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1. 发明申请

WO2007006716A1 CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译： CYSTEINE PROTEASE抑制剂
公开(公告)号：WO2007006716A1
公开(公告)日：2007-01-18
申请号：PCT/EP2006/063952
申请日：2006-07-06
申请人： MEDIVIR AB , TICKLE, David , PARKES, Kevin , TOZER, Matt , GRABOWSKA, Urszula
发明人： TICKLE, David , PARKES, Kevin , TOZER, Matt , GRABOWSKA, Urszula
IPC分类号： C07D471/04 , A61K31/407 , A61P19/00
CPC分类号： C07D471/04
摘要： A compound of the formula (II) wherein one of R 1 and R 2 is halo and the other is H or halo; R 3 is -C 1 -C 5 straight or branched chain, optionally fluorinated, alkyl or -CH 2 CR 5 C 3 -C 4 -Cycloalkyl; R 4 is H; R 5 is H, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, hydroxyl, OC 1 -C 2 alkyl, fluoro; R 6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle wherein the or each ring has 4, 5 or 6 ring atoms and 0 to 3 hetero atoms selected from S, O and N; Rb is haloalkyl; Rc is H or C 1 -C 4 alkyl; and pharmaceutically acceptable salts, hydrates or N-oxides thereof have utility in the treatment of disorders characterised by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
摘要翻译：其中R 1和R 2中的一个为卤素且另一个为H或卤素的式（II）化合物; R 3是C 1 -C 5直链或支链，任选氟化的烷基或-CH 2 O 2， CR ^{5 C _{3 -C _{4 - 环烷基; R 4是H; R 5是H，C 1 -C 2烷基，C 1 -C 2烷基，C 1 -C 2烷基，C 1 -C 2烷基，卤代烷基，羟基，OC 1 -C 2烷基，氟; R 6是一个稳定的，任选取代的单环或双环的碳环或hetorocycle，其中该环或每个环具有4,5或6个环原子和0至3个选自S，O和N的杂原子; Rb是卤代烷基; R c是H或C 1 -C 4烷基; 其药学上可接受的盐，水合物或N-氧化物可用于治疗组织蛋白酶K不适当表达或活化的疾病，例如骨质疏松症，骨关节炎，类风湿性关节炎或骨转移。}}}

2. 发明申请

WO2005000309A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2005000309A2
公开(公告)日：2005-01-06
申请号：PCT/GB2004/002697
申请日：2004-06-24
申请人： IONIX PHARMACEUTICALS LIMITED , JENNINGS, Neil, Stuart , STOKES, Stephen , HAMLYN, Richard, John , TICKLE, David, Christopher , HUCKSTEP, Michael, Richard , LYNCH, Rosemary , KNUTSEN, Lars, Jacob, Stray
发明人： JENNINGS, Neil, Stuart , STOKES, Stephen , HAMLYN, Richard, John , TICKLE, David, Christopher , HUCKSTEP, Michael, Richard , LYNCH, Rosemary , KNUTSEN, Lars, Jacob, Stray
IPC分类号： A61K31/4439
CPC分类号： C07D277/28 , A61K31/4439 , C07C311/29 , C07D207/335 , C07D211/96 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/14 , C07D263/10 , C07D263/32 , C07D277/52 , C07D285/06 , C07D285/135 , C07D295/13 , C07D333/20 , C07D417/12
摘要： Compounds of the formulae (I) and (II), and pharmaceutically acceptable salts thereof, are found to be inhibitors of sensory neurone specific (SNS) sodium channels. They are therefore useful as analgesic and neuroprotective agents. Formula (I) & Formula (II) wherein, in the formula (I), R 1 is an organic substituent, X 1 and X 2 are direct bonds or spacer moieties, Ar is aryl or heteroaryl and Y is a substituted aminoalkyl group or a heteroaryl-, heterocyclyl- or phenyl-containing moiety and, in the formula(II), R 1 , R 2 , R 3 , Ar and R 4 are organic substituents, X is a spacer moiety and Het is a 5-membered heteroaryl or heterocyclyl group.
摘要翻译：发现式（I）和（II）的化合物及其药学上可接受的盐是感觉神经元特异性（SNS）钠通道的抑制剂。因此它们可用作镇痛剂和神经保护剂。式（I）＆amp; 式（II）其中在式（I）中，R 1是有机取代基，X 1和X 2是直接键或间隔基部分，Ar为芳基或杂芳基，并且Y为取代的氨基烷基或含杂芳基 - ，杂环基或苯基的部分，并且在式（II）中，R 1，R 2， 2R 3，Ar和R 4是有机取代基，X是间隔基部分，Het是5元杂芳基或杂环基基团。 p>

3. 发明申请

WO2009019508A1 CALCIUM ION CHANNEL MODULATORS & USES THEREOF 审中-公开
标题翻译：钙离子通道调制器及其用途
公开(公告)号：WO2009019508A1
公开(公告)日：2009-02-12
申请号：PCT/GB2008/050652
申请日：2008-08-01
申请人： LECTUS THERAPEUTICS LIMITED , BOFFEY, Raymond, John , BURCKHARDT, Svenja , CANSFIELD, Julie, Elaine , KHAN, Nawaz, Mohammed , LAWTON, Geoff , TICKLE, David , VO, Ngoc-Tri , KANUMILLI, Srinivasan , BUSTON, Jonathan, E., H. , SMITH, Andy , WYBROW, Robert, A., J. , KOZLOWSKI, Roland Zbigniew , HOGG, Dayle Spencer
发明人： BOFFEY, Raymond, John , BURCKHARDT, Svenja , CANSFIELD, Julie, Elaine , KHAN, Nawaz, Mohammed , LAWTON, Geoff , TICKLE, David , VO, Ngoc-Tri , KANUMILLI, Srinivasan , BUSTON, Jonathan, E., H. , SMITH, Andy , WYBROW, Robert, A., J. , KOZLOWSKI, Roland Zbigniew , HOGG, Dayle Spencer
IPC分类号： C07D209/18 , C07D333/60 , A61K31/404 , A61K31/381
CPC分类号： C07D209/18 , C07D333/60 , C07D401/12 , C07D409/12
摘要： The present invention relates to ion channel modulators, and more particularly to compounds which inhibit the interaction between the pore-forming (α) subunits of Cav voltage-gated calcium channels and accessory (Cavβ subunit) proteins. Coumpounds are of use in the treatment and prevention of a number of diseases and conditions including pain and lower urinary tract disorders, and have the following Formula (I).
摘要翻译：本发明涉及离子通道调节剂，更具体地涉及抑制Cav电压门控钙通道的成孔（a）亚基与辅助（Cavβ亚基）蛋白质之间相互作用的化合物。辅助治疗剂用于治疗和预防多种疾病和病症，包括疼痛和下尿路疾病，并具有下式（I）。

4. 发明申请

WO2007144379A1 BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS 审中-公开
标题翻译：双相化合物有效用作CATHEPSIN S INBHIBITORS
公开(公告)号：WO2007144379A1
公开(公告)日：2007-12-21
申请号：PCT/EP2007/055831
申请日：2007-06-13
申请人： MEDIVIR AB , HEWITT, Ellen , HARDICK, David , JACKSON, Philip , FALLON, Philip , TICKLE, David , KAHNBERG, Pia , ODEN, Lourdes , NILSSON, Magnus
发明人： HEWITT, Ellen , HARDICK, David , JACKSON, Philip , FALLON, Philip , TICKLE, David , KAHNBERG, Pia , ODEN, Lourdes , NILSSON, Magnus
IPC分类号： C07D491/04 , A61K31/407 , A61P11/06 , A61P17/06 , A61P25/00 , A61P29/00 , A61P7/00
CPC分类号： C07D491/048
摘要： Compounds of formula (I), wherein R 1 , R 2 , R 3 , Ra and E are are defined within, and pharmaceutically acceptable salts, solvates, hydrates and N-oxides thereof having utility in the treatment of disorders mediated by cathepsin S.
摘要翻译：其中R 1，R 2，R 3，R A和E的式（I）化合物定义在其药学上可接受的盐，溶剂合物，水合物和N-氧化物，其用于治疗组织蛋白酶S介导的病症。

5. 发明申请

WO2005000309A3 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2005000309A3
公开(公告)日：2005-03-03
申请号：PCT/GB2004002697
申请日：2004-06-24
申请人： IONIX PHARMACEUTICALS LTD , JENNINGS NEIL STUART , STOKES STEPHEN , HAMLYN RICHARD JOHN , TICKLE DAVID CHRISTOPHER , HUCKSTEP MICHAEL RICHARD , LYNCH ROSEMARY , KNUTSEN LARS JACOB STRAY
发明人： JENNINGS NEIL STUART , STOKES STEPHEN , HAMLYN RICHARD JOHN , TICKLE DAVID CHRISTOPHER , HUCKSTEP MICHAEL RICHARD , LYNCH ROSEMARY , KNUTSEN LARS JACOB STRAY
IPC分类号： A61K31/4439 , C07C311/29 , C07D207/32 , C07D207/335 , C07D211/96 , C07D231/12 , C07D233/54 , C07D249/04 , C07D249/14 , C07D263/10 , C07D263/32 , C07D277/28 , C07D277/52 , C07D285/06 , C07D285/12 , C07D285/135 , C07D295/13 , C07D333/20 , C07D417/12
CPC分类号： C07D277/28 , A61K31/4439 , C07C311/29 , C07D207/335 , C07D211/96 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/14 , C07D263/10 , C07D263/32 , C07D277/52 , C07D285/06 , C07D285/135 , C07D295/13 , C07D333/20 , C07D417/12
摘要： Compounds of the formulae (I) and (II), and pharmaceutically acceptable salts thereof, are found to be inhibitors of sensory neurone specific (SNS) sodium channels. They are therefore useful as analgesic and neuroprotective agents. Formula (I) & Formula (II) wherein, in the formula (I), R1 is an organic substituent, X1 and X2 are direct bonds or spacer moieties, Ar is aryl or heteroaryl and Y is a substituted aminoalkyl group or a heteroaryl-, heterocyclyl- or phenyl-containing moiety and, in the formula(II), R1, R2, R3, Ar and R4 are organic substituents, X is a spacer moiety and Het is a 5-membered heteroaryl or heterocyclyl group.
摘要翻译：发现式（I）和（II）的化合物及其药学上可接受的盐是感觉神经元特异性（SNS）钠通道的抑制剂。因此它们可用作止痛剂和神经保护剂。式（I）和式（II）其中，在式（I）中，R 1是有机取代基，X 1和X 2是直接键或间隔部分，Ar是芳基或杂芳基，Y是取代的氨基烷基或杂芳基 - （II）中，R 1，R 2，R 3，Ar和R 4为有机取代基，X为间隔基，Het为5元杂芳基或杂环基。

6. 发明申请

WO1997046407A1 MOTOR VEHICLE POWER TRAIN 审中-公开
标题翻译：电动车动力火车
公开(公告)号：WO1997046407A1
公开(公告)日：1997-12-11
申请号：PCT/GB1997001516
申请日：1997-06-05
申请人： ROVER GROUP LIMITED , NESBITT, David, Charles , TICKLE, David, John , WOOLMER, Clive, David
发明人： ROVER GROUP LIMITED
IPC分类号： B60K17/346
CPC分类号： B60K17/346 , B60K5/02 , B60K17/08 , B60K17/22
摘要： A motor vehicle power train includes an engine (26) mounted longitudinally in the vehicle adjacent one end, a change speed transmission (28) spaced from and drivably connected to the engine through an input propshaft (31) and a transfer transmission (29) mounted on the change speed transmission and drivably connected to a front differential through a front propshaft (34) and to a rear differential through a rear propshaft (35). The change speed transmission has an input shaft (39) to receive drive at one end from the engine and an output shaft (41) axially offset from the input shaft and having a drive output at the opposite end. The transfer transmission is arranged at the opposite end of the change speed transmission and includes a centre differential (56) having differential output shafts (57, 58) drivably connected to the front and rear propshafts and axially offset from the input shaft and the change speed transmission output shaft.
摘要翻译：机动车动力传动系包括一个纵向安装在邻近一端的车辆中的发动机（26），一个通过输入传动轴（31）与传动传动装置（29）间隔开并可驱动地连接到发动机的变速传动装置（28）在变速传动上，通过前传动轴（34）可驱动地连接到前差速器，并通过后传动轴（35）与后差速器相连。变速传动装置具有输入轴（39），用于在一端接收来自发动机的驱动和从输入轴轴向偏移并在相对端具有驱动输出的输出轴（41）。传动传动装置设置在变速传动装置的相对端，并且包括一个具有差动输出轴（57,58）的中心差速器（56），该差速器输出轴可驱动地连接到前后轴承轴，并且与输入轴轴向偏移，变速箱输出轴。

7. 发明申请

WO2006082354A1 AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) 审中-公开
标题翻译：作为感觉神经元特异性通道（SNS）的抑制剂的AZACYCLIC化合物
公开(公告)号：WO2006082354A1
公开(公告)日：2006-08-10
申请号：PCT/GB2006/000040
申请日：2006-01-06
申请人： VERNALIS (R & D) LIMITED , HAMLYN, Richard , HUCKSTEP, Mike , EARNSHAW, Christopher, Geoffrey , STOKES, Stephen , TICKLE, David , ALLART, Brigitte , BOYD, Joseph, William , KNUTSEN, Lars, Jacob, Stray , LYNCH, Rosemary , PATIENT, Lee
发明人： HAMLYN, Richard , HUCKSTEP, Mike , EARNSHAW, Christopher, Geoffrey , STOKES, Stephen , TICKLE, David , ALLART, Brigitte , BOYD, Joseph, William , KNUTSEN, Lars, Jacob, Stray , LYNCH, Rosemary , PATIENT, Lee
IPC分类号： C07D217/04 , A61K31/472 , C07D209/48 , A61K31/4035 , A61P25/04 , A61P25/06 , C07D401/12 , A61K31/4725 , C07D417/04 , A61K31/5415 , C07D413/04 , A61K31/538 , C07D405/12 , C07D495/04 , A61K31/4365
CPC分类号： C07D495/04 , C07D209/48 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06
摘要： Compounds of the formula (I) , and pharmaceutically acceptable salts thereof , are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents. wherein: - Ar represents a phenyl ring or a 5 - to 6- membered heteroaryl group; - m is 1 , 2 or 3 .
摘要翻译：发现式（I）化合物及其药学上可接受的盐是SNS钠通道的拮抗剂。因此它们可用作止痛剂和神经保护剂。其中：-Ar表示苯环或5-至6-元杂芳基; - m为1,2或3。

8. 发明申请

WO2005005392A1 AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS 审中-公开
标题翻译：作为感觉神经元特异性通道的抑制剂的AZACYCLIC化合物
公开(公告)号：WO2005005392A1
公开(公告)日：2005-01-20
申请号：PCT/GB2004/002945
申请日：2004-07-07
申请人： IONIX PHARMACEUTICALS LIMITED , HAMLYN, Richard, John , HUCKSTEP, Michael, Richard , LYNCH, Rosemary , STOKES, Stephen , TICKLE, David, Christopher , PATIENT, Lee
发明人： HAMLYN, Richard, John , HUCKSTEP, Michael, Richard , LYNCH, Rosemary , STOKES, Stephen , TICKLE, David, Christopher , PATIENT, Lee
IPC分类号： C07D217/04
CPC分类号： C07D223/16 , C07D209/44 , C07D209/86 , C07D217/02 , C07D217/10 , C07D217/14 , C07D217/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D409/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.
摘要翻译：发现式（I）化合物及其药学上可接受的盐是SNS钠通道的拮抗剂。因此它们可用作止痛剂和神经保护剂，其中：X为-N-或-CH-; n为0〜3。

9. 发明申请

WO2004087125A1 AMINO ACID DERIVATIVES AS INHIBITORS OF MAMMALIAN SODIUM CHANNELS 审中-公开
标题翻译：氨基酸衍生物作为MAMMALIAN SODIUM通道的抑制剂
公开(公告)号：WO2004087125A1
公开(公告)日：2004-10-14
申请号：PCT/GB2004/001474
申请日：2004-04-02
申请人： IONIX PHARMACEUTICALS LIMITED , HAMLYN, Richard, John , TICKLE, David, Christopher , HUCKSTEP, Michael, Richard , LYNCH, Rosemary
发明人： HAMLYN, Richard, John , TICKLE, David, Christopher , HUCKSTEP, Michael, Richard , LYNCH, Rosemary
IPC分类号： A61K31/18
CPC分类号： C07K14/705
摘要： Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment or prevention of a condition selected from chronic and acute pain, tinnitus, bowel disorders, bladder dysfunctions and demyelinating diseases, Formula (I) wherein: - R 1 is C l -C 6 alkyl, C 6 -C 10 aryl, a 5- to 10- membered heteroaryl group, a 5- to 10- membered heterocyclyl group or a C 3 -C 6 carbocyclyl group; each R 2 is the same or different and represents C l -C 6 alkyl, halogen, C l -C 6 alkoxy, C l -C 6 alkythio, hydroxy, nitro, cyano, amino, (C l -C 6 alkyl)amino or di-( C l -C 6 alkyl)amino; - R 3 represents hydrogen, C l -C 6 alkyl, or together with R 4 represents a C 2 -C 4 alkylene group; - R 4 is hydrogen, C l -C 6 alkyl, C 6 -C 10 aryl, C 3 -C 6 carbocyclyl, a 5- to 10membered heteroaryl group, a 5- to 10- membered heterocyclyl group, -( C l -C 6 alkyl)-(C 6 -C 10 aryl), -(C 1 -C 6 alkyl)-(C 3 -C 6 carbocyclyl), -(C 1 -C 6 alkyl)-(5-to 10- membered heteroaryl), - ( C l -C 6 alkyl)-(5- to 10- membered heterocyclyl) or, together with R 3 represents a C 2 -C 4 alkylene group; - R 5 and R 6 are the same or different and each represent hydrogen or a C l -C 6 alkyl group; - n is 0,1, 2, 3 or 4; X 1 represents a direct bond or a methylene group; and X 2 represents a -CH 2 -, -CO-, -SO- or -S(O)2- group, wherein: the alkyl and alkylene groups and moieties in the substituents R 1 to R 6 and X, are unsubstituted or are substituted by 1, 2 or 3 substituents which are the same or different and are selected from hydroxy, amino, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylamino and di(C 1 -C 4 alkyl)amino substituents; and the aryl, heteroaryl, heterocyclyl and carbocyclyl groups and moieties in the substituents R 1 and R 4 are unsubstituted or are substituted by 1, 2 or 3 substituents which are the same or different and are selected from halogen, C l -C 6 alkyl, C l -C 6 alkoxy, C l -C 6 alkylthio, hydroxy, amino, C l -C 6 alkylamino, di-( C l -C 6 alkyl)amino, C l -C 6 haloalkyl, C l -C 6 haloalkoxy and C l -C 6 haloalkylthio substituents. provided that, when n is 1, 2, 3 or 4, R 4 is other than hydrogen and when n is 0, X 2 is -CH 2 - and R 1 is an aryl or heteroaryl group, then either: (a) R, is a phenyl group which carries at least one -SCF 3 substituent or is a thienyl group which carries at least one chloro substituent; (d) R 1 is a phenyl group which carries at least one -CF 3 substituent or at least two halogen substituents; or (e) R 4 is benzyl or hydroxybenzyl and R 1 is a phenyl group which carries a fluorine or -OCH 3 substituent.
摘要翻译：式（I）化合物或其药学上可接受的盐在制备用于治疗或预防选自慢性和急性疼痛，耳鸣，肠病，膀胱功能障碍和脱髓鞘疾病中的病症的药物中的用途式（I）其中：-R 1是C 1 -C 6烷基，C 6 -C 10芳基，5-至10-元杂芳基，5-至10-元杂环基或C 3 -C 6碳环基; 每个R 2相同或不同，表示C 1 -C 6烷基，卤素，C 1 -C 6烷氧基，C 1 -C 6连接基，羟基，硝基，氰基，氨基，（C 1 -C 6烷基）氨基或二 - （C 1 -C 6烷基）氨基; -R 3表示氢，C 1 -C 6烷基或与R 4一起代表C 2 -C 4亚烷基; R 4是氢，C 1 -C 6烷基，C 6 -C 10芳基，C 3 -C 6碳环基，5-至10元杂芳基，5-至10-元杂环基， - （C 1 -C 6烷基） - （C 6 -C 10）（C 1 -C 6烷基） - （C 3 -C 6碳环基）， - （C 1 -C 6烷基） - （5-至10-元杂芳基）， - （C 1 -C 6烷基） - （5-至10 元环杂环基）或与R 3一起代表C 2 -C 4亚烷基; -R 5和R 6相同或不同，各自表示氢或C 1 -C 6烷基; - n为0,1,2,3或4; X1表示直接键或亚甲基; 并且X 2表示-CH 2 - ， - CO - ， - SO-或-S（O）2 - 基团，其中：取代基R 1至R 6和X中的烷基和亚烷基和部分未被取代或被1 2或3个相同或不同并且选自羟基，氨基，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基氨基和二（C 1 -C 4烷基）氨基取代基的取代基; 并且取代基R 1和R 4中的芳基，杂芳基，杂环基和碳环基团和部分是未取代的或被1,2或3个相同或不同并且选自卤素，C 1 -C 6烷基，C 1 -C 6 烷氧基，C1-C6烷硫基，羟基，氨基，C1-C6烷基氨基，二（C1-C6烷基）氨基，C1-C6卤代烷基，C1-C6卤代烷氧基和C1-C6卤代烷硫基取代基。条件是当n为1,2,3或4时，R4不为氢，当n为0时，X2为-CH2-，R1为芳基或杂芳基，则：（a）R为苯基携带至少一个-SCF 3取代基的基团，或是携带至少一个氯取代基的噻吩基; （d）R 1是携带至少一个-CF 3取代基或至少两个卤素取代基的苯基; 或（e）R 4为苄基或羟基

10. 发明申请

WO1997046406A1 MOTOR VEHICLE POWER TRAIN 审中-公开
标题翻译：电动车动力火车
公开(公告)号：WO1997046406A1
公开(公告)日：1997-12-11
申请号：PCT/GB1997001515
申请日：1997-06-05
申请人： ROVER GROUP LIMITED , NESBITT, David, Charles , TICKLE, David, John , WOOLMER, Clive, David , EBREY, John, Samuel
发明人： ROVER GROUP LIMITED
IPC分类号： B60K17/346
CPC分类号： B60K17/346 , B60K5/02 , B60K17/08 , B60K17/22 , Y10T74/19093
摘要： A motor vehicle power train includes an engine (26) mounted longitudinally near the front of the vehicle and a transmission assembly (35) mounted intermediate front and rear differentials (17, 18). The transmission assembly is connected to the engine through an input propshaft (31), to the front differential through a front propshaft (37) and to the rear differential through a rear propshaft (38). The transmission assembly comprises a change speed transmission (28) which receives drive from the input propshaft and a hollow output shaft (49), a transfer transmission comprising a centre differential (30) which is drivably connected to the hollow output shaft, has a front differential output shaft (54) for transmitting drive to the front propshaft and a rear differential output shaft (56) for transmitting drive to the rear propshaft, one of the differential output shafts (54) extending coaxially through the hollow output shaft. The transmission assembly also comprises an auxiliary output transmission (39) in the drive from the front differential output shaft to the front propshaft, the transmission assembly being arranged so that front and rear rotary outputs (37B, 38B) to the front and rear propshafts are axially offset from a rotary input (33) from the input propshaft, the front rotary output by an amount greater than that of the rear rotary output. The change speed transmission is conveniently adapted from a known automatic transmission for front wheel drive vehicles and can be connected using an input transmission (34).
摘要翻译：机动车动力传动系包括纵向安装在车辆前部的发动机（26）和安装在前后差速器（17,18）之间的传动组件（35）。传动组件通过输入传动轴（31）连接到发动机，通过前传动轴（37）连接到前差速器，并通过后传动轴（38）连接到后差速器。传动组件包括一个变速传动装置（28），该变速传动装置（28）从输入传动轴和中空输出轴（49）接收传动，传动传动装置包括可驱动地连接到中空输出轴的中心差速器（30）用于将驱动传递到前传动轴的差动输出轴（54）和用于将驱动传递到后传动轴的后差速器输出轴（56），差动输出轴（54）中的一个同轴地延伸穿过中空输出轴。传动组件还包括从前差速器输出轴到前传动轴的驱动器中的辅助输出传动装置（39），传动组件布置成使得前后传动轴（37B，38B）从旋转输入端（33）轴向偏离输入传动轴，前旋转输出量大于后旋转输出量。变速传动方便地适用于已知的用于前轮驱动车辆的自动变速器，并且可以使用输入变速器（34）连接。

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