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1. 发明申请

WO2012057628A2 CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE 审中-公开
标题翻译：交联聚合物和来自电泳激活的聚恶唑啉的植入物
公开(公告)号：WO2012057628A2
公开(公告)日：2012-05-03
申请号：PCT/NL2012/050001
申请日：2012-01-02
申请人： BENDER ANALYTICAL HOLDING B.V. , HOOGENBOOM, Richard , BENDER, Johannes Caspar Mathias Elizabeth , VAN HEST, Jan Cornelis Maria
发明人： HOOGENBOOM, Richard , BENDER, Johannes Caspar Mathias Elizabeth , VAN HEST, Jan Cornelis Maria
IPC分类号： A61K47/48 , A61L27/18 , A61L31/06 , A61L31/14 , C08G73/02 , C08J3/24
CPC分类号： A61L24/046 , A61K47/50 , A61L24/06 , A61L27/18 , A61L31/06 , C08G73/0233 , C08J3/246 , C08J2300/10 , C08J2379/02 , C08L79/02
摘要： One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m≥2, n≥2 and m+n ≥5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.
摘要翻译：本发明的一个方面涉及通过使亲电活化的聚恶唑啉（EL-POX）与亲核性交联剂反应获得的生物相容性共价交联聚合物，所述亲电活化的POX 包含m个亲电子基团; 并且所述亲核交联剂包含n个亲核基团，其中所述m个亲电子基团能够与所述n个亲核基团反应以形成共价键; 其中m≥2，n≥2且m +n≥5; 其中所述m个亲电子基团中的至少一个是侧基亲电子基团和/或其中m≥3; 并且其中相对于亲核交联剂中所含的亲核基团的量，EL-POX包含过量的亲电子基团。本发明进一步涉及包含这种交联的POX-聚合物的生物相容性医疗产品。还提供了用于生产生物相容性交联POX聚合物的试剂盒。本发明还提供了包含至少1重量％干物质EL-POX的组织粘附医药产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧挂亲电子基团。根据本发明的聚合物具有优异的植入和/或密封特性。

2. 发明申请

WO2008035971A2 BIORESORBABLE COMPOSITION AND A MEDICAL DEVICE COMPRISING SAID COMPOSITION 审中-公开
标题翻译：生物可吸收组合物和包含所述组合物的医疗装置
公开(公告)号：WO2008035971A2
公开(公告)日：2008-03-27
申请号：PCT/NL2007/050458
申请日：2007-09-19
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, MEER IN HET BIJZONDER HET UNIVERSITAIR MEDISCH CENTRUM ST RADBOUD , VERDONSCHOT, Nicolaas, Jacobus, Joseph , VAN HEST, Jan, Cornelis, Maria , BUMA, Pieter , AYRES, Lee , VRIEZEMA, Dennis, M.
发明人： VERDONSCHOT, Nicolaas, Jacobus, Joseph , VAN HEST, Jan, Cornelis, Maria , BUMA, Pieter , AYRES, Lee , VRIEZEMA, Dennis, M.
IPC分类号： A61K41/00 , A61L27/44 , A61L27/34
CPC分类号： A61L31/14 , A61K41/0028 , A61L31/10 , A61L31/148
摘要： The invention provides a bioresorbable composition comprising a mixture of at least one polymer and capsules, which capsules comprise an inner part which is encapsulated by a shell which shell is at least partly decomposable by application of an external stimulation source. The invention also relates to a medical device comprising said composition.
摘要翻译：本发明提供了一种包含至少一种聚合物和胶囊的混合物的生物可吸收组合物，该胶囊包含被壳体包封的内部部分，该壳体通过施加外部刺激可至少部分分解资源。本发明还涉及包含所述组合物的医疗器械。

3. 发明申请

WO2006080849A2 POLYISOCYANIDE POLYMERSOMES 审中-公开
标题翻译：聚异氰酸酯聚合物
公开(公告)号：WO2006080849A2
公开(公告)日：2006-08-03
申请号：PCT/NL2006000052
申请日：2006-01-31
申请人： NL ORGANISATIE VAN WETENSCHAPP , VRIEZEMA DENNIS MANUEL , LEANDRO GARCIA PAULA MARIA , VAN HEST JAN CORNELIS MARIA , ROWAN ALAN EDWARD , NOLTE ROELAND JOHANNES MARIA
发明人： VRIEZEMA DENNIS MANUEL , LEANDRO GARCIA PAULA MARIA , VAN HEST JAN CORNELIS MARIA , ROWAN ALAN EDWARD , NOLTE ROELAND JOHANNES MARIA
CPC分类号： C08G73/00 , C09J2400/263
摘要： The present invention relates to polyisocyanide polymersomes, optionally having substances associated therewith, methods of making the same, and to methods of using the same. The polymersomes comprise a vesicular polymer membrane of a PS-PIAT polymer. The substances optionally associated with the polymersomes may comprise catalysts or enzymes, either encapsulated therein, i.e., inside the vesicular membrane of the polymersome, or in the polymeric membrane of the polymersome, or both.
摘要翻译：本发明涉及任选具有与其相关的物质的多异氰化物聚合物囊泡，其制备方法及其使用方法。聚合物囊泡包含PS-PIAT聚合物的泡状聚合物膜。任选地与聚合物组合物相关的物质可以包含被包封在其中的催化剂或酶，即在聚合体的泡囊膜内部，或在聚合体的聚合物膜的聚合物膜中，或者两者。

4. 发明申请

WO2006111399A2 HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING 审中-公开
标题翻译：包含生物活性分子的多孔聚合物材料通过共价接枝
公开(公告)号：WO2006111399A2
公开(公告)日：2006-10-26
申请号：PCT/EP2006003677
申请日：2006-04-21
申请人： DSM IP ASSETS BV , THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
发明人： THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
IPC分类号： C12N11/06 , C12N11/08
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔聚合物材料。本发明还涉及制备包含能够接枝至生物活性分子物质的官能单体的高度多孔材料的方法，其包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明进一步涉及将生物活性物质接枝到这种高度多孔聚合物材料上的方法，其包括以下步骤：（i）将高度多孔材料暴露于生物活性物质在合适溶剂介质中的溶液中，（ii）任选地（iii）任选加热，和（iv）用溶剂介质冲洗多孔材料以除去未接枝物质。包含共价接枝的生物活性物质的高度多孔聚合物材料可用于例如作为非均相催化剂，用于生物传感器，用于色谱法，用于生物医学装置和植入物。

5. 发明申请

WO2006080849A3 POLYISOCYANIDE POLYMERSOMES 审中-公开
公开(公告)号：WO2006080849A3
公开(公告)日：2006-08-03
申请号：PCT/NL2006/000052
申请日：2006-01-31
申请人： NEDERLANDSE ORGANISATIE VAN WETENSCHAPPELIJK ONDERZOEK , VRIEZEMA, Dennis, Manuel , LEANDRO GARCIA, Paula, Maria , VAN HEST, Jan, Cornelis, Maria , ROWAN, Alan, Edward , NOLTE, Roeland, Johannes, Maria
发明人： VRIEZEMA, Dennis, Manuel , LEANDRO GARCIA, Paula, Maria , VAN HEST, Jan, Cornelis, Maria , ROWAN, Alan, Edward , NOLTE, Roeland, Johannes, Maria
IPC分类号： C08G73/00
摘要： The present invention relates to polyisocyanide polymersomes, optionally having substances associated therewith, methods of making the same, and to methods of using the same. The polymersomes comprise a vesicular polymer membrane of a PS-PIAT polymer. The substances optionally associated with the polymersomes may comprise catalysts or enzymes, either encapsulated therein, i.e., inside the vesicular membrane of the polymersome, or in the polymeric membrane of the polymersome, or both.

6. 发明申请

WO2012057628A3 CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE 审中-公开
标题翻译：交联聚合物和从电活性聚酰胺衍生的嵌入物
公开(公告)号：WO2012057628A3
公开(公告)日：2012-06-28
申请号：PCT/NL2012050001
申请日：2012-01-02
申请人： BENDER ANALYTICAL HOLDING BV , HOOGENBOOM RICHARD , BENDER JOHANNES CASPAR MATHIAS ELIZABETH , VAN HEST JAN CORNELIS MARIA
发明人： HOOGENBOOM RICHARD , BENDER JOHANNES CASPAR MATHIAS ELIZABETH , VAN HEST JAN CORNELIS MARIA
IPC分类号： A61K47/48 , A61L27/18 , A61L31/06 , A61L31/14 , C08G73/02 , C08J3/24 , C08L79/02
CPC分类号： A61L24/046 , A61L24/06 , A61L27/18 , A61L31/06 , C08G73/0233 , C08J3/246 , C08J2300/10 , C08J2379/02 , C08L79/02
摘要： One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m=2, n=2 and m+n =5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m=3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.
摘要翻译：本发明的一个方面涉及通过使亲电子活化的聚恶唑啉（EL-POX）与亲核交联剂反应而获得的生物相容的，共价交联的聚合物，所述亲电活化的POX包含m个亲电基团; 并且所述亲核交联剂包含n个亲核基团，其中m个亲电基团能够与n个亲核基团反应形成共价键; 其中m = 2，n = 2和m + n = 5; 其中所述m亲电子基团中的至少一个是侧链亲电子基团和/或其中m = 3; 并且其中所述EL-POX相对于所述亲核交联剂中所含的亲核基团的量包含过量的亲电子基团。本发明还涉及包含这种交联的POX-聚合物的生物相容性医疗产品。还提供了用于生产生物相容的交联POX-聚合物的试剂盒。本发明还提供了包含至少1重量％的EL-POX的干物质的组织粘合剂医疗产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧链亲电子基团。根据本发明的聚合物具有优异的植入物和/或密封特性。

7. 发明申请

WO2008049447A1 CHIP HOLDER, FLUIDIC SYSTEM AND CHIP HOLDER SYSTEM 审中-公开
标题翻译：芯片保持器，流体系统和芯片保持器系统
公开(公告)号：WO2008049447A1
公开(公告)日：2008-05-02
申请号：PCT/EP2006/010299
申请日：2006-10-25
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , NIJMEGEN UNIVERSITY , TRIEU, Hoc Khiem , SLOTKOWSKI, Johann , KLIEBER, Robert , VAN HEST, Jan Cornelis Maria , KOCH, Kaspar , RUTJES, Floris Petrus Johannes Theodorus , NIEUWLAND, Pieter Jos , WIEBE, Peter
发明人： TRIEU, Hoc Khiem , SLOTKOWSKI, Johann , KLIEBER, Robert , VAN HEST, Jan Cornelis Maria , KOCH, Kaspar , RUTJES, Floris Petrus Johannes Theodorus , NIEUWLAND, Pieter Jos , WIEBE, Peter
IPC分类号： B01L9/00
CPC分类号： B01L3/565 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844
摘要： A chip holder (10) for holding a fluidic chip (22) and for providing a fluid connection to the fluidic chip comprises a guide (20a, 20b), the guide being adapted such that the fluidic chip can be slid into the chip holder in a guiding direction (24). The chip holder further comprises fastening means (30a), the fastening means being adapted to press a fluidic connection (34) toward the fluidic chip, such that the fluidic chip is fixed within the chip holder. The guide and the fastening means are adapted such that the guiding direction and the direction, in which the fluidic connection is pressed, exhibit an angle in the range between 45° and 135°, including 45° and 135°. A fluidic system comprises a chip holder and a fluidic chip inserted in the chip holder. A chip holder system comprises a chip holder and an extension module attached to the chip holder such that the extension module is in contact with the fluidic chip, when the fluidic chip is inserted in the chip holder.
摘要翻译：用于保持流体芯片（22）并用于提供与流体芯片的流体连接的芯片保持器（10）包括引导件（20a，20b），引导件适于使得流体芯片可以滑入芯片保持器引导方向（24）。芯片保持器还包括紧固装置（30a），紧固装置适于将流体连接（34）压向流体芯片，使得流体芯片固定在芯片保持器内。引导件和紧固装置适于使得流体连接被挤压的引导方向和方向呈45度到135度之间的角度，包括45度和135度。流体系统包括芯片保持器和插入芯片保持器中的流体芯片。芯片保持器系统包括芯片保持器和附接到芯片保持器的延伸模块，使得当流体芯片插入芯片保持器时，延伸模块与流体芯片接触。

8. 发明申请

WO2006111399A3 HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING 审中-公开
公开(公告)号：WO2006111399A3
公开(公告)日：2006-10-26
申请号：PCT/EP2006/003677
申请日：2006-04-21
申请人： DSM IP ASSETS B.V. , THIES, Jens Christoph , PIERRE, Sébastien , CAMERON, Neil Ronald , VAN HEST, Jan Cornelis Maria , WYMAN, Paul
发明人： THIES, Jens Christoph , PIERRE, Sébastien , CAMERON, Neil Ronald , VAN HEST, Jan Cornelis Maria , WYMAN, Paul
IPC分类号： C12N11/06 , C12N11/08 , C08F2/32 , A61K47/48
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.

9. 发明申请

WO2006111399A8 HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING 审中-公开
标题翻译：包含生物活性分子的高分子聚合材料
公开(公告)号：WO2006111399A8
公开(公告)日：2006-12-28
申请号：PCT/EP2006003677
申请日：2006-04-21
申请人： DSM IP ASSETS BV , THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
发明人： THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
IPC分类号： C12N11/06 , A61K47/48 , C08F2/32 , C12N11/08
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔的聚合物材料。本发明还涉及一种制备包含能够接枝到生物活性分子物质的官能单体的高度多孔材料的方法，包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明还涉及将生物活性物质接枝到这种高度多孔的聚合物材料的方法，包括以下步骤：（i）将高度多孔的材料暴露于生物活性物质在合适的溶剂介质中的溶液，（ii）任选地加入活化剂，（iii）任选地加热，和（iv）用溶剂介质漂洗多孔材料以除去未接枝的物质。包含共价接枝的生物活性物质的高度多孔的聚合物材料可以例如使用。作为非均相催化剂，生物传感器，色谱法，生物医学装置和植入物。

10. 发明申请

WO2008035971A3 BIORESORBABLE COMPOSITION AND A MEDICAL DEVICE COMPRISING SAID COMPOSITION 审中-公开
标题翻译：生物可降解组合物和包含上述组合物的医疗装置
公开(公告)号：WO2008035971A3
公开(公告)日：2008-05-08
申请号：PCT/NL2007050458
申请日：2007-09-19
申请人： STICHTING KATHOLIEKE UNIV , VERDONSCHOT NICOLAAS JACOBUS J , VAN HEST JAN CORNELIS MARIA , BUMA PIETER , AYRES LEE , VRIEZEMA DENNIS M
发明人： VERDONSCHOT NICOLAAS JACOBUS J , VAN HEST JAN CORNELIS MARIA , BUMA PIETER , AYRES LEE , VRIEZEMA DENNIS M
IPC分类号： A61K41/00 , A61L27/34 , A61L27/44
CPC分类号： A61L31/14 , A61K41/0028 , A61L31/10 , A61L31/148
摘要： The invention provides a bioresorbable composition comprising a mixture of at least one polymer and capsules, which capsules comprise an inner part which is encapsulated by a shell which shell is at least partly decomposable by application of an external stimulation source. The invention also relates to a medical device comprising said composition.
摘要翻译：本发明提供了包含至少一种聚合物和胶囊的混合物的生物可再吸收组合物，该胶囊包含由外壳包封的内部，所述壳体通过施加外部刺激源至少部分可分解。本发明还涉及包含所述组合物的医疗装置。

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