专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0149688A8 PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF 审中-公开
标题翻译：嘌呤衍生物，其制备和使用的方法
公开(公告)号：WO0149688A8
公开(公告)日：2001-10-04
申请号：PCT/EP0100150
申请日：2001-01-08
申请人： UNIVERSITAIRE INSTELLING ANTWE , USTAV EX BOTAN AKADEMIE VED CE , HAVLICEK LIBOR , KRYSTOF VLADIMIR , SIGLEROVA VERA , LENOBEL RENE , ONCKELEN HENRI VAN , BERNEMAN ZWI NISAN , SLEGERS HERMAN , ESMANS EDGARD , STRNAD MIROSLAV , VERMEULEN KATRIEN
发明人： HAVLICEK LIBOR , KRYSTOF VLADIMIR , SIGLEROVA VERA , LENOBEL RENE , ONCKELEN HENRI VAN , BERNEMAN ZWI NISAN , SLEGERS HERMAN , ESMANS EDGARD , STRNAD MIROSLAV , VERMEULEN KATRIEN
IPC分类号： A61K31/52 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , C07D473/16 , C07D473/34 , C07D473/40
CPC分类号： C07D473/40 , C07D473/16 , C07D473/34
摘要： 2-, 6-, 8-, 9-monosubstituted, 2,6-, 2,9-, 6,8-, 6,9-disubstituted and 2,6,8-, 2,6,9-, 6,8,9-trisubstituted purine derivatives and their deaza- and aza- analogues with an inhibitor effect with respect to cyclin-dependent kinase proteins (cdks). Their use as anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds.
摘要翻译： 2-，6-，8-，9-单取代，2,6-，2,9-，6,8-，6,9-二取代和2,6,8-，2,6,9-， 8,9-三取代的嘌呤衍生物及其对于细胞周期蛋白依赖性激酶蛋白（cdks）具有抑制作用的脱氮和氮杂类似物。它们用作抗癌，抗炎，抗病毒，抗神经变性，神经抑制和免疫抑制化合物。

2. 发明申请

WO2010139289A1 SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES 审中-公开
标题翻译：取代的6-（2-羟基苄基）嘌呤衍生物，它们作为含有这些衍生物的药物和组合物使用
公开(公告)号：WO2010139289A1
公开(公告)日：2010-12-09
申请号：PCT/CZ2010/000067
申请日：2010-06-02
申请人： UNIVERZITA PALACKEHO V OLOMOUCI , BIOPATTERNS s.r.o. , ZATLOUKAL, Marek , KRYSTOF, Vladimir , HAVLICEK, Libor , POPA, Igor , DOLEZAL, Karel , STRNAD, Miroslav
发明人： ZATLOUKAL, Marek , KRYSTOF, Vladimir , HAVLICEK, Libor , POPA, Igor , DOLEZAL, Karel , STRNAD, Miroslav
IPC分类号： C07D473/16 , A61K31/52
CPC分类号： C07D473/16
摘要： The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
摘要翻译：本发明涉及通式I的取代的6-（2-羟基苄基氨基）嘌呤，其作为细胞周期蛋白依赖性激酶2,5,7和9抑制剂的活性及其作为药物的用途，特别是用于治疗涉及细胞增殖的疾病或炎症。本发明还包括含有取代的6-（2-羟基苄基氨基）嘌呤的药物组合物。

3. 发明申请

WO2010085924A2 SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：取代的6-（2-氨基苯甲酰胺）嘌呤衍生物，它们作为含有这些化合物的药物和制剂使用
公开(公告)号：WO2010085924A2
公开(公告)日：2010-08-05
申请号：PCT/CZ2010/000004
申请日：2010-01-22
申请人： UNIVERZITA PALACKEHO V OLOMOUCI , BIOAPEX, S.R.O. , HAVLICEK, Libor , KRYSTOF, Vladimir , ZATLOUKAL, Marek , DOLEZAL, Karel , STRNAD, Miroslav , VOJTESEK, Borivoj
发明人： HAVLICEK, Libor , KRYSTOF, Vladimir , ZATLOUKAL, Marek , DOLEZAL, Karel , STRNAD, Miroslav , VOJTESEK, Borivoj
IPC分类号： C07D473/16
CPC分类号： C07D473/16 , A61K31/52
摘要： The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.˙
摘要翻译：本发明涉及可用于CDK抑制，特别是用于治疗病毒感染和涉及细胞增殖的疾病的由通式I表示的新的取代的6-（2-氨基苄基氨基）嘌呤。本发明还包括含有取代的6-（2-氨基苄基氨基）嘌呤的药物制剂。

4. 发明申请

WO2006024858A1 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF 审中-公开
标题翻译： 4-ARYLAZO-3,5-二氨基 - 吡唑化合物及其用途
公开(公告)号：WO2006024858A1
公开(公告)日：2006-03-09
申请号：PCT/GB2005/003383
申请日：2005-09-01
申请人： INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC , CYCLACEL LIMITED , CANKAR, Petr , FRISOVA, Iveta , KRYSTOF, Vladimir , LENOBEL, Rene , SLOUKA, Jan , STRNAD, Miroslav , FISHER, Peter, Martin
发明人： CANKAR, Petr , FRISOVA, Iveta , KRYSTOF, Vladimir , LENOBEL, Rene , SLOUKA, Jan , STRNAD, Miroslav , FISHER, Peter, Martin
IPC分类号： C07D231/38
CPC分类号： C07D231/38
摘要： A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK9). Hence they can be used as antimitotic-, pro-apoptotic and antünflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer's disease or as antineurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors.
摘要翻译：一系列用于抑制细胞周期蛋白依赖性激酶（优选CDK9）的单 - 和双核4-芳基偶氮-3,5-二氨基 - 吡唑。因此，它们可以用作抗生素，促凋亡和抗炎药，特别是在癌症和哮喘的化学疗法中，作为由真菌或原生生物引起的牛皮癣和寄生虫的治疗，阿尔茨海默氏病的治疗或抗神经退行性药物的治疗，或抑制免疫刺激。这些化合物可用于多种用途，包括作为制备阻燃剂，诊断试剂和治疗剂的中间体，包括抗病毒剂和免疫抑制剂。

5. 发明申请

WO2004098608A1 PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE 审中-公开
标题翻译：吡咯并[4,3-D]吡啶，其制备方法和使用方法
公开(公告)号：WO2004098608A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004855
申请日：2004-05-06
申请人： ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
IPC分类号： A61K31/505
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an -NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.
摘要翻译：本发明涉及由通式I（I）表示的3-，7-二取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3选自烷基，环烷基，环烷基烷基，环杂烷基烷基，环杂烷基，芳基，杂环，杂芳基，芳基烷基，杂芳基烷基和杂烷基，其中每个基团可任选被取代，R 7选自卤素，羟基，羟基氨基，氨基，羧基，氰基，取代或未取代的芳烷基，取代或未取代的杂烷基，取代或未取代的杂芳基烷基，取代或未取代的环烷基烷基，取代或未取代的环杂烷基烷基;取代或未取代的芳基烷基，其中X是-NH-，-N（烷基） - ， - O-或-S-部分，并且R 7'选自H，烷基，环烷基，芳基，烷基环烷基，芳基烷基，杂环，杂环烷基，取代的烷基，取代的环烷基，取代的芳基，取代的芳基烷基，取代的杂环，取代的杂芳基，取代的杂芳基烷基，取代的杂烷基，取代的环烷基烷基和取代的环杂烷基烷基，其中基团优选被多于一个的卤素，羟基，氨基，巯基，羧基，氰基，硝基，酰胺基，磺基，氨基磺酰氨基，氨基氨基，烷基，烷氧基和取代的烷基。

6. 发明申请

WO2010085924A3 SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：取代的6-（2-氨基苯甲酰胺）嘌呤衍生物，它们作为含有这些化合物的药物和制剂使用
公开(公告)号：WO2010085924A3
公开(公告)日：2010-09-30
申请号：PCT/CZ2010000004
申请日：2010-01-22
申请人： UNIVERZITA PALACKEHO V OLOMOUC , BIOAPEX S R O , HAVLICEK LIBOR , KRYSTOF VLADIMIR , ZATLOUKAL MAREK , DOLEZAL KAREL , STRNAD MIROSLAV , VOJTESEK BORIVOJ
发明人： HAVLICEK LIBOR , KRYSTOF VLADIMIR , ZATLOUKAL MAREK , DOLEZAL KAREL , STRNAD MIROSLAV , VOJTESEK BORIVOJ
IPC分类号： C07D473/16 , A61K31/52
CPC分类号： C07D473/16 , A61K31/52
摘要： The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.
摘要翻译：本发明涉及可用于CDK抑制，特别是用于治疗病毒感染和涉及细胞增殖的疾病的由通式I表示的新的取代的6-（2-氨基苄基氨基）嘌呤。本发明还包括含有取代的6-（2-氨基苄基氨基）嘌呤的药物制剂。

7. 发明申请

WO2004018473A3 AZAPURINE DERIVATIVES 审中-公开
标题翻译： AZAPURINE衍生物
公开(公告)号：WO2004018473A3
公开(公告)日：2004-05-21
申请号：PCT/IB0304188
申请日：2003-08-22
申请人： INST OF EX BOTANY ASCR , FUKSOVA KVETA , HAVLICEK LIBOR , KRYSTOF VLADIMIR , LENOBEL RENE , STRNAD MIROSLAV
发明人： FUKSOVA KVETA , HAVLICEK LIBOR , KRYSTOF VLADIMIR , LENOBEL RENE , STRNAD MIROSLAV
IPC分类号： A61P3/10 , A61P9/00 , A61P25/00 , A61P31/12 , A61P35/00 , C07D239/48 , C07D249/04 , C07D409/12 , C07D487/04 , A61K31/505
CPC分类号： C07D239/48 , C07D249/04 , C07D409/12 , C07D487/04
摘要： The present invention relates to a compound of formula (I), or a pharmaceutically acceptable acid salt thereof. The invention further relates to the use of said compounds in the treatment of hyperproliferative skin disorders, viral infections, cancer, rheumatoid arthritis, lupus, type I diabetes, multiple sclerosis, restenosis, polycystic kidney disease, graft rejection, graft versus host disease and gout, or for psoriasis, parasitoses such as those caused by fungi or protists, or Alzheimer's disease. Further aspects of the invention relate to the use of such compounds in the inhibition of cell proliferation, in the induction of apoptosis, to modulate the activity of adrenergic and/or purinergic receptors or to suppress immunostimulation. The invention also relates to the use of 2,6,9-trisubstituted 8-azapurines in maintaining mammalian ooctyes at the germinal vesicle stage.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的酸式盐。本发明进一步涉及所述化合物在治疗过度增殖性皮肤病，病毒感染，癌症，类风湿性关节炎，狼疮，I型糖尿病，多发性硬化症，再狭窄，多囊肾病，移植排斥，移植物抗宿主病和痛风或牛皮癣，寄生虫病如由真菌或原生生物引起的寄生虫病，或阿尔茨海默氏病。本发明的其他方面涉及这些化合物在抑制细胞增殖，诱导细胞凋亡，调节肾上腺素能和/或嘌呤能受体的活性或抑制免疫刺激中的用途。本发明还涉及2,6,9-三取代的8-氮杂嘌呤在维持生发泡阶段的哺乳动物卵黄中的用途。

8. 发明申请

WO2003082872A1 NOVEL PYRAZOLO[4,3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS FOR THERAPY 审中-公开
标题翻译：新型吡咯并[4,3-D]吡嗪类，其制备方法和治疗方法
公开(公告)号：WO2003082872A1
公开(公告)日：2003-10-09
申请号：PCT/EP2003/003207
申请日：2003-03-27
申请人： USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC) , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , STRNAD, Miroslav
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula (I), and pharmaceutically acceptable salts thereof, wherein, R3 is an optionally substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl alkyl, aryl or alkylaryl group; R5 is halogen, -NHNH 2 , -NHOH, NHCONH 2 , guanylo (NH-C(NH)NH 2 ) an optionally substituted C 1 -C 6 alkyl, alkenyl, alkinyl, C 3 -C 15 cycloalkyl, R f (C 3 -C 15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group, the group -C(O)-R a , -C(O)NR b R c - SO 3 R d , or -NHC(O)R e , wherein R a and R f are an optionally substituted C 1 -C 6 alkyl, alkenyl, or alkinyl group, R b , R c and R d are independently selected from the group consisting of H, optionally substituted C 1 -C 6 alkyl, alkenyl, or alkinyl group, and R e is a hydroxy, amino, alkoxy, alkylamino, optionally substituted C 1 -C 6 alkyl, alkenyl or alkinyl group; or the group -X-R 5' , wherein X is -NH-, -O-, -S- or -N(alkyl)- and R 5' is hydrogen, an optionally substituted C 1 -C 6 alkyl, alkenyl, alkinyl, C 3 -C 15 cycloalkyl, Rf(C 3 -C 15 cycloalkyl), aryl, heterocycle, hetero C 1 -C 6 alkyl, arylalkyl, heteroaryl, cycloheteroalkyl, cycloheteroalkyl alkyl, or heteroarylalkyl group, the group -C(O)-R a , -C(O)NR b R c , -SO 3 R d , or -NHC(O)R e , wherein R a , R b , R c , R d , R e and R f have the above meaning, and R7 is halogen, -NHNH 2 , NHOH, NHCONH 2 , guanylo (NH-C(NH)NH 2 ) or the group -X-R 7 , wherein X has the above meaning and the meaning of R 7 , is as defined for R 5' .
摘要翻译：本发明涉及由通式（I）表示的3-，5-，7-三取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3是任选取代的烷基，环烷基，环杂烷基，环烷基烷基，芳基或烷基芳基; R5是卤素，-NHNH2，-NHOH，NHCONH2，胍基（NH-C（NH）NH2），任意取代的C1-C6烷基，烯基，炔基，C3-C15环烷基，Rf（C3-C15环烷基），杂环，，芳基，杂芳基，芳基烷基，环杂烷基，环杂烷基烷基，杂芳基烷基，基团-C（O）-Ra，-C（O）NRbRc-SO3Rd或-NHC（O）Re，其中Ra和Rf是任选取代的 C 1 -C 6烷基，烯基或炔基，R b，R c和R d独立地选自H，任选取代的C 1 -C 6烷基，烯基或炔基，Re是羟基，氨基，烷氧基，烷基氨基，任选取代的C 1 -C 6烷基，烯基或炔基; 或基团-X-R5'，其中X是-NH-，-O - ， - S-或-N（烷基） - ，并且R 5'是氢，任选取代的C 1 -C 6烷基，烯基，炔基， C 15环烷基，R f（C 3 -C 15环烷基），芳基，杂环，杂C 1 -C 6烷基，芳烷基，杂芳基，环杂烷基，环杂烷基烷基或杂芳基烷基，基团-C（O）-R a，-C（O）NR b R c ，-SO 3 R d或-NHC（O）R e，其中R a，R b，R c，R d，R e和R f具有上述含义，并且R 7是卤素，-NHNH 2，NHOH，NHCONH 2，胍基（NH-C（NH））或-X-R7基团，其中X具有上述含义并且R7的含义如R5'所定义。

9. 发明申请

WO2010130233A1 SUBSTITUTED 6-(BENZYLAMINO) PURINE RIBOSIDE DERIVATIVES, USE THEREOF AND COMPOSITIONS CONTAINING THESE DERIVATIVES 审中-公开
标题翻译：取代的6-（苄氧基）嘌呤衍生物，其使用及其含有这些衍生物的组合物
公开(公告)号：WO2010130233A1
公开(公告)日：2010-11-18
申请号：PCT/CZ2010/000061
申请日：2010-05-12
申请人： UNIVERZITA PALACKEHO V OLOMOUCI , BIOPATTERNS, S.R.O. , SZUCOVA, Lucie , KRYSTOF, Vladimir , ZATLOUKAL, Marek , DOLEZAL, Karel , STRNAD, Miroslav , SPICHAL, Lukas
发明人： SZUCOVA, Lucie , KRYSTOF, Vladimir , ZATLOUKAL, Marek , DOLEZAL, Karel , STRNAD, Miroslav , SPICHAL, Lukas
IPC分类号： C07H19/167 , A61K31/7076
CPC分类号： C07H19/16 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/7076 , C07H19/167
摘要： The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients. ˙
摘要翻译：本发明涉及通式I的2-取代-6-（取代苄基氨基）嘌呤核苷衍生物。这些化合物具有抗细胞凋亡，抗炎和分化活性。本发明还涉及含有这些衍生物作为活性成分的组合物。？

10. 发明申请

WO2004018473A2 AZAPURINE DERIVATIVES 审中-公开
标题翻译：亚胺嘌呤衍生物
公开(公告)号：WO2004018473A2
公开(公告)日：2004-03-04
申请号：PCT/IB2003/004188
申请日：2003-08-22
申请人： INSTITUTE OF EXPERIMENTAL BOTANY ASCR , FUKSOVA, Kveta , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, Rene , STRNAD, Miroslav
发明人： FUKSOVA, Kveta , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, Rene , STRNAD, Miroslav
IPC分类号： C07D487/00
CPC分类号： C07D239/48 , C07D249/04 , C07D409/12 , C07D487/04
摘要： The present invention relates to a compound of formula (I), or a pharmaceutically acceptable acid salt thereof. The invention further relates to the use of said compounds in the treatment of hyperproliferative skin disorders, viral infections, cancer, rheumatoid arthritis, lupus, type I diabetes, multiple sclerosis, restenosis, polycystic kidney disease, graft rejection, graft versus host disease and gout, or for psoriasis, parasitoses such as those caused by fungi or protists, or Alzheimer's disease. Further aspects of the invention relate to the use of such compounds in the inhibition of cell proliferation, in the induction of apoptosis, to modulate the activity of adrenergic and/or purinergic receptors or to suppress immunostimulation. The invention also relates to the use of 2,6,9-trisubstituted 8-azapurines in maintaining mammalian ooctyes at the germinal vesicle stage.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的酸式盐。本发明还涉及所述化合物在治疗过度增生性皮肤病，病毒感染，癌症，类风湿性关节炎，狼疮，I型糖尿病，多发性硬化，再狭窄，多囊肾病，移植排斥，移植物抗宿主病和痛风中的用途，或用于牛皮癣，诸如由真菌或原生生物引起的寄生虫或阿尔茨海默病。本发明的其它方面涉及这些化合物在抑制细胞增殖，诱导凋亡中调节肾上腺素能和/或嘌呤能受体的活性或抑制免疫刺激的用途。本发明还涉及2,6,9-三取代的8-氮杂嘌呤在维持生殖囊泡阶段的哺乳动物卵母的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式