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1. 发明申请

WO2014134561A3 QUANTIFICATION OF VACCINE COMPOSITIONS 审中-公开
标题翻译：疫苗组合物的定量
公开(公告)号：WO2014134561A3
公开(公告)日：2014-10-23
申请号：PCT/US2014019643
申请日：2014-02-28
申请人： BOEHRINGER INGELHEIM VETMED , EICHMEYER MARC ALLAN , ROOF MICHAEL B , SCHAEFFER MERRILL LYNN , VAUGHN ERIC MARTIN , YANG KUN , RUSH JEREMY RICHARD , MURFIN DANIEL JOHN
发明人： EICHMEYER MARC ALLAN , ROOF MICHAEL B , SCHAEFFER MERRILL LYNN , VAUGHN ERIC MARTIN , YANG KUN , RUSH JEREMY RICHARD , MURFIN DANIEL JOHN
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , G01N33/68
CPC分类号： C12Q1/37 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/005 , G01N33/56983 , G01N33/6848 , G01N2333/01
摘要： The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.
摘要翻译：本发明提供了用于所述方法中的方法和质量标记的肽，用于使用样品和标准品的质谱分析对含有与所述病毒蛋白质结合的试剂的制剂样品中的一种或多种病毒蛋白质的存在进行定量含有已知量的标记和未标记的标记肽，特别是其中所述病毒蛋白是猪圆环病毒疫苗中的抗原。

2. 发明申请

WO2012110489A3 NOVEL EUROPEAN PRRSV STRAIN 审中-公开
标题翻译：新欧洲PRRSV菌株
公开(公告)号：WO2012110489A3
公开(公告)日：2012-10-11
申请号：PCT/EP2012052475
申请日：2012-02-14
申请人： BOEHRINGER INGELHEIM VETMED , BURGARD KIM , KROLL JEREMY , LAYTON SARAH M , OHLINGER VOLKER , ORVEILLON FRANCOIS-XAVIER , PESCH STEFAN , PIONTKOWSKI MICHAEL DENNIS , ROOF MICHAEL B , UTLEY PHILIP , VAUGHN ERIC MARTIN
发明人： BURGARD KIM , KROLL JEREMY , LAYTON SARAH M , OHLINGER VOLKER , ORVEILLON FRANCOIS-XAVIER , PESCH STEFAN , PIONTKOWSKI MICHAEL DENNIS , ROOF MICHAEL B , UTLEY PHILIP , VAUGHN ERIC MARTIN
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
摘要翻译：本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。

3. 发明申请

WO2012054907A3 NOVEL HEMAGGLUTININ 5 (H5) PROTEINS FOR THE TREATMENT AND PREVENTION OF INFLUENZA INFECTIONS 审中-公开
标题翻译：新型HEMAGGLUTININ 5（H5）用于治疗和预防感染流行性感冒的蛋白质
公开(公告)号：WO2012054907A3
公开(公告)日：2012-06-21
申请号：PCT/US2011057406
申请日：2011-10-22
申请人： BOEHRINGER INGELHEIM VETMED , BOEHRINGER INGELHEIM VETMED , GONZALEZ-HERNANDEZ PAULINO CARLOS , LEON KEMPIS MARIA DEL ROCIO , REALPE-QUINTERO MAURICIO ALBERTO , STADLER KONRAD , VAUGHN ERIC MARTIN
发明人： GONZALEZ-HERNANDEZ PAULINO CARLOS , LEON KEMPIS MARIA DEL ROCIO , REALPE-QUINTERO MAURICIO ALBERTO , STADLER KONRAD , VAUGHN ERIC MARTIN
IPC分类号： C07K14/11 , A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55566 , C12N2760/16134
摘要： The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals, in particular for the treatment and prevention of influenza infections with H5N1 of North African origin.
摘要翻译：本发明涉及新的血凝素H5蛋白，核酸和编码这些蛋白的载体以及包含任何这样的H5蛋白，核酸或编码这些H5蛋白的载体的疫苗。此外，本发明还涉及任何这样的组合物在人和动物中的药物用途，特别是用于治疗和预防来自北非H5N1的流感感染。

4. 发明申请

WO2005041890A2 ERYSIPELOTHRIX RHUSIOPATHIAE-HAEMOPHILUS PARASUIS VACCINE AND METHODS OF USING THE SAME 审中-公开
标题翻译： ERYSIPELOTHRIX RHUSIOPATHIAE-HAEMOPHILUS PARASUIS疫苗及其使用方法
公开(公告)号：WO2005041890A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036336
申请日：2004-10-29
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , SWART, John, Randall , VAUGHN, Eric, Martin , FREKING, KAREN, E. , ROOF, Michael, B. , HAYES, Phillip, Wayne , PHILLIPS, Reid, C.
发明人： SWART, John, Randall , VAUGHN, Eric, Martin , FREKING, KAREN, E. , ROOF, Michael, B. , HAYES, Phillip, Wayne , PHILLIPS, Reid, C.
IPC分类号： A61K
CPC分类号： A61K39/102 , A61K39/0241 , A61K2039/54 , A61K2039/552 , A61K2039/55566
摘要： The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which provides one or more of the following: 1) confers effective immunity against E. rhusiopathiae and/or H. parasuis ; 2) decreases the risk of developing clinical signs of E. rhusiopathiae and/or H. parasuis infection; 3) induces an immune response against E. rhusiopathiae and/or H. parasuis ; and 4) has a DOI against E. rhusiopathiae and/or H. parasuis of at least four months. The composition or E. rhusiopathiae vaccine as well as the combined E. rhusiopathiae-H. parasuis composition or vaccine each includes a bacterial component of inactivated E. rhusiopathiae bacteria and a suitable adjuvant. The combined E. rhusiopathiae-H. parasuis composition or vaccine further includes an amount of H. parasuis antigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount of E. rhusiopathiae and/or H. parasuis antigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting from E. rhusiopathiae and/or H. parasuis infection for a suitable duration of immunity.
摘要翻译：本发明提供了针对E的组合物和改进的单剂量疫苗。以及改善抗猪红斑丹毒丝菌和H的单剂量疫苗。提供以下一种或多种方法的副猪嗜血杆菌：1）赋予针对E的有效免疫力。（rhusiopathiae）和/或H。副猪嗜血杆菌的; 2）降低发展为E的临床体征的风险。猪红斑痤疮和/或副猪嗜血杆菌感染; 3）诱导针对E的免疫应答。（rhusiopathiae）和/或H。副猪嗜血杆菌的; 和4）具有针对E的DOI。（rhusiopathiae）和/或H。副猪至少四个月。该组合物或E。 rhusiopathiae疫苗以及组合的E。丝菌-H。副猪嗜血杆菌组合物或疫苗各自包含灭活E的细菌组分。猪红斑丹毒丝菌和一种合适的佐剂。合并的E。丝菌-H。副猪嗜血杆菌组合物或疫苗还包含一定量的H。副猪嗜血杆菌抗原。疫苗可以以任何常规方式给予动物。肌内给药的剂量优选小于5ml。猪红斑痤疮和/或H的量。每种剂量的副猪嗜血杆菌抗原应足以在接受疫苗或组合物的动物中诱导免疫应答，并且将优选赋予针对由E引起的临床体征的有效免疫力并降低产生临床体征的风险。（rhusiopathiae）和/或H。副猪嗜血杆菌感染一段时间的免疫力。

5. 发明申请

WO2014150822A3 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, COMPOSITIONS, VACCINE AND METHODS OF USE 审中-公开
标题翻译： PORCINE生殖和呼吸道综合症病毒，组合物，疫苗和使用方法
公开(公告)号：WO2014150822A3
公开(公告)日：2014-12-11
申请号：PCT/US2014024321
申请日：2014-03-12
申请人： BOEHRINGER INGELHEIM VETMED , JORDAN DIANNA M MURPHY , MARTINSON BRIAN THOMAS , ROOF MICHAEL B , VAUGHN ERIC MARTIN , VICTORIA JOSEPH GILBERT
发明人： JORDAN DIANNA M MURPHY , MARTINSON BRIAN THOMAS , ROOF MICHAEL B , VAUGHN ERIC MARTIN , VICTORIA JOSEPH GILBERT
IPC分类号： A61K39/12 , A61P31/00 , C07K14/08 , C12N15/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.
摘要翻译：本发明涉及具有增加的稳定性的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有从其衍生的菌株或抗原的组合物; 含有菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 特异性结合所述多肽的抗体及其制备和使用方法。

6. 发明申请

WO2014179200A1 ORF2 PROTEIN OF PCV2 SUBTYPE A (PCV2A) FOR USE IN CROSS-PROTECTION 审中-公开
标题翻译：用于交叉保护的PCV2亚型A（PCV2A）的ORF2蛋白质
公开(公告)号：WO2014179200A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/035640
申请日：2014-04-28
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , HAIWICK, Gregory , HERNANDEZ, Luis , JOHNSON, Wesley Scott , MUEHLENTHALER, Christine Margaret , VAUGHN, Eric Martin
发明人： HAIWICK, Gregory , HERNANDEZ, Luis , JOHNSON, Wesley Scott , MUEHLENTHALER, Christine Margaret , VAUGHN, Eric Martin
IPC分类号： A61K39/12 , C07K14/01
CPC分类号： A61K39/12 , A61K39/0208 , A61K39/0258 , A61K39/04 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/092 , A61K39/145 , A61K39/215 , A61K39/23 , A61K39/235 , A61K39/245 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/70 , C12N7/00 , C12N2750/10022 , C12N2750/10034
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype a (PCV2a) ORF2 proteins or immunogenic compositions comprising a PCV2a ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of a different subtype, the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of a different subtype, or the prevention or treatment of a disease caused by an infection with PCV2 of a different subtype.
摘要翻译：公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。具体地说，将PCV2亚型（PCV2a）ORF2蛋白质或包含PCV2a ORF2蛋白质的免疫原性组合物用于治疗或预防不同亚型的PCV2感染的方法，减少，预防或治疗由不同亚型的PCV2的感染，或预防或治疗由不同亚型的PCV2的感染引起的疾病。

7. 发明申请

WO2014150822A2 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, COMPOSITIONS, VACCINE AND METHODS OF USE 审中-公开
标题翻译：猪繁殖与呼吸综合症病毒，组合物，疫苗和使用方法
公开(公告)号：WO2014150822A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/024321
申请日：2014-03-12
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , JORDAN, Dianna M. Murphy , MARTINSON, Brian Thomas , ROOF, Michael B. , VAUGHN, Eric Martin , VICTORIA, Joseph Gilbert
发明人： JORDAN, Dianna M. Murphy , MARTINSON, Brian Thomas , ROOF, Michael B. , VAUGHN, Eric Martin , VICTORIA, Joseph Gilbert
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.
摘要翻译：本发明涉及稳定性增加的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有由其衍生的菌株或抗原的组合物; 含有该菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 与所述多肽特异性结合的抗体，以及制备和使用其的方法。

8. 发明申请

WO2007053446A2 USE OF VACCINES FOR THE TREATMENT/PREVENTION OF THE TRANSMISSION OF PATHOGENS 审中-公开
标题翻译：使用疫苗进行治疗/预防传染病
公开(公告)号：WO2007053446A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041989
申请日：2006-10-27
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , BOEHRINGER INGELHEIM VETMEDICA, INC , DAEMMGEN, Juergen , VAUGHN, Eric, Martin
发明人： DAEMMGEN, Juergen , VAUGHN, Eric, Martin
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5252 , A61K2039/5256 , A61K2039/55 , A61K2039/552 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a method for prevention of the transmission of a pathogen of an animal of a first species to an animal of a second species characterized in that antigen of the pathogen of the animal of the first species is used for the immunization of the animal of the second species against the pathogen of the animal of the first species, wherein the administration of said antigen results in the reduction or the absence of the reproduction of pathogen of the animal of the first species in the animal of the second species.
摘要翻译：本发明涉及一种用于预防第一种动物的病原体向第二物种的动物传播的方法，其特征在于将第一种动物的病原体的抗原用于免疫针对第一种动物的病原体的第二物种的动物，其中所述抗原的施用导致第二物种动物中第一物种的动物的病原体的繁殖的减少或不存在。

9. 发明申请

WO2014099669A1 PORCINE PARVOVIRUS 5A, METHODS OF USE AND VACCINE 审中-公开
标题翻译： PORCINE PARVOVIRUS 5A，使用方法和疫苗
公开(公告)号：WO2014099669A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/075059
申请日：2014-01-15
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , IYER, Arun V. , JORDAN, Dianna M. Murphy , PATTERSON, Abby Rae , ROOF, Michael B. , VAUGHN, Eric Martin , VICTORIA, Joseph Gilbert , VISEK, Callie Ann
发明人： IYER, Arun V. , JORDAN, Dianna M. Murphy , PATTERSON, Abby Rae , ROOF, Michael B. , VAUGHN, Eric Martin , VICTORIA, Joseph Gilbert , VISEK, Callie Ann
IPC分类号： C07K14/015 , A61K39/23 , C12N7/00 , C07K16/08 , G01N33/569
CPC分类号： A61K39/23 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/14021 , C12N2750/14022 , C12N2750/14034 , G01N33/6893
摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia , domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.
摘要翻译：本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗以及涉及制造和使用感染尤其是家猪的新型猪细小病毒5A（PPV5A）的方法。组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和牛群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。

10. 发明申请

WO2012110489A2 NOVEL EUROPEAN PRRSV STRAIN 审中-公开
标题翻译：新的欧洲PRRSV菌株
公开(公告)号：WO2012110489A2
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052475
申请日：2012-02-14
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , BURGARD, Kim , KROLL, Jeremy , LAYTON, Sarah M. , OHLINGER, Volker , ORVEILLON, Francois-Xavier , PESCH, Stefan , PIONTKOWSKI, Michael Dennis , ROOF, Michael B. , UTLEY, Philip , VAUGHN, Eric Martin
发明人： BURGARD, Kim , KROLL, Jeremy , LAYTON, Sarah M. , OHLINGER, Volker , ORVEILLON, Francois-Xavier , PESCH, Stefan , PIONTKOWSKI, Michael Dennis , ROOF, Michael B. , UTLEY, Philip , VAUGHN, Eric Martin
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
摘要翻译：本发明涉及含有新型PRRSV欧洲PRRSV毒株的改良的改良活PRRS疫苗及其使用和生产方法。

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