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1. 发明申请

WO2012110489A2 NOVEL EUROPEAN PRRSV STRAIN 审中-公开
标题翻译：新的欧洲PRRSV菌株
公开(公告)号：WO2012110489A2
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052475
申请日：2012-02-14
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH , BURGARD, Kim , KROLL, Jeremy , LAYTON, Sarah M. , OHLINGER, Volker , ORVEILLON, Francois-Xavier , PESCH, Stefan , PIONTKOWSKI, Michael Dennis , ROOF, Michael B. , UTLEY, Philip , VAUGHN, Eric Martin
发明人： BURGARD, Kim , KROLL, Jeremy , LAYTON, Sarah M. , OHLINGER, Volker , ORVEILLON, Francois-Xavier , PESCH, Stefan , PIONTKOWSKI, Michael Dennis , ROOF, Michael B. , UTLEY, Philip , VAUGHN, Eric Martin
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
摘要翻译：本发明涉及含有新型PRRSV欧洲PRRSV毒株的改良的改良活PRRS疫苗及其使用和生产方法。

2. 发明申请

WO2011059950A1 ACTINOBACILLUS SUIS ANTIGENS 审中-公开
公开(公告)号：WO2011059950A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055951
申请日：2010-11-09
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , JORDAN, Dianna Marie Murphy , KROLL, Jeremy J. , UTLEY, Philip
发明人： JORDAN, Dianna Marie Murphy , KROLL, Jeremy J. , UTLEY, Philip
IPC分类号： A61K39/102 , A61P31/04
CPC分类号： G01N33/56911 , A61K39/102 , A61K2039/552
摘要： The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection by Actinobacillus suis . These immunogenic compositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective against A. suis. In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.
摘要翻译：本发明提供了可用于抑制，治疗，保护或预防由放线杆菌感染的免疫原性组合物。证明这些免疫原性组合物有效刺激处理的猪的免疫原性反应。一些疫苗刺激的反应足以防止A. suis。此外，本发明提供了包含免疫原性组合物的试剂盒; 以及使用组合物和试剂盒的方法。

3. 发明申请

WO2008063959A1 VACCINATION OF HORSES AGAINST LAWSONIA INTRACELLULARIS 审中-公开
标题翻译：革兰氏阴性细菌侵袭
公开(公告)号：WO2008063959A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/084435
申请日：2007-11-12
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , KROLL, Jeremy , NEUBAUER, Axel , UTLEY, Philip , ROOF, Michael , DAEMMGEN, Juergen , ELBERS, Knut
发明人： KROLL, Jeremy , NEUBAUER, Axel , UTLEY, Philip , ROOF, Michael , DAEMMGEN, Juergen , ELBERS, Knut
IPC分类号： A61K39/02
CPC分类号： A61K39/105 , A61K2039/522 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/552
摘要： The present invention is broadly concerned with vaccination of horses against proliferative enteritis, preferably equine proliferative ileitis, which is caused by an obligate intracellular bacterium Lawsonia Intracellularis (L intracellularis). Specifically, the invention provides for a method of providing immune protection against L intracellularis by vaccinating horses, preferably foals starting from one (1) week of age. Preferably the foals are vaccinated with about 4.9 ioglO to about 6.9 logl Oof a live modified L intracellularis bacteria per dose.
摘要翻译：本发明广泛涉及针对增殖性肠炎，优选马属增殖性回肠炎的马的免疫接种，其是由专性细胞内细菌细胞内劳森氏细菌（L细胞内）引起的。具体而言，本发明提供了一种通过接种马，优选从一（1）周龄开始的驹来提供针对细胞内毒素L的免疫保护的方法。优选地，以每剂量的活体修饰的细胞内源细菌细胞接种约4.9IgglO至约6.9log1O的驹。

4. 发明申请

WO2018083154A1 VACCINE AGAINST PORCINE PARVOVIRUS 审中-公开
标题翻译：疫苗对抗PORCINE PARVOVIRUS
公开(公告)号：WO2018083154A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078015
申请日：2017-11-02
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： VAUGHN, Eric, Martin , BUCKLIN, Scott, Eugene , KAISER, Troy, James , KROLL, Jeremy , UTLEY, Philip
IPC分类号： A61K39/23 , A61K39/00
摘要： The present invention relates i.a. to a porcine parvovirus (PPV) viral protein 2 (VP2) having at amino acid position 228 a glutamic acid residue or a glutamate residue, and/or at amino acid position 414 a serine residue, and/or at amino acid position 419 a glutamine residue, and/or at amino acid position 436 a threonine residue. Further, the present invention relates to immunogenic compositions comprising said PPV viral protein 2 (VP2). Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by PPV infection in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
摘要翻译：本发明涉及i.a. 涉及在氨基酸位置228处具有谷氨酸残基或谷氨酸残基，和/或在氨基酸位置414处为丝氨酸残基，和/或在氨基酸位置419处具有谷氨酰胺的猪细小病毒（PPV）病毒蛋白2（VP2）残基和/或氨基酸位置436处的苏氨酸残基。此外，本发明涉及包含所述PPV病毒蛋白2（VP2）的免疫原性组合物。此外，本发明涉及用于免疫受试者的方法，其包括向该受试者施用本发明的免疫原性组合物。此外，本发明涉及治疗或预防需要受试者中由PPV感染引起的临床体征的方法，所述方法包括向所述受试者施用治疗有效量的根据本发明的免疫原性组合物。

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