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1. 发明申请

WO2008016335A1 A MICROARRAY SYSTEM AND A PROCESS FOR PRODUCING MICROARRAYS 审中-公开
标题翻译：微波炉系统和微波炉生产工艺
公开(公告)号：WO2008016335A1
公开(公告)日：2008-02-07
申请号：PCT/SG2007/000232
申请日：2007-08-03
申请人： NATIONAL UNIVERSITY OF SINGAPORE , TRAU, Dieter , LIU, Wen-Tso , NG, Kian Kok, Johnson
发明人： TRAU, Dieter , LIU, Wen-Tso , NG, Kian Kok, Johnson
IPC分类号： G01N21/29 , C07K17/14 , C12Q1/68
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/0054 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/0074 , C12Q1/6834 , C12Q1/6837 , C12Q1/6883 , C40B20/02 , C40B30/04 , C40B40/04 , C40B50/16 , C40B50/18 , C40B60/14 , G01N21/6452 , G01N33/54313 , G01N33/545 , G06T5/50 , G06T7/0008 , G06T7/33 , C12Q2537/149 , C12Q2563/149 , C12Q2565/513 , C12Q2565/619
摘要： A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on differences between each image. Also disclosed in a system for using the microarray.
摘要翻译：制作微阵列的过程。该方法包括在具有至少一个基准的基底上沉积一群微珠的步骤。群体由至少两个亚群组成，优选多个亚群，每个亚群包含能够与至少一种目标分析物特异性结合的已知活性剂。所述亚群是以彼此不连续的时间顺序地沉积的。该方法还包括在每个亚群沉积后制作基底的图像的步骤。然后使用基准作为参考来比较图像，从而基于每个图像之间的差异来确定每个微珠的位置并识别亚群及其已知的活性剂。还在用于使用微阵列的系统中公开。

2. 发明申请

WO2008091228A2 REVERSE PHASE LAYER-BY-LAYER ENCAPSULATION OF HIGHLY WATER SOLUBLE MATERIALS 审中-公开
标题翻译：高水溶性材料的反相层叠包层
公开(公告)号：WO2008091228A2
公开(公告)日：2008-07-31
申请号：PCT/SG2008/000028
申请日：2008-01-23
申请人： NATIONAL UNIVERSITY OF SINGAPORE , TRAU, Dieter , BEYER, Sebastian , MAK, Wing Cheung
发明人： TRAU, Dieter , BEYER, Sebastian , MAK, Wing Cheung
IPC分类号： B01J13/00
CPC分类号： B01J13/22
摘要： The present invention refers to a method and process for the encapsulation of highly water soluble materials in the further termed "Reverse Phase Layer-by-Layer (RP-LbL) Encapsulation". State of the art polyelectrolyte self assembly Layer-by-Layer coating or encapsulation methods are only applicable to non water soluble materials. The current invention provide a novel method to extend the material spectrum to highly water soluble materials by using non-ionized polyelectrolytes in an organic phase (Reverse Phase) instead of polyelectrolyte salts in an aqueous environment of the common art. Reverse Phase LbL is applicable to encapsulate highly water soluble substances, such as proteins, sugars, ascorbic acid, fragrants, inorganic salts, amino acids and vitamins, which could not be encapsulated by the current LbL technology.
摘要翻译：本发明涉及一种用于将高水溶性材料封装在进一步称为“反相层析（RP-LbL）封装”中的方法和方法。现有技术的聚电解质自组装层叠涂层或包封方法仅适用于非水溶性材料。本发明提供了一种通过在有机相（反相）中使用非电离聚电解质而不是普通技术的水性环境中的聚电解质盐将材料谱扩展到高度水溶性材料的新方法。反相LbL适用于包封高度水溶性物质，如蛋白质，糖类，抗坏血酸，香料，无机盐，氨基酸和维生素，不能被目前的LbL技术所包封。

3. 发明申请

WO0212888A3 CAPSULES ENCAPSULATING SOLID PARTICLES OF SIGNAL-GENERATING ORGANIC SUBSTANCES 审中-公开
标题翻译：封装信号产生有机物质的固体颗粒
公开(公告)号：WO0212888A3
公开(公告)日：2002-05-16
申请号：PCT/EP0109114
申请日：2001-08-07
申请人： 8SENS BIOGNOSTIC AG , TRAU DIETER , RENNEBERG REINHARD , CARUSO FRANK , LEHMANN MATTHIAS
发明人： TRAU DIETER , RENNEBERG REINHARD , CARUSO FRANK , LEHMANN MATTHIAS
IPC分类号： G01N33/58 , G01N33/543 , G01N33/558
CPC分类号： G01N33/587
摘要： The present invention refers to capsules encapsulating solid particles of signal-generating organic substances and carrying on the outer surface affinity molecules for secific recognition of and binding to target molecules in a sample. The invention is directed to teh use of these capsules for signal production in the optical, electrochemical or chemical detection of target molecules. To obtain a signal the signal-generating organic substances are released and dissolved. A detection method and a kit are provided.
摘要翻译：本发明涉及封装信号产生有机物质的固体颗粒的胶囊，并且携带外表面亲和分子以便对样品中的目标分子进行识别和结合。本发明涉及在目标分子的光学，电化学或化学检测中使用这些胶囊用于信号产生。为了获得信号，产生信号的有机物质被释放并溶解。提供检测方法和试剂盒。

4. 发明申请

WO9841843A3 DEVICE AND METHOD FOR CARRYING OUT FLUORESCENCE IMMUNOTESTS 审中-公开
标题翻译：携带荧光免疫的装置和方法
公开(公告)号：WO9841843A3
公开(公告)日：1998-11-19
申请号：PCT/DE9800729
申请日：1998-03-11
申请人： INST CHEMO BIOSENSORIK , MEUSEL MARKUS , TRAU DIETER , KATERKAMP ANDREAS
发明人： MEUSEL MARKUS , TRAU DIETER , KATERKAMP ANDREAS
IPC分类号： G01N21/55 , G01N21/05 , G01N21/64 , G01N33/543
CPC分类号： G01N21/648 , G01N21/6428 , G01N33/54373
摘要： The invention relates to a device and a method for carrying out especially quantitative fluorescence immunotests by exciting an evanescent field. These fluorescence immunotests can be based on a wide range of known biochemical assays of general receptor-ligand systems. Light from at least one light source is directed at an angle α onto the boundary surface of two media with different refraction indices. The light source chosen should be one which emits almost monochromatic light with one wavelength, said wavelength being suitable for exciting a tracer material. The light is directed onto a boundary surface (20) located between an optically transparent base plate (1) consisting of material with a refraction index n1 greater than the refraction index n2 of the material above said boundary surface (20), and a cell-shaped accommodating area (2) for the sample. Said accommodating area (2) is covered with a cover plate (3) on the side facing the base plate (1), at least one functional layer (26, 27, 28, 28', 29) being located between said base plate (1) and said cover plate (3), and a detector (5) for detecting the fluorescent light being positioned on the same side of the base plate (1) as the light source.

5. 发明申请

WO2011090441A1 A PROCESS FOR MAKING A MICROARRAY 审中-公开
标题翻译：制作微波的方法
公开(公告)号：WO2011090441A1
公开(公告)日：2011-07-28
申请号：PCT/SG2011/000033
申请日：2011-01-25
申请人： NATIONAL UNIVERSITY OF SINGAPORE , LUBRICH, Daniel , TRAU, Dieter
发明人： LUBRICH, Daniel , TRAU, Dieter
IPC分类号： G01N1/36 , C40B20/04 , G01N33/53 , B81B1/00 , G01N21/63
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00317 , B01J2219/00421 , B01J2219/00466 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00648 , B01J2219/00725 , B01J2219/0074
摘要： There is provided a process for making a microarray. The process comprises the steps of: a) providing a plurality of holes that extend into a substrate; b) providing a population of microparticles that are chemically or biologically active; and c) forcing the microparticles at least partially into said holes, wherein the holes and microparticles are dimensioned relative to each other to enable locking engagement of said microparticles at least partially within said holes.
摘要翻译：提供了制备微阵列的过程。该方法包括以下步骤：a）提供延伸到衬底中的多个孔; b）提供化学或生物活性的微粒群; 以及c）将所述微粒至少部分地推入所述孔中，其中所述孔和微粒相对于彼此确定尺寸，以使所述微粒至少部分地锁定在所述孔内。

6. 发明申请

WO2008091228A3 REVERSE PHASE LAYER-BY-LAYER ENCAPSULATION OF HIGHLY WATER SOLUBLE MATERIALS 审中-公开
标题翻译：高水溶性材料的反相层叠包层
公开(公告)号：WO2008091228A3
公开(公告)日：2009-04-02
申请号：PCT/SG2008000028
申请日：2008-01-23
申请人： UNIV SINGAPORE , TRAU DIETER , BEYER SEBASTIAN , MAK WING CHEUNG
发明人： TRAU DIETER , BEYER SEBASTIAN , MAK WING CHEUNG
IPC分类号： B01J13/00
CPC分类号： B01J13/22
摘要： The present invention refers to a method and process for the encapsulation of highly water soluble materials in the further termed "Reverse Phase Layer-by-Layer (RP-LbL) Encapsulation". State of the art polyelectrolyte self assembly Layer-by-Layer coating or encapsulation methods are only applicable to non water soluble materials. The current invention provide a novel method to extend the material spectrum to highly water soluble materials by using non-ionized polyelectrolytes in an organic phase (Reverse Phase) instead of polyelectrolyte salts in an aqueous environment of the common art. Reverse Phase LbL is applicable to encapsulate highly water soluble substances, such as proteins, sugars, ascorbic acid, fragrants, inorganic salts, amino acids and vitamins, which could not be encapsulated by the current LbL technology.
摘要翻译：本发明涉及一种用于将高水溶性材料封装在进一步称为“反相层析（RP-LbL）封装”中的方法和方法。现有技术的聚电解质自组装层叠涂层或包封方法仅适用于非水溶性材料。本发明提供了一种通过在有机相（反相）中使用非电离聚电解质而不是普通技术的水性环境中的聚电解质盐将材料谱扩展到高度水溶性材料的新方法。反相LbL适用于包封高度水溶性物质，如蛋白质，糖类，抗坏血酸，香料，无机盐，氨基酸和维生素，不能被目前的LbL技术所包封。

7. 发明申请

WO2003078659A3 MICROCAPSULES WITH CONTROLABLE PERMEABILITY ENCAPSULATING A NUCLEIC ACID AMPLIFICATION REACTION MIXTURE AND THEIR USE AS REACTION COMPARTMENTS FOR PARALLELS REACTIONS 审中-公开
公开(公告)号：WO2003078659A3
公开(公告)日：2003-09-25
申请号：PCT/EP2003/002926
申请日：2003-03-20
申请人： INNOVATIVEBIO.BIZ , TRAU, Dieter , RENNEBERG, Reinhard , MAK, Wing, Cheung
发明人： TRAU, Dieter , RENNEBERG, Reinhard , MAK, Wing, Cheung
IPC分类号： C12Q1/68
摘要： The present invention refers to microcapsules with high permeability for low molecular weight molecules and no permeability for high molecular weight molecules encapsulating a nucleic acid amplification reaction mixture, in particular, a PCR reaction mixture and providing a compartment to perform a nucleic acid amplification, in particular, a PCR reaction and to applications of such capsules to perform parallel PCR, screening, construction of DNA libraries and sequencing.

8. 发明申请

WO2003078659A2 MICROCAPSULES ENCAPSULATING A NUCLEIC ACID AMPLIFICATION REACTION MIXTURE AND THEIR USE AS REACTION COMPARTMENTS FOR PARALLEL REACTIONS 审中-公开
标题翻译：包裹核酸扩增反应混合物的微胶囊及其作为用于平行反应的反应室的用途
公开(公告)号：WO2003078659A2
公开(公告)日：2003-09-25
申请号：PCT/EP2003/002926
申请日：2003-03-20
申请人： INNOVATIVEBIO.BIZ , TRAU, Dieter , RENNEBERG, Reinhard , MAK, Wing, Cheung
发明人： TRAU, Dieter , RENNEBERG, Reinhard , MAK, Wing, Cheung
IPC分类号： C12Q1/68
CPC分类号： C12N15/1075 , B01J13/02 , B01J13/14 , B82Y10/00 , B82Y30/00 , C12Q1/6844 , C12Q1/6869
摘要： The present invention refers to microcapsules with high permeability for low molecular weight molecules and no permeability for high molecular weight molecules encapsulating a nucleic acid amplification reaction mixture, in particular, a PCR reaction mixture and providing a compartment to perform a nucleic acid amplification, in particular, a PCR reaction and to applications of such capsules to perform parallel PCR, screening, construction of DNA libraries and sequencing.
摘要翻译：本发明涉及低分子量分子具有高渗透性并且对于包封核酸扩增反应混合物，特别是PCR反应混合物的高分子量分子不具有渗透性的微胶囊，特别是PCR反应混合物，进行核酸扩增，特别是PCR反应，并进行这种胶囊的应用以进行平行PCR，筛选，构建DNA文库和测序。

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