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1. 发明申请

WO2007087548A9 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007087548A9
公开(公告)日：2007-09-27
申请号：PCT/US2007060938
申请日：2007-01-24
申请人： SMITHKLINE BEECHAM CORP , GUDMUNDSSON KRISTJAN , TURNER ELIZABETH MADALENA , SVOLTO ANGILIQUE CHRISTINA
发明人： GUDMUNDSSON KRISTJAN , TURNER ELIZABETH MADALENA , SVOLTO ANGILIQUE CHRISTINA
IPC分类号： A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) including salts, solvates, and pharmaceutically acceptable derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
摘要翻译：本发明提供式（I）化合物，包括其盐，溶剂合物和药学上可接受的衍生物，含有它们的药物制剂，其制备方法和使用它们的治疗方法。

2. 发明申请

WO2007087548A3 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007087548A3
公开(公告)日：2007-12-13
申请号：PCT/US2007060938
申请日：2007-01-24
申请人： SMITHKLINE BEECHAM CORP , GUDMUNDSSON KRISTJAN , TURNER ELIZABETH MADALENA , SVOLTO ANGILIQUE CHRISTINA
发明人： GUDMUNDSSON KRISTJAN , TURNER ELIZABETH MADALENA , SVOLTO ANGILIQUE CHRISTINA
IPC分类号： C07D491/00
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) including salts, solvates, and pharmaceutically acceptable derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
摘要翻译：本发明提供了式（I）化合物，包括其盐，溶剂化物和药学上可接受的衍生物，含有它们的药物制剂，其制备方法以及使用它们的治疗方法。

3. 发明申请

WO2006020415A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2006020415A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/026797
申请日：2005-07-29
申请人： SMITHKLINE BEECHAM CORPORATION , GUDMUNDSSON, Kristjan , MILLER, John, Franklin , TURNER, Elizabeth, Madalena
发明人： GUDMUNDSSON, Kristjan , MILLER, John, Franklin , TURNER, Elizabeth, Madalena
IPC分类号： A61K31/47
CPC分类号： C07D409/14 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
摘要翻译：本发明提供了新型化合物，其以特异性结合趋化因子受体的方式证明了对来自HIV感染的靶细胞的保护作用，并且其影响天然配体或趋化因子与受体如目标细胞的CXCR4和/或CCR5。

4. 发明申请

WO2010017962A1 MODIFIED THROMBOXANE A2 RECEPTOR PROMOTER SEQUENCE 审中-公开
标题翻译：改性的噻唑烷酮A2受体促进剂序列
公开(公告)号：WO2010017962A1
公开(公告)日：2010-02-18
申请号：PCT/EP2009/005822
申请日：2009-08-11
申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN , KINSELLA, Therese , GANNON, AnneMarie , TURNER, Elizabeth , KEATING, Garrett
发明人： KINSELLA, Therese , GANNON, AnneMarie , TURNER, Elizabeth , KEATING, Garrett
IPC分类号： C12N15/63 , A61K48/00 , C12N5/16
CPC分类号： C07K14/705 , C12N15/85 , C12N2830/002 , G01N2800/32 , G01N2800/347
摘要： The invention provides nucleic acid sequences useful in regulating the transcription of a gene. In particular, the invention relates to a promoter sequence, and variants thereof, that can be used to differentially regulate the transcription of a gene. The present invention, accordingly, provides methods for regulating transcription of a gene, the method comprising providing a gene transcription- regulating polynucleotide in operable association with the gene, optionally within a host cell, wherein the gene transcription-regulating polynucleotide comprises the nucleic acid sequence of SEQ ID NO:1 of the nucleic acid sequence of thromboxane A2 receptor promoter or a fragment thereof, the gene transcription-regulating polynucleotide or the fragment thereof further comprising at least one nucleic acid modification and/or substitution. The nucleic acid sequences and probes of the present invention also find utility as predictive markers for alterations in gene transcription in disease settings; or can be used to achieve over-expression of recombinant proteins in mammalian cells. Accordingly, the present invention also provides recombinant expression vectors and host cells for use in regulating the transcription of a gene.
摘要翻译：本发明提供了可用于调节基因转录的核酸序列。特别地，本发明涉及可用于差异调节基因转录的启动子序列及其变体。因此，本发明提供了调节基因转录的方法，所述方法包括提供可任选地在宿主细胞内与所述基因可操作关联的基因转录调节多核苷酸，其中所述基因转录调节多核苷酸包含所述核酸序列 SEQ ID NO：1的凝血恶烷A2受体启动子或其片段的核酸序列，所述基因转录调节多核苷酸或其片段还包含至少一个核酸修饰和/或取代。本发明的核酸序列和探针也可用作疾病环境中基因转录改变的预测标记; 或可用于实现哺乳动物细胞中重组蛋白的过表达。因此，本发明还提供用于调节基因转录的重组表达载体和宿主细胞。

5. 发明申请

WO2008001130A1 BIOMARKERS FOR PREECLAMPSIA 审中-公开
标题翻译：生物标志物为前驱物
公开(公告)号：WO2008001130A1
公开(公告)日：2008-01-03
申请号：PCT/GB2007/050357
申请日：2007-06-26
申请人： UNIVERSITY OF LEEDS , FISHER, Julie , TURNER, Elizabeth , WALKER, James
发明人： FISHER, Julie , TURNER, Elizabeth , WALKER, James
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2800/368 , G01N2800/52
摘要： The present invention relates to novel biomarkers such as histidine and ketone bodies and methods of use thereof for detecting preeclampsia in pregnant individuals and for identifying individuals at risk at an early stage of pregnancy.
摘要翻译：本发明涉及诸如组氨酸和酮体的新型生物标志物及其用于检测怀孕个体中先兆子痫的方法和用于鉴定在怀孕早期阶段处于危险中的个体。

6. 发明申请

WO2007087548A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007087548A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/060938
申请日：2007-01-24
申请人： SMITHKLINE BEECHAM CORPORATION , SVOLTO, Angilique, Christina , GUDMUNDSSON, Kristjan , TURNER, Elizabeth, Madalena
发明人： GUDMUNDSSON, Kristjan , TURNER, Elizabeth, Madalena
IPC分类号： A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) including salts, solvates, and pharmaceutically acceptable derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
摘要翻译：本发明提供了式（I）化合物，包括其盐，溶剂化物和药学上可接受的衍生物，含有它们的药物制剂，其制备方法和使用它们的治疗方法。

7. 发明申请

WO2006015035A8 USEFUL COMPOUNDS FOR HPV INFECTION 审中-公开
标题翻译： HPV感染的有用化合物
公开(公告)号：WO2006015035A8
公开(公告)日：2006-03-09
申请号：PCT/US2005026619
申请日：2005-07-27
申请人： SMITHKLINE BEECHAM CORP , GUDMUNDSSON KRISTJAN , MILLER JOHN FRANKLIN , SHERRILL RONALD GEORGE , TURNER ELIZABETH MADALENA
发明人： GUDMUNDSSON KRISTJAN , MILLER JOHN FRANKLIN , SHERRILL RONALD GEORGE , TURNER ELIZABETH MADALENA
IPC分类号： A61K31/437 , A61P31/20
CPC分类号： A61K31/437
摘要： The present invention relates to compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
摘要翻译：本发明涉及可用于治疗人类乳头瘤病毒的化合物，还涉及制备和使用这些化合物的方法。

8. 发明申请

WO2006015035A1 USEFUL COMPOUNDS FOR HPV INFECTION 审中-公开
标题翻译： HPV感染的有用化合物
公开(公告)号：WO2006015035A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/026619
申请日：2005-07-27
申请人： SMITHKLINE BEECHAM CORPORATION , GUDMUNDSSON, Kristjan , MILLER, John Franklin , SHERRILL, Ronald George , TURNER, Elizabeth Madalena
发明人： GUDMUNDSSON, Kristjan , MILLER, John Franklin , SHERRILL, Ronald George , TURNER, Elizabeth Madalena
IPC分类号： A61K31/437 , A61P31/20
CPC分类号： A61K31/437
摘要： The present invention relates to compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
摘要翻译：本发明涉及可用于治疗人乳头状瘤病毒的化合物，以及涉及制备和使用这些化合物的方法。

9. 发明申请

WO2011097491A1 BENZIMIDAZOLE ANTIVIRAL AGENTS 审中-公开
标题翻译：苯并咪唑抗病毒剂
公开(公告)号：WO2011097491A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023763
申请日：2011-02-04
申请人： GLAXOSMITHKLINE LLC , BANKA, Anna , CATALANO, John G , FANG, Jing , PEAT, Andrew James , TAI, Vincent , TURNER, Elizabeth
发明人： BANKA, Anna , CATALANO, John G , FANG, Jing , PEAT, Andrew James , TAI, Vincent , TURNER, Elizabeth
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K45/06 , A61K31/496 , A61K31/675 , A61K31/7056 , A61K38/21 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/14 , C07F7/1856 , C07F9/65583 , A61K2300/00
摘要： Provided are compounds of Formula (I) and (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
摘要翻译：提供式（I）和（II）的化合物及其药学上可接受的盐，其药物组合物，它们的制备方法及其用于治疗由病毒如丙型肝炎病毒的黄病毒科家族介导的病毒感染的用途（ HCV）。

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