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1. 发明申请

WO2019122819A1 NERVE STIMULATION DEVICE FOR UNIDIRECTIONAL STIMULATION AND CURRENT STEERING 审中-公开
公开(公告)号：WO2019122819A1
公开(公告)日：2019-06-27
申请号：PCT/GB2018/053602
申请日：2018-12-11
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： BASHIRULLAH, Rizwan , HUNSBERGER, Gerald Edwin , DONEGA, Matteo , CHEW, Daniel , HOLDER, David , ARISTOVICH, Kirill
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0556 , A61N1/3605 , A61N1/36053 , A61N1/36182
摘要： A nerve interface device comprising: at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes comprising a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion comprises an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.

2. 发明申请

WO2018234824A1 NERVE STIMULATION AND MONITORING DEVICE 审中-公开
公开(公告)号：WO2018234824A1
公开(公告)日：2018-12-27
申请号：PCT/GB2018/051749
申请日：2018-06-22
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： HOLDER, David , ARISTOVICH, Kirill , CHEW, Daniel , DONEGA, Matteo
IPC分类号： A61B5/00 , A61B5/04 , A61N1/05
摘要： There is provided a nerve interface device (1, 3) comprising:at least one cuff portion; and a first pair of electrodes (15, 17) mounted on the at least one cuff portion (5, 7). The cuff portion (5, 7)has an assembled position in which the cuff portion (5, 7) forms at least part of a passageway for receiving a nerve (13) along a cuff axis (19) passing through the passageway. The electrodes of the first pair (15, 17) are spaced apart from one another in the direction of the cuff axis (19).

3. 发明申请

WO2019122818A1 NERVE STIMULATION DEVICE FOR CURRENT STEERING 审中-公开
公开(公告)号：WO2019122818A1
公开(公告)日：2019-06-27
申请号：PCT/GB2018/053601
申请日：2018-12-11
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： DONEGA, Matteo , CHEW, Daniel , HOLDER, David , ARISTOVICH, Kirill , BASHIRULLAH, Rizwan
IPC分类号： A61N1/36 , A61N1/05 , A61B5/04
CPC分类号： A61N1/3605 , A61B5/04 , A61N1/0556 , A61N1/36053 , A61N1/36135 , A61N1/36139
摘要： A nerve stimulation system is disclosed including a nerve interface device having a cuff that receives a nerve of a user; and first and second rings of electrodes mounted on the cuff, each ring of electrodes comprising a plurality of electrodes and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes, a signal routing module to store signal routing information necessary to cause a physiological response in a user and to cause the signals to be delivered accordingly, and a configuration module for monitoring and updating the signal routing information based on information detected or received by the nerve stimulation system.

4. 发明申请

WO2018234825A3 NERVE ACTIVITY MONITORING 审中-公开
公开(公告)号：WO2018234825A3
公开(公告)日：2018-12-27
申请号：PCT/GB2018/051750
申请日：2018-06-22
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： ARISTOVICH, Kirill , HOLDER, David , CHEW, Daniel , DONEGA, Matteo
IPC分类号： A61B5/00
摘要： There is provided a nerve activity monitoring method (100) comprising: receiving (102) an input signal (50) indicative of activity in a nerve (10) of a subject; receiving physiological data (54) indicative of physiological activity in the subject; establishing a relationship between the physiological data (54) and the input signal (50); identifying a plurality of periodic portions (56', 56") in the input signal (50) based on the relationship between the physiological data (54) and the input signal (50); and outputting the periodic portions (68) identified.

5. 发明申请

WO2019122817A1 NERVE STIMULATION DEVICE FOR CURRENT STEERING 审中-公开
公开(公告)号：WO2019122817A1
公开(公告)日：2019-06-27
申请号：PCT/GB2018/053600
申请日：2018-12-11
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： DONEGA, Matteo , CHEW, Daniel , HOLDER, David , ARISTOVICH, Kirill
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0556 , A61N1/3605 , A61N1/36053 , A61N1/36182
摘要： A nerve stimulation system including at least one nerve interface device is disclosed. The device comprises a cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the cuff portion, each ring of electrodes comprising a plurality of electrodes, and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes and a control system that causes the different signals to causes different physiological responses.

6. 发明申请

WO2018234825A2 NERVE ACTIVITY MONITORING 审中-公开
公开(公告)号：WO2018234825A2
公开(公告)日：2018-12-27
申请号：PCT/GB2018/051750
申请日：2018-06-22
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： ARISTOVICH, Kirill , HOLDER, David , CHEW, Daniel , DONEGA, Matteo
IPC分类号： A61B5/00
摘要： There is provided a nerve activity monitoring method (100) comprising: receiving (102) an input signal (50) indicative of activity in a nerve (10) of a subject; receiving physiological data (54) indicative of physiological activity in the subject; establishing a relationship between the physiological data (54) and the input signal (50); identifying a plurality of periodic portions (56', 56") in the input signal (50) based on the relationship between the physiological data (54) and the input signal (50); and outputting the periodic portions (68) identified.

7. 发明申请

WO2017218413A2 NEURAL INTERFACE FABRICATION 审中-公开
标题翻译：神经接口的制造
公开(公告)号：WO2017218413A2
公开(公告)日：2017-12-21
申请号：PCT/US2017/037010
申请日：2017-06-12
申请人： GALVANI BIOELECTRONICS LIMITED
发明人： WALKER, Dwight Sherod , CHEW, Daniel
IPC分类号： A61N1/05
摘要： Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.
摘要翻译：制造用于接触或至少部分地围绕内部身体组织例如神经，平滑肌，横纹肌，动脉，静脉，韧带组织，结缔组织，软骨组织等的可植入套囊电极的方法。骨，或其他类似的身体组织，结构和器官。一种示例性方法包括：准备包括可植入套囊电极形状的基底，将模具材料施加到基底，固化模具材料以形成模具，从基底释放模具，将至少一个导体插入到穿过将可成型材料压入模具的通道中以形成围绕所述至少一个导体的可植入箍电极的主体，固化可植入箍电极的主体，并从可植入箍电极的主体释放可植入箍电极的主体模具。

8. 发明申请

WO2017218413A3 NEURAL INTERFACE FABRICATION 审中-公开
公开(公告)号：WO2017218413A3
公开(公告)日：2017-12-21
申请号：PCT/US2017/037010
申请日：2017-06-12
申请人： GALVANI BIOELECTRONICS LIMITED
发明人： WALKER, Dwight Sherod , CHEW, Daniel
IPC分类号： A61N1/05
摘要： Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.

9. 发明申请

WO2023026061A1 SYSTEMS AND METHODS FOR AN IMPLANTABLE DEVICE 审中-公开
公开(公告)号：WO2023026061A1
公开(公告)日：2023-03-02
申请号：PCT/GB2022/052205
申请日：2022-08-26
申请人： GALVANI BIOELECTRONICS LIMITED
发明人： PETERSON, David Karl Lee , KWONG, Kevin , HUNSBERGER, Gerald, Edwin , MIRANDA, Jason , GUPTA, Isha , MATTEUCCI, Paul , CHEW, Daniel
IPC分类号： A61N1/36 , A61N1/08 , A61N1/37
摘要： Systems for applying electrical stimulation to a nerve and determining a change in measured impedance or sensed electrical fields that is indicative of an electrical event, are disclosed herein. The system comprises an implantable housing comprising a signal generator, an implantable neural interface, an impedance measuring circuit or an electrical field sensing circuit, and processing circuitry. Methods for determining the presence of an electrical event in a system for applying electrical stimulation to a nerve, are also disclosed herein. The method comprises periodically sensing an impedance in an electrical pathway and determining an electrical event in the electrical pathway by identifying a change in the sensed impedance.

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