会员体验
专利管家（专利管理）
工作空间（专利管理）
风险监控（情报监控）
数据分析（专利分析）
侵权分析（诉讼无效）
联系我们
交流群
官方交流：
QQ群： 891211   
微信请扫码    >>>
现在联系顾问~
下载
著录项
PDF全文
热词
    • 4. 发明申请
      WO0048642A3 BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY 审中-公开
    • BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY
    • 具有新功能的生物材料
    • WO0048642A3
    • 2000-12-21
    • PCT/DK0000065
    • 2000-02-17
    • SURFARC APS , THOM VOLKMAR , JONSSON GUNNAR , ULBRICHT MATHIAS , JANKOVA KATJA , ALTANKOV GEORGE
    • THOM VOLKMAR , JONSSON GUNNAR , ULBRICHT MATHIAS , JANKOVA KATJA , ALTANKOV GEORGE
    • A61L27/00 , A61K9/00 , A61L27/34 , A61L29/08 , A61L31/10 , C12N5/00
    • A61K9/0024 , A61L27/34 , A61L29/085 , A61L31/10 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N2533/30
    • The present invention is in the area of biomaterials, i.e. materials that are used in contact with living tissue and biological fluids for prosthetical, therapeutical, storage and the like. In particular, the invention relates to a novel approach of creating biocompatible surfaces, said surfaces being capable of functionally interacting with biological material. Said biocompatible surfaces comprise at least two components, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, that cooperatively form a novel biocompatible surface. The novel approach is based on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of hydrophilic and flexible macromolecules that exhibit a pronounced excluded volume. The surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by, i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and, ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecule(s) is in turn determined by synthesis.
    • 本发明涉及生物材料领域，即用于与生物体组织接触的材料和用于假体，治疗，储存等的生物流体。 特别地，本发明涉及一种创建生物相容性表面的新方法，所述表面能够与生物材料进行功能相互作用。 所述生物相容性表面包含至少两种组分，例如疏水性底物和亲水性质的大分子，其共同形成新的生物相容性表面。 该新方法基于使所述疏水性底物与亲水性和柔性大分子的横向图案化单分子层接触，其显示明显的排除体积。 在极性和形态方面，表面是分子异质表面。 所述大分子单层的结构特征（例如层厚度或其横向密度）由以下因素决定：i）形成大分子层的结构特征（例如它们的MW或其分子结构），和ii）产生所述 单分子层（例如通过物理或化学吸附，或通过化学结合所述大分子）。 层的形成大分子的结构特征又由合成确定。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 9. 发明申请
      WO0215955A3 BIOCOMPATIBLE MATERIALS 审中-公开
    • BIOCOMPATIBLE MATERIALS
    • 生物兼容材料
    • WO0215955A3
    • 2002-05-02
    • PCT/DK0100557
    • 2001-08-23
    • SURFARC APS , ULBRICHT MATHIAS , THOM VOLKMAR , JANKOVA KATJA , ALTANKOV GEORGE , JONSSON GUNNAR
    • ULBRICHT MATHIAS , THOM VOLKMAR , JANKOVA KATJA , ALTANKOV GEORGE , JONSSON GUNNAR
    • A61L27/34 , A61L27/50 , A61L27/14 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/08
    • B82Y30/00 , A61L27/34 , A61L27/50 , B82Y5/00
    • The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.
    • 本发明教导了一种创造生物可压缩表面的新颖方法，所述表面能够与生物材料进行功能性相互作用。 所述生物相容性表面包含至少两种组分，例如疏水性基质和亲水性大分子，其在协同作用下形成新型生物相容性表面。 使所述疏水性基质与所述亲水性和柔性大分子的横向图案化的单分子层接触时显示出明显的排除体积。 在极性和形态方面，形成两个组分的表面是分子异质表面。 所述大分子单层的结构特征（例如层厚度或其横向密度）通过以下确定：i）形成层的大分子（例如其MW或其分子结构）的结构特征和ii）产生所述单分子层 层（例如通过物理吸附或化学吸附，或通过化学结合所述大分子）。 层形成大分子的结构特征又由合成决定。 通过底层疏水性基质和大分子层的协同作用来确定和维持与新型生物相容性表面接触的生物材料（例如多肽）的量和构象以及生物学活性。 以这种方式，可以维持和控制所述接触的多肽与其它生物化合物例如生物体之间的生物相互作用。 细胞，抗体等。 因此，本发明旨在减少和/或消除与多肽和/或其他生物材料与疏水性基底表面接触相关的失活和/或变性。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 10. 发明申请
      WO0048642B1 BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY 审中-公开
    • BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY
    • 具有新功能的生物材料
    • WO0048642B1
    • 2001-02-22
    • PCT/DK0000065
    • 2000-02-17
    • SURFARC APS , THOM VOLKMAR , JONSSON GUNNAR , ULBRICHT MATHIAS , JANKOVA KATJA , ALTANKOV GEORGE
    • THOM VOLKMAR , JONSSON GUNNAR , ULBRICHT MATHIAS , JANKOVA KATJA , ALTANKOV GEORGE
    • A61L27/00 , A61K9/00 , A61L27/34 , A61L29/08 , A61L31/10 , C12N5/00 , A61L29/00 , A61L31/00 , A61L33/00
    • A61K9/0024 , A61L27/34 , A61L29/085 , A61L31/10 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N2533/30
    • The present invention is in the area of biomaterials, i.e. materials that are used in contact with living tissue and biological fluids for prosthetical, therapeutical, storage and the like. In particular, the invention relates to a novel approach of creating biocompatible surfaces, said surfaces being capable of functionally interacting with biological material. Said biocompatible surfaces comprise at least two components, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, that cooperatively form a novel biocompatible surface. The novel approach is based on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of hydrophilic and flexible macromolecules that exhibit a pronounced excluded volume. The surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by, i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and, ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecule(s) is in turn determined by synthesis.
    • 本发明涉及生物材料领域，即用于与生物体组织接触的材料和用于假体，治疗，储存等的生物流体。 特别地，本发明涉及一种创建生物相容性表面的新方法，所述表面能够与生物材料进行功能相互作用。 所述生物相容性表面包含至少两种组分，例如疏水性底物和亲水性质的大分子，其共同形成新的生物相容性表面。 该新方法基于使所述疏水性底物与亲水性和柔性大分子的横向图案化单分子层接触，其显示明显的排除体积。 在极性和形态方面，表面是分子异质表面。 所述大分子单层的结构特征（例如层厚度或其横向密度）由以下因素决定：i）形成大分子层的结构特征（例如它们的MW或其分子结构），和ii）产生所述 单分子层（例如通过物理或化学吸附，或通过化学结合所述大分子）。 层的形成大分子的结构特征又由合成确定。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
每页展示10个专利
每页展示10个专利
每页展示20个专利
每页展示50个专利
每页展示100个专利

IPRDB

最新中国发明专利 最新美国发明专利 技术领域 专利库 专利分类库 国际专利分类库

热门服务

会员版试用 API 数据接口 找代理 知嘟嘟专利交易 排行榜 大学排行榜 专利百科

关于我们

平台介绍 战略合作 网站地图

友情链接

知嘟嘟专利交易 国家知识产权局 中国商标网

联系方式


©2019-2023 上海吉码数字技术有限公司 版权所有，并保留所有权利 沪ICP备20016256号-6 沪公网安备31011702005475号