/02 , A61H2205/083
摘要： An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (Gl) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the Gl wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
摘要翻译：提供了用于通过交替地和反复地加压和/或振动来机械刺激胃肠（G1）壁的一部分的可摄入胃肠胶囊（GIC）。 GIC被编程为在预定义的时间延迟之后被激活。激活的GIC搅动，摇动，摇晃，颠簸，振动和/或以往复的伸缩运动移动，从而在目标位置机械地刺激G1壁的相邻部分。 GIC的激活可以包括许多自动完成的部分激活，例如当从设置GIC开始的时刻经过等于预定时间延迟的时间时; 当施加到GIC上的机械载荷超过和/或变得低于相应的预定水平的机械载荷时; 当环境pH达到预定义的水平或变化时，和/或与用户相关联的温度达到预定阈值。搅拌是通过嵌入GIC中的搅拌装置来实现的。这种搅拌装置包括附接到电动机的轴的不平衡重物，由例如电磁螺线管执行的致动器，嵌入在GIC中的电活性聚合物（EAP），介电弹性体致动器（DEA）发明。

5. 发明申请

WO2020152574A2 DEVICE AND METHOD FOR DELIVERING A FLOWABLE INGESTIBLE MEDICAMENT INTO THE GASTROINTESTINAL TRACT OF A USER 审中-公开
公开(公告)号：WO2020152574A2
公开(公告)日：2020-07-30
申请号：PCT/IB2020/050433
申请日：2020-01-21
申请人： VIBRANT LTD.
发明人： BEN-TSUR, Lior , SHABAT, Roni , MOLNAR, Shai
摘要： A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to, or including, a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitation mechanism is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.

6. 发明申请

WO2020141469A1 DEVICE AND METHOD FOR DELIVERING AN INGESTIBLE MEDICAMENT INTO THE GASTROINTESTINAL TRACT OF A USER 审中-公开
公开(公告)号：WO2020141469A1
公开(公告)日：2020-07-09
申请号：PCT/IB2020/050008
申请日：2020-01-02
申请人： VIBRANT LTD.
发明人： BEN-TSUR, Lior , MOLNAR, Shai , SHABBAT, Ronny
IPC分类号： A61M31/00 , A61H21/00
摘要： Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

7. 发明申请

WO2020161619A1 TEMPERATURE ACTIVATED VIBRATING CAPSULE FOR GASTROINTESTINAL TREATMENT 审中-公开
公开(公告)号：WO2020161619A1
公开(公告)日：2020-08-13
申请号：PCT/IB2020/050873
申请日：2020-02-04
申请人： VIBRANT LTD.
发明人： MOLNAR, Shai
IPC分类号： A61H21/00 , A61B5/07 , A61H23/00
摘要： A vibrating ingestible capsule includes a housing having a longitudinal axis, and having a vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A power supply disposed within the housing is adapted to power the vibrating agitation mechanism. A temperature sensor provides temperature information signals with respect to a temperature in an environment surrounding the vibrating ingestible capsule over a period of time. A control element is adapted to receive the temperature information signals from the temperature sensor, to identify a current temperature-overtime pattern based on the temperature information signals received from said temperature sensor, to compare the current temperature-over-time pattern to a predetermined temperature-over-time pattern, and, after the current temperature-overtime matches the predetermined temperature-over-time pattern, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation.

8. 发明申请

WO2019186445A1 GASTROINTESTINAL TREATMENT SYSTEM INCLUDING A VIBRATING CAPSULE, AND METHOD OF USE THEREOF 审中-公开
公开(公告)号：WO2019186445A1
公开(公告)日：2019-10-03
申请号：PCT/IB2019/052529
申请日：2019-03-28
申请人： VIBRANT LTD.
发明人： BEN-TSUR, Lior , MOLNAR, Shai , SHABAT, Roni
IPC分类号： A61H23/00 , A61H21/00 , A61H23/02
摘要： A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitation mechanism, powered by the battery, the vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; and (d) a control mechanism adapted, in response to receipt of an activation input, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.

9. 发明申请

WO2018055487A1 METHODS AND SYSTEMS FOR ADAPTIVE TREATMENT OF DISORDERS IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：用于胃肠道病变适应性治疗的方法和系统
公开(公告)号：WO2018055487A1
公开(公告)日：2018-03-29
申请号：PCT/IB2017/055565
申请日：2017-09-14
申请人： VIBRANT LTD.
发明人： BEN-TSUR, Lior , MOLNAR, Shai , SHABAT, Roni , LAMPERT, Shalom
IPC分类号： A61H21/00 , A61H23/02 , A61B10/00
摘要： A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
摘要翻译：一种使用治疗方案治疗受试者的胃肠道病症的系统和方法，所述治疗方案至少部分基于与其他受试者有关的数据及其对于治疗各种治疗方案。

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