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1. 发明申请

WO2004100885A3 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2004100885A3
公开(公告)日：2005-07-28
申请号：PCT/US2004014263
申请日：2004-05-07
申请人： UNIV PENNSYLVANIA , THOMPSON CRAIG B , BAUER DANIEL , HATZIVASSILIOU GEORGIA
发明人： THOMPSON CRAIG B , BAUER DANIEL , HATZIVASSILIOU GEORGIA
IPC分类号： A61K20060101 , A61K31/34
CPC分类号： A61K31/34 , A61K51/0491
摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
摘要翻译：公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。公开了治疗患有癌症的个体的方法，包括将癌症鉴定为具有高比例的有氧糖酵解的步骤，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。公开了鉴定具有抗癌活性的化合物的方法。

2. 发明申请

WO2011028540A1 DETERMINING SENSITIVITY OF CELLS TO B-RAF INHIBITOR TREATMENT BY DETECTING KRAS MUTATION AND RTK EXPRESSION LEVELS 审中-公开
标题翻译：通过检测KRAS突变和RTK表达水平确定细胞对B-RAF抑制剂治疗的敏感性
公开(公告)号：WO2011028540A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/046520
申请日：2010-08-24
申请人： GENENTECH, INC. , HATZIVASSILIOU, Georgia , MALEK, Shiva
发明人： HATZIVASSILIOU, Georgia , MALEK, Shiva
IPC分类号： G01N33/48
CPC分类号： A61K31/517 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57438 , G01N33/57449 , G01N33/57492 , G01N33/57496 , G01N2333/91205 , G01N2333/914 , G01N2800/52
摘要： The present invention relates to prognostic methods for identifying tumors that are not susceptible to B-Raf inhibitor treatment by detecting mutations in a K-ras gene or protein or by detecting overexpression of RTKs and/or their ligands. Kits are also disclosed for carrying out the methods.
摘要翻译：本发明涉及通过检测K-ras基因或蛋白质中的突变或通过检测RTK和/或其配体的过表达鉴定对B-Raf抑制剂治疗不敏感的肿瘤的预后方法。还披露了用于实施这些方法的试剂盒。

3. 发明申请

WO2004100885A2 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2004100885A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014263
申请日：2004-05-07
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THOMPSON, Craig, B. , BAUER, Daniel , HATZIVASSILIOU, Georgia
发明人： THOMPSON, Craig, B. , BAUER, Daniel , HATZIVASSILIOU, Georgia
IPC分类号： A61K
CPC分类号： A61K31/34 , A61K51/0491
摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
摘要翻译：公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。公开了治疗患有癌症的个体的方法，包括将癌症鉴定为具有高比例的有氧糖酵解的步骤，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。公开了鉴定具有抗癌活性的化合物的方法。

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