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1. 发明申请

WO2016166418A2 IN VITRO MODEL OF CHRONIC INFLAMMATION 审中-公开
标题翻译：慢性炎症体温模型
公开(公告)号：WO2016166418A2
公开(公告)日：2016-10-20
申请号：PCT/FI2016/050245
申请日：2016-04-13
申请人： TAMPEREEN YLIOPISTO
发明人： HEINONEN, Tuula , SARKANEN, Jertta-Riina , YLIKOMI, Timo , HUTTALA, Outi
IPC分类号： C12N5/0775
CPC分类号： C12N5/0697 , C12N2500/25 , C12N2500/38 , C12N2501/39 , C12N2501/395 , C12N2501/91 , C12N2502/1157 , C12N2502/1305 , C12N2502/1382 , C12N2502/28 , C12N2503/04
摘要： The present invention relates to an in vitro model of chronic inflammation for use e.g. in pharmacological and toxicological studies and studies of development of chronic inflammation, type 2 diabetes and as a general model in basic and applied research.
摘要翻译：本发明涉及一种用于使用的慢性炎症的体外模型。在药物和毒理学研究和慢性炎症发展研究，2型糖尿病和基础和应用研究中的一般模型。

2. 发明申请

WO2015049677A1 DIRECTED DIFFERENTIATION OF ASTROCYTES FROM HUMAN PLURIPOTENT STEM CELLS FOR USE IN DRUG SCREENING AND THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) 审中-公开
标题翻译：来自用于药物筛选的人类潜在干细胞的ASTROCYTES的指导性差异和治疗AMYOTROPHIC侧向SCLEROSIS（ALS）
公开(公告)号：WO2015049677A1
公开(公告)日：2015-04-09
申请号：PCT/IL2014/050846
申请日：2014-09-23
申请人： KADIMASTEM LTD.
发明人： IZRAEL, Michal , REVEL, Michel , HASSON, Arik , MOLAKANDOV, Kfir , CHEBATH, Judith
IPC分类号： A61P25/28 , C12N5/07 , A61K35/30 , G01N33/50
CPC分类号： C12N5/0622 , A61K35/30 , C12N5/0619 , C12N2500/25 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/385 , C12N2502/081 , C12N2502/086 , C12N2503/02 , C12N2503/04 , C12N2506/02 , C12N2533/32 , C12N2533/52 , C12N2533/90 , G01N33/5058 , G01N33/5073 , G01N2510/00
摘要： The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.
摘要翻译：本发明公开了使用离体分化多能干细胞（PSC）鉴定影响人星形胶质细胞功能的试剂的方法。此外，还公开了人类祖细胞或人星形胶质细胞在人类受试者中用于治疗肌萎缩性侧索硬化症（ALS）的用途。

3. 发明申请

WO2012023093A1 THREE-DIMENSIONAL POLY-CAPROLACTONE POLYMERIC SCAFFOLD 审中-公开
标题翻译：三维聚碳酸酯聚合物SCAFFOLD
公开(公告)号：WO2012023093A1
公开(公告)日：2012-02-23
申请号：PCT/IB2011/053586
申请日：2011-08-11
申请人： FONDAZIONE T. CAMPANELLA - C.O.E. , TASSONE, Pierfrancesco , CAUSA, Filippo , TAGLIAFERRI, Pierosandro , CALIMERI, Teresa , DI MARTINO, Maria, Teresa , BATTISTA, Edmondo
发明人： TASSONE, Pierfrancesco , CAUSA, Filippo , TAGLIAFERRI, Pierosandro , CALIMERI, Teresa , DI MARTINO, Maria, Teresa , BATTISTA, Edmondo
IPC分类号： A01K67/027 , C12N5/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61L27/18 , A61L27/3604 , A61L27/56 , C12N5/0694 , C12N2502/1394 , C12N2503/04 , C12N2533/40 , C08L67/04
摘要： The present invention refers to a three-dimensional scaffold consisting of poly-ε- caprolactone, optionally pre-coated with human bone marrow stromal cells, to its use for engraftment and in vivo growth of human primary or IL6-dependent multiple myeloma cells in a non-human animal. The present invention also refers to a non-human animal carrying the scaffold of the invention.
摘要翻译：本发明涉及由聚己内酯（任选预先包被人骨髓基质细胞）组成的三维支架，其用于在人原代或IL6依赖性多发性骨髓瘤细胞中的植入和体内生长非人类动物。本发明还涉及携带本发明的支架的非人动物。

4. 发明申请

WO2005104755A3 ARTIFICIAL IMMUNE SYSTEM: METHODS FOR MAKING AND USE 审中-公开
标题翻译：人工免疫系统：制造和使用的方法
公开(公告)号：WO2005104755A3
公开(公告)日：2008-08-21
申请号：PCT/US2005014444
申请日：2005-04-28
申请人： VAXDESIGN CORP , WARREN WILLIAM L , FAHLENKAMP HEATHER , HIGBEE RUSSELL , KACHURIN ANATOLY , LI CONAN K N , NGUYEN MIKE , PARKHILL ROBERT , SANCHEZ GUZMAN , IRVINE DARRELL J , RANDLOLPH GWENDALYN , NACOHEN NIR , TORBETT BRUCE
发明人： WARREN WILLIAM L , FAHLENKAMP HEATHER , HIGBEE RUSSELL , KACHURIN ANATOLY , LI CONAN K N , NGUYEN MIKE , PARKHILL ROBERT , SANCHEZ GUZMAN , IRVINE DARRELL J , RANDLOLPH GWENDALYN , NACOHEN NIR , TORBETT BRUCE
IPC分类号： C12Q1/68 , A01N63/00 , A61K35/26 , C12N5/00 , C12N5/071 , G01N33/50
CPC分类号： C12N5/0697 , C12N2501/21 , C12N2502/11 , C12N2502/28 , C12N2503/04 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5047 , G01N33/5064 , G01N33/5088
摘要： The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
摘要翻译：本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。

5. 发明申请

WO03004655A3 USE OF THE CD24 MARKER GENE FOR THE SELECTION OF KERATINOCYTE STEM CELLS TRANSFORMED BY EXOGENOUS SEQUENCES 审中-公开
标题翻译：使用CD24标记基因选择由异常序列转化的杀伤细胞干细胞
公开(公告)号：WO03004655A3
公开(公告)日：2003-10-02
申请号：PCT/FR0202347
申请日：2002-07-04
申请人： CENTRE NAT RECH SCIENT , MAGNALDO THIERRY , SARASIN ALAIN
发明人： MAGNALDO THIERRY , SARASIN ALAIN
IPC分类号： A61K35/12 , A61K48/00 , C07K14/705 , C12N5/071 , C12N5/074 , C12N15/65 , C12N5/08 , C12N5/10 , C12Q1/02 , C12Q1/68
CPC分类号： C12N5/0629 , A01K2217/075 , A61K35/12 , A61K48/00 , C07K14/70596 , C12N5/063 , C12N15/65 , C12N2501/599 , C12N2503/02 , C12N2503/04 , C12N2510/00 , C12N2799/027
摘要： The invention relates to the use of the CD 24 marker gene in mammals, such as the human CD24 human gene, for the transformation of keratinocyte stem cells when carrying out methods for preparing homogeneous batches of epidermal stem cells transformed in such a way that they contain an exogenous nucleotide sequence of interest, in addition to said transformed keratinocyte stem cells, epidermal tissue reconstituted from said keratinocytes and the uses thereof.
摘要翻译：本发明涉及当进行用于制备均匀批次的表皮干细胞的方法时，例如人CD24人基因的哺乳动物中的CD 24标记基因用于角化细胞干细胞的转化，所述方法使得它们含有除了所述转化的角质形成细胞干细胞，从所述角质形成细胞重建的表皮组织及其用途之外，还有一种外源核苷酸序列。

6. 发明申请

WO2003043674A1 AUGMENTATION OF ORGAN FUNCTION 审中-公开
标题翻译：有机功能的完成
公开(公告)号：WO2003043674A1
公开(公告)日：2003-05-30
申请号：PCT/US2002/036202
申请日：2002-11-12
申请人： CHILDREN'S MEDICAL CENTER CORPORATION ¨
发明人： ATALA, Anthony
IPC分类号： A61L27/38
CPC分类号： C12N5/0068 , A61F2/022 , A61K35/12 , A61L27/3641 , A61L27/3683 , A61L27/3839 , A61L27/3886 , A61L2430/26 , C12N5/0685 , C12N5/0686 , C12N2501/11 , C12N2502/28 , C12N2503/04 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention provides methods and compositions for augmenting organ functions using small-scale matrix implants generated by seeding tissue-specific or undifferentiated cells onto a matrix materials (e.g., a wafer, sponge, or hydrogel). The seeded matrix composition can then be implanted and will develop into an organ-supplementing structure in vivo . Continued growth and differentiation of the seeded cells on the implanted matrix results in the formation of a primitive vascular system in the tissue. The primitive vascular system can then develop into a mature vascular system, and can also support the growth and development of additional cultured cell populations. The seeded matrix system can be used to introduce a variety of different cells and tissues in vivo .
摘要翻译：本发明提供使用通过将组织特异性或未分化细胞接种到基质材料（例如，晶片，海绵或水凝胶）上产生的小规模基质植入物来增强器官功能的方法和组合物。然后可以植入接种的基质组合物，并在体内发育成器官补充结构。种植细胞在植入基质上的持续生长和分化导致组织中原始血管系统的形成。然后，原始血管系统可以发育成成熟的血管系统，并且还可以支持额外培养的细胞群体的生长和发育。种子基质系统可用于在体内引入各种不同的细胞和组织。

7. 发明申请

WO0220729A3 IN VITRO HUMAN ANGIOGENESIS MODEL 审中-公开
标题翻译：人体血管生成模型
公开(公告)号：WO0220729A3
公开(公告)日：2002-10-03
申请号：PCT/CA0101276
申请日：2001-09-05
申请人： UNIV LAVAL , GERMAIN LUCIE , AUGER FRANCOIS A , ROCHON MARIE-HELENE , BLACK ANNIE F
发明人： GERMAIN LUCIE , AUGER FRANCOIS A , ROCHON MARIE-HELENE , BLACK ANNIE F
IPC分类号： A61L27/38 , C12N5/071 , C12N5/08 , G01N33/50
CPC分类号： A61L27/3813 , A61L27/3608 , A61L27/3633 , A61L27/3804 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2502/28 , C12N2502/30 , C12N2503/04 , C12N2503/06
摘要： The present invention relates to a tridimensional living tissue construct free of exogenous extracellular matrix material, and in which angiogenesis occurs. Network of capillaries formed into the living tissue construct allows to provide blood vessels for replacement or repair in human and animals, and is also useful in screening compounds or agents potentially having capability of modulating the angiogenesis in vitro or in vivo .
摘要翻译：本发明涉及不含外源细胞外基质材料的三维生物体组织结构，其中发生血管生成。形成活组织结构的毛细管网络允许提供血管用于人和动物的置换或修复，并且还可用于筛选潜在地具有调节体外或体内血管发生能力的化合物或试剂。

8. 发明申请

WO01048153A1 RECONSTRUCTING ORGANS FROM DECELLULARIZED BIOMATERIAL SCAFFOLD 审中-公开
标题翻译：从细菌生物膜SCAFFED重建机构
公开(公告)号：WO01048153A1
公开(公告)日：2001-07-05
申请号：PCT/US2000/033891
申请日：2000-12-14
IPC分类号： C12Q1/02 , A61K35/12 , A61K35/22 , A61K35/23 , A61K35/34 , A61K35/37 , A61K35/39 , A61K35/407 , A61L27/38 , A61P1/00 , A61P1/16 , A61P1/18 , A61P9/00 , A61P13/02 , A61P13/10 , A61P13/12 , C12N5/00 , C12N5/071 , C12N5/06 , A61M1/14
CPC分类号： A61L27/3891 , A61K35/12 , A61L27/3604 , A61L27/3808 , A61L27/3839 , C12N5/0068 , C12N5/0686 , C12N2502/28 , C12N2503/04 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The invention is directed to compositions and methods for reconstructing an artificial organ. The artificial organ is reconstructed using a three-dimensional scaffold produced by decellularizing biostructures from a donor organ. The three-dimensional scaffold is perfused with endothelial cells that develop to produce an endothelial tissue layer with a primitive vascular system that sustains the growth and development of a second cultured cell population. When grown in the three-dimensional scaffold and endothelial tissue layer, with the primitive vascular system, the cells of the second cell population proliferate, mature and differentiate into neomorphic organ structures that are analogous to their in vivo counterparts.
摘要翻译：本发明涉及用于重建人造器官的组合物和方法。使用通过从供体器官脱细胞化生物结构产生的三维支架重建人造器官。三维支架被内皮细胞灌注，内皮细胞发育以产生具有维持第二培养细胞群的生长和发育的原始血管系统的内皮组织层。当在三维支架和内皮组织层中生长时，与原始血管系统一起，第二细胞群的细胞增殖，成熟并分化为类似于其体内对应物的新型器官结构。

9. 发明申请

WO0075286A3 3-DIMENSIONAL IN VITRO MODELS OF MAMMALIAM TISSUES 审中-公开
标题翻译：马氏体组织模型中的三维体细胞模型
公开(公告)号：WO0075286A3
公开(公告)日：2001-05-03
申请号：PCT/CA0000650
申请日：2000-06-02
申请人： CA NAT RESEARCH COUNCIL , JOUISHOMME HERVE , PHIPPS JENNY , PHIPPS MICHEL , LACELLE SUZANNE
发明人： JOUISHOMME HERVE , PHIPPS JENNY , PHIPPS MICHEL , LACELLE SUZANNE
IPC分类号： C12N5/00 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0062 , C12N5/0697 , C12N2502/1323 , C12N2502/25 , C12N2502/30 , C12N2503/04
摘要： Novel 3-dimensional in vitro models of mammalian tissues are provided. In a preferred embodiment, the models simulate behavior of human cancerous tissues at various stages of a solid tumour progression or the cell senescence, apoptosis or tissue regeneration in normal or cancerous human cells. The models are particularly useful for screening and testing of anticancerous drugs and assessing their toxicity for both the tumour and the surrounding tissue. Novel cellular automaton models for analysis and simulation of 3-dimensional cell organoids have also been developed. These models are useful for studying intercellular communication and predicting effects of gap junction channels modulating drugs.
摘要翻译：提供了哺乳动物组织的新型3维体外模型。在优选的实施方案中，模型模拟在正常或癌性人细胞中的实体肿瘤进展或细胞衰老，细胞凋亡或组织再生的不同阶段的人类癌组织的行为。这些模型对于抗癌药物的筛选和测试以及评估其对肿瘤和周围组织的毒性特别有用。还开发了用于三维细胞组织的分析和模拟的新型细胞自动机模型。这些模型对于研究细胞间通讯和预测间隙连接通道调节药物的作用是有用的。

10. 发明申请

WO00075286A2 3-DIMENSIONAL IN VITRO MODELS OF MAMMALIAM TISSUES 审中-公开
标题翻译：马氏体组织模型中的三维体细胞模型
公开(公告)号：WO00075286A2
公开(公告)日：2000-12-14
申请号：PCT/CA2000/000650
申请日：2000-06-02
IPC分类号： C12N5/00 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0062 , C12N5/0697 , C12N2502/1323 , C12N2502/25 , C12N2502/30 , C12N2503/04
摘要： Novel 3-dimensional in vitro models of mammalian tissues are provided. In a preferred embodiment, the models simulate behavior of human cancerous tissues at various stages of a solid tumour progression or the cell senescence, apoptosis or tissue regeneration in normal or cancerous human cells. The models are particularly useful for screening and testing of anticancerous drugs and assessing their toxicity for both the tumour and the surrounding tissue. Novel cellular automaton models for analysis and simulation of 3-dimensional cell organoids have also been developed. These models are useful for studying intercellular communication and predicting effects of gap junction channels modulating drugs.
摘要翻译：提供了哺乳动物组织的新型3维体外模型。在优选的实施方案中，模型模拟在正常或癌性人细胞中的实体肿瘤进展或细胞衰老，细胞凋亡或组织再生的不同阶段的人类癌组织的行为。这些模型对于抗癌药物的筛选和测试以及评估其对肿瘤和周围组织的毒性特别有用。还开发了用于三维细胞有机体分析和模拟的新型细胞自动机模型。这些模型对于研究细胞间通讯和预测间隙连接通道调节药物的作用是有用的。

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