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1. 发明申请

WO2006023704A2 LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT 审中-公开
标题翻译：罗丹明类似物及其在男性接受和癌症治疗中的应用
公开(公告)号：WO2006023704A2
公开(公告)日：2006-03-02
申请号：PCT/US2005029505
申请日：2005-08-19
申请人： UNIV KANSAS , UNIV KANSAS MEDICAL CENTER , GEORG GUNDA I , TASH JOSEPH S , CHAKRASALI RAMAPPA , JAKKARAJ SUDHAKAR RAO
发明人： GEORG GUNDA I , TASH JOSEPH S , CHAKRASALI RAMAPPA , JAKKARAJ SUDHAKAR RAO
IPC分类号： C07D231/04 , C07D471/02
CPC分类号： C07D231/56 , C07D471/04
摘要： Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.
摘要翻译：用于抑制精子发生和癌症治疗的新型化合物，特别是作为热休克蛋白和/或延伸因子1α的抑制剂。

2. 发明申请

WO2011146090A3 PRODUCTION OF GRAPHENE NANORIBBONS WITH CONTROLLED DIMENSIONS AND CRYSTALLOGRAPHIC ORIENTATION 审中-公开
标题翻译：具有控制尺寸和晶体取向的石墨纳米粒子的生产
公开(公告)号：WO2011146090A3
公开(公告)日：2012-03-01
申请号：PCT/US2010057593
申请日：2010-11-22
申请人： UNIV KANSAS STATE , UNIV KANSAS , BERRY VIKAS , MOHANTY NIHAR , MOORE DAVID S
发明人： BERRY VIKAS , MOHANTY NIHAR , MOORE DAVID S
IPC分类号： C01B31/02 , B82B1/00 , B82B3/00 , B82Y40/00
CPC分类号： C01B31/0469 , B82Y30/00 , B82Y40/00 , C01B32/19 , C01B2204/065 , C01B2204/22 , Y10T428/2982
摘要： Graphene particulates, especially graphene nanoribbons (GNRs) and graphene quantum dots (GQDs), and a high-throughput process for the production of such particulates is provided. The graphene particulates are produced by a nanotomy process in which graphene blocks are cut from a source of graphite and then exfoliated into a plurality of graphene particulates. Graphene particulates having narrow widths, on the order of 100 nm or less, can be produced having band gap properties suitable for use in a variety of electrical applications.
摘要翻译：提供石墨烯颗粒，特别是石墨烯纳米带（GNR）和石墨烯量子点（GQD），以及用于生产这种颗粒的高通量方法。石墨烯颗粒通过纳米切割工艺生产，其中石墨烯块从石墨源切割，然后剥离成多个石墨烯颗粒。可以制造具有适合用于各种电气应用中的带隙特性的窄度为100nm或更小的窄度的石墨烯颗粒。

3. 发明申请

WO2008055151A9 TEMPLATED ISLET CELLS AND SMALL ISLET CELL CLUSTERS FOR DIABETES TREATMENT 审中-公开
公开(公告)号：WO2008055151A9
公开(公告)日：2008-10-23
申请号：PCT/US2007082989
申请日：2007-10-30
申请人： UNIV KANSAS , UNIV KANSAS MEDICAL CENTER , BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA
发明人： BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA
IPC分类号： C12N5/00
CPC分类号： C12N5/0676 , A61K35/39 , A61L27/18 , A61L27/3882 , A61L27/3895 , C12N5/0677 , C12N2509/00 , C12N2533/40 , C12N2535/10 , C08L67/04
摘要： An implantable biomaterial scaffold having islet cells or small islet cell clusters attached thereto in a multilayer. The cells are derived by enzymatic dispersion and/or calcium depletion of large adult intact islets.

4. 发明申请

WO2015023777A3 EXPRESSION OF THERMOSTABLE STARCH SYNTHASE GENES IMPROVES THE YIELD IN HEAT STRESS 审中-公开
标题翻译：热稳定性淀粉酶基因的表达改善了热应激中的产量
公开(公告)号：WO2015023777A3
公开(公告)日：2015-11-12
申请号：PCT/US2014050932
申请日：2014-08-13
申请人： UNIV KANSAS STATE
发明人： TRICK HAROLD N , FRITZ ALLAN , TALUKDER SHYAMAL
IPC分类号： C07H21/04 , A01H1/00
CPC分类号： C12N15/8271 , C12N9/1051 , C12N15/8261 , C12Y204/01021 , Y02A40/146
摘要： Genetically-modified plants having increased tolerance to heat stress are described. Methods of producing such genetically-modified plants are also disclosed. The genetically-modified plants comprise exogenous nucleic acid encoding a thermostable protein having starch synthase activity. Genetically-modified plants have increased yield when grown under elevated conditions as compared to control plants.
摘要翻译：描述了具有增加的耐热应激性的遗传修饰植物。还公开了生产这种转基因植物的方法。遗传修饰的植物包含编码具有淀粉合成酶活性的热稳定蛋白质的外源核酸。与对照植物相比，在升高的条件下生长时，转基因植物的产量增加。

5. 发明申请

WO2015070238A2 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS 审中-公开
标题翻译：基于COUMARIN的HSP90抑制剂与尿素和替代物
公开(公告)号：WO2015070238A2
公开(公告)日：2015-05-14
申请号：PCT/US2014065059
申请日：2014-11-11
申请人： UNIV KANSAS
发明人： BLAGG BRIAN S J , ZHAO HUIPING
IPC分类号： C07D405/14
CPC分类号： C07D405/12 , A61K31/352 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D311/16 , C07D405/14 , C07D413/12 , G16H50/50
摘要： Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.
摘要翻译：下式的化合物：其中：R1-R4，X1，Y1和A如本文所定义。还提供了化合物的药物组合物。在一些方面，这些化合物可用于治疗疾病或病症。在一些实施方案中，疾病或病症是增殖性疾病，例如癌症。

6. 发明申请

WO2014130250A2 LOW PH CROSSSLINKING OF POLYMERS 审中-公开
标题翻译：聚合物的低PH交联
公开(公告)号：WO2014130250A2
公开(公告)日：2014-08-28
申请号：PCT/US2014014985
申请日：2014-02-06
申请人： CONOCOPHILLIPS CO , UNIV KANSAS
发明人： GUAN HUILI , BERKLAND CORY , MORADI-ARAGHI AHMED , LIANG JENN-TAI , CHRISTIAN TERRY M , NEEDHAM RILEY B , HEDGES JAMES H , CHENG MIN , SCULLY FAYE L
IPC分类号： C09K8/594 , E21B43/16
CPC分类号： C09K8/588 , C08F220/56 , C08F2800/10 , C08L33/26 , C09K8/594 , E21B33/138 , E21B43/164 , Y02P90/70
摘要： The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. Methods of making and using such polymers are also provided.
摘要翻译：本发明涉及在酸性pH下自交联或可在盐水中由酚类试剂进行交联的聚合物。这样的聚合物具有较低的粘度并且可以深入泵入储层，在那里它们将原位交联，从而增加其粘度和/或形成凝胶并阻止小偷区。还提供了制备和使用这些聚合物的方法。

7. 发明申请

WO2014052836A3 METHODS AND COMPOSITIONS FOR TREATING INFECTION 审中-公开
标题翻译：治疗感染的方法和组合物
公开(公告)号：WO2014052836A3
公开(公告)日：2014-05-22
申请号：PCT/US2013062309
申请日：2013-09-27
申请人： UNIV ROCHESTER , UNIV KANSAS
发明人： DUNMAN PAUL M , KRYSAN DAMIAN J , FLAHERTY DANIEL P
IPC分类号： A61K31/435 , A61K31/05 , A61P31/04 , A61P31/10 , A61P31/12
CPC分类号： A61K31/138 , A61K31/4152 , A61K31/445 , A61K31/4515 , A61K31/4525 , A61K31/4545 , A61K31/566 , A61K31/66 , C12Q1/18 , C12Q1/485
摘要： Provided herein are compositions and methods for treating or preventing infection.
摘要翻译：本文提供了用于治疗或预防感染的组合物和方法。

8. 发明申请

WO2013052180A3 METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION 审中-公开
标题翻译：用于桥接脑区域以改善功能的方法和相关神经前体装置
公开(公告)号：WO2013052180A3
公开(公告)日：2014-05-01
申请号：PCT/US2012042381
申请日：2012-06-14
申请人： UNIV KANSAS , UNIV CASE WESTERN RESERVE , NUDO RANDOLPH J , AZIN MEYSAM , MOHSENI PEDRAM , GUGGENMOS DAVID
发明人： NUDO RANDOLPH J , AZIN MEYSAM , MOHSENI PEDRAM , GUGGENMOS DAVID
IPC分类号： A61N1/36
CPC分类号： A61N1/36103 , A61B5/04001 , A61B5/6868 , A61N1/0529 , A61N1/0531 , A61N1/0536 , A61N1/36139
摘要： Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided herein. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. Although any neural prosthetic device capable of detecting a spike in a first site and delivering a stimulus in a second site may be used, the present disclosure further provides a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
摘要翻译：本文提供了桥接基本上没有有效通信的脑部位置和相关联的神经修复装置的方法。检测受试者中第一神经位点中的神经尖峰，并且在检测到神经穗之后的确定的时间段内传递对受试者中的第二神经部位的刺激，其中基本上没有有效的通信第一和第二神经位点。该方法在两个神经位点之间形成人造桥梁，并建立了两个站点之间的持久通信。尽管可以使用能够检测第一部位中的尖峰并且在第二部位中传递刺激的任何神经修复装置，但是本公开还提供了一种包括集成电路的神经假体装置，所述集成电路包括记录前端，所述记录前端包括多个录音频道; 处理器单元; 以及传送后端的刺激物，其包括多个刺激通道。

9. 发明申请

WO2014015181A3 METAL ABSTRACTION PEPTIDE WITH RELEASE OF METAL 审中-公开
标题翻译：金属萃取金属的金属萃取肽
公开(公告)号：WO2014015181A3
公开(公告)日：2014-03-13
申请号：PCT/US2013051151
申请日：2013-07-18
申请人： UNIV KANSAS , ECHOGEN INC , STOWELL LAURENCE JENNIFER ANN , KRAUSE MARY ELIZABETH , LAURENCE GEORGE
发明人： STOWELL LAURENCE JENNIFER ANN , KRAUSE MARY ELIZABETH , LAURENCE GEORGE
IPC分类号： G01N33/00 , G01N33/20
CPC分类号： C07K7/06 , A61K38/08
摘要： Compositions comprising peptides that are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed. Such compositions can be used for binding and releasing a metal in a variety of contexts and environments, such as the treatment of cancer.
摘要翻译：公开了包含能够以正方形平面取向，正方形金字塔方向或两者结合金属的肽的组合物。这种组合物可以用于在各种背景和环境中结合和释放金属，例如治疗癌症。

10. 发明申请

WO2013181461A3 METAL ABSTRACTION PEPTIDE WITH SUPEROXIDE DISMUTASE ACTIVITY 审中-公开
标题翻译：具有超氧化物歧化酶活性的金属吸收肽
公开(公告)号：WO2013181461A3
公开(公告)日：2014-03-13
申请号：PCT/US2013043467
申请日：2013-05-30
申请人： UNIV KANSAS , ECHOGEN INC , STOWELL LAURENCE JENNIFER ANN , KRAUSE MARY ELIZABETH , JACKSON TIMOTHY A , GLASS AMANDA MICHELLE , LAURENCE GEORGE
发明人： STOWELL LAURENCE JENNIFER ANN , KRAUSE MARY ELIZABETH , JACKSON TIMOTHY A , GLASS AMANDA MICHELLE , LAURENCE GEORGE
IPC分类号： A61K38/06 , C07K5/00 , C07K16/00 , C07K19/00 , C12P7/00 , G01N33/20
CPC分类号： C12N9/0089 , A61K38/00 , C07K14/62 , C12P7/62 , C12Y115/01001
摘要： Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various embodiments, peptides are used for antioxidant activity, anti-inflammatory activity, anti-pain therapy, as chemical reagents, and/or as superoxide dismutase mimics.
摘要翻译：公开了包含能够结合金属的肽的组合物。这些组合物可用于在各种环境和环境中结合金属。在各种实施方案中，肽用于抗氧化活性，抗炎活性，抗疼痛治疗，作为化学试剂，和/或作为超氧化物歧化酶模拟物。

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