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1. 发明申请

WO2006111399A8 HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING 审中-公开
标题翻译：包含生物活性分子的高分子聚合材料
公开(公告)号：WO2006111399A8
公开(公告)日：2006-12-28
申请号：PCT/EP2006003677
申请日：2006-04-21
申请人： DSM IP ASSETS BV , THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
发明人： THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
IPC分类号： C12N11/06 , A61K47/48 , C08F2/32 , C12N11/08
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔的聚合物材料。本发明还涉及一种制备包含能够接枝到生物活性分子物质的官能单体的高度多孔材料的方法，包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明还涉及将生物活性物质接枝到这种高度多孔的聚合物材料的方法，包括以下步骤：（i）将高度多孔的材料暴露于生物活性物质在合适的溶剂介质中的溶液，（ii）任选地加入活化剂，（iii）任选地加热，和（iv）用溶剂介质漂洗多孔材料以除去未接枝的物质。包含共价接枝的生物活性物质的高度多孔的聚合物材料可以例如使用。作为非均相催化剂，生物传感器，色谱法，生物医学装置和植入物。

2. 发明申请

WO2006111399A2 HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING 审中-公开
标题翻译：包含生物活性分子的多孔聚合物材料通过共价接枝
公开(公告)号：WO2006111399A2
公开(公告)日：2006-10-26
申请号：PCT/EP2006003677
申请日：2006-04-21
申请人： DSM IP ASSETS BV , THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
发明人： THIES JENS CHRISTOPH , PIERRE SEBASTIEN , CAMERON NEIL RONALD , VAN HEST JAN CORNELIS MARIA , WYMAN PAUL
IPC分类号： C12N11/06 , C12N11/08
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔聚合物材料。本发明还涉及制备包含能够接枝至生物活性分子物质的官能单体的高度多孔材料的方法，其包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明进一步涉及将生物活性物质接枝到这种高度多孔聚合物材料上的方法，其包括以下步骤：（i）将高度多孔材料暴露于生物活性物质在合适溶剂介质中的溶液中，（ii）任选地（iii）任选加热，和（iv）用溶剂介质冲洗多孔材料以除去未接枝物质。包含共价接枝的生物活性物质的高度多孔聚合物材料可用于例如作为非均相催化剂，用于生物传感器，用于色谱法，用于生物医学装置和植入物。

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