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1. 发明申请

WO0009543A3 HEPATITIS C INHIBITOR TRI-PEPTIDES 审中-公开
标题翻译： HEPATITIS C抑制剂TRI-PEPTIDES
公开(公告)号：WO0009543A3
公开(公告)日：2000-05-25
申请号：PCT/CA9900736
申请日：1999-08-09
申请人： BOEHRINGER INGELHEIM CA LTD , LLINAS BRUNET MONTSE , BAILEY MURRAY D , CAMERON DALE , FAUCHER ANNE MARIE , GHIRO ELISE , GOUDREAU NATHALIE , HALMOS TEDDY , POUPART MARC ANDRE , RANCOURT JEAN , TSANTRIZOS YOULA S , WERNIC DOMINIK M , SIMONEAU BRUNO
发明人： LLINAS-BRUNET MONTSE , BAILEY MURRAY D , CAMERON DALE , FAUCHER ANNE-MARIE , GHIRO ELISE , GOUDREAU NATHALIE , HALMOS TEDDY , POUPART MARC-ANDRE , RANCOURT JEAN , TSANTRIZOS YOULA S , WERNIC DOMINIK M , SIMONEAU BRUNO
IPC分类号： C12N15/09 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K38/06 , A61K38/21 , A61P1/16 , A61P31/12 , A61P31/14 , C07C229/48 , C07K1/06 , C07K5/08 , C07K5/083 , C07K5/087 , C12N9/50 , C12N9/99 , C12P21/02 , C12P41/00
CPC分类号： C12P13/02 , A61K38/21 , A61K45/06 , C07D207/16 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C12P41/005 , A61K2300/00
摘要： Racemates, diastereoisomers and optical isomers of a compound of formula (I) wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or B is an acyl derivative of formula R4-C(O)-; a carboxyl of formula R4-O-C(O)-; an amide of formula R4-N(R5)-C(O)-; a thioamide of formula R4-N(R5)-C(S)-;or a sulfonyl of formula R4-SO2; R5 is H or C1-6 alkyl; and Y is H or C1-6 alkyl; R is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl; R2 is CH2-R20, NH-R20, O-R20or S-R20, wherein R20 is a saturated or unsaturated C3-7 cycloalkyl or C4-10 (alkylcycloalkyl), all of which being optionally mono-, di- or tri-substituted with R21, or R20 is a C6 or C10 aryl or C7-14 aralkyl optionally substituted, or R20 is Het or (lower alkyl)-Het, both optionally substituted, Het or (lower alkyl)-Het; carboxyl; carboxy(lower alkyl); C6 or C10 aryl, C7-14 aralkyl or Het, said aryl, aralkyl or Het being optionally substituted; and R is H; C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl, or C2-6 alkynyl, all optionally substituted with halogen; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：式（I）化合物的外消旋物，非对映异构体和光学异构体，其中B是H，C6或C10芳基，C7-16芳烷基; Het或（低级烷基）-Het，其全部任选被C 1-6烷基取代; C 1-6烷氧基; C 1-6烷酰基; 羟基; 羟; 光环; 卤代; 硝基; 氰基; 氰; 任选被C 1-6烷基取代的氨基; 酰胺基; 或（低级烷基）酰胺; 或B是式R4-C（O） - 的酰基衍生物; 式R4-O-C（O） - 的羧基; 式R 4 -N（R 5）-C（O） - 的酰胺; 式R 4 -N（R 5）-C（S） - 的硫代酰胺;或式R4-SO2的磺酰基; R5是H或C1-6烷基; Y为H或C 1-6烷基; R 3是C 1-8烷基，C 3-7环烷基或C 4-10烷基环烷基，其全部被羟基，C 1-6烷氧基，C 1-6硫代烷基，酰氨基，（低级烷基）酰氨基，C 6或C 10芳基取代，或C7-16芳烷基; R2是CH2-R20，NH-R20，O-R20或S-R20，其中R20是饱和或不饱和的C3-7环烷基或C4-10（烷基环烷基），它们全部是任选的一，二或三取代 R 21或R 20为任选取代的C 6或C 10芳基或C 7-14芳烷基，或R 20为Het或（低级烷基）-Het，均为任选取代的Het或（低级烷基）-Het; 羧基; 羧基（低级烷基）; C6或C10芳基，C7-14芳烷基或Het，所述芳基，芳烷基或Het任选被取代; 并且R 1是H; C 1-6烷基，C 3-7环烷基，C 2-6烯基或C 2-6炔基，全部被卤素取代; 或其药学上可接受的盐或酯。

2. 发明申请

WO2004108673A2 INHIBITORS OF PAPILLOMA VIRUS 审中-公开
标题翻译： PAPILLOMA病毒的抑制剂
公开(公告)号：WO2004108673A2
公开(公告)日：2004-12-16
申请号：PCT/CA2004000839
申请日：2004-06-07
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , TSANTRIZOS YOULA S , FAUCHER ANNE-MARIE , RANCOURT JEAN , WHITE PETER
发明人： TSANTRIZOS YOULA S , FAUCHER ANNE-MARIE , RANCOURT JEAN , WHITE PETER
IPC分类号： A61K31/451 , C07D211/38 , C07D211/46 , C07D295/135 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/36 , C07D211/00
CPC分类号： C07C235/34 , A61K31/451 , C07D211/38 , C07D211/46 , C07D295/135 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/36
摘要： The use of a compound of formula (II): or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma virus in a mammal, wherein R ; X4; X5; X6; R ; R ; W; Z; Y; T; and R are defined herein. The present invention also provides novel compounds, pharmaceutical compositions and methods for using these compounds and compositions in the treatment or prevention of papilloma virus infection. More particularly, the present invention provides compounds, compositions and methods for inhibiting papilloma virus DNA replication by interfering with the E1-E2 protein-protein interaction essential for viral DNA replication.
摘要翻译：式（II）化合物或其对映体或非对映异构体或其盐或药学上可接受的酯在哺乳动物中治疗或预防乳头状瘤病毒感染，特别是人乳头状瘤病毒中的用途，其中R 11 >; X4; X5; X6; [R <13>; [R <14>; 瓦; Z者除外; Ÿ; 吨; 和R 18在本文中定义。本发明还提供了用于治疗或预防乳头状瘤病毒感染的新化合物，药物组合物和使用这些化合物和组合物的方法。更具体地，本发明提供通过干扰病毒DNA复制所必需的E1-E2蛋白质 - 蛋白质相互作用来抑制乳头状瘤病毒DNA复制的化合物，组合物和方法。

3. 发明申请

WO2003007945A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2003007945A1
公开(公告)日：2003-01-30
申请号：PCT/CA2002/001129
申请日：2002-07-18
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S.
发明人： BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S.
IPC分类号： A61K31/4184
CPC分类号： C07D401/04 , C07D235/18 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04
摘要： An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula (I): wherein R 1 is selected from: H, haloalkyl, (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 3-7 )cycloalkyl, (C 2-6 )alkynyl, (C 5-7 )cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C 1-6 )alkyl, (C 3-7 )cycloalkyl, (C 6-10 )bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR 5 , wherein R 5 is H, halogen, haloalkyl, (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; X is N or CR 5 ; D is N or CR 5 ; each of Y 1 and Y 2 is independently O or S; Z is O, N, or NR z wherein R z is H, (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; R 3 and R 4 are each independently H, (C 1-6 )alkyl, first (C 3-7 )cycloalkyl, 6- or 10-membered aryl, Het (C 1-6 )alkyl-6- or 10-membered aryl, (C 1-6 )alkyl-Het; or each R 3 and R 4 are independently covalently bonded together to form second (C 3-7 )cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R 3 or R 4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R 7 is H, (C 1-6 alkyl), (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; or R 7 is covalently bonded to either of R 3 or R 4 to form a heterocycle; A is (C 1-6 ) alkyl-CONHR 8 wherein R 8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.
摘要翻译：由式（I）表示的化合物的异构体，对映异构体，非对映异构体或互变异构体：其中R 1选自：H，卤代烷基，（C 1-6）烷基，（C 2-6）烯基，（C 3 -C 6） 7）环烷基，（C 2-6）炔基，（C 5-7）环烯基，6或10元芳基，Het全部被取代; R 2选自（C 1-6）烷基，（C 3-7）环烷基，（C 6-10）双环烷基，6-或10-元芳基，或任选取代的Het; B是N或CR 5，其中R 5是H，卤素，卤代烷基，（C 1-6）烷基，（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; X为N或CR <5>; D为N或CR 5; Y1和Y2各自独立地为O或S; Z是O，N或NR z，其中R z是H，（C 1-6）烷基，（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; R 3和R 4各自独立地为H，（C 1-6）烷基，第一（C 3-7）环烷基，6-或10-元芳基，Het（C 1-6）烷基-6-或10- （C 1-6）烷基-Het; 或每个R 3和R 4独立地共价键合在一起形成全部任意取代的第二（C 3-7）环烷基或杂环; 或当Z为N时，R 3或R 4独立地与其共价键合形成含氮杂环; R 7是H，（C 1-6烷基），（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; 或R 7共价键合到R 3或R 4中的任一个以形成杂环; A是（C 1-6）烷基-CONHR 8，其中R 8是6-元或10元芳基，或Het; 或A是6-或10-元芳基，或Het表示芳基或Het任选被取代; 或其盐或衍生物; 这些化合物是HCV NS5B聚合酶的有效抑制剂。

4. 发明申请

WO2007131350A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 审中-公开
标题翻译：人类免疫缺陷病毒复制的抑制剂
公开(公告)号：WO2007131350A1
公开(公告)日：2007-11-22
申请号：PCT/CA2007/000845
申请日：2007-05-14
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BOEHRINGER INGELHEIM PHARMA GmbH & CO KG , TSANTRIZOS, Youla, S. , BOES, Michael , BROCHU, Christian , FENWICK, Craig , MALENFANT, Eric , MASON, Stephen , PESANT, Marc
发明人： TSANTRIZOS, Youla, S. , BOES, Michael , BROCHU, Christian , FENWICK, Craig , MALENFANT, Eric , MASON, Stephen , PESANT, Marc
IPC分类号： C07D311/08 , A61K31/352 , A61K31/47 , A61P31/18 , C07D215/22
CPC分类号： C07D215/22 , C07D215/14 , C07D215/18 , C07D215/227 , C07D311/08 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12
摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
摘要翻译：本发明涉及式（I）化合物及其组合物及其在治疗人类免疫缺陷病毒（HIV）感染中的用途的衍生物。特别地，本发明提供HIV复制的新型抑制剂，含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法。

5. 发明申请

WO2006007693A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2006007693A1
公开(公告)日：2006-01-26
申请号：PCT/CA2005/001103
申请日：2005-07-15
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BOEHRINGER INGELHEIM PHARMA GmbH & CO KG , BEAULIEU, Pierre, L. , BROCHU, Christian , KAWAI, Stephen , RANCOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , TSANTRIZOS, Youla, S.
发明人： BEAULIEU, Pierre, L. , BROCHU, Christian , KAWAI, Stephen , RANCOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , TSANTRIZOS, Youla, S.
IPC分类号： C07D417/04
CPC分类号： C07D403/04 , C07D209/08 , C07D209/12 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04
摘要： A compound, represented by formula (I) or an enantiomer, diastereoisomer or tautomer thereof : wherein either A or B is nitrogen and the other B or A is C, and the radicals R 1 , R 2 , R 3 , R 5 , R 6 , R 7 , R 9 , and R 10 are as defined herein, or a salt, ester or derivative thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particulary those viral polymerases within the Flaviviridae family, more particulary to HCV polymerase.
摘要翻译：由式（I）表示的化合物或其对映异构体，非对映异构体或互变异构体：其中A或B为氮，另一个B或A为C，基团R

6. 发明申请

WO2004065367A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2004065367A1
公开(公告)日：2004-08-05
申请号：PCT/CA2004/000018
申请日：2004-01-19
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO KG , BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Chatherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
发明人： BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Chatherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
IPC分类号： C07D209/08
CPC分类号： C07D401/04 , C07D209/08 , C07D209/30 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
摘要翻译：由式（I）表示的化合物的异构体，对映体，非对映异构体或互变异构体：其中A，B，R2，R3，L，M1，M2，M3，M4，Y1，Y0，Z和Sp如权利要求1或其盐作为HCV NS5B聚合酶的抑制剂。

7. 发明申请

WO2003010141A2 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2003010141A2
公开(公告)日：2003-02-06
申请号：PCT/CA2002/001128
申请日：2002-07-18
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S. , JOLICOEUR, Eric , GILLARD, James , POUPART, Marc-André , RANCOURT, Jean
发明人： BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S. , JOLICOEUR, Eric , GILLARD, James , POUPART, Marc-André , RANCOURT, Jean
IPC分类号： C07D209/00
CPC分类号： C07D333/62 , C07D209/08 , C07D209/30 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR 1 , or CR 1 , wherein R 1 is defined herein; represents either a single or a double bond;R 2 is selected from: H, halogen, R 21 , OR 21 , SR 21 , COOR 21 ,SO 2 N(R 22 ) 2 , N(R 22 ) 2 , , CON(R 22 ) 2 ,NR 22 C(O)R 22 or NR 22 C(O)NR 22 wherein R 21 and each R 22 is defined herein; B is NR 3 or CR 3 , with the proviso that one of A or B is either CR 1 or CR 3 , wherein R 3 is defined herein; K is N or CR 4 , wherein R 4 is defined herein; L is N or CR 5 , wherein R 5 has the same definition as R 4 ; M is N or CR 7 , wherein R 7 has the same definition as R 4 ; Y 1 is O or S; Z is N(R 6a )R 6 or OR 6 , wherein R 6a is H or alkyl or NR 61 R 62 wherein R 61 and R 62 are defined herein; and R 6 is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R 6 is wherein R 7 and R 8 and Q are as defined herein; Y 2 is O or S; R 9 is H, (C 1-6 alkyl), (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl, aryl, Het, (C 1-6 )alkyl-aryl or (C 1-6 )alkyl-Het, all of which optionally substituted with R 90 ; or R 9 is covalently bonded to either of R 7 or R 8 to form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.
摘要翻译：由式I表示的化合物的异构体，对映异构体，非对映异构体或互变异构体：其中：A是O，S，NR 1或CR 1，其中R 1在本文中定义; 表示单键或双键; R 2选自：H，卤素，R 21，OR 21，SR 21，COOR 21，SO 2 N（R 22）2， N（R 22）2，CON（R 22）2，NR 22 C（O）R 22或NR 22 C（O）NR 22其中R 21和每个R 22在本文中定义; B是NR 3或CR 3，条件是A或B中的一个是CR 1或CR 3，其中R 3在本文中定义; K是N或CR 4，其中R 4在本文中定义; L是N或CR 5，其中R 5具有与R 4相同的定义; M是N或CR 7，其中R 7具有与R 4相同的定义; Y 1是O或S; Z是N（R 6a）R 6或OR 6，其中R 6a是H或烷基或NR 61 R 62，其中R 61和R 62定义在本文中 ; 且R 6为H，烷基，环烷基，烯基，Het，烷基 - 芳基，烷基-Het;或R 6为其中R 7和R 8和Q如本文所定义; Y 2为O或S; R 9是H，（C 1-6烷基），（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基，芳基，Het，（C 1-6）烷基 - 芳基或（C 1 -6）烷基-Het，它们全部被R 90取代; 或R 9与R 7或R 8中的任一个共价键合以形成5-或6-元杂环; 其盐或其衍生物，作为HCV NS5B聚合酶的抑制剂。

8. 发明申请

WO2009062288A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 审中-公开
标题翻译：人类免疫缺陷病毒复制的抑制剂
公开(公告)号：WO2009062288A1
公开(公告)日：2009-05-22
申请号：PCT/CA2008/001935
申请日：2008-11-03
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , CARSON, Rebekah J. , FADER, Lee , KAWAI, Stephen , LANDRY, Serge , TSANTRIZOS, Youla S. , BROCHU, Christian , MORIN, Sébastien , PARISIEN, Mathieu , SIMONEAU, Bruno
发明人： CARSON, Rebekah J. , FADER, Lee , KAWAI, Stephen , LANDRY, Serge , TSANTRIZOS, Youla S. , BROCHU, Christian , MORIN, Sébastien , PARISIEN, Mathieu , SIMONEAU, Bruno
IPC分类号： C07D495/04 , A61K31/4365 , A61K31/4709 , A61K31/4741 , A61K31/538 , A61P31/18 , C07D519/00
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein c, X, Y, R 2 , R 3 , R 4 and R 6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
摘要翻译：本发明涉及其中c，X，Y，R 2，R 3，R 4和R 6如本文所定义的式（I）化合物，其用于治疗人类免疫缺陷病毒（HIV）感染的组合物和用途。特别地，本发明提供HIV整合酶的新型抑制剂，含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法

9. 发明申请

WO2009062285A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 审中-公开
标题翻译：人类免疫缺陷病毒复制的抑制剂
公开(公告)号：WO2009062285A1
公开(公告)日：2009-05-22
申请号：PCT/CA2008/001611
申请日：2008-09-11
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BILODEAU, François , CARSON, Rebekah, J. , COULOMBE, René , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , MORIN, Sébastien , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
发明人： TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BILODEAU, François , CARSON, Rebekah, J. , COULOMBE, René , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , MORIN, Sébastien , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
IPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06
CPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要： Compounds of formula (I): wherein R 4 , R 6 and R 7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译：式（I）化合物：其中R 4，R 6和R 7在本文中定义，可用作HIV复制的抑制剂。

10. 发明申请

WO2005080388A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2005080388A1
公开(公告)日：2005-09-01
申请号：PCT/CA2005/000208
申请日：2005-02-18
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BOEHRINGER INGELHEIM PHARMA GmbH & CO KG , TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D417/14
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.
摘要翻译：由式（I）表示的化合物的对映体，非对映异构体或互变异构体：其中A或B为氮，另一个B或A为C，基团R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8，R 9和R 10如本文所定义，或其盐或酯作为病毒聚合酶抑制剂。该化合物用作RNA依赖性RNA聚合酶的抑制剂，特别是黄病毒科中的那些病毒聚合酶，更特别地涉及HCV聚合酶。

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