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    • 2. 发明申请
    • CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE
    • 交联聚合物和从电活性聚酰胺衍生的嵌入物
    • WO2012057628A3
    • 2012-06-28
    • PCT/NL2012050001
    • 2012-01-02
    • BENDER ANALYTICAL HOLDING BVHOOGENBOOM RICHARDBENDER JOHANNES CASPAR MATHIAS ELIZABETHVAN HEST JAN CORNELIS MARIA
    • HOOGENBOOM RICHARDBENDER JOHANNES CASPAR MATHIAS ELIZABETHVAN HEST JAN CORNELIS MARIA
    • A61K47/48A61L27/18A61L31/06A61L31/14C08G73/02C08J3/24C08L79/02
    • A61L24/046A61L24/06A61L27/18A61L31/06C08G73/0233C08J3/246C08J2300/10C08J2379/02C08L79/02
    • One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m=2, n=2 and m+n =5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m=3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.
    • 本发明的一个方面涉及通过使亲电子活化的聚恶唑啉(EL-POX)与亲核交联剂反应而获得的生物相容的,共价交联的聚合物,所述亲电活化的POX包含m个亲电基团; 并且所述亲核交联剂包含n个亲核基团,其中m个亲电基团能够与n个亲核基团反应形成共价键; 其中m = 2,n = 2和m + n = 5; 其中所述m亲电子基团中的至少一个是侧链亲电子基团和/或其中m = 3; 并且其中所述EL-POX相对于所述亲核交联剂中所含的亲核基团的量包含过量的亲电子基团。 本发明还涉及包含这种交联的POX-聚合物的生物相容性医疗产品。 还提供了用于生产生物相容的交联POX-聚合物的试剂盒。 本发明还提供了包含至少1重量%的EL-POX的干物质的组织粘合剂医疗产品,所述EL-POX包含至少2个亲电子基团,包括至少一个侧链亲电子基团。 根据本发明的聚合物具有优异的植入物和/或密封特性。