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1. 发明申请

WO2016141338A3 MARKER SYSTEM, IN PARTICULAR FOR BACULOVIRUS-EXPRESSED SUBUNIT ANTIGENS 审中-公开
标题翻译：标记系统，特别是针对乙型肝炎表达的亚型抗原
公开(公告)号：WO2016141338A3
公开(公告)日：2016-10-06
申请号：PCT/US2016021003
申请日：2016-03-04
申请人： BOEHRINGER INGELHEIM VETMEDICA INC
发明人： IYER ARUN V , HERMANN JOSEPH RALPH , ROOF MICHAEL B , VAUGHN ERIC MARTIN , SCHAEFFER MERRILL LYNN
IPC分类号： A61K39/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C07K2319/21 , C07K2319/50 , C12N7/00 , C12N2710/14021 , C12N2710/14022 , C12N2710/14043 , C12N2710/14051 , C12N2710/14143 , C12N2750/10034 , C12N2750/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20022 , C12N2760/20034 , C12N2760/20051 , C12P21/00 , C12Q1/701 , G01N33/5091 , G01N33/6854 , G01N2333/01
摘要： The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
摘要翻译：本发明属于适应性标记和标记疫苗领域，其允许感染和接种个体之间的分化。具体地说，本发明涉及一种确定个体是否接受了包含由培养的昆虫细胞中的杆状病毒表达系统产生的重组蛋白质的免疫原性组合物的方法。

2. 发明申请

WO2015042254A1 BK VIRUS SEROLOGY ASSESSMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) RISK 审中-公开
标题翻译：进展性多发性白血病（PML）风险的BK病毒学评估
公开(公告)号：WO2015042254A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056290
申请日：2014-09-18
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： VISCIDI, Raphael, Paul
IPC分类号： G01N33/53 , C07K16/46
CPC分类号： G01N33/6854 , C07K16/2839 , C07K2317/24 , C07K2317/76 , G01N33/56983 , G01N2333/01 , G01N2333/025 , G01N2333/52 , G01N2469/20 , G01N2800/24 , G01N2800/28 , G01N2800/50 , G01N2800/7095
摘要： The present invention provides methods, compositions, kits, etc. related to the assessment of progressive multifocal leukoencephalopathy (PML) risk, based upon detecting the presence, absence and/or relative levels of serum antibody to BK virus and/or other indication of BK virus infection of a subject, in a subject and/or a sample of a subject. In certain embodiments, such assessment can also include detection of the presence or absence of serum antibody to JC virus in a subject and/or a sample of a subject, optionally to improve the predictive power of such risk assessment.
摘要翻译：本发明基于检测BK病毒的血清抗体的存在，不存在和/或相对水平和/或BK的其他指征，提供与进行性多灶性脑白质病（PML）风险评估相关的方法，组合物，试剂盒等受试者和/或受试者样品中受试者的病毒感染。在某些实施方案中，这种评估还可以包括检测受试者和/或受试者样品中JC病毒血清抗体的存在或不存在，任选地提高这种风险评估的预测能力。

3. 发明申请

WO2014113855A1 ANTÍGENOS RECOMBINANTES DO PORCINE CIRCOVIRUS 2 (PCV-2) PARA FORMULAÇÕES VACINAIS, KIT DE DIAGNÓSTICO E USO 审中-公开
标题翻译： PECCINE CIRCOVIRUS 2（PCV-2）用于疫苗制剂，诊断试剂盒及其用途的重组抗原
公开(公告)号：WO2014113855A1
公开(公告)日：2014-07-31
申请号：PCT/BR2014/000019
申请日：2014-01-23
申请人： FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG , UNIVERSIDADE FEDERAL DE VIÇOSA
发明人： DE ALMEIDA, Márcia Rogéria , JUNIOR, Abelardo Silva , FIETTO, Juliana Lopes Rangel , BRESSAN, Gustavo Costa , SALGAO, Rafael Locatelli , ONOFRE, Thiago Souza , FAUSTO, Mariana Costa , VIDIGAL, Pedro Marcus Pereira , KALKS, Sthefany Patareli , CRISPIM, Josicelli Souza
IPC分类号： A61K39/12 , C07K14/01 , C12N15/34 , A61P31/20 , G01N33/53
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C12N7/00 , C12N2750/10023 , C12N2750/10034 , G01N33/56983 , G01N2333/01 , G01N2333/015 , G01N2469/20
摘要： A presente invenção se refere à obtenção do antigeno recombinante do capsídeo viral do Porcine circovirus 2 (PCV-2) e suas modificações, mediante expressão em sistema procariótico, purificação na forma monomérica, recuperação de partículas semelhantes a vírus (VLPs) e sua utilização em formulações vacinais, kits de diagnóstico e num sistema de quantificação nas partidas vacinais do antigeno do PCV-2 por meio de um ELISA de captura. Os antígenos e as formulações vacinais podem ser empregados na imunização de animais em programas de controle das doenças associadas ao PCV-2 nos sistemas de produção de suínos convencionais e representam alternativas às vacinas disponíveis no mercado. O Kit de ELISA pode ser empregado para testes de qualidade em vacinas comerciais e/ou experimentais contra o PCV-2.
摘要翻译：本发明涉及通过在原核系统中表达，单体形式的纯化，病毒样颗粒（VLPs）的回收，制备猪圆环病毒2（PCV-2）的病毒衣壳重组抗原及其修饰物，以及它们在疫苗制剂，诊断试剂盒和用于通过捕获ELISA测定法在疫苗批次中定量PCV-2抗原的系统中的用途。抗原和疫苗制剂可用于在常规猪育种系统中用于对抗PCV-2相关疾病的程序中免疫动物，并且代表可商购的疫苗的替代物。 ELISA试剂盒可用于测试针对PCV-2的商业和/或实验疫苗的质量。

4. 发明申请

WO2014036265A2 TRANSPORT OF LIQUIDS AND SOLUTE MATERIALS IN NANOCHANNELS 审中-公开
标题翻译：纳米通道中液体和溶质物质的运输
公开(公告)号：WO2014036265A2
公开(公告)日：2014-03-06
申请号：PCT/US2013057298
申请日：2013-08-29
申请人： ATFI
发明人： SAMBASIVAN SANKAR , CHAPMAN FRANCIS RICHARD , DONELAN JEFFREY WILLIAM , GARCIA CHRISTOPHER JEFFREY
IPC分类号： A61M5/44
CPC分类号： B01L3/50273 , B01D67/0088 , B01D2323/283 , B01D2323/36 , B01L2200/0642 , B01L2300/0816 , B01L2300/0896 , B01L2400/0466 , C12Q1/04 , F28F2255/20 , G01N2333/01
摘要： Transport of a vaporizable liquid containing at least one solute through a material containing nanochannels is performed by contacting material with at least one vaporizable liquid component and inducing liquid transport along nanochannel interior wall surfaces, wherein the material contains nanochannels having an average diameter up to about 300 nm, preferably up to about 100 nm, and liquid transport is induced by partial liquid vaporization. A film of solid material is deposited onto an interior nanochannel wall surface by removing the transport liquid.
摘要翻译：含有至少一种溶质的可汽化液体通过含纳米通道的材料的输送通过使材料与至少一种可蒸发液体组分接触并诱导沿纳米通道内壁表面的液体输送来实现，其中所述材料含有平均直径高达约300的纳米通道 nm，优选高达约100nm，并且通过部分液体汽化引起液体转运。通过去除输送液体将固体材料膜沉积到内部纳米通道壁表面上。

5. 发明申请

WO2007119987A3 KIT AND METHOD FOR QUANTITATIVELY DETECTING MULTIPLEPATHOGENS WITHOUT GENE AMPLIFICATION 审中-公开
标题翻译：用于定量检测多基因不具有基因扩增的试剂盒和方法
公开(公告)号：WO2007119987A3
公开(公告)日：2007-12-13
申请号：PCT/KR2007001820
申请日：2007-04-13
申请人： KIM JAE MAN , RO EUI CHUL
发明人： KIM JAE MAN , RO EUI CHUL
IPC分类号： G01N33/53
CPC分类号： G01N33/569 , C12Q1/6837 , G01N2333/01 , G01N2333/08 , C12Q2563/131 , C12Q2561/113 , C12Q2545/114
摘要： A non-amplification multiple quantitative detection kit is characterized in that there are provided a single strand poly nucleotide having a base sequence invented to recognize a specific gene portion of a multilepathogens microorganism to be detected by a fishing probe, and a double strand poly nucleotide indicated with a tag having a base sequence invented to recognize different gene portions which are not duplicated with the recognition portion of the fishing probe in the specific genes of the multilepathogens microorganism to be detected by a reporter probe.
摘要翻译：非扩增多重定量检测试剂盒的特征在于提供了单链多核苷酸，其具有本发明的碱基序列，以识别待检测的多发病原体微生物的特定基因部分，并指示双链多核苷酸具有发明的碱基序列的标签，以识别不同基因部分，所述不同基因部分与通过报道探针检测的多发病原体微生物的特定基因中的捕鱼探针的识别部分不重复。

6. 发明申请

WO99029871A2 CIRCOVIRUS SEQUENCES RELATED TO PIGLET WEIGHT LOSS DISEASE (PWD) 审中-公开
标题翻译：与重量损失疾病相关的循环序列
公开(公告)号：WO99029871A2
公开(公告)日：1999-06-17
申请号：PCT/FR1998/002634
申请日：1998-12-04
IPC分类号： A61K39/00 , A61K48/00 , C07K14/01 , C12N5/02 , C12N15/34 , C12N15/86 , C12N7/04 , C12N5/10 , C12N7/00 , A01K67/027 , C12Q1/68 , C07K16/08 , G01N33/569
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The invention concerns the genome sequence and the nucleotide sequences coding for the PWD circovirus polypeptides, such as said circovirus structural and non-structural polypeptides, and vectors including said sequences and cells or animals transformed by said vectors. The invention also concerns methods for detecting said nucleic acids or polypeptides and kits for diagnosing infection by a PWD circovirus. The invention further concerns a method for selecting compounds capable modulating the viral infection. Finally the invention concerns pharmaceutical, in particular vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of said vector for preventing and/or treating diseases by gene therapy.
摘要翻译：本发明涉及编码PWD圆环病毒多肽的基因组序列和核苷酸序列，例如所述圆环病毒结构和非结构多肽，以及包含所述序列的载体和由所述载体转化的细胞或动物。本发明还涉及用于检测所述核酸或多肽的方法以及用于诊断PWD圆环病毒感染的试剂盒。本发明还涉及一种选择能够调节病毒感染的化合物的方法。最后，本发明涉及用于预防和/或治疗由PWD圆环病毒引起的病毒感染的药物，特别是疫苗组合物，以及所述载体用于通过基因治疗预防和/或治疗疾病的用途。

7. 发明申请

WO2016141338A2 MARKER SYSTEM, IN PARTICULAR FOR BACULOVIRUS-EXPRESSED SUBUNIT ANTIGENS 审中-公开
标题翻译：标记系统，特别是用于BACULOVIRUS-表达的亚单位抗原
公开(公告)号：WO2016141338A2
公开(公告)日：2016-09-09
申请号：PCT/US2016/021003
申请日：2016-03-04
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.
发明人： IYER, Arun V. , HERMANN, Joseph Ralph , ROOF, Michael B. , VAUGHN, Eric Martin , SCHAEFFER, Merrill Lynn
IPC分类号： A61K39/00 , G01N33/68 , G01N33/50
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C07K2319/21 , C07K2319/50 , C12N7/00 , C12N2710/14021 , C12N2710/14022 , C12N2710/14043 , C12N2710/14051 , C12N2710/14143 , C12N2750/10034 , C12N2750/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20022 , C12N2760/20034 , C12N2760/20051 , C12P21/00 , C12Q1/701 , G01N33/5091 , G01N33/6854 , G01N2333/01
摘要： The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
摘要翻译：本发明属于依从性标记和标记疫苗领域，其允许区分感染和接种疫苗的个体。特别涉及一种确定个体是否接受了包含由杆状病毒表达系统在培养的昆虫细胞中产生的重组蛋白的免疫原性组合物的方法。

8. 发明申请

WO2016049101A1 ATTENUATED AFRICAN SWINE FEVER VIRUS STRAIN INDUCES PROTECTION AGAINST CHALLENGE WITH HOMOLOGOUS VIRULENT PARENTAL VIRUS GEORGIA 2007 ISOLATE 审中-公开
标题翻译：衰弱的非洲SWINE FEV病毒菌株诱导与同种异体病毒性家禽病毒GEORGIA 2007分离的挑战的保护
公开(公告)号：WO2016049101A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/051574
申请日：2015-09-23
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE , THE UNIVERSITY OF CONNECTICUT
发明人： BORCA, Manuel V. , HOLINKA-PATTERSON, Lauren G. , GLADUE, Douglas , RISATTI, Guillermo R. , O'DONNELL, Vivian K.
IPC分类号： C12N7/00 , C12N7/04 , A61K39/12 , C12Q1/68 , G01N33/569
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2710/12021 , C12N2710/12034 , C12Q1/701 , C12Q2600/158 , G01N33/56983 , G01N2333/01
摘要： African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs that has significant economic consequences for swine breeding. Control of ASF has been hampered by the unavailability of vaccines. Recombinant viruses harboring engineered deletions of specific virulence-associated genes induce solid protection against the challenge with parental viruses. Here we report the construction of a recombinant Δ9GL virus derived from the highly virulent ASFV Georgia 2007 (ASFV-G) isolate. In vivo, ASFV-G Δ9GL administered intramuscularly (IM) to swine at relatively high doses (104 HAD50) retains a virulent phenotype practically indistinguishable from the parental virus. Conversely, at low IM doses (102 or 103 HAD50), ASFV-G Δ9GL does not induce disease. Importantly, animals infected with 103 HAD50 are protected against the presentation of clinical disease when challenge at 28 days post infection with the virulent parental strain Georgia 2007.
摘要翻译：非洲猪瘟病毒（ASFV）是一种传染性和经常致命的家禽病毒性疾病的病原体，对猪繁殖具有重大的经济后果。无法获得疫苗阻碍了ASF的控制。携带特异性毒力相关基因工程缺失的重组病毒诱导了针对亲本病毒攻击的固体保护。在这里，我们报告了源自高毒性ASFV Georgia 2007（ASFV-G）分离株的重组Δ9GL病毒的构建。在体内，以相当高剂量（104HAD50）肌肉内（IM）施用的猪ASFV-GΔ9GL保留了与亲本病毒几乎无法区分的毒性表型。相反，在低IM剂量（102或103HAD50）下，ASFV-GΔ9GL不诱导疾病。重要的是，感染103 HAD50的动物在感染后28天用有毒的亲本菌株Georgia 2007进行攻击时可以免受临床疾病的表现。

10. 发明申请

WO2011031438A2 PORCINE TORQUE TENO VIRUS VACCINES AND DIAGNOSIS 审中-公开
标题翻译： PORCINE TORQUE TENO VIRUS疫苗和诊断
公开(公告)号：WO2011031438A2
公开(公告)日：2011-03-17
申请号：PCT/US2010046330
申请日：2010-08-23
申请人： VIRGINIA TECH INTELL PROP , MENG XIANG-JIN , HUANG YAOWEI
发明人： MENG XIANG-JIN , HUANG YAOWEI
IPC分类号： C12N15/34 , A01K67/027 , A61K39/12 , C12N15/63 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
摘要： The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
摘要翻译：本发明提供了含有编码猪扭转腱病毒（PTTV）基因型或亚型PTTV1a-VA，PTTV1b-VA，PTTV2b-VA和PTTV2c-VA的多核酸分子的四种纯化制剂。本发明还提供含有感染性核酸基因组分子的感染性DNA克隆，生物功能质粒或病毒载体。本发明进一步提供活的，减毒的载体表达和纯化的重组衣壳亚单位或灭活的病毒疫苗以防止PTTV感染。本发明另外提供了包含PTTV特异性基因产物的亚单位疫苗，特别是用于保护免受PTTV感染的ORF1衣壳基因产物。此外，本发明提供了使用PTTV1，PTTV2和个体PTTV1基因型的特异性引物通过聚合酶链反应（PCR）诊断PTTV感染的方法。最后，本发明提供了通过免疫学方法诊断PTTV感染的方法，例如使用PTTV特异性抗原检测血清PTTV特异性抗体的酶联免疫吸附测定（ELISA）和蛋白质印迹。

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