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1. 发明申请

WO2012096970A1 SYSTEMS AND METHODS FOR IED DESIGN TEMPLATES 审中-公开
标题翻译：用于IED设计模板的系统和方法
公开(公告)号：WO2012096970A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020793
申请日：2012-01-10
申请人： SCHWEITZER ENGINEERING LABORATORIES, INC. , LEE, Tony, J. , THOMPSON, Craig
发明人： LEE, Tony, J. , THOMPSON, Craig
IPC分类号： G06F17/50
CPC分类号： G06F17/00 , G01R19/2513 , G06F3/00 , G06F13/00 , Y02T10/82
摘要： Disclosed herein are a variety of systems and methods that may be utilized to facilitate the configuration of intelligent electronic devices using design templates. A design template may be configured to make available to the user only particular inputs that might need to be modified for a specific application of the intelligent electronic device. Use of templates, as disclosed herein, may simplify the task of configuring an intelligent electronic device. Data entered by the user may be utilized to generate a plurality of intelligent electronic device settings. According to various embodiments, the data entered by a user may be stored on the intelligent electronic device in an archive file. The archive file may also include other design information that a user may desire to store on the intelligent electronic device.
摘要翻译：本文公开了可以利用设计模板来促进智能电子设备的配置的各种系统和方法。设计模板可以被配置为仅向用户提供对于智能电子设备的特定应用可能需要修改的特定输入。使用如本文所公开的模板可以简化配置智能电子设备的任务。可以利用用户输入的数据来生成多个智能电子设备设置。根据各种实施例，用户输入的数据可以存储在归档文件中的智能电子设备上。归档文件还可以包括用户可能想要存储在智能电子设备上的其他设计信息。

2. 发明申请

WO2010057083A1 METHODS OF TREATING CANCER 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：WO2010057083A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064569
申请日：2009-11-16
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THOMPSON, Craig, B. , WISE, David, R.
发明人： THOMPSON, Craig, B. , WISE, David, R.
IPC分类号： G01N33/574
CPC分类号： A61K31/00
摘要： The invention concerns methods of treating cancer comprising contacting said tumors with a chemical inhibitor of glutaminolysis. These inhibitors include amino-oxyacetate, phenylbutyrate, phenylacetate, and 3,7-bis(dimethylamino)-phenazathionium chloride (methylene blue).
摘要翻译：本发明涉及治疗癌症的方法，其包括使所述肿瘤与谷氨酸分解的化学抑制剂接触。这些抑制剂包括氨基 - 氧基乙酸酯，苯基丁酸酯，苯乙酸酯和3,7-双（二甲基氨基） - 吩噻嗪鎓（亚甲基蓝）。

3. 发明申请

WO2006078774A3 REGULATION OF AUTOPHAGY AND CELL SURVIVAL 审中-公开
公开(公告)号：WO2006078774A3
公开(公告)日：2006-07-27
申请号：PCT/US2006/001831
申请日：2006-01-19
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THOMPSON, Craig, B. , LUM, Julian , BAUER, Daniel
发明人： THOMPSON, Craig, B. , LUM, Julian , BAUER, Daniel
IPC分类号： C12N5/06
摘要： Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.

4. 发明申请

WO2004100885A2 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2004100885A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014263
申请日：2004-05-07
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THOMPSON, Craig, B. , BAUER, Daniel , HATZIVASSILIOU, Georgia
发明人： THOMPSON, Craig, B. , BAUER, Daniel , HATZIVASSILIOU, Georgia
IPC分类号： A61K
CPC分类号： A61K31/34 , A61K51/0491
摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
摘要翻译：公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。公开了治疗患有癌症的个体的方法，包括将癌症鉴定为具有高比例的有氧糖酵解的步骤，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。公开了鉴定具有抗癌活性的化合物的方法。

5. 发明申请

WO1998022510A3 METHODS FOR THE PRODUCTION OF CHICKEN MONOCLONAL ANTIBODIES 审中-公开
公开(公告)号：WO1998022510A3
公开(公告)日：1998-05-28
申请号：PCT/US1997021077
申请日：1997-11-18
申请人： ARCH DEVELOPMENT CORPORATION , UAB RESEARCH FOUNDATION , MICHAEL, Nancy, M. , ACCAVITTI, Mary, Ann, V. , THOMPSON, Craig, B.
发明人： ARCH DEVELOPMENT CORPORATION , UAB RESEARCH FOUNDATION
IPC分类号： C07K16/46

6. 发明申请

WO1995000642A1 VERTEBRATE APOPTOSIS GENE: COMPOSITIONS AND METHODS 审中-公开
标题翻译： VERTEBRATE APOPTOSIS GENE：组合物和方法
公开(公告)号：WO1995000642A1
公开(公告)日：1995-01-05
申请号：PCT/US1994007089
申请日：1994-06-22
申请人： ARCH DEVELOPMENT CORPORATION , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THOMPSON, Craig, B. , BOISE, Lawrence, H. , NUNEZ, Gabriel
发明人： ARCH DEVELOPMENT CORPORATION , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12N15/12
CPC分类号： C07K14/4747 , C07K14/465
摘要： The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 (SEQ ID NO.5) that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得和使用影响程序性脊椎动物细胞死亡的BCL-2（SEQ ID NO.5）以外的多肽的组合物和方法。本发明还涉及编码那些多肽的多核苷酸，携带那些序列的重组载体，包含序列或载体的重组宿主细胞和重组多肽。本发明还提供了在分析设计用于选择和改善能够改变程序性细胞死亡的物质用于诊断，药物设计和治疗应用的测定中使用分离的重组多肽的方法。

7. 发明申请

WO1994028123A1 MAMMALS LACKING EXPRESSION OF CD28 TRANSGENIC 审中-公开
标题翻译：。OF。。。。。。。。。。。。。。。
公开(公告)号：WO1994028123A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005913
申请日：1994-05-25
申请人： ONTARIO CANCER INSTITUTE , THOMPSON, Craig, Bernie
发明人： ONTARIO CANCER INSTITUTE , MAK, Tak, Wah
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K38/00 , C07K14/70503 , C07K14/70521 , C07K14/70589
摘要： Mammals lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mammals.
摘要翻译：提供了在免疫系统的某些细胞中缺乏CD28或特定CD45亚型表达的哺乳动物。还提供了使用这些哺乳动物的方法。

8. 发明申请

WO2022216903A1 NADK2 INHIBITION IN CANCER AND FIBROTIC DISORDERS 审中-公开
公开(公告)号：WO2022216903A1
公开(公告)日：2022-10-13
申请号：PCT/US2022/023788
申请日：2022-04-07
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , THOMPSON, Craig, B. , SCHWOERER, Simon , ZHU, Jiajun
发明人： THOMPSON, Craig, B. , SCHWOERER, Simon , ZHU, Jiajun
IPC分类号： A61K35/13 , A61K45/06 , A61P1/16 , A61P11/00 , A61P35/00
摘要： Aspects of the disclosure provide methods for inhibiting cell proliferation and protein synthesis utilizing an antagonist of nicotinamide adenine dinucleotide kinase 2 (NADK2). In some aspects, these methods are used to treat a disease such as cancer or a disorder such as a fibrotic disorder. Further provided herein are compositions comprising a nutrient-deficient cell culture medium and an antagonist of NADK2.

9. 发明申请

WO2011020018A1 SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS FO THEIR PREPARATION AND USE 审中-公开
标题翻译：单氟尿嘧啶的单一脱氧酶及其制备和使用方法
公开(公告)号：WO2011020018A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045470
申请日：2010-08-13
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , KUNG, Hank, F. , THOMPSON, Craig, B. , QU, Wenchao , PLOESSL, Karl
发明人： KUNG, Hank, F. , THOMPSON, Craig, B. , QU, Wenchao , PLOESSL, Karl
IPC分类号： A01N37/12
CPC分类号： C07C309/73 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C231/12 , C07C237/06 , C07C271/22
摘要： The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
摘要翻译：本发明涉及具有至少80％的非对映异构体过量的4-氟谷氨酰胺的单一非对映异构体。还描述了制备单一非对映体的方法，以及使用放射性标记的4-氟谷氨酰胺的单一非对映异构体作为成像剂的方法。

10. 发明申请

WO2010114805A1 METHODS OF TREATING CANCER WITH PHENFORMIN 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：WO2010114805A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029112
申请日：2010-03-30
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THOMPSON, Craig, B. , KOBLAUCH, Roland
发明人： THOMPSON, Craig, B. , KOBLAUCH, Roland
IPC分类号： A01N37/52 , A61K31/155
CPC分类号： A61K31/155
摘要： Methods of using phenformin to treat certain types of cancers are described.
摘要翻译：描述了使用苯乙双胍治疗某些类型的癌症的方法。

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