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1. 发明申请

WO2014035206A3 METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND 审中-公开
标题翻译：制备用于栓塞的微球的方法和用于制备含药物载体的微球的方法
公开(公告)号：WO2014035206A3
公开(公告)日：2014-04-24
申请号：PCT/KR2013007867
申请日：2013-08-30
申请人： UNIV CHUNG ANG IND
发明人： LEE JAE HWI , KWAK BYUNG KOOK , KIM HYEONG MIN , LEE GA HYEON
IPC分类号： A61K9/16 , A61K9/127 , A61P27/00
CPC分类号： A61L24/08 , A61K9/0019 , A61K9/1271 , A61K9/1652 , A61K9/19 , A61K9/5123 , A61K31/704 , A61K47/26 , A61L24/001 , A61L24/0015 , A61L24/0042 , A61L31/042 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/626 , A61L2430/36 , C08L5/08
摘要： The present invention relates to a process for optimizing the recoverability of lyophilized microspheres for emboli and to chitosan microspheres to which a drug-containing carrier is bound. More particularly, the present invention relates to a recoverability optimization process for adding trehalose as a lyophilization protectant prior to a lyophilization for the stable storage of microspheres, and swirling the lyophilized microspheres in order to rehydrate the microspheres. The present invention also relates to microspheres in which the quantity of the drug released from the chitosan microspheres having a drug-containing nanocarrier bound thereto is adjusted based on a drug/chitosan ratio, thus enabling precise drug release adjustment. The present invention also relates to a method for preparing the microspheres. The optimization process of the present invention has the advantages of maintaining the physical properties, shape, and the drug release speed of the microspheres even after the lyophilization of the microspheres for emboli. The chitosan microspheres to which a drug-containing carrier is bound according to the present invention may stably cause emboli in blood vessels, and may precisely adjust the release of a drug and therefore can be used in cancer treatment.
摘要翻译：本发明涉及优化用于栓子的冻干微球体和结合有含药物载体的壳聚糖微球体的可恢复性的方法。更具体地说，本发明涉及用于在冻干之前添加海藻糖作为冻干保护剂以稳定储存微球体并涡旋冻干微球体以再水化微球体的可恢复性优化方法。本发明还涉及微球，其中基于药物/壳聚糖比率调节从其上结合有含药纳米载体的壳聚糖微球释放的药物的量，由此能够精确地进行药物释放调节。本发明还涉及制备微球体的方法。本发明的优化方法具有保持微球体的物理性质，形状和药物释放速度的优点，甚至在冻干微球体用于栓子后也是如此。根据本发明的含有药物的载体所结合的壳聚糖微球体可以稳定地在血管中引起栓子，并且可以精确地调节药物的释放，因此可以用于癌症治疗。

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