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1. 发明申请

WO2014035206A3 METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND 审中-公开
标题翻译：制备用于栓塞的微球的方法和用于制备含药物载体的微球的方法
公开(公告)号：WO2014035206A3
公开(公告)日：2014-04-24
申请号：PCT/KR2013007867
申请日：2013-08-30
申请人： UNIV CHUNG ANG IND
发明人： LEE JAE HWI , KWAK BYUNG KOOK , KIM HYEONG MIN , LEE GA HYEON
IPC分类号： A61K9/16 , A61K9/127 , A61P27/00
CPC分类号： A61L24/08 , A61K9/0019 , A61K9/1271 , A61K9/1652 , A61K9/19 , A61K9/5123 , A61K31/704 , A61K47/26 , A61L24/001 , A61L24/0015 , A61L24/0042 , A61L31/042 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/626 , A61L2430/36 , C08L5/08
摘要： The present invention relates to a process for optimizing the recoverability of lyophilized microspheres for emboli and to chitosan microspheres to which a drug-containing carrier is bound. More particularly, the present invention relates to a recoverability optimization process for adding trehalose as a lyophilization protectant prior to a lyophilization for the stable storage of microspheres, and swirling the lyophilized microspheres in order to rehydrate the microspheres. The present invention also relates to microspheres in which the quantity of the drug released from the chitosan microspheres having a drug-containing nanocarrier bound thereto is adjusted based on a drug/chitosan ratio, thus enabling precise drug release adjustment. The present invention also relates to a method for preparing the microspheres. The optimization process of the present invention has the advantages of maintaining the physical properties, shape, and the drug release speed of the microspheres even after the lyophilization of the microspheres for emboli. The chitosan microspheres to which a drug-containing carrier is bound according to the present invention may stably cause emboli in blood vessels, and may precisely adjust the release of a drug and therefore can be used in cancer treatment.
摘要翻译：本发明涉及优化用于栓子的冻干微球体和结合有含药物载体的壳聚糖微球体的可恢复性的方法。更具体地说，本发明涉及用于在冻干之前添加海藻糖作为冻干保护剂以稳定储存微球体并涡旋冻干微球体以再水化微球体的可恢复性优化方法。本发明还涉及微球，其中基于药物/壳聚糖比率调节从其上结合有含药纳米载体的壳聚糖微球释放的药物的量，由此能够精确地进行药物释放调节。本发明还涉及制备微球体的方法。本发明的优化方法具有保持微球体的物理性质，形状和药物释放速度的优点，甚至在冻干微球体用于栓子后也是如此。根据本发明的含有药物的载体所结合的壳聚糖微球体可以稳定地在血管中引起栓子，并且可以精确地调节药物的释放，因此可以用于癌症治疗。

2. 发明申请

WO2012173390A3 METHOD FOR ENHANCING THE PRODUCTION YIELD OF HUMAN PAPILLOMAVIRUS L1 PROTEIN 审中-公开
标题翻译：用于增强人羊毛病L1蛋白生产力的方法
公开(公告)号：WO2012173390A3
公开(公告)日：2013-03-14
申请号：PCT/KR2012004667
申请日：2012-06-13
申请人： UNIV CHUNG ANG IND , KIM HONG JIN , KIM HYOUNG JIN
发明人： KIM HONG JIN , KIM HYOUNG JIN
IPC分类号： C12N15/33 , C07K14/025 , C12N1/19 , C12N15/81
CPC分类号： C07K14/005 , C12N1/18 , C12N2710/20022 , C12N2710/20051 , C12P21/02
摘要： The present invention relates to a method for enhancing the production yield of human papillomavirus (HPV) L1 protein, comprising a step of culturing cells expressing HPV L1 protein in a medium containing a high concentration of a total carbon source. According to the culturing method using a medium containing a high concentration of a carbon source, the production yield of HPV L1 protein can be remarkably enhanced, and furthermore, the immunogenicity of the produced L1 protein can be greatly increased.
摘要翻译：本发明涉及提高人乳头瘤病毒（HPV）L1蛋白的产量的方法，其包括在含有高浓度总碳源的培养基中培养表达HPV L1蛋白的细胞的步骤。根据使用含有高浓度碳源的培养基的培养方法，可以显着提高HPV L1蛋白的产生量，而且可以大大提高产生的L1蛋白的免疫原性。

3. 发明申请

WO2012087004A2 USE OF UPR SIGNALING PATHWAY GENES IRE1 AND HXL1 FOR TREATMENT OF FUNGAL INFECTION AND MENINGITIS 审中-公开
标题翻译： UPR信号通路基因IRE1和HXL1在治疗真菌感染和脑膜炎中的应用
公开(公告)号：WO2012087004A2
公开(公告)日：2012-06-28
申请号：PCT/KR2011009862
申请日：2011-12-20
申请人： UNIV YONSEI IACF , UNIV CHUNG ANG IND , BAHN YONG SUN , JUNG KWANG WOO , KANG HYUN AH , CHEON SEON AH
发明人： BAHN YONG SUN , JUNG KWANG WOO , KANG HYUN AH , CHEON SEON AH
IPC分类号： G01N33/68 , A61P31/04 , C12Q1/68 , G01N33/15
CPC分类号： G01N33/5041 , A61K31/7088 , C07K14/4702 , C12N9/12 , C12N9/22 , C12N15/1137 , C12N2310/14 , C12Y301/26 , G01N2333/37 , G01N2500/10 , G01N2800/26 , G01N2800/28
摘要： The present invention relates to the use of the UPR signaling pathway genes IRE1 and HXL1 for treatment of fungal infection and meningitis. In the invention, it was newly found that disruption of Ire1 and Hxl1 (HAC1 and XBP1-Like gene 1) proteins, newly identified in Cryptococcus neoformans, genes encoding the proteins, provides an antifungal effect and a meningitis-treating effect. Based on this finding, a candidate which can show a synergistic effect when being co-administered with an existing antifungal agent or meningitis-treating agent can be screened and a novel pharmaceutical composition having an antifungal effect and a meningitis-treating effect can be provided.
摘要翻译：本发明涉及UPR信号传导途径基因IRE1和HXL1用于治疗真菌感染和脑膜炎的用途。在本发明中，新发现在新隐球菌新编码的编码蛋白质的基因Ire1和Hxl1（HAC1和XBP1-样基因1）蛋白质的破坏提供了抗真菌作用和脑膜炎治疗作用。基于该发现，可以筛选当与现有的抗真菌剂或脑膜炎治疗剂共同施用时能够显示协同效应的候选物，并且可以提供具有抗真菌作用和脑膜炎治疗效果的新型药物组合物。

4. 发明申请

WO2011136506A9 METHOD FOR PRODUCING RECOMBINANT COMPLEX ANTIGENS USING NANOPARTICLES OF HUMAN ROTAVIRUS 审中-公开
标题翻译：使用人类脊髓损伤的纳米颗粒生产重组复合抗原的方法
公开(公告)号：WO2011136506A9
公开(公告)日：2012-03-01
申请号：PCT/KR2011002937
申请日：2011-04-22
申请人： UNIV CHUNG ANG IND , KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
发明人： KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
IPC分类号： C12N15/46 , C07K19/00 , C12N15/51 , C12N15/866
CPC分类号： A61K39/29 , A61K39/12 , A61K39/15 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14143 , C12N2720/12322 , C12N2720/12334 , C12N2770/32234 , C12N2770/32422 , C12N2770/32434 , G01N33/56983 , G01N2333/14
摘要： The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.
摘要翻译：本发明涉及将含有异源病毒抗原表位的轮状病毒复合抗原，包含轮状病毒复合抗原的疫苗组合物，包含轮状病毒复合物抗原的轮状病毒样颗粒，以及包含轮状病毒样颗粒的疫苗组合物。根据本发明，可以以低成本批量生产包含轮状病毒抗原和不同于轮状病毒的异源病毒的表位的复合抗原和包含复合抗原的轮状病毒样颗粒。本发明的方法可用于研究和开发抗轮状病毒和异源病毒的新型复合疫苗。

5. 发明申请

WO2011105826A3 METHOD USING CAMP EXPRESSION MEASUREMENT TO DIAGNOSE PROSTATE INFLAMMATION, AND DIAGNOSTIC KIT 审中-公开
标题翻译：使用CAMP表达测量法诊断前列腺炎的方法和诊断试剂盒
公开(公告)号：WO2011105826A3
公开(公告)日：2012-01-12
申请号：PCT/KR2011001290
申请日：2011-02-24
申请人： UNIV CHUNG ANG IND , MYUNG SOON CHUL , KIM WON YONG , LEE TAE JIN , KIM HAE JONG , JUNG JA RANG , KIM HEA JIN
发明人： MYUNG SOON CHUL , KIM WON YONG , LEE TAE JIN , KIM HAE JONG , JUNG JA RANG , KIM HEA JIN
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/158 , G01N2800/342
摘要： The present invention relates to a method for diagnosing prostate inflammation, and to a kit using the method. More particularly, the present invention relates to a method for diagnosing prostate inflammation by measuring the expression of CAMP (human cathelicidin antimicrobial peptide) in a prostate tissue sample taken from a subject, and to a prostate inflammation diagnostic kit including a primer, probe, or antibody capable of measuring the expression of CAMP. The present invention is based on the correlation between an increase in CAMP expression level in prostate tissue or cells and the occurrence of prostate inflammation. According to the method and kit of the present invention, accurate and quick diagnosis of prostate inflammation can be performed on a large scale using a simple molecular biological analysis.
摘要翻译：本发明涉及一种用于诊断前列腺炎症的方法以及使用该方法的试剂盒。更具体地，本发明涉及一种通过测量取自受试者的前列腺组织样品中的CAMP（人导管肽抗微生物肽）的表达以及前列腺炎症诊断试剂盒来诊断前列腺炎症的方法，所述前列腺炎症诊断试剂盒包括引物，探针或能够测量CAMP表达的抗体。本发明基于前列腺组织或细胞中CAMP表达水平的增加与前列腺炎症的发生之间的相关性。根据本发明的方法和试剂盒，可以使用简单的分子生物学分析大规模地进行准确和快速的前列腺炎症诊断。

6. 发明申请

WO2011049380A3 SIGNAL DETECTION APPARATUS AND METHOD IN SPATIAL MULTIPLEXING SYSTEM 审中-公开
标题翻译：空间复用系统中的信号检测装置和方法
公开(公告)号：WO2011049380A3
公开(公告)日：2011-08-25
申请号：PCT/KR2010007217
申请日：2010-10-21
申请人： UNIV CHUNG ANG IND , CHO YONG-SOO , IM TAE-HO
发明人： CHO YONG-SOO , IM TAE-HO
IPC分类号： H04B7/08
CPC分类号： H04B7/0697 , H04B7/0434 , H04B7/0617 , H04B7/0848
摘要： The present invention provides a signal detection method and apparatus in a spatial multiplexing system. According to the present invention, the signal detection apparatus of a single receiver is formed with a plurality of antennas in a system in which at least one transmitter transmits data streams by a spatial multiplexing method, the signal detection apparatus comprises: a partial linear coefficient generator which generates a linear weight matrix by using the preset algorithm in a channel matrix that is formed between the at least one transmitter and a single receiver; a partial symbol eliminator which generates a first symbol vector by eliminating all transferable symbols of each transmission antenna in all of the data streams received; and a partial symbol detector which generates a transmission symbol candidate vector by using the first symbol vector and the generated linear weight matrix. Thus, according to the present invention, there is no big performance difference of errors between the data streams.
摘要翻译：本发明提供了一种空间复用系统中的信号检测方法和装置。根据本发明，单个接收机的信号检测装置在其中至少一个发射机通过空间复用方法发射数据流的系统中形成有多个天线，所述信号检测装置包括：部分线性系数发生器其通过使用在至少一个发射机和单个接收机之间形成的信道矩阵中的预设算法来生成线性权重矩阵; 部分符号消除器，其通过消除接收的所有数据流中的每个发送天线的所有可传送符号来产生第一符号向量; 以及部分符号检测器，其通过使用第一符号向量和所生成的线性权重矩阵来生成发送符号候选向量。因此，根据本发明，数据流之间的差错没有很大的性能差异。

7. 发明申请

WO2010082797A3 A DEVICE AND METHOD FOR TRANSMITTING RELAY SYNCHRONIZATION SIGNAL ON LTE-A SYSTEM BASED ON ORTHOGONAL FREQUENCY DIVISION HAVING A MULTI-HOP RELAY 审中-公开
标题翻译：基于具有多跳中继的正交频分的LTE-A系统上发送中继同步信号的装置和方法
公开(公告)号：WO2010082797A3
公开(公告)日：2010-10-21
申请号：PCT/KR2010000301
申请日：2010-01-18
申请人： KOREA ELECTRONICS TELECOMM , UNIV CHUNG ANG IND , LEE HEESOO , AHN JAE YOUNG , NOH TAEGYUN , LEE KYOUNG SEOK , YOO HYUN-IL , PARK CHANG-HWAN , WOO KYUNG SOO , CHO YONG SOO
发明人： LEE HEESOO , AHN JAE YOUNG , NOH TAEGYUN , LEE KYOUNG SEOK , YOO HYUN-IL , PARK CHANG-HWAN , WOO KYUNG SOO , CHO YONG SOO
IPC分类号： H04W56/00
CPC分类号： H04W56/00 , H04B7/2606 , H04L27/261
摘要： The present invention provides a device and method for transmitting a relay synchronization signal on an LTE-A system based on orthogonal frequency division having a multi-hop relay. In one example of the present invention, the device for transmitting a relay synchronization signal employs a synchronization signal for synchronization between a relay and a base station, and for synchronising one relay and a lower relay, and also for synchronization with a terminal for the purpose of having one relay monitor a neighbouring base station or relay; the synchronization signal being employed in such a way as to generate a relay synchronization signal having low correlation properties and having the same PAPR characteristics as the synchronization signal, and also to generate a frame comprising a relay synchronization signal.
摘要翻译：本发明提供了一种用于基于具有多跳中继的正交频分在LTE-A系统上发送中继同步信号的设备和方法。在本发明的一个示例中，用于发送中继同步信号的设备采用用于中继站和基站之间的同步的同步信号，并且用于同步一个中继站和下一个中继站，并且还用于与终端同步用于该目的具有一个中继器监视相邻基站或中继器; 所述同步信号以产生具有低相关特性并具有与所述同步信号相同的PAPR特性的中继同步信号并且还产生包括中继同步信号的帧的方式被采用。

8. 发明申请

WO2010056080A3 A COMPOSITION COMPRISING THE EXTRACT OF RUMEX AQUATICUS HERBA FOR THE PREVENTION AND TREATMENT OF GASTRITIS DISEASE OR ULCER DISEASE AND THE USE THEREOF 审中-公开
标题翻译：一种组合物，用于预防和治疗胃肠疾病或溃疡病及其使用的RUMEX AQUATICUS HERBA的提取物
公开(公告)号：WO2010056080A3
公开(公告)日：2010-09-16
申请号：PCT/KR2009006727
申请日：2009-11-16
申请人： UNIV CHUNG ANG IND , SOHN UY DONG , WHANG WAN KYUNN
发明人： SOHN UY DONG , WHANG WAN KYUNN
IPC分类号： A61K36/70 , A61P1/04
CPC分类号： A61K36/70 , A61K9/0019 , A61K9/146 , A61K9/2059
摘要： The present invention is related to a composition comprising the extract of Rumex Aquaticus Herba for the prevention and treatment of gastritis disease or ulcer disease and the use thereof. The inventive extract significantly decreasethe area of damaged gastric lesion caused by acute gastritis when the inventive extract of the present invention was orally administrated to indomethacin-induced acute gastritis animal model. The inventive compositions according to the present invention are useful in the prevention and treatment of gastritis disease or ulcer disease.
摘要翻译：本发明涉及包含Rumex Aquaticus Herba提取物用于预防和治疗胃炎疾病或溃疡病的组合物及其用途。当将本发明的本发明提取物口服给予吲哚美辛诱导的急性胃炎动物模型时，本发明的提取物显着减少由急性胃炎引起的损伤的胃损伤的面积。根据本发明的本发明组合物可用于预防和治疗胃炎疾病或溃疡病。

9. 发明申请

WO2011105841A3 RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS 审中-公开
标题翻译：用于表达布拉泽星的重组表达载体，以及具有较大尺寸的新型多重突变布拉泽宁变化
公开(公告)号：WO2011105841A3
公开(公告)日：2012-04-05
申请号：PCT/KR2011001309
申请日：2011-02-24
申请人： UNIV CHUNG ANG IND , KONG KWANG HOON
发明人： KONG KWANG HOON
IPC分类号： C12N15/29 , C07K14/415 , C12N15/70 , C12N15/81 , C12P21/02
CPC分类号： C07K14/43 , C12N15/815 , C12P21/02
摘要： The present invention relates to a recombinant expression vector for expressing brazzein and to a method for the mass production of brazzein using the vector, in which a brazzein expression system is constructed in Kluyveromyces lactis, which is a lactose-fermenting yeast, and particularly, in which an optimum condition is established to achieve significantly superior expression than conventional E. coli or yeast expression systems, thus enabling the mass production of brazzein. In addition, the present invention relates to a novel biquadratic brazzein variant having greater sweetness, which has the same thermal stability as that of conventional brazzein, and a sweetness that is at least 15 to 50 times higher than that of conventional brazzein. Therefore, the brazzein variant of the present invention can be used together with other sweeteners such as sugar (sucrose), and further less brazzein variant may be used as a substitute for the same amount of sugar, and can be variously used as additives in food production.
摘要翻译：本发明涉及用于表达brazzein的重组表达载体和使用该载体大规模生产brazzein的方法，其中在乳糖发酵酵母中的克鲁维酵母克鲁维酵母构建了brazzein表达系统，特别是在其建立了最佳条件以实现比常规大肠杆菌或酵母表达系统显着优异的表达，从而使得大量生产brazzein。此外，本发明涉及一种具有较高甜度的新颖的双二价乳酪蛋白变体，其具有与常规乳糖凝胶相同的热稳定性，并且甜度比常规乳糖凝胶的甜度高至少15至50倍。因此，本发明的纤维素变体可以与其他甜味剂如糖（蔗糖）一起使用，而更少的乳糖变体可用作相同量的糖的替代物，并且可以各种用作食物中的添加剂生产。

10. 发明申请

WO2011105841A9 RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS 审中-公开
标题翻译：用于表达BRAZZEIN的重组表达载体，以及具有更大的甜度的新的多突变BRAZZEIN变体
公开(公告)号：WO2011105841A9
公开(公告)日：2012-01-26
申请号：PCT/KR2011001309
申请日：2011-02-24
申请人： UNIV CHUNG ANG IND , KONG KWANG HOON
发明人： KONG KWANG HOON
IPC分类号： C12N15/29 , C07K14/415 , C12N15/70 , C12N15/81 , C12P21/02
CPC分类号： C07K14/43 , C12N15/815 , C12P21/02
摘要： The present invention relates to a recombinant expression vector for expressing brazzein and to a method for the mass production of brazzein using the vector, in which a brazzein expression system is constructed in Kluyveromyces lactis, which is a lactose-fermenting yeast, and particularly, in which an optimum condition is established to achieve significantly superior expression than conventional E. coli or yeast expression systems, thus enabling the mass production of brazzein. In addition, the present invention relates to a novel biquadratic brazzein variant having greater sweetness, which has the same thermal stability as that of conventional brazzein, and a sweetness that is at least 15 to 50 times higher than that of conventional brazzein. Therefore, the brazzein variant of the present invention can be used together with other sweeteners such as sugar (sucrose), and further less brazzein variant may be used as a substitute for the same amount of sugar, and can be variously used as additives in food production.
摘要翻译：本发明涉及用于表达布拉霉素的重组表达载体和使用该载体大量生产布拉霉素的方法，其中在作为乳糖发酵酵母的乳酸克鲁维酵母中构建了布丁蛋白表达系统，并且特别地，其中建立了最佳条件以实现比常规大肠杆菌或酵母表达系统显着优越的表达，从而能够大规模生产brazzein。此外，本发明涉及一种具有更高甜度的新颖的双四方形Brazzein变体，其具有与常规Brazzein相同的热稳定性，并且甜度比常规Brazzein高至少15至50倍。因此，本发明的布氏蛋白变体可以与其他甜味剂如糖（蔗糖）一起使用，并且可以使用更少的布氏蛋白变体作为相同量的糖的替代物，并且可以不同地用作食物中的添加剂生产。

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