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1. 发明申请

WO2017137930A1 A DEVICE FOR ENHANCING A USER'S GRASPING CAPABILITY 审中-公开
标题翻译：一种提高用户抓取能力的设备
公开(公告)号：WO2017137930A1
公开(公告)日：2017-08-17
申请号：PCT/IB2017/050725
申请日：2017-02-09
申请人： UNIVERSITA' DEGLI STUDI DI SIENA
发明人： CIONCOLONI, David , HUSSAIN, Irfan , PRATTICHIZZO, Domenico , ROSSI, Simone , SALVIETTI, Gionata , SPAGNOLETTI, Giovanni
IPC分类号： B25J15/08 , A61F2/58 , B25J9/00 , B25J13/08 , B25J15/00 , B25J15/02 , B25J15/12
CPC分类号： B25J9/0006 , A61F2/54 , B25H3/00 , B25J13/081 , B25J13/085 , B25J13/088 , B25J15/0009 , B25J15/0233 , B25J15/083 , B25J15/12
摘要： A device (100) for enhancing a user's (1) grasping capability comprises a belt- like support (102) configured to be tightly fitted about a user's (1 ) part of the body (3); at least one articulated gripping element (130) having a plurality of phalanxes: proximal (131), fixed to the support (102), intermediate (132) and distal (133), which are articulated to each other by articular joints (135); a motor unit (120) fixed to the support (102); a winding drum (125); at least one tendon (140) partially wound on the drum (125) and extending along the phalanxes (131,132,133) and the joints (135), arranged in such a way that, by pulling it from the drum (125), the phalanxes (131,132,133) rotate about respective articular joints (135) and move the articulated gripping element (130) from an extended position (A) to a gripping bow-shaped position (B), causing a flexion/extension movement of the articulated gripping element (130), the joints (135) configured in such a way that by releasing the tendon (140) from the drum (125), the phalanxes (131,132,133) rotate about the respective joints (135) and move the articulated gripping element (130) between gripping bow-shaped position (B) and extended position (A).
摘要翻译：用于增强用户（1）抓握能力的设备（100）包括：带状支撑件（102），其被配置为紧密地装配在身体（3）的用户的（1）部分周围; 至少一个具有多个指骨的铰接式夹紧元件（130）：固定到支撑件（102），中间部分（132）和远侧部分（133）的近侧部分（131），其通过关节接合部（135）彼此铰接， ; 固定到所述支撑件（102）的电机单元（120）; 一个卷筒（125）; 至少一个部分地缠绕在鼓（125）上并且沿着指骨（131,132,133）和接头（135）延伸的肌腱（140），所述肌腱（140）以这样的方式布置，即，通过将其从鼓（125）中拉出来，方阵（135）绕相应的关节关节（135）旋转并且使铰接的夹紧元件（130）从伸出位置（A）移动到夹紧弓形位置（B），引起铰接夹紧元件（130）的弯曲/伸展运动），关节（135）以这样的方式构造，即通过从鼓（125）释放腱（140），方阵（131,132,133）围绕相应的关节（135）旋转并且使关节式夹紧元件（130）抓住弓形位置（B）和延伸位置（A）。

2. 发明申请

WO2011001457A2 DEVICE FOR THE ANALYSIS OF THE CENTRAL NERVOUS SYSTEM BY MEANS OF THE APPLICATION OF A COMBINATION OF STIMULI OF DIFFERENT TYPE AND THE STUDY OF CORRESPONDING REACTIONS 审中-公开
标题翻译：通过应用不同类型的刺激和相关反应研究的中央神经系统分析装置
公开(公告)号：WO2011001457A2
公开(公告)日：2011-01-06
申请号：PCT/IT2010/000300
申请日：2010-07-05
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , RUFA, Alessandra , VENERI, Giacomo , FEDERICO, Antonio , FEDERIGHI, Pamela , SANTARNECCHI, Emililano
发明人： RUFA, Alessandra , VENERI, Giacomo , FEDERICO, Antonio , FEDERIGHI, Pamela , SANTARNECCHI, Emililano
IPC分类号： A61B5/11
CPC分类号： A61B5/1104 , A61B3/113 , A61B5/16 , A61B5/4064 , A61B5/4082 , A61B5/6821
摘要： The invention relates to a device for the analysis of the central nervous system by means of the application of stimuli on a patient (100) and the study of the reaction of the same patient (100), comprising a plurality of multi-sensorial stimulus apparatuses (120, 121, 122, 123) and a plurality of reaction data acquisition apparatuses (110, 111), combined together in order to realise a stimulus and data acquisition interface (A) by means of a management and analysis interface (B) and arranged on a support interface (60), wherein said data acquisition apparatuses comprise means for detecting eye movements and means for detecting the movement of limbs.
摘要翻译：本发明涉及一种用于通过在患者（100）上施加刺激来分析中枢神经系统的装置以及同一患者（100）的反应研究，该装置包括多个多感觉刺激装置（120,121,122,123）以及多个反应数据采集装置（110,111）组合在一起，以便通过管理和分析接口（B）实现刺激和数据采集接口（A）和布置在支撑界面（60）上，其中所述数据采集装置包括用于检测眼睛运动的装置和用于检测四肢运动的装置。

3. 发明申请

WO2009013779A2 SUBSTANTIVE PHOTOSTABLE DYES AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：实质性可光敏染料及其生产方法
公开(公告)号：WO2009013779A2
公开(公告)日：2009-01-29
申请号：PCT/IT2008/000494
申请日：2008-07-22
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , ANSELMI, Cecilia , CENTINI, Marisanna , LUPIA, Simona
发明人： ANSELMI, Cecilia , CENTINI, Marisanna , LUPIA, Simona
IPC分类号： C09B67/22
CPC分类号： C09B67/0097 , A61K8/11 , A61K8/8147 , A61K2800/412 , A61K2800/432 , A61K2800/52 , A61Q5/065 , B82Y30/00 , C09B67/0005 , C09B67/0013
摘要： A substantive and photostable dye suitable for cosmetic applications is provided by encapsulating a dye in substantive microspheres, binding to keratin. The microspheres protect the dye against detrimental effect of light and UV radiation, and ensures binding of the dye to the hair or other keratinaceous substance.
摘要翻译：通过将染料包封在实体微球体中，与角蛋白结合，提供适用于美容应用的实质性和可光稳定的染料。微球保护染料免受光和紫外线辐射的不利影响，并确保染料与头发或其他角蛋白物质结合。

4. 发明申请

WO2011067715A1 CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND 审中-公开
标题翻译：三甲基合成酶（TS）与配体的复合物的晶体结构
公开(公告)号：WO2011067715A1
公开(公告)日：2011-06-09
申请号：PCT/IB2010/055503
申请日：2010-11-30
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI MODENA E REGGIO EMILIA , MANGANI, Stefano , POZZI, Cecilia , COSTI, Maria Paola , FERRARI, Stefania , GUAITOLI, Giambattista
发明人： MANGANI, Stefano , POZZI, Cecilia , COSTI, Maria Paola , FERRARI, Stefania , GUAITOLI, Giambattista
IPC分类号： C12N9/10 , G06F19/00
CPC分类号： G06F19/706 , C07K2299/00 , C12N9/1007 , C12Y201/01045 , G06F19/16
摘要： The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular human TS, in the presence of a ligand, methods of crystallization thereof and uses thereof. The invention also relates to the three- dimensional structure of a new binding site located in the dimerization interface region of TS protein and applications thereof in the design and obtainment of new inhibitors with pharmacological activity, in particular antitumour activity.
摘要翻译：本发明涉及蛋白质胸苷酸合成酶（TS），特别是人类TS，在配体存在下的晶体，其结晶方法及其用途。本发明还涉及位于TS蛋白的二聚化界面区域中的新结合位点的三维结构及其在设计和获得具有药理活性，特别是抗肿瘤活性的新抑制剂中的应用。

5. 发明申请

WO2003076659A3 FACL4 AND MUTATION THEREOF ON X-LINKEND MENTAL RETARDATION SYNDROME 审中-公开
公开(公告)号：WO2003076659A3
公开(公告)日：2003-09-18
申请号：PCT/IT2003/000134
申请日：2003-03-06
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , MELONI, Ilaria , RENIERI, Alessandra
发明人： MELONI, Ilaria , RENIERI, Alessandra
IPC分类号： C12Q1/68
摘要： A nucleic acid comprising at least one fragment of the human FACL4 gene or FACL4 protein or functional portions thereof for diagnostic or therapeutic purposes applied to syndromes associated with mental retardation is described. Appropriate diagnostic kits are also described.

6. 发明申请

WO2014207069A1 MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF 审中-公开
标题翻译：多功能HEDGEHOG PATHWAY抑制剂及其用途
公开(公告)号：WO2014207069A1
公开(公告)日：2014-12-31
申请号：PCT/EP2014/063449
申请日：2014-06-25
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA"
发明人： BOTTA, Bruno , GULINO, Alberto , BOTTA, Maurizio , MORI, Mattia , DI MARCOTULLIO, Lucia , INFANTE, Paola , GHIRGA, Francesca , TOSCANO, Sara , INGALLINA, Cinzia , ALFONSI, Romina
IPC分类号： A61K31/121 , A61K31/343 , A61K31/35 , A61K31/352 , A61P35/00
CPC分类号： C07D311/34 , A61K9/0019 , A61K9/127 , A61K31/121 , A61K31/343 , A61K31/35 , A61K31/352 , A61K45/06
摘要： The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
摘要翻译：本发明涉及选择性抑制刺猬（Hh）途径的活性及其制备和用途的化合物。本发明的化合物可用于治疗Hh依赖性肿瘤，例如成神经管细胞瘤（MB）。

7. 发明申请

WO2011073959A2 CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF 审中-公开
标题翻译： HIV-1逆转录酶结合核苷酸竞争性逆转录酶抑制剂的晶体结构及其应用
公开(公告)号：WO2011073959A2
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055952
申请日：2010-12-20
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , UNIVERSITA` DEGLI STUDI DI SIENA , CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , RADI, Marco , BOTTA, Maurizio , ANGELI, Lucilla , MAGA, Giovanni , ENNIFAR, Eric , DUMAS, Philippe , WOLFF, Philippe , BEC, Guillaume , FREISZ, Severine
发明人： RADI, Marco , BOTTA, Maurizio , ANGELI, Lucilla , MAGA, Giovanni , ENNIFAR, Eric , DUMAS, Philippe , WOLFF, Philippe , BEC, Guillaume , FREISZ, Severine
IPC分类号： C07K14/16 , C07D239/00
CPC分类号： C07K14/005 , C07D239/47 , C07D471/04 , C07K2299/00 , C12N2740/16222
摘要： The present invention relates to a co-crystal comprising a HIV-1 reverse transcriptase (RT) polypeptide and a nucleotide competing reverse transcriptase inhibitor (NcRTI). In particular, the HIV-1 reverse transcriptase polypeptide comprises a ligand binding pocket (LBP) in a hinge region at the interface between a p66 thumb domain defined by residues 1 to 84 and 120 to 150 in the p66 subunit of SEQ ID No. 1 and palm domains defined by residues 85 to 119 and 151 to 242 in the p66 subunit of SEQ ID No. 1, in the vicinity of the polymerase active site defined by residues 110, 185 and 186 of SEQ ID No. 1 and close to the ATP binding site of the RT.
摘要翻译：本发明涉及包含HIV-1逆转录酶（RT）多肽和核苷酸竞争性逆转录酶抑制剂（NcRTI）的共晶体。特别地，HIV-1逆转录酶多肽在由SEQ ID NO：1的p66亚基中残基1至84定义的p66 thumb结构域与120至150之间的界面处的铰链区中包含配体结合口袋（LBP）和由SEQ ID No.1的p66亚基中的残基85至119和151至242定义的棕榈结构域，其位于由SEQ ID No.1的残基110,185和186限定的聚合酶活性位点附近并且靠近 RT的ATP结合位点。

8. 发明申请

WO2009115509A2 ANTIGENIC PROTEIN FRAGMENTS OF STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：抗原蛋白抗原蛋白片段
公开(公告)号：WO2009115509A2
公开(公告)日：2009-09-24
申请号：PCT/EP2009/053121
申请日：2009-03-17
申请人： BENINATI, Concetta , FELICI, Franco , UNIVERSITA DEGLI STUDI DI SIENA , OGGIONI, Marco , POZZI, Gianni , RICCI, Susanna
发明人： BENINATI, Concetta , FELICI, Franco , OGGIONI, Marco , POZZI, Gianni , RICCI, Susanna
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C12Q1/04
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/3156
摘要： Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
摘要翻译：公开了用于制备用于预防和治疗细菌感染的药物的肺炎链球菌的抗原性蛋白质片段及其检测方法，以及使用所述表位的相关组合物。

9. 发明申请

WO2007074491A1 HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS 审中-公开
标题翻译：作为NEUROKININ-1（NK1）受体配体的异构化酰胺衍生物
公开(公告)号：WO2007074491A1
公开(公告)日：2007-07-05
申请号：PCT/IT2006/000860
申请日：2006-12-20
申请人： UNIVERSITA DEGLI STUDI DI SIENA , CAPPELLI, Andrea , GIULIANI, Germano , ANZINI, Maurizio , VOMERA, Salvatore
发明人： CAPPELLI, Andrea , GIULIANI, Germano , ANZINI, Maurizio , VOMERA, Salvatore
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula 1, method of preparation and uses thereof.
摘要翻译：本发明涉及式1的化合物，其制备方法和用途。

10. 发明申请

WO2007043094A2 6-VINYL PYRIMIDINE AND PYRIMIDINONE DERIVATIVES AND THE USE THEREOF 审中-公开
标题翻译： 6-乙烯基吡啶和吡嗪酮衍生物及其用途
公开(公告)号：WO2007043094A2
公开(公告)日：2007-04-19
申请号：PCT/IT2006/000734
申请日：2006-10-13
申请人： UNIVERSITA DEGLI STUDI DI SIENA , BOTTA, Maurizio , CORELLI, Federico , PETRICCI, Elena , RADI, Marco , MAGA, Giovanni , ESTE'A., José , MAI, Antonello
发明人： BOTTA, Maurizio , CORELLI, Federico , PETRICCI, Elena , RADI, Marco , MAGA, Giovanni , ESTE'A., José , MAI, Antonello
IPC分类号： C07D239/46 , C07D239/56 , A61K31/513 , A61P31/18
CPC分类号： C07D239/47 , C07D239/56
摘要： The invention relates to 6-vinyl pyrimidine pyrimidinone derivatives and the use thereof as medicaments in particular for the treatment of HTV infections, the use thereof for preparing pharmaceutical compositions and methods for the preparation thereof.
摘要翻译：本发明涉及6-乙烯基嘧啶嘧啶酮衍生物及其作为特别用于治疗HTV感染的药物的用途，其用于制备药物组合物的用途及其制备方法。

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