专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004098608A1 PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE 审中-公开
标题翻译：吡咯并[4,3-D]吡啶，其制备方法和使用方法
公开(公告)号：WO2004098608A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004855
申请日：2004-05-06
申请人： ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
IPC分类号： A61K31/505
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an -NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.
摘要翻译：本发明涉及由通式I（I）表示的3-，7-二取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3选自烷基，环烷基，环烷基烷基，环杂烷基烷基，环杂烷基，芳基，杂环，杂芳基，芳基烷基，杂芳基烷基和杂烷基，其中每个基团可任选被取代，R 7选自卤素，羟基，羟基氨基，氨基，羧基，氰基，取代或未取代的芳烷基，取代或未取代的杂烷基，取代或未取代的杂芳基烷基，取代或未取代的环烷基烷基，取代或未取代的环杂烷基烷基;取代或未取代的芳基烷基，其中X是-NH-，-N（烷基） - ， - O-或-S-部分，并且R 7'选自H，烷基，环烷基，芳基，烷基环烷基，芳基烷基，杂环，杂环烷基，取代的烷基，取代的环烷基，取代的芳基，取代的芳基烷基，取代的杂环，取代的杂芳基，取代的杂芳基烷基，取代的杂烷基，取代的环烷基烷基和取代的环杂烷基烷基，其中基团优选被多于一个的卤素，羟基，氨基，巯基，羧基，氰基，硝基，酰胺基，磺基，氨基磺酰氨基，氨基氨基，烷基，烷氧基和取代的烷基。

2. 发明申请

WO2003040144A2 HETEROCYCLIC COMPOUND BASED ON N6-SUBSTITUTED ADENINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：基于N6取代的腺嘌呤的杂环化合物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂
公开(公告)号：WO2003040144A2
公开(公告)日：2003-05-15
申请号：PCT/CZ2002/000045
申请日：2002-08-01
申请人： USTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , DOLEZAL, Karel , POPA, Igor , HOLUB, Jan , LENOBEL, René , WERBROUCK, Stefaan , STRNAD, Miroslav , ZATLOUKAL, Marek
发明人： DOLEZAL, Karel , POPA, Igor , HOLUB, Jan , LENOBEL, René , WERBROUCK, Stefaan , STRNAD, Miroslav , ZATLOUKAL, Marek
IPC分类号： C07D473/00
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： New heterocyclic derivatives based on N 6 -substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译：基于N6取代腺嘌呤的新型杂环衍生物，具有抗癌，有丝分裂，抑制和抗衰老的植物，动物和人类细胞的特性，以及它们的制备方法。还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。

3. 发明申请

WO2003040144A3 HETEROCYCLIC COMPOUND BASED ON N6-SUBSTITUTED ADENINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 审中-公开
公开(公告)号：WO2003040144A3
公开(公告)日：2003-05-15
申请号：PCT/CZ2002/000045
申请日：2002-08-01
申请人： USTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , DOLEZAL, Karel , POPA, Igor , HOLUB, Jan , LENOBEL, René , WERBROUCK, Stefaan , STRNAD, Miroslav , ZATLOUKAL, Marek
发明人： DOLEZAL, Karel , POPA, Igor , HOLUB, Jan , LENOBEL, René , WERBROUCK, Stefaan , STRNAD, Miroslav , ZATLOUKAL, Marek
IPC分类号： C07D473/00
摘要： New heterocyclic derivatives of formula (1) based on N 6 -substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

4. 发明申请

WO2004058791A2 SUBSTITUTION DERIVATIVES OF N6-BENZYLADENOSINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译： N 6 - 苯基腺苷的替代衍生物，其制备方法，其制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂
公开(公告)号：WO2004058791A2
公开(公告)日：2004-07-15
申请号：PCT/CZ2003/000078
申请日：2003-12-29
申请人： USTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , DOLEZAL, Karel , POPA, Igor , ZATLOUKAL, Marek , LENOBEL, René , HRADECKÁ, Dana , VOJTESEK, Borivoj , ULDRIJAN, Stjepan , MLEJNEK, Petr , WERBROUCK, Stefaan , STRNAD, Miroslav
发明人： DOLEZAL, Karel , POPA, Igor , ZATLOUKAL, Marek , LENOBEL, René , HRADECKÁ, Dana , VOJTESEK, Borivoj , ULDRIJAN, Stjepan , MLEJNEK, Petr , WERBROUCK, Stefaan , STRNAD, Miroslav
IPC分类号： C07H19/00
CPC分类号： C07H19/16 , A61K8/606 , A61Q19/08
摘要： The invention concerns novel substitution derivatives of N 6 -benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N 6 -benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译：本发明涉及对植物，动物和人细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N 6 - 苄基腺苷的新型取代衍生物。本发明还涉及这些N 6 - 苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和生长调节剂的用途，其包含这些衍生物作为活性化合物以及这些衍生物用于制备药物组合物在生物技术过程中的用途，在化妆品和农业。

5. 发明申请

WO2003082872A1 NOVEL PYRAZOLO[4,3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS FOR THERAPY 审中-公开
标题翻译：新型吡咯并[4,3-D]吡嗪类，其制备方法和治疗方法
公开(公告)号：WO2003082872A1
公开(公告)日：2003-10-09
申请号：PCT/EP2003/003207
申请日：2003-03-27
申请人： USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC) , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , STRNAD, Miroslav
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula (I), and pharmaceutically acceptable salts thereof, wherein, R3 is an optionally substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl alkyl, aryl or alkylaryl group; R5 is halogen, -NHNH 2 , -NHOH, NHCONH 2 , guanylo (NH-C(NH)NH 2 ) an optionally substituted C 1 -C 6 alkyl, alkenyl, alkinyl, C 3 -C 15 cycloalkyl, R f (C 3 -C 15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group, the group -C(O)-R a , -C(O)NR b R c - SO 3 R d , or -NHC(O)R e , wherein R a and R f are an optionally substituted C 1 -C 6 alkyl, alkenyl, or alkinyl group, R b , R c and R d are independently selected from the group consisting of H, optionally substituted C 1 -C 6 alkyl, alkenyl, or alkinyl group, and R e is a hydroxy, amino, alkoxy, alkylamino, optionally substituted C 1 -C 6 alkyl, alkenyl or alkinyl group; or the group -X-R 5' , wherein X is -NH-, -O-, -S- or -N(alkyl)- and R 5' is hydrogen, an optionally substituted C 1 -C 6 alkyl, alkenyl, alkinyl, C 3 -C 15 cycloalkyl, Rf(C 3 -C 15 cycloalkyl), aryl, heterocycle, hetero C 1 -C 6 alkyl, arylalkyl, heteroaryl, cycloheteroalkyl, cycloheteroalkyl alkyl, or heteroarylalkyl group, the group -C(O)-R a , -C(O)NR b R c , -SO 3 R d , or -NHC(O)R e , wherein R a , R b , R c , R d , R e and R f have the above meaning, and R7 is halogen, -NHNH 2 , NHOH, NHCONH 2 , guanylo (NH-C(NH)NH 2 ) or the group -X-R 7 , wherein X has the above meaning and the meaning of R 7 , is as defined for R 5' .
摘要翻译：本发明涉及由通式（I）表示的3-，5-，7-三取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3是任选取代的烷基，环烷基，环杂烷基，环烷基烷基，芳基或烷基芳基; R5是卤素，-NHNH2，-NHOH，NHCONH2，胍基（NH-C（NH）NH2），任意取代的C1-C6烷基，烯基，炔基，C3-C15环烷基，Rf（C3-C15环烷基），杂环，，芳基，杂芳基，芳基烷基，环杂烷基，环杂烷基烷基，杂芳基烷基，基团-C（O）-Ra，-C（O）NRbRc-SO3Rd或-NHC（O）Re，其中Ra和Rf是任选取代的 C 1 -C 6烷基，烯基或炔基，R b，R c和R d独立地选自H，任选取代的C 1 -C 6烷基，烯基或炔基，Re是羟基，氨基，烷氧基，烷基氨基，任选取代的C 1 -C 6烷基，烯基或炔基; 或基团-X-R5'，其中X是-NH-，-O - ， - S-或-N（烷基） - ，并且R 5'是氢，任选取代的C 1 -C 6烷基，烯基，炔基， C 15环烷基，R f（C 3 -C 15环烷基），芳基，杂环，杂C 1 -C 6烷基，芳烷基，杂芳基，环杂烷基，环杂烷基烷基或杂芳基烷基，基团-C（O）-R a，-C（O）NR b R c ，-SO 3 R d或-NHC（O）R e，其中R a，R b，R c，R d，R e和R f具有上述含义，并且R 7是卤素，-NHNH 2，NHOH，NHCONH 2，胍基（NH-C（NH））或-X-R7基团，其中X具有上述含义并且R7的含义如R5'所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式