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1. 发明申请

WO2009100147A2 UNIVERSAL HANDLE 审中-公开
标题翻译：通用手柄
公开(公告)号：WO2009100147A2
公开(公告)日：2009-08-13
申请号：PCT/US2009033101
申请日：2009-02-04
申请人： UNIV CLEVELAND HOSPITALS , AMIN TUROCY & CALVIN LLP , NEARMAN HOWARD , VOLTZ DONALD , AHARON ALON
发明人： NEARMAN HOWARD , VOLTZ DONALD , AHARON ALON
IPC分类号： A61B5/00 , B65D25/28 , G06Q50/00 , G06Q90/00 , G16H10/60
CPC分类号： A61B1/00066 , A61B1/04 , A61B1/267 , A61B5/0059 , A61B5/6898 , A61B5/742 , A61F9/008 , A61F2009/00844 , B25J9/1689 , G05B15/02 , G06Q50/24 , Y10T16/44
摘要： The claimed subject matter provides systems and/or methods that facilitate employing a universal handle that provides various functionality and communicates with various network(s), device(s), and the like. The universal handle can be a handheld device that is auto-configured to implement rich functionality. Further, the universal handle can support remote diagnostic, prognostic, and control capabilities. Moreover, the universal handle can mate with disparate device(s), network(s), instrument(s), node(s), universal handle(s), and so forth to communicate data there between. Applications of the universal handle can be medically related, industry related, military related, etc. The universal handle can collect data directly and/or by controlling managed external device(s); the collected data can thereafter be analyzed, aggregated, stored, transmitted, outputted, and so forth by the universal handle.
摘要翻译：所要求保护的主题提供了便于采用提供各种功能并与各种网络，设备等进行通信的通用手柄的系统和/或方法。通用手柄可以是自动配置以实现丰富功能的手持设备。此外，通用手柄可以支持远程诊断，预测和控制功能。此外，通用手柄可以与不同的设备，网络，仪器，节点，通用手柄等进行通信，以在其间传送数据。通用手柄的应用可以在医学上相关，行业相关，军事相关等。通用手柄可以直接和/或通过控制被管理的外部设备来收集数据; 收集的数据随后可以被通用手柄分析，聚合，存储，发送，输出等。

2. 发明申请

WO2008115387A3 SCREENING, DIAGNOSING, TREATING AND PROGNOSIS OF PATHOPHYSIOLOGIC STATES BY RNA REGULATION 审中-公开
标题翻译： RNA法规筛选，诊断，治疗和预测病理生理状态
公开(公告)号：WO2008115387A3
公开(公告)日：2008-11-13
申请号：PCT/US2008003298
申请日：2008-03-13
申请人： UNIV CLEVELAND HOSPITALS , ROSILAND FRANKLIN UNIVERSITY O , RIBONOMICS INC , GORODESKI GEORGE , POTASHKIN JUDY , CHEATHAM BENTLEY
发明人： GORODESKI GEORGE , POTASHKIN JUDY , CHEATHAM BENTLEY
IPC分类号： C12Q1/70 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/178 , C12Q2522/10
摘要： A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that may be a reflection of either reduced mRNA expression and/or increased mRNA degradation. miRNAs are identified that hybridize to an mRNA that are suspected to mediate intracellular mRNA steady state levels. Alternatively, ribonucleic acid binding protein (RBP) levels may also mediate intracellular mRNA steady state levels. In particular, this invention demonstrates an effective clinical management strategy for uterine cell cancers may be implemented by taking advantage of an exemplary relationship between P2X 7 mRNA and miRNAs including, but not limited to, miR-186 and/or miR-150.
摘要翻译：通过确定细胞内niRN A调节剂水平来描述癌症与核糖核酸（RNA）调节之间的关系。通常，癌细胞中的mRNA水平降低，这可能是mRNA表达降低和/或mRNA降解增加的反映。鉴定出与怀疑介导细胞内mRNA稳态水平的mRNA杂交的miRNA。或者，核糖核酸结合蛋白（RBP）水平也可以介导细胞内mRNA稳态水平。特别地，本发明证实子宫细胞癌的有效临床管理策略可以通过利用P2X mRNA与miRNA之间的示例性关系来实现，所述miRNA包括但不限于miR-186和/ 或miR-150。

3. 发明申请

WO2008079298A2 CELLS FOR DETECTION AND PRODUCTION OF INFLUENZA AND PARAINFLUENZA VIRUSES 审中-公开
标题翻译：用于检测和产生流感病毒和副流感病毒的细胞
公开(公告)号：WO2008079298A2
公开(公告)日：2008-07-03
申请号：PCT/US2007026077
申请日：2007-12-19
申请人： UNIV CLEVELAND HOSPITALS , DIAGNOSTIC HYBRIDS INC , LI YUNSHENG , HUANG YUNG T
发明人： LI YUNSHENG , HUANG YUNG T
IPC分类号： C12Q1/70 , C12N5/071
CPC分类号： A61K39/155 , A61K39/00 , A61K39/12 , A61K39/145 , C12N5/0688 , C12N7/00 , C12N9/64 , C12N2760/16111 , C12N2760/16134 , C12N2760/16151 , C12N2760/18611 , C12N2760/18651 , G01N33/56983 , G01N2333/11 , G01N2333/115
摘要： The invention provides cell lines that are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic cells with increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.
摘要翻译：本发明提供可用于快速检测和产生流感和副流感病毒的细胞系。特别地，本发明涉及对甲型流感，乙型流感或副流感病毒3感染的敏感性增加或能提高感染性病毒粒子生产力的转基因细胞。本发明适用于培养临床流行性感冒和副流感病毒分离物，以及用于生产用于疫苗制剂的流感和副流感病毒，作为用于诊断应用的抗原制剂和用于筛选抗病毒药物。

4. 发明申请

WO2005094324A3 MIXED CELL DIAGNOSTIC SYSTEMS 审中-公开
标题翻译：混合细胞诊断系统
公开(公告)号：WO2005094324A3
公开(公告)日：2006-01-19
申请号：PCT/US2005010426
申请日：2005-03-29
申请人： DIAGNOSTIC HYBRIDS INC , UNIV CLEVELAND HOSPITALS , SCHOLL DAVID R , GOODRUM PATRICIA GAIL RAY , HUANG YUNG T
发明人： SCHOLL DAVID R , GOODRUM PATRICIA GAIL RAY , HUANG YUNG T
IPC分类号： C12N5/071 , C12Q1/04 , G01N33/50 , C12Q1/68
CPC分类号： C12N5/0697 , C12N5/0688 , C12N2502/256 , C12N2502/27 , C12N2503/04 , C12Q1/04 , G01N33/5091 , G01N2333/11 , G01N2333/115
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

5. 发明申请

WO2012112761A3 METHOD AND SYSTEM FOR EXTRACTION AND ANALYSIS OF INPATIENT AND OUTPATIENT ENCOUNTERS FROM ONE OR MORE HEALTHCARE RELATED INFORMATION SYSTEMS 审中-公开
标题翻译：从一个或多个健康相关信息系统中提取和分析患者和外部感染者的方法和系统
公开(公告)号：WO2012112761A3
公开(公告)日：2014-04-17
申请号：PCT/US2012025421
申请日：2012-02-16
申请人： UNIV CLEVELAND HOSPITALS , DELANEY CONOR , STULBERG JONAH
发明人： DELANEY CONOR , STULBERG JONAH
IPC分类号： G06F17/30
CPC分类号： G06Q50/24 , G06Q10/06 , G06Q10/0637 , G06Q50/22
摘要： A system and method for the analysis of one or more patient encounters from one or more healthcare related information systems of a healthcare organization are disclosed. The system and method include a data processing system, which provides a graphical user interface which accepts a query regarding the patient encounters, which receives data in response to the query from the one or more healthcare related information systems about a plurality of pre-selected objects concerning the one or more patient encounters, and which arranges the data according to a data model which sets relations between the pre-selected objects. The system and method also employ the relations between the pre-selected objects to provide a report to the accepted query, and output the report.
摘要翻译：公开了一种用于分析来自医疗保健组织的一个或多个保健相关信息系统的一个或多个患者遭遇的系统和方法。该系统和方法包括数据处理系统，其提供图形用户界面，其接受关于患者遭遇的查询，所述查询响应于来自所述一个或多个医疗相关信息系统的关于多个预选对象的查询而接收数据涉及一个或多个患者遭遇，并且根据设置预选对象之间的关系的数据模型排列数据。系统和方法还采用预选对象之间的关系，向接受的查询提供报告，并输出报告。

6. 发明申请

WO2007103146A3 TRUNCATED PROTEINS AS CANCER MARKERS 审中-公开
标题翻译：截短蛋白作为癌症标志物
公开(公告)号：WO2007103146A3
公开(公告)日：2009-04-30
申请号：PCT/US2007005304
申请日：2007-03-01
申请人： UNIV CLEVELAND HOSPITALS , JACKSON H M FOUND MILITARY MED , GORODESKI GEORGE , FENG YING-HONG , LI XIN
发明人： GORODESKI GEORGE , FENG YING-HONG , LI XIN
IPC分类号： C07H21/04 , C07K14/82 , C07K16/30 , C12P21/06 , G01N33/574
CPC分类号： C07K16/30 , C07K14/4747 , C07K14/4748 , C07K14/705 , G01N33/57492
摘要： Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment, methods and reagents for decreasing the amount and/or activity of truncated P2X7 in cells are described.
摘要翻译：公开了用于检测和/或治疗癌症或潜在癌症的方法/试剂。在一个实施方案中，描述了用于检测细胞中P2X7蛋白的截短形式的方法和试剂。在一个实施方案中，描述了用于增加细胞中全长P2X7的量和/或活性的方法和试剂。在一个实施方案中，描述了减少细胞中截短的P2X7的量和/或活性的方法和试剂。

7. 发明申请

WO2005041847A2 METHOD AND APPARATUS FOR APPLYING MEDICATION TO INTERNAL TISSUE 审中-公开
标题翻译：将药物用于内部组织的方法和装置
公开(公告)号：WO2005041847A2
公开(公告)日：2005-05-12
申请号：PCT/US2004034782
申请日：2004-10-21
申请人： UNIV CLEVELAND HOSPITALS , GORODESKI GEORGE
发明人： GORODESKI GEORGE
IPC分类号： A61J20060101 , A61M31/00 , A61J
CPC分类号： A61M31/00 , A61K9/0036 , A61M37/00
摘要： A method and apparatus for applying medication to internal human tissue. One drug delivery member for applying medication to internal human tissue includes a medication impermeable barrier and a medication carrying matrix. The medication impermeable barrier is shaped to conform to a contour of the internal tissue The medication carrying matrix is disposed on the barrier. The medication carrying matrix releases the medication to the human tissue upon being applied to the internal human tissue. The matrix may be adapted to adhere to the internal human tissue and/or a retainer may be used to secure the drug delivery member to the internal tissue.
摘要翻译：一种用于向内部人体组织施用药物的方法和装置。用于向内部人体组织施用药物的一种药物递送部件包括药物不可渗透屏障和药物输送基质。药物不渗透屏障被成形为符合内部组织的轮廓。药物传送矩阵设置在屏障上。药物输送基质在施用于内部人体组织时将药物释放到人体组织。基质可以适于粘附到内部人体组织，和/或可以使用保持器来将药物递送构件固定到内部组织。

8. 发明申请

WO02060480A9 METHODS FOR TREATING OR PREVENTING SKIN DISORDERS USING CD2-BINDING AGENTS 审中-公开
标题翻译：使用CD2结合剂治疗或预防皮肤疾病的方法
公开(公告)号：WO02060480A9
公开(公告)日：2004-05-27
申请号：PCT/US0202314
申请日：2002-01-25
申请人： BIOGEN INC , UNIV CLEVELAND HOSPITALS , VAISHNAW AKSHAY K , COOPER KEVIN D , SHRAGER DANIEL , MCCORMICK THOMAS S
发明人： VAISHNAW AKSHAY K , COOPER KEVIN D , SHRAGER DANIEL , MCCORMICK THOMAS S
IPC分类号： A61K45/00 , A61K38/00 , A61K39/00 , A61K39/395 , A61P3/10 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/08 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00
CPC分类号： C07K16/2824 , A61K2039/505 , C07K16/00 , C07K2319/00 , C07K2319/30
摘要： Methods for treating or preventing an epidermal or dermal disorder, e.g., psoriasis, using a CD2-binding agent, e.g., an inhibitor of the CD2/LFA-3 interaction (e.g., an LFA-3/IgG fusion polypeptide), in combination with an auxiliary agent, e.g., UVB irradiation, are disclosed.
摘要翻译：使用CD2结合剂（例如CD2 / LFA-3相互作用的抑制剂（例如LFA-3 / IgG融合多肽））结合治疗或预防表皮或皮肤病症（例如牛皮癣）的方法与公开了一种辅助剂，例如UVB照射。

9. 发明申请

WO02090934A2 EVALUATION OF ULTRAVIOLET RADIATION DAMAGE TO SKIN USING NEW GENEMARKERS, METHODS AND COMPOSITIONS RELATED THERETO 审中-公开
标题翻译：使用新的生物标志物评估超紫外线对皮肤的损伤，方法和组合物
公开(公告)号：WO02090934A2
公开(公告)日：2002-11-14
申请号：PCT/US0214884
申请日：2002-05-09
申请人： UNIV CLEVELAND HOSPITALS , JONES BRIAN C , BOSKO CAROL , COOPER KEVIN , MCCORMICK THOMAS
发明人： JONES BRIAN C , BOSKO CAROL , COOPER KEVIN , MCCORMICK THOMAS
IPC分类号： G01N33/50 , A23L33/00 , A61K45/00 , A61P17/16 , C07H21/04 , C12N15/01 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N20060101 , G01N33/15 , G01N33/53 , G01N33/58 , G01N37/00 , G01N
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/158
摘要： The present invention describes a method for treating and/or evaluating photodamage and/or photoaging of skin caused by exposure to solar ultraviolet (UV) radiation. The method employs a unique set of marker genes whose expression was newly found to be altered following exposure of skin to UV radiation. The invention provides an advantageous system of identifying and assessing substances that are capable of modulating, e.g., via attenuation, UV radiation induced alteration or change in the expression of at least one of the newly provided marker genes in skin relative to the gene expression level in skin not exposed to UV radiation. Also provided are compositions comprising materials that upon application to skin can modulate the gene expression of at least one gene of the marker gene set after exposure of skin to UV radiation, thereby affording protective and therapeutic effects and treatments for photodamage and photoaging. The potential benefit of, e.g., skincare, hair care, cosmetic, and personal care agents, and nutritional supplements, as materials having antiphotodamage and/or antiphotoaging properties can be assessed using the present method.
摘要翻译：本发明描述了一种用于治疗和/或评估由暴露于太阳紫外线（UV）辐射引起的皮肤光损伤和/或光老化的方法。该方法采用独特的一组标记基因，其表达在皮肤暴露于紫外线辐射后被新发现被改变。本发明提供了一种鉴定和评估能够通过衰减，UV辐射诱导的改变或皮肤中至少一种新提供的标记基因在表达中相对于基因表达水平进行调节的物质的有利系统皮肤未暴露于紫外线辐射。还提供了包含施用于皮肤的材料的组合物，其可以在将皮肤暴露于UV辐射后调节标记基因集合的至少一个基因的基因表达，由此提供光损伤和光老化的保护和治疗效果和治疗。可以使用本发明的方法来评估例如护肤品，头发护理剂，化妆品和个人护理剂以及营养补充剂作为具有防重染性和/或抗重复性能的材料的潜在益处。

10. 发明申请

WO2009100147A3 UNIVERSAL HANDLE 审中-公开
标题翻译：万用手柄
公开(公告)号：WO2009100147A3
公开(公告)日：2009-10-08
申请号：PCT/US2009033101
申请日：2009-02-04
申请人： UNIV CLEVELAND HOSPITALS , AMIN TUROCY & CALVIN LLP , NEARMAN HOWARD , VOLTZ DONALD , AHARON ALON
发明人： NEARMAN HOWARD , VOLTZ DONALD , AHARON ALON
IPC分类号： A61B1/267 , G16H10/60
CPC分类号： A61B1/00066 , A61B1/04 , A61B1/267 , A61B5/0059 , A61B5/6898 , A61B5/742 , A61F9/008 , A61F2009/00844 , B25J9/1689 , G05B15/02 , G06Q50/24 , Y10T16/44
摘要： The claimed subject matter provides systems and/or methods that facilitate employing a universal handle that provides various functionality and communicates with various network(s), device(s), and the like. The universal handle can be a handheld device that is auto-configured to implement rich functionality. Further, the universal handle can support remote diagnostic, prognostic, and control capabilities. Moreover, the universal handle can mate with disparate device(s), network(s), instrument(s), node(s), universal handle(s), and so forth to communicate data there between. Applications of the universal handle can be medically related, industry related, military related, etc. The universal handle can collect data directly and/or by controlling managed external device(s); the collected data can thereafter be analyzed, aggregated, stored, transmitted, outputted, and so forth by the universal handle.
摘要翻译：所要求保护的主题提供了便于采用提供各种功能并且与各种网络，（多个）设备等通信的通用句柄的系统和/或方法。通用手柄可以是自动配置以实现丰富功能的手持设备。此外，通用手柄可以支持远程诊断，预测和控制功能。此外，通用手柄可以与不同设备，网络，仪器，节点，通用手柄等配合以在其间传递数据。通用手柄的应用可以是医学相关的，与工业有关的，与军事相关的等。通用手柄可以直接收集数据和/或通过控制受管理的外部设备; 之后可以通过通用句柄分析，汇总，存储，传输，输出等。

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