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1. 发明申请

WO2004098608A1 PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE 审中-公开
标题翻译：吡咯并[4,3-D]吡啶，其制备方法和使用方法
公开(公告)号：WO2004098608A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004855
申请日：2004-05-06
申请人： ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
IPC分类号： A61K31/505
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an -NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.
摘要翻译：本发明涉及由通式I（I）表示的3-，7-二取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3选自烷基，环烷基，环烷基烷基，环杂烷基烷基，环杂烷基，芳基，杂环，杂芳基，芳基烷基，杂芳基烷基和杂烷基，其中每个基团可任选被取代，R 7选自卤素，羟基，羟基氨基，氨基，羧基，氰基，取代或未取代的芳烷基，取代或未取代的杂烷基，取代或未取代的杂芳基烷基，取代或未取代的环烷基烷基，取代或未取代的环杂烷基烷基;取代或未取代的芳基烷基，其中X是-NH-，-N（烷基） - ， - O-或-S-部分，并且R 7'选自H，烷基，环烷基，芳基，烷基环烷基，芳基烷基，杂环，杂环烷基，取代的烷基，取代的环烷基，取代的芳基，取代的芳基烷基，取代的杂环，取代的杂芳基，取代的杂芳基烷基，取代的杂烷基，取代的环烷基烷基和取代的环杂烷基烷基，其中基团优选被多于一个的卤素，羟基，氨基，巯基，羧基，氰基，硝基，酰胺基，磺基，氨基磺酰氨基，氨基氨基，烷基，烷氧基和取代的烷基。

2. 发明申请

WO2004058791A3 SUBSTITUTION DERIVATIVES OF N<6>-BENZYLADENOSINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译： N 6 - 苄基二氢腺苷的取代衍生物，它们的制备方法，它们在制备药物中的用途，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂
公开(公告)号：WO2004058791A3
公开(公告)日：2004-10-28
申请号：PCT/CZ0300078
申请日：2003-12-29
申请人： USTAV EX BOTAN AKADEMIE VED CE , DOLEZAL KAREL , POPA IGOR , ZATLOUKAL MAREK , LENOBEL RENE , HRADECKA DANA , VOJTESEK BORIVOJ , ULDRIJAN STJEPAN , MLEJNEK PETR , WERBROUCK STEFAAN , STRNAD MIROSLAV
发明人： DOLEZAL KAREL , POPA IGOR , ZATLOUKAL MAREK , LENOBEL RENE , HRADECKA DANA , VOJTESEK BORIVOJ , ULDRIJAN STJEPAN , MLEJNEK PETR , WERBROUCK STEFAAN , STRNAD MIROSLAV
IPC分类号： C07D473/34 , A01N43/48 , A61K8/60 , A61K31/52 , A61K31/7076 , A61P35/00 , A61P37/06 , A61Q19/08 , C07H19/16 , C07H19/167 , A61K8/49
CPC分类号： C07H19/16 , A61K8/606 , A61Q19/08
摘要： The invention concerns novel substitution derivatives of N -benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N -benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译：本发明涉及对植物，动物和人细胞具有抗癌，有丝分裂，免疫抑制和抗衰老性质的N 6 - 苄基腺苷的新取代衍生物。本发明还涉及制备这些N 6 - 苄基腺苷衍生物的方法及其作为药物，化妆品制剂和包含这些衍生物作为活性化合物的生长调节剂的用途，以及这些衍生物在制备药物组合物，生物技术方法，在化妆品和农业中。

3. 发明申请

WO2004058791A2 SUBSTITUTION DERIVATIVES OF N6-BENZYLADENOSINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译： N 6 - 苯基腺苷的替代衍生物，其制备方法，其制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂
公开(公告)号：WO2004058791A2
公开(公告)日：2004-07-15
申请号：PCT/CZ2003/000078
申请日：2003-12-29
申请人： USTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , DOLEZAL, Karel , POPA, Igor , ZATLOUKAL, Marek , LENOBEL, René , HRADECKÁ, Dana , VOJTESEK, Borivoj , ULDRIJAN, Stjepan , MLEJNEK, Petr , WERBROUCK, Stefaan , STRNAD, Miroslav
发明人： DOLEZAL, Karel , POPA, Igor , ZATLOUKAL, Marek , LENOBEL, René , HRADECKÁ, Dana , VOJTESEK, Borivoj , ULDRIJAN, Stjepan , MLEJNEK, Petr , WERBROUCK, Stefaan , STRNAD, Miroslav
IPC分类号： C07H19/00
CPC分类号： C07H19/16 , A61K8/606 , A61Q19/08
摘要： The invention concerns novel substitution derivatives of N 6 -benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N 6 -benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译：本发明涉及对植物，动物和人细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N 6 - 苄基腺苷的新型取代衍生物。本发明还涉及这些N 6 - 苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和生长调节剂的用途，其包含这些衍生物作为活性化合物以及这些衍生物用于制备药物组合物在生物技术过程中的用途，在化妆品和农业。

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