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1. 发明申请

WO2016164821A1 SYSTEMS, APPARATUS, AND ASSEMBLING METHOD THEREOF FOR ADMINISTERING A SUBSTANCE 审中-公开
标题翻译：用于管理物质的系统，装置及其组装方法
公开(公告)号：WO2016164821A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026779
申请日：2016-04-08
申请人： SCHOELLHAMMER, Carl Magnus , TRAVERSO, Carlo Giovanni , SCHROEDER, Avraham , POLAT, Baris , BLANKSCHTEIN, Daniel , LANGER, Robert S. , BRUGGE, William
发明人： SCHOELLHAMMER, Carl Magnus , TRAVERSO, Carlo Giovanni , SCHROEDER, Avraham , POLAT, Baris , BLANKSCHTEIN, Daniel , LANGER, Robert S. , BRUGGE, William
IPC分类号： A61M37/00
CPC分类号： A61M3/0275 , A61M3/0233 , A61M3/0254 , A61M3/0279 , A61M31/00 , A61M37/0092 , A61M2205/0238 , A61M2205/0294 , A61M2205/123 , A61M2205/3368 , A61M2205/586 , A61M2210/1067 , A61M2250/00
摘要： A device 2600 for administering a substance includes an elongated body 2606 having a proximal end and a distal end, the elongated body defining an internal chamber 2614 extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip 2610, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.
摘要翻译：用于施用物质的装置2600包括具有近端和远端的细长主体2606，细长主体限定在近端和远端之间延伸的内部腔室2614，以将物体引导到远端，远端为了连接尖端2610，尖端至少部分地插入到受试者的体腔的孔中，该尖端具有被配置为在至少部分插入时减少物质从孔中的泄漏的形状。尖端包括将物质从内部室传递到体腔的开口; 以及换能器，其从尖端发射超声波进入体腔，从而将该物质施用于体腔内的组织。

2. 发明申请

WO2005017182A2 MULTI-COLOR IN VITRO TRANSLATION 审中-公开
标题翻译：多色翻译
公开(公告)号：WO2005017182A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/019097
申请日：2004-07-21
申请人： THE JOHNS HOPINKS UNIVERSITY SCHOOL OF MEDICINE , TRAVERSO, Carlo, Giovanni , DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
发明人： TRAVERSO, Carlo, Giovanni , DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12Q
CPC分类号： G01N33/6845 , G01N33/542
摘要： In vitro translation is a widely used tool for both analytical and preparative purposes. For analytical purposes, small amounts of proteins are synthesized and visualized through labeled amino acids incorporated during translation. The radioactively labeled amino acids originally used, such as [ 35 S]methionine or [ 14 C]leucine, have been superceded by the addition of antigenic tags or the incorporation of biotin-labeled or fluorescently-labeled amino acids. Such non-radioactive tags are simpler to visualize following translation and do not pose a radiation hazard. Among the non-radioactive tags, fluorescently labeled-lysine is the most convenient, as proteins that have incorporated this amino acid can be directly visualized following gel electrophoresis. Multiple fluorophores introduced into proteins significantly extend their utility, particularly for the comparison of in vitro translated proteins from related sources. This methodology can be employed for several purposes, including the simplified detection of rare truncating mutations in clinical samples from cancer patients.
摘要翻译：体外翻译是用于分析和制备目的的广泛使用的工具。为了分析的目的，通过在翻译过程中并入的标记氨基酸合成少量蛋白质并使其可视化。最初使用的放射性标记的氨基酸，例如[35 S]甲硫氨酸或[[14 C]亮氨酸）已经通过加入抗原标签或引入生物素标记或荧光标记的氨基酸而被替代。这种非放射性标签更容易可视化翻译，并且不会造成辐射危害。在非放射性标签中，荧光标记的赖氨酸是最方便的，因为结合了该氨基酸的蛋白质可以在凝胶电泳后直接显现。引入蛋白质的多种荧光团显着扩展其效用，特别是用于比较来自相关来源的体外翻译蛋白质。该方法可用于多种目的，包括简化检测癌症患者临床样品中罕见的截短突变。

3. 发明申请

WO2022235653A2 A HANDHELD CLOSED-LOOP AUTOMATIC INSULIN DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2022235653A2
公开(公告)日：2022-11-10
申请号：PCT/US2022/027450
申请日：2022-05-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TRAVERSO, Carlo, Giovanni , HUANG, Hen, Wei , YOU, Siheng , RAFTERY, Erin
发明人： TRAVERSO, Carlo, Giovanni , HUANG, Hen, Wei , YOU, Siheng , RAFTERY, Erin
IPC分类号： A61B5/168 , A61B5/145 , A61M5/00 , A61M5/20 , A61M31/00 , A61B5/14532 , A61B5/151 , A61B5/157 , A61B5/4839 , A61M2205/3592 , A61M2207/00 , A61M5/2053 , A61M5/31546
摘要： An all-in-one insulin pen includes a handheld housing that houses a glucose testing module, an insulin delivery module, a wireless communication module, and a microcontroller. The glucose testing module tests a one-time glucose concentration of a patient. The insulin delivery module automatically administers an insulin bolus to the patient based at least in part on the one-time glucose concentration.

4. 发明申请

WO2019071075A1 FLEXIBLE PIEZOELECTRIC DEVICES FOR GASTROINTESTINAL MOTILITY SENSING 审中-公开
公开(公告)号：WO2019071075A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054523
申请日：2018-10-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , DAGDEVIREN, Canan , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S.
发明人： DAGDEVIREN, Canan , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S.
IPC分类号： A61B5/07 , A61B5/11 , A61B5/00 , G01L1/16
CPC分类号： A61B5/42 , A61B5/073 , A61B5/1107 , A61B5/1126 , A61B5/4255 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61B2562/162 , A61B2562/164 , G01L1/16 , G01L9/0022 , G01L19/086 , H01L41/042 , H01L41/0477 , H01L41/053 , H01L41/1132 , H01L41/1873 , H01L41/1876 , H01L41/23 , H01L41/29 , H01L41/333
摘要： Improvements in ingestible electronics with the capacity to sense physiologic and pathophysiologic states have transformed the standard of care for patients. Yet despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we disclose an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantified its key behaviors in the GI tract by using computational modeling, and validated its functionality in awake and ambulating swine. Our piezoelectric devices can safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for diagnosing and treating motility disorders and for monitoring ingestion in bariatric applications.

5. 发明申请

WO2012158648A1 METHOD AND APPARATUS FOR DELIVERING A SUBSTANCE 审中-公开
标题翻译：用于输送物质的方法和装置
公开(公告)号：WO2012158648A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/037848
申请日：2012-05-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SCHROEDER, Avraham D. , TRAVERSO, Carlo Giovanni , POLAT, Baris E. , WHITEHEAD, Kathryn A. , ANDERSON, Daniel G. , LANGER, Robert S. , SCHOELLHAMMER, Carl Magnus , BLANKSCHTEIN, Daniel
发明人： SCHROEDER, Avraham D. , TRAVERSO, Carlo Giovanni , POLAT, Baris E. , WHITEHEAD, Kathryn A. , ANDERSON, Daniel G. , LANGER, Robert S. , SCHOELLHAMMER, Carl Magnus , BLANKSCHTEIN, Daniel
IPC分类号： A61B5/07 , A61M31/00 , A61M37/00 , A61N7/02
CPC分类号： A61N7/00 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/14546 , A61B5/4839 , A61M31/002 , A61M37/0092
摘要： A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.
摘要翻译：递送物质的方法包括在生物体的胃肠（GI）道（不包括颊膜）的位置处提供物质; 并且在该位置施加具有约20kHz至约10MHz之间的频率的超声波。该方法可以包括将物质储存在至少一个储存器中并将GI道内或介质中的介质暴露于物质。该方法还可以包括将装置递送到胃肠道，该装置包括至少一个超声换能器和电路; 为设备内的至少一个超声换能器和电路供电; 以及使得所述至少一个超声换能器以使得所述至少一个超声换能器向胃肠道内或胃肠道内的介质发射超声波的方式来驱动所述至少一个超声换能器。

6. 发明申请

WO2005017182A3 MULTI-COLOR IN VITRO TRANSLATION 审中-公开
标题翻译：多色翻译
公开(公告)号：WO2005017182A3
公开(公告)日：2007-12-06
申请号：PCT/US2004019097
申请日：2004-07-21
申请人： JOHNS HOPINKS UNIVERSITY SCHOO , TRAVERSO CARLO GIOVANNI , DIEHL FRANK , KINZLER KENNETH W , VOGELSTEIN BERT
发明人： TRAVERSO CARLO GIOVANNI , DIEHL FRANK , KINZLER KENNETH W , VOGELSTEIN BERT
IPC分类号： C12Q1/68 , C07K14/00 , C12Q20060101
CPC分类号： G01N33/6845 , G01N33/542
摘要： In vitro <
摘要翻译：体外

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