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1. 发明申请

WO2014155174A8 A COMPUTER IMPLEMENTED METHOD FOR ASSESSING VASCULAR NETWORKS FROM MEDICAL IMAGES AND USES THEREOF 审中-公开
标题翻译：一种计算机实现的从医学图像评估血管网络的方法及其应用
公开(公告)号：WO2014155174A8
公开(公告)日：2014-11-27
申请号：PCT/IB2014000392
申请日：2014-03-20
申请人： EXPERT YMAGING SL , FUNDACIÓ CLINIC PER A LA RECERCA BIOMÈDICA FCRB , HOSPITAL CLINIC I PROVINCIAL BARCELONA , UNIV BARCELONA , CT DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES HEPÁTICAS Y DIGESTIVAS CIBEREHD
发明人： AMAT ROLDAN IVAN , BOSCH GENOVER JAIME , BERZIGOTTI ANNALISA , GILABERT SOLÉ MARIA ROSA
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , A61B8/0891 , A61B8/481 , G06T11/206 , G06T2207/10016 , G06T2207/10096 , G06T2207/10121 , G06T2207/10132 , G06T2207/20104 , G06T2207/30024 , G06T2207/30056 , G06T2207/30101
摘要： The method comprising acquiring and analysing by computer means image information of video sequences of two or more dimensions obtained from contrast-enhanced signals, for example ultrasound, coherence tomography, fluorescence images, or Magnetic Resonance Imaging, of a body part or tissue, for example of an organ, of a living subject; detecting events from said information of video sequences; selecting a Region of Interest of said body part or tissue; computing a first graph representative of a local vascular network of said image information of video sequences in which the edges of the graph are estimated by the temporal relationship among spatially remote signals of said image information of video sequences within a set of video sequences; and using said graph for assessment of vascular networks.
摘要翻译：该方法包括通过计算机装置获取并分析例如身体部位或组织的对比度增强信号（例如超声波，相干断层扫描，荧光图像或磁共振成像）获得的两维或更多维的视频序列的图像信息器官的生物体的; 从视频序列的所述信息中检测事件; 选择所述身体部位或组织的感兴趣区域; 计算代表视频序列的所述图像信息的局部血管网络的第一图形，其中通过一组视频序列内的视频序列的所述图像信息的空间远程信号之间的时间关系来估计所述图形的边缘; 并使用所述图表评估血管网络。

2. 发明申请

WO2011016741A4 AMORPHOUS MULTICOMPONENT DIELECTRIC BASED ON THE MIXTURE OF HIGH BAND GAP AND HIGH K MATERIALS, RESPECTIVE DEVICES AND MANUFACTURE 审中-公开
标题翻译：基于高带隙和高K材料的混合物的非均匀多组分电介质，相关器件和制造
公开(公告)号：WO2011016741A4
公开(公告)日：2012-01-05
申请号：PCT/PT2010000037
申请日：2010-08-05
申请人： UNIV NOVA DE LISBOA , INST STEFAN JOSEF , UNIV BARCELONA , DE PAIVA MARTINS RODRIGO FERRAO , CORREIA FORTUNATO ELVIRA MARIA , CANDIDO BARQUINHA PEDRO MIGUEL , NUNES PEREIRA LUIS MIGUEL , GONCALVES GONCALO PEDRO , KUSCER HROVATIN DANJELA , KOSEC MARIJA
发明人： DE PAIVA MARTINS RODRIGO FERRAO , CORREIA FORTUNATO ELVIRA MARIA , CANDIDO BARQUINHA PEDRO MIGUEL , NUNES PEREIRA LUIS MIGUEL , GONCALVES GONCALO PEDRO , KUSCER HROVATIN DANJELA , KOSEC MARIJA
IPC分类号： H01L21/316
CPC分类号： H01L21/31604 , H01L21/0215 , H01L21/02178 , H01L21/02183 , H01L21/02194 , H01L21/02266 , H01L21/28194 , H01L29/517 , H01L29/7869
摘要： High performance thin-film, transistors entirely processed at temperatures not exceeding 150°C, using amorphous multi component dielectrics based on t.he mixture of high band gap and high dielectric constant ( K) materials are presented in this invention. The invention relates to the use of sputtered or ink jet printed mixed dielectric materials such as Ta2O5 with SiO2 or Al2O3 or HfO2 with SiO2 or Al2O3. These multicomponent dielectrics allow producing amorphous dielectrics to be introduced in high stable electronic devices with low leakage currents, while preserving a high dielectric constant. This results in producing thin film transistors with remarkable electrical properties, such as the ones produced based on Ga-In-Zn oxide as channel layers and where the dielectric was the combination of the mixture Ta2O5:SiO2, exhibiting field- effect mobility exceeding 35 cm2 V-1 s-1, close to 0 V turn- on voltage, on/off ratio higher than 106 and subthreshold slope below 0.24 V dec-1.
摘要翻译：本发明提出了使用基于高带隙和高介电常数（K）材料的混合物的非晶多组分电介质，在不超过150℃的温度下完全加工的高性能薄膜。本发明涉及使用溅射或喷墨印刷的混合电介质材料，例如具有SiO 2或Al 2 O 3或HfO 2的Ta 2 O 5与SiO 2或Al 2 O 3。这些多组分电介质允许产生非晶电介质，以便在具有低泄漏电流的高稳定电子器件中引入，同时保持高的介电常数。这导致产生具有显着电性能的薄膜晶体管，例如基于Ga-In-Zn氧化物作为沟道层产生的薄膜晶体管，并且其中电介质是混合物Ta 2 O 5：SiO 2的组合，显示场效应迁移率超过35cm 2 V-1 s-1，接近0 V导通电压，开/关比高于106，亚阈值斜率低于0.24 V dec-1。

3. 发明申请

WO2011012763A3 METHOD AND KIT FOR DIAGNOSING MANTLE CELL LYMPHOMA 审中-公开
标题翻译：用于诊断MAN细胞淋巴瘤的方法和试剂盒
公开(公告)号：WO2011012763A3
公开(公告)日：2011-08-11
申请号：PCT/ES2010070531
申请日：2010-07-30
申请人： HOSPITAL CLINIC BARCELONA , INST INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER , FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA , UNIV BARCELONA , CAMPO GUEERRI ELIAS , SALAMERO GARCIA OLGA , FERNANDEZ PASCUAL VERONICA , JARES GERBOLES PEDRO , LOPEZ GUILLERMO ARMANDO
发明人： CAMPO GUEERRI ELIAS , SALAMERO GARCIA OLGA , FERNANDEZ PASCUAL VERONICA , JARES GERBOLES PEDRO , LOPEZ GUILLERMO ARMANDO
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118
摘要： The invention relates to a method and kit as useful tools for classifying a patient diagnosed with mantle cell lymphoma as indolent or conventional. The method comprises: a) providing a sample from a patient with MCL; b) defining the level of expression of at least one selected gene from the group consisting of: RNGTT, HDGFRP3, FARP1, HMGB3, LGALS3BP, PON2, CDK2AP1, DBN1, CNR1, CNN3, SOX11, SETMAR and CSNK1E in the sample; and c) comparing the level of expression of each of the genes measured with respect to the level of expression of the same genes in a control sample, in which the absence of expression or poor expression of the genes with respect to the same genes in the control sample indicates a clinical course of an indolent MCL.
摘要翻译：本发明涉及用于将诊断为套细胞淋巴瘤的患者分类为惰性或常规的有用工具的方法和试剂盒。该方法包括：a）提供患有MCL的患者的样品; b）定义样品中至少一种选自由RNGTT，HDGFRP3，FARP1，HMGB3，LGALS3BP，PON2，CDK2AP1，DBN1，CNR1，CNN3，SOX11，SETMAR和CSNK1E组成的组的基因的表达水平; 和c）比较相对于对照样品中相同基因的表达水平测量的每种基因的表达水平，其中所述基因的表达水平或表达水平相对于对照样品指示惰性MCL的临床过程。

4. 发明申请

WO2010046377A3 IMMUNOACTIVATING CONJUGATES COMPRISING NANOPARTICLES COATED WITH PEPTIDES 审中-公开
标题翻译：纳米胶囊包裹的免疫组织联合试验
公开(公告)号：WO2010046377A3
公开(公告)日：2010-12-16
申请号：PCT/EP2009063777
申请日：2009-10-21
申请人： FUNDACIO PRIVADA INST CATALA DE NANOTECNOLOGIA , INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS , UNIV BARCELONA , FUNDACIO PRIVADA INST DE RECERCA BIOMEDICA , FRANCO PUNTES VICTOR , GOMEZ BASTUS NEUS , SANCHEZ TILLO ESTER , FARRERA SINFREU CONSOL , CELADA COTARELO ANTONIO , LLOBERAS CAVERO JORGE , GIRALT LLEDO ERNEST , PUJALS RIATOS SILVIA
发明人： FRANCO PUNTES VICTOR , GOMEZ BASTUS NEUS , SANCHEZ TILLO ESTER , FARRERA SINFREU CONSOL , CELADA COTARELO ANTONIO , LLOBERAS CAVERO JORGE , GIRALT LLEDO ERNEST , PUJALS RIATOS SILVIA
IPC分类号： A61K47/48 , A61P37/02
CPC分类号： A61K47/6923
摘要： The present invention relates to a conjugate having colloidal stability in a medium comprising a metallic nanoparticle coated with a non-activating peptide which is ordered on the nanoparticle surface. It also relates to a pharmaceutical composition and to a process for the preparation thereof. The conjugates of the invention are used for the activation of the immune system, in particular the innate immune system, as well as for the modulation of immune responses, production of antibodies and detection of substances via antigen-antibody interactions. Inventors have found that non-activating peptides which, in themselves, do not trigger any activation of the immune system, even when they are in an aggregated state, are capable to activate the immune system, in particular the innate immune system, when ordered onto the surface of a metallic nanoparticle. These conjugates are able to achieve activation of the innate immune system, in particular the innate immune system despite their small size. Thus, the use of the conjugates of the invention offers the possibility to render molecules, otherwise undetectable, visible to the immune system.
摘要翻译：本发明涉及一种在介质中具有胶体稳定性的缀合物，所述介质包含涂覆有纳米颗粒表面上的非活化肽的金属纳米颗粒。它还涉及药物组合物及其制备方法。本发明的缀合物用于免疫系统的激活，特别是先天免疫系统的激活，以及免疫应答的调节，抗体的产生和通过抗原 - 抗体相互作用的物质检测。发明人已经发现，即使当它们处于聚集状态时本身也不会触发免疫系统的任何活化的非活化肽能够激活免疫系统，特别是先天免疫系统，当被命令到金属纳米颗粒的表面。这些缀合物能够实现先天免疫系统的激活，特别是先天免疫系统的激活，尽管它们的体积小。因此，本发明的缀合物的使用提供了使免疫系统可见的分子，否则不可检测的可能性。

5. 发明申请

WO2009071725A2 USE OF VALPROATE FOR THE TREATMENT OF FEAR AND PHOBIA IN SUBJECTS WITH ALZHEIMER'S DISEASE 审中-公开
标题翻译：在阿尔茨海默病的治疗中使用有效的治疗恐惧和焦虑症
公开(公告)号：WO2009071725A2
公开(公告)日：2009-06-11
申请号：PCT/ES2008000765
申请日：2008-12-05
申请人： UNIV BARCELONA AUTONOMA , SAURA ANTOLIN CARLOS ALBERTO , CASAS LOUZAO CATALINA , GIMENEZ LLORT LYDIA , ESPANA AGUSTI JUDIT
发明人： SAURA ANTOLIN CARLOS ALBERTO , CASAS LOUZAO CATALINA , GIMENEZ LLORT LYDIA , ESPANA AGUSTI JUDIT
IPC分类号： A61K31/19 , A61P25/18
CPC分类号： A61K31/19
摘要： The invention relates to the use of valproate for the production of a drug for the treatment of fear and phobia in a subject with Alzheimer's disease. The invention also relates to a method for the treatment of fear and phobia in a subject with Alzheimer's disease, whereby the subject is administered an effective quantity of valproate.
摘要翻译：本发明涉及丙戊酸盐在阿尔茨海默氏病患者中用于治疗恐惧和恐惧症的药物的生产用途。本发明还涉及用于治疗患有阿尔茨海默病的受试者的恐惧和恐惧症的方法，由此给予受试者有效量的丙戊酸。

6. 发明申请

WO2007014968A2 DEVICE FOR PROCESSING AN ELECTRIC SIGNAL 审中-公开
标题翻译：处理电信号的装置
公开(公告)号：WO2007014968A2
公开(公告)日：2007-02-08
申请号：PCT/ES2006000438
申请日：2006-07-26
申请人： UNIV BARCELONA AUTONOMA , ORIOL PLADEVALL XAVIER , ALARCON PARDO ALFONSO , FERNANDEZ-DIAZ SERAROLS EDUARD
发明人： ORIOL PLADEVALL XAVIER , ALARCON PARDO ALFONSO , FERNANDEZ-DIAZ SERAROLS EDUARD
CPC分类号： H01L29/882 , H01L29/7391 , H01L29/772
摘要： The invention relates to a device (30) for processing an electric signal, comprising a first terminal (31) and a second terminal (32) and at least one element (34) which generates a potential profile (36), in order to separate the first terminal from the second terminal, through which a quantum current (I) flows by means of the tunnel effect between the first and second terminals, said current corresponding to an electric signal output from the device. The invention is characterised in that the device also comprises a third terminal (33) to which an input electric signal (v(t)) is applied in order to control the quantum current established between the first and second terminals, by means of oscillations in the potential profile with frequencies of the order of the inverse of the transit time of the electrons between the first and second terminals.
摘要翻译：用于处理电信号的装置（30）技术领域本发明涉及一种用于处理电信号的装置（30），该装置包括第一端子（31）和第二端子（32）以及至少一个产生电势分布（36）的元件（34）来自第二端子的第一端子，量子电流（I）通过第一和第二端子之间的隧道效应流过该第一端子，所述电流对应于从器件输出的电信号。本发明的特征在于，该设备还包括第三端子（33），为了控制在第一和第二端子之间建立的量子电流，输入电信号（v（t））被施加到该第三端子（33），通过具有第一和第二端子之间的电子传播时间的倒数的阶数的频率的电位分布。

7. 发明申请

WO2005059505A3 METHOD AND KIT FOR THE GENOTYPIFICATION OF HLA-B27 BASED ON REAL TIME PCR 审中-公开
标题翻译：基于实时PCR的HLA-B27基因的方法和工具包
公开(公告)号：WO2005059505A3
公开(公告)日：2005-12-29
申请号：PCT/ES2004070105
申请日：2004-12-03
申请人： UNIV BARCELONA AUTONOMA , JUAN OTERO MANUEL , CASAMITJANA PONCES NATALIA , PUJOL BORRELL RICARDO , COLOBRAN ORIOL ROGER , PALOU RIVERA EDUARDO , FANER CANET MARIA ROSA , RIBERA CRUSAFONT ANA
发明人： JUAN OTERO MANUEL , CASAMITJANA PONCES NATALIA , PUJOL BORRELL RICARDO , COLOBRAN ORIOL ROGER , PALOU RIVERA EDUARDO , FANER CANET MARIA ROSA , RIBERA CRUSAFONT ANA
IPC分类号： C07K14/74 , C12Q1/68 , G01N20060101
CPC分类号： C07K14/70539 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to a method for determining alleles of the allele group 27 of locus B of the human leukocyte antigen (HLA-B27) from a nucleic acid sample and to a kit for implementing such method. The kit is comprised of allele-specific primers used in the polymerase chain reaction (PCR) in real time, and fluorescently marked allele-specific probes, or an intercalary agent, to detect fluorescence signals. The analysis is completed with the determination of the temperatures of fusion of amplified sequences of nucleic acids. The invention overcomes the limitations of conventional methods for DNA-based typification, in terms of time, possibility of automation, and increase of the resolution, while reducing the number of PCR reactions. It is useful for example to determine the predisposition to a specific disease.
摘要翻译：本发明涉及一种用于确定来自核酸样品的人类白细胞抗原（HLA-B27）的座位B的等位基因组27等位基因的方法和用于实施该方法的试剂盒。该试剂盒由实时聚合酶链式反应（PCR）中使用的等位基因特异性引物和荧光标记的等位基因特异性探针或闰月组成，用于检测荧光信号。通过测定扩增的核酸序列的融合温度来完成分析。本发明克服了基于DNA的代表性的常规方法在时间，自动化的可能性和提高分辨率的同时减少PCR反应的数量的限制。例如，确定特定疾病的倾向是有用的。

8. 发明申请

WO2015181604A1 A COMPUTER IMPLEMENTED METHOD FOR IDENTIFYING CHANNELS FROM REPRESENTATIVE DATA IN A 3D VOLUME AND A COMPUTER PROGRAM PRODUCT IMPLEMENTING THE METHOD 审中-公开
标题翻译：用于从3D体积中的代表性数据识别信道的计算机实现方法和实现该方法的计算机程序产品
公开(公告)号：WO2015181604A1
公开(公告)日：2015-12-03
申请号：PCT/IB2015000730
申请日：2015-05-22
申请人： GALGO MEDICAL SL , HOSPITAL CLINIC BARCELONA , UNIV BARCELONA
发明人： STEGHÖFER MARTIN , SERRA DEL MOLINO LUIS , BRUGADA TERRADELLAS JOSEP , MONT GIRBAU JOSEP LLUIS , BERRUEZO SÁNCHEZ
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/162 , G06T2207/10028 , G06T2207/10096 , G06T2207/20044 , G06T2207/20072 , G06T2207/30048 , G06T2207/30104 , G06T2207/30172
摘要： The method comprises identifying, in a 3D volume, a zone of a first type (H), a zone of a second type (BZ) and a zone of a third type (C) and: - automatically identifying as a candidate channel (bz) a path running through the zone of a second type (BZ) and extending between two points of the zone of a first type (H); and - automatically performing, on a topological space (H_and_BZ_topo), homotopic operations between the candidate channel (bz) and paths (h) running only through the zone of a first type (H), and if the result of said homotopic operations is that the candidate channel (bz) is not homotopic to any path running only through the zone of a first type (H) identifying the candidate channel (bz) as a constrained channel. The computer program product implements the steps of the method of the invention.
摘要翻译：该方法包括在3D体积中识别第一类型（H），第二类型（BZ）的区域和第三类型（C）的区域的区域，以及： - 自动标识为候选信道（bz ）穿过第二类型（BZ）的区域并在第一类型（H）的区域的两个点之间延伸的路径）的路径; 以及 - 在拓扑空间（H_and_BZ_topo）上自动执行在仅通过第一类型（H）的区域运行的候选信道（bz）和路径（h）之间的同伦操作，并且如果所述同位素操作的结果是候选信道（bz）不与仅通过识别作为约束信道的候选信道（bz）的第一类型（H）的区域运行的任何路径同源。计算机程序产品实现了本发明方法的步骤。

9. 发明申请

WO2011110716A3 PEPTIDE COMPOUNDS THAT CAN BE USED AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：可用作抗菌剂的肽类化合物
公开(公告)号：WO2011110716A3
公开(公告)日：2012-12-20
申请号：PCT/ES2011070153
申请日：2011-03-09
申请人： UNIV BARCELONA , RABANAL ANGLADA FRANCESC , CAJAL VISA YOLANDA , GARCIA SUBIRATS MARIA , RODRIGUEZ NUNEZ MONTSERRAT
发明人： RABANAL ANGLADA FRANCESC , CAJAL VISA YOLANDA , GARCIA SUBIRATS MARIA , RODRIGUEZ NUNEZ MONTSERRAT
IPC分类号： C07K7/62 , A61K38/12 , A61P31/04
CPC分类号： C07K7/06
摘要： The invention relates to peptide compounds that can be used as antibacterial agents, said compounds having formula (I), in which: R0 is branched (C8-C11) alkyl, CH3-(CH2)m-, CH3-O-(CH2CH2O)2CH2- or phenyl-(CH2)x-; m = 6-10; x = 1-3; R1, R3, R4, R7 and R8 are selected independently from the formula GF-(CH2)n-, with n = 1-4 and GF = -NH2 or -NH-C(=NH)-NH2; R2 is -CH(CH3)(OH), -CH(CH3)2, -CH2NH2 or -CH2OH; R5 and R6 are selected independently from H, linear or branched -(C1-C4) alkyl, -(CH2)-R10, -CH2-CH2-S-CH3 and -CH-(CH3)-OH; R9 is CONH2, -CH(CH3)(OH) or CONHR11; R10 is phenyl, 3-indolyl, 4-imidazolyl, 4-hydroxyphenyl, a- or ß-naphthyl or 2-, 3- or 4-pyridyl; R11 is a specific peptide sequence; u is CH2 or S; v is NH or S; w is CH2 or CO; provided that when R9 is CONH2, then (a) R5 or R6 is -CH(CH3)(OH), or (b) R5 and R6 are H; or (c) the configuration of C bonded to R9 is S, or (d) the configuration of C bonded to R5 is R; and provided that when R9 is CH(CH3)OH, then R8 is GF(CH2)n wherein n is 3 and GF is NH-C(=NH)-NH2, and R7 is GF(CH2)n wherein n is 2 and GF is NH2. These compoundshave been found to be useful in the treatment of bacterial infections.
摘要翻译：本发明涉及可用作抗菌剂的肽化合物，所述具有式（I）的化合物，其中：R 0是支链（C8-C11）烷基，CH3-（CH2）m-，CH3-O-（CH2CH2O） 2 CH 2 - 或苯基 - （CH 2）x - ; m = 6-10; x = 1-3; R 1，R 3，R 4，R 7和R 8独立地选自式GF-（CH 2）n - ，其中n = 1-4和GF = -NH 2或-NH-C（= NH）-NH 2; R2是-CH（CH3）（OH），-CH（CH3）2，-CH2NH2或-CH2OH; R 5和R 6独立地选自H，直链或支链 - （C 1 -C 4）烷基， - （CH 2）-R 10，-CH 2 -CH 2 -S-CH 3和-CH-（CH 3）-OH; R9是CONH 2，-CH（CH 3）（OH）或CONHR 11; R 10是苯基，3-吲哚基，4-咪唑基，4-羟基苯基，α-或β-萘基或2-，3-或4-吡啶基; R11是特异性肽序列; u是CH2或S; v是NH或S; w是CH 2或CO; 条件是当R9为CONH2时，（a）R5或R6为-CH（CH3）（OH），或（b）R5和R6为H; 或（c）与R 9结合的C构型为S，或（d）与R 5结合的C构型为R; 并且条件是当R 9为CH（CH 3）OH时，则R 8为GF（CH 2）n，其中n为3，GF为NH-C（= NH）-NH 2，R 7为GF（CH 2）n，n为2， GF是NH2。已经发现这些化合物可用于治疗细菌感染。

10. 发明申请

WO2012007615A3 DENTAL-IMPLANT PLANNING METHOD 审中-公开
标题翻译：牙科植入式方法
公开(公告)号：WO2012007615A3
公开(公告)日：2012-03-08
申请号：PCT/ES2011000239
申请日：2011-07-15
申请人： UNIV BARCELONA AUTONOMA , JIMENEZ JIMENEZ DAVID
发明人： JIMENEZ JIMENEZ DAVID
IPC分类号： A61C1/08 , A61C8/00 , G06F19/00
CPC分类号： A61C8/0089 , A61C1/084
摘要： A dental-implant planning method comprises: constructing a surgical guide (2) and placing the latter on a buccal structure (1) of a patient, pressing the gums (1a) included therein; acquiring three-dimensional anatomical information on said buccal structure (1) with the surgical guide fitted therein; producing a physical reconstruction (3) of the buccal structure (1), on a one-to-one scale, including indications of a planned trajectory for the dental implant, and recessed zones (3a, 3b) corresponding to the gums (1a) being pressed; and positioning the surgical guide (2) on the physical reconstruction (3) and making a hole (5) through the surgical guide (2), following the indications of the planned trajectory.
摘要翻译：牙种植体计划方法包括：构造手术引导件（2）并将其放置在患者的颊部结构（1）上，挤压其中包括的牙龈（1a）; 在装配有外科手术导管的情况下，在所述颊部结构（1）上获取三维解剖信息; 包括口腔结构（1）的物理重建（3），一对一尺度，包括牙植入物的计划轨迹的指示，以及对应于牙龈（1a）的凹陷区域（3a，3b）被压并且将手术引导件（2）定位在物理重建（3）上，并且通过外科引导器（2）沿着计划的轨迹的指示来形成孔（5）。

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