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1. 发明申请

WO2006032158A1 ELECTROCHEMICAL PATTERNING ON MULTI-CHANNEL MICROELECTRODE ARRAY FOR BIOSENSING APPLICATIONS 审中-公开
标题翻译：用于生物传感应用的多通道微电极阵列的电化学方法
公开(公告)号：WO2006032158A1
公开(公告)日：2006-03-30
申请号：PCT/CH2005/000550
申请日：2005-09-20
申请人： ETH ZURICH , EMPA, EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT , VÖRÖS, Janos , TEXTOR, Marcus , TANG, Clarence , KELLER, Beat
发明人： VÖRÖS, Janos , TEXTOR, Marcus , TANG, Clarence , KELLER, Beat
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00495 , B01J2219/00531 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00635 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074
摘要： Described is a method for electrochemically patterning a microelectrode array (MEA) with at least two different kinds of macromolecules. Said method comprising the steps of: providing a platform with a surface that comprises individually addressable conductive microelectrode surfaces; covering said platform surface with an adlayer of resistant polymer; desorbing said adlayer from a first kind of conductive microelectrodes intended for the selective adsorption of a first kind of macromolecules, in particular proteins, by applying a potential; subjecting the desorbed surfaces to the first macromolecule under conditions such that said first macromolecule adsorbs to said desorbed surfaces, and repeating the desorption/adsorption steps with a second or further kind of macromolecules until all kinds of desired macromolecules are adsorbed. A microchip array produced by the inventive method is also described. Such chip arrays can be used to study a large diversity of biological interactions, e.g. protein-protein interactions, protein-cell interactions, protein-nucleic acid interactions, etc.
摘要翻译：描述了用至少两种不同种类的大分子电化学构图微电极阵列（MEA）的方法。所述方法包括以下步骤：提供具有包括单独可寻址的导电微电极表面的表面的平台; 用抗性聚合物的覆层覆盖所述平台表面; 从用于通过施加电位选择性吸附第一种大分子，特别是蛋白质的第一种导电微电极解吸附子; 在使所述第一高分子吸附到所述解吸附表面的条件下使解吸附的表面经受脱附表面到达第一高分子，并用第二种或其它种类的大分子重复解吸附/吸附步骤，直到吸附所有种类的所需大分子。还描述了通过本发明方法制造的微芯片阵列。这种芯片阵列可用于研究大量生物相互作用，例如，蛋白质 - 蛋白质相互作用，蛋白质 - 细胞相互作用，蛋白质 - 核酸相互作用等。

2. 发明申请

WO2003072156A1 BIOMEDICAL IMPLANT SURFACES WITH OSTEOGENIC PROPERTIES 审中-公开
标题翻译：生物医学植物表面与生物特性
公开(公告)号：WO2003072156A1
公开(公告)日：2003-09-04
申请号：PCT/CH2002/000125
申请日：2002-02-28
申请人： EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH OBERFLÄCHENTECHNIK , SIMPSON, James, P. , DENZER, Alain, J. , BOYAN, Barbara, D. , SCHWARTZ, Zvi, D. , TOSATTI, Samuele , SPENCER, Nicholas, D. , TEXTOR, Marcus
发明人： SIMPSON, James, P. , DENZER, Alain, J. , BOYAN, Barbara, D. , SCHWARTZ, Zvi, D. , TOSATTI, Samuele , SPENCER, Nicholas, D. , TEXTOR, Marcus
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , C08L101/02
摘要： The invention relates to a device with a surface covered by a thin film or monolayer of a poly (ethylene glycol)-grafted copolymer exhibiting osteogenic properties, defined in an osteoblastic cell culture test as a surface that increases the expression of growth factor TFG-β1, the expression of hormone PGE 2 and/or the expression of mineralization marker osteocalcin by at least a factor of 2 in comparison to the corresponding control surface consisting of either unmodified substrate surface or of tissue-culture polystyrene (TCPS).
摘要翻译：本发明涉及一种具有表面覆盖的表面的器件，其表现出成骨细胞培养试验中定义的表现成骨形成特性的聚（乙二醇）移植共聚物的薄膜或单层，作为增加生长因子TFG-β1的表达的表面，与由未修饰的底物表面或组织培养聚苯乙烯（TCPS）组成的相应的对照表面相比，激素PGE2的表达和/或矿化标记骨钙素的表达至少为2倍。

3. 发明申请

WO2007022645A1 CATECHOL FUNCTIONALIZED POLYMERS AND METHOD FOR PREPARING THEM 审中-公开
标题翻译： CATECHOL功能化聚合物及其制备方法
公开(公告)号：WO2007022645A1
公开(公告)日：2007-03-01
申请号：PCT/CH2005/000494
申请日：2005-08-24
申请人： ETH ZURICH , TEXTOR, Marcus , ZÜRCHER, Stefan , GADEMANN, Karl , TOSATTI, Samuele
发明人： TEXTOR, Marcus , ZÜRCHER, Stefan , GADEMANN, Karl , TOSATTI, Samuele
IPC分类号： C08G65/329 , A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/329 , Y10T428/265 , Y10T428/31511 , Y10T428/31663 , Y10T428/31725 , Y10T428/31855
摘要： Described are compounds that are capable of forming adlayers, said compounds comprising at least one headgroup A, an optional linker B, a polymer C, a terminal group D and an optionally present crosslinking group R, wherein the headgroup A is a compound of the following formula wherein X is independently from each other selected from an acidic group, such as OH, SH, phosphate, phosphornate and N + R 2 H, Y is a group derived from a convenient coupling group, in particular NL 3 , or N + (L 3 )2, Z 1 , Z 3 , and Z 4 are C or N + Z 2 , Z 5 and Z 6 are C-L 1 or N + -L, wherein L 1 is H or an electron withdrawing group, L is C 1 -C 6 alkyl, in particular C 1 -C 4 alkyl L 2 and L 3 are independently selected from H or C 1 -C 6 alkyl, preferably C 1 -C 4 alkyl, or L 2 may form together with L 1 or L of Z 6 a heterocycle, in particular a positively charged heterocycle, n is 0, or 1, or 2, or 3, m is 0 or 1 with the proviso that at most one of Z 1 to Z 6 is N + and that in case that Z 1 is N + , L 2 may additionally be an ester, an amide, or a heterocycle.
摘要翻译：描述的是能够形成层的化合物，所述化合物包含至少一个头基A，任选的接头B，聚合物C，末端基D和任选存在的交联基团R，其中头基A是下列化合物其中X彼此独立地选自酸性基团如OH，SH，磷酸酯，膦酸酯和N，R 2 H，Y是衍生自一个方便的耦合组，特别是NL 3或N 3+（L 3 3）2，Z 1， Z 3和Z 4是C或N + Z 2，Z 5，...， >和Z 6是CL 1或N + L，其中L 1是H或吸电子基团，L为C 1 -C 6烷基，特别是C 1 -C 4烷基L SUP > 2和L 3独立地选自H或C 1 -C 6烷基，优选C 1〜 C 1 -C 4烷基或L 2可以与L 1，L 2或L 6的杂环形成，特别是带正电荷的杂环，n为0，或1或2或3，m为0或1，条件是Z 1至Z 6中的至少一个为N + >而在Z 1是N +的情况下，L 2可以另外是酯，酰胺或杂环。

4. 发明申请

WO2003020966A2 OBERFLÄCHE ZUR IMMOBILISIERUNG VON NUKLEINSÄUREN 审中-公开
标题翻译：用于固定核酸的表面
公开(公告)号：WO2003020966A2
公开(公告)日：2003-03-13
申请号：PCT/EP2002/009490
申请日：2002-08-24
申请人： ZEPTOSENS AG , ABEL, Andreas, P. , EHRAT, Markus , KAUFFMANN, Eckehard , UTINGER, Dominic , BENOIT, Vincent , DE PAUL, Susan, Margaret , TEXTOR, Marcus , VANDEVONDELE, Stephanie , HUBBELL, Jeffrey, A.
发明人： ABEL, Andreas, P. , EHRAT, Markus , KAUFFMANN, Eckehard , UTINGER, Dominic , BENOIT, Vincent , DE PAUL, Susan, Margaret , TEXTOR, Marcus , VANDEVONDELE, Stephanie , HUBBELL, Jeffrey, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00529 , B01J2219/0054 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00
摘要： Die vorliegende Erfindung betrifft eine Oberfläche zur Immobilisierung einer oder mehrerer erster Nukleinsäuren als Erkennungselemente ("Immobilisierungsoberfläche") zur Herstellung einer Erkennungsoberfläche zum Nachweis einer oder mehrerer zweiter Nukleinsäuren in einer oder mehr mit der Erkennungsoberfläche in Kontakt gebrachten Proben, wobei die ersten Nukleinsäuren auf einer PLL- g -PEG-Schicht als Oberfläche zur Immobilisierung aufgebracht sind, dadurch gekennzeichnet, dass das Propfverhältnis ("Grafting Ratio") g , d.h. der Quotient aus der Anzahl der Lysineinheiten und der Anzahl der Poly(ethylenglycol)-Seitenketten ("PEG"-Seitenketten), einen Wert zwischen 7 und 13 hat. Die Erfindung betrifft auch ein Verfahren zum qualitativen und/oder quantitativen Nachweis einer oder mehrerer zweiter Nukleinsäuren in einer oder mehreren Proben, dadurch gekennzeichnet, dass besagte Proben und gegebenenfalls weitere Reagentien mit einer erfindungsgemässen Immobilisierungsoberfläche in Kontakt gebracht werden, auf welcher Oberfläche eine oder mehrere erste Nukleinsäuren als Erkennungselemente zur spezifischen Bindung/Hyridisierung mit besagten zweiten Nukleinsäuren immobilisiert sind und aus der Bindung/Hybridisierung dieser zweiten Nukleinsäuren oder weiterer zum Analytnachweis eingesetzter Nachweissubstanzen resultierende Änderungen von optischen oder elektronischen Signalen gemessen werden.
摘要翻译：
本发明涉及一种表面BEAR表面用于固定一个或多个第一核酸BEAR酸（QUOT＆; Immobilisierungsoberfl＆AUML;枝＆QUOT;）作为识别元件的制造Erkennungsoberfl＆AUML;枝，用于检测一个或多个第二核酸BEAR酸在与检测表面接触的一个或多个样品中，其中第一核酸被施加到PLL层上作为用于固定的表面，其特征在于，接枝率（接枝率）g，即，的赖氨酸单位的数量和侧链的聚（乙二醇）的数量的商（QUOT; PEG＆QUOT;侧链），具有7至13的值本发明还涉及一种用于一个或多个样品中的一个或多个第二核酸BEAR氨基酸，其特征在于所述样品中，并用根据本发明的BEAR SEN Immobilisierungsoberfl BEAR表面任选地另外的试剂进行定性和/或定量检测的方法相接触时，上该表面BEAR枝的一个或多个第一核酸BEAR酸作为与所述第二核酸BEAR酸被固定，并且从结合/杂交，所述第二核酸BEAR酸或进一步用于所得的光学BEAR变更或分析物检测物质识别元件，用于特异性结合/ Hyridisierung 电子信号。

5. 发明申请

WO0220873A3 METHOD FOR PRECIPITATING MONO AND MULTIPLE LAYERS OF ORGANOPHOSPHORIC AND ORGANOPHOSPHONIC ACIDS AND THE SALTS THEREOF IN ADDITION TO USE THEREOF 审中-公开
标题翻译：工艺单声道和有机磷和膦多层及其盐，以及它们的使用分离
公开(公告)号：WO0220873A3
公开(公告)日：2003-01-09
申请号：PCT/EP0110077
申请日：2001-08-31
申请人： ZEPTOSENS AG , HOFER ROLF , PAWLAK MICHAEL , TEXTOR MARCUS , SCHUERMANN-MADER EVELINE , EHRAT MARKUS , TOSATTI SAMUELE
发明人： HOFER ROLF , PAWLAK MICHAEL , TEXTOR MARCUS , SCHUERMANN-MADER EVELINE , EHRAT MARKUS , TOSATTI SAMUELE
IPC分类号： A61B17/68 , A61F2/00 , A61F2/30 , A61F2/958 , A61K9/32 , A61L27/34 , C04B41/49 , C04B41/84 , C23C22/68 , G01Q40/02 , G01Q70/00 , G01Q70/18 , G01N33/544 , A61L27/30 , A61L29/10 , A61L31/08 , A61L33/00 , G01N33/551
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphosphoric acids of general formula (I(A)) Y-B-OPO3 H2 (IA) or organophosphonic acids of general formula (I(B)) Y-B-PO3 H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl alkyl radical and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl- substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulphate, sulphonate, maleimide, succinimydyl, epoxy, acrylate series. A biological, biochemical or synthetic indicator element can be coupled to B or Y as addition or substitution reaction, whereby compounds can also be added imparting on the substrate surface a resistance against protein absorption and/or cell adhesion and in the B chain can be, optionally, composed of one or more ethylene oxide groups rather than one or more CH2 groups. According to the invention, said precipitation occurs on the surfaces of the substrates of pure or mixed oxides, nitrides or carbides of metals and semi-conductors. The invention is characterised in that the water-soluble salts composed of formula (IA) or (IB) are used to treat said surfaces, especially the surfaces of sensor platforms, implants and medical accessory devices.
摘要翻译：本发明涉及一种用于单或通式的有机膦酸多层的分离的方法I（A）：YB-OPO 3 H 2（IA）或通式I（B）YB-PO 3 H 2（IB）的有机膦酸和其盐，其中 B是烷基，烯基，炔基，芳基，芳烷基，杂芳基或杂芳基烷基残基，Y是氢或选自羟基，羧基，氨基，任选地被低级烷基取代的官能团，单或二烷基氨基，巯基，或从酯，磷酸酯，膦酸酯，硫酸酯，磺酸酯，马来酰亚胺，琥珀酰亚胺，环氧，丙烯酸酯的装置，其特征在于，通过加成或取代反应的生物，生化或合成的识别元件可以停靠到B或Y，由此化合物附着负酸基可赋予基材表面至蛋白吸附和/或细胞粘附和在乙在链中任选地电阻，而不是一个或多个-CH 2基团，一个或多个环氧乙烷基团可以包含上的金属和半导体的纯的或混合的氧化物，氮化物或碳化物，其特征在于对这些表面的处理，特别是作为传感器平台，植入物和医疗附件装置表面的衬底表面，可以使用的式（IA）或（IB）的化合物的水溶性盐。

6. 发明申请

WO2011147926A3 MAGNETICALLY RESPONSIVE MEMBRANE STRUCTURES 审中-公开
标题翻译：磁性响应膜结构
公开(公告)号：WO2011147926A3
公开(公告)日：2012-05-31
申请号：PCT/EP2011058654
申请日：2011-05-26
申请人： REIMHULT ERIK , AMSTAD ESTHER , TEXTOR MARCUS
发明人： REIMHULT ERIK , AMSTAD ESTHER , TEXTOR MARCUS
IPC分类号： A61K49/18 , A61K9/00 , A61K9/127 , A61K9/50 , A61K41/00 , A61P43/00 , B82Y5/00
CPC分类号： A61K49/1812 , A61K9/0009 , A61K9/127 , A61K9/1273 , A61K9/5094 , A61K41/0028 , A61K49/1806 , A61K49/1833 , A61K49/1839 , A61K49/186 , B82Y5/00
摘要： The present invention is directed towards magnetically responsive vesicular compositions comprising (a) a vesicular structure having a membrane enclosing a cavity and (b) at least one stabilized magnetic nanoparticle embedded in said membrane, and in particular towards lipid and/or polymeric vesicular compositions comprising stabilized superparamagnetic iron oxide nanoparticles. The vesicular compositions may further be functionalized with reactive groups for attachment of active agents or tethers for attachment to surfaces. Methods of preparation and their use in (targeted) delivery of an active agent, as a nanoreactor, for imaging purposes and combinations thereof are also disclosed.
摘要翻译：本发明涉及磁响应性泡囊组合物，其包含（a）囊状结构，其具有包围空腔的膜，和（b）至少一种嵌入所述膜中的稳定化磁性纳米颗粒，特别是涉及脂质和/或聚合物囊泡组合物，其包含稳定的超顺磁性氧化铁纳米粒子。囊泡组合物可以进一步用反应性基团官能化，以附着活性剂或连接臂以附着于表面。还公开了制备方法及其用于（靶向）递送活性剂，作为纳米反应器用于成像目的及其组合的方法。

7. 发明申请

WO2011026572A1 DISPERSANT STABILIZATION OF INORGANIC NON-METALLIC PARTICLES 审中-公开
标题翻译：无机非金属颗粒的分散稳定
公开(公告)号：WO2011026572A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/005129
申请日：2010-08-20
申请人： ETH Zurich , AMSTAD, Esther , REIMHULT, Erik , TEXTOR, Marcus
发明人： AMSTAD, Esther , REIMHULT, Erik , TEXTOR, Marcus
IPC分类号： A61K41/00 , A61K49/00
CPC分类号： A61K49/00
摘要： 1. A dispersant for stabilizing nanoparticles, in particular inorganic non-metallic nanoparticles is described. Said dispersant comprises at least one anchor group A, and at least one spacing group R covalently linked to said anchor group, said anchor group A is an unsaturated at least partially conjugated substituted six- membered homocyclic ringand comprises two surface interacting oxygen or hydroxy substituents on adjacent carbon atoms in the ring and. at least one further electro-negative substituent.
摘要翻译：描述了用于稳定纳米颗粒的分散剂，特别是无机非金属纳米颗粒。所述分散剂包含至少一个锚定基团A和与所述锚定基团共价连接的至少一个间隔基团R，所述锚定基团A是不饱和的至少部分共轭的取代的六元级环状环，并且包含两个表面相互作用的氧或羟基取代基环中相邻的碳原子。至少一个另外的电 - 负取代基。

8. 发明申请

WO2006050617A1 MICROFLUIDIC DEVICE FOR PATTERNED SURFACE MODIFICATION 审中-公开
标题翻译：用于图形表面改性的微流体装置
公开(公告)号：WO2006050617A1
公开(公告)日：2006-05-18
申请号：PCT/CH2004/000687
申请日：2004-11-12
申请人： EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH , VÖRÖS, Janos , DUSSEILLER, Marc , NIEDERBERGER, Brigitte , TEXTOR, Marcus
发明人： VÖRÖS, Janos , DUSSEILLER, Marc , NIEDERBERGER, Brigitte , TEXTOR, Marcus
IPC分类号： B01L3/00
CPC分类号： B01L3/502776 , B01J19/0046 , B01J2219/00286 , B01J2219/00432 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L2200/0636 , B01L2300/0636 , B01L2300/0816 , B01L2400/0487 , B82Y30/00 , Y10T156/10
摘要： A microfluidic device and its use for the production of micro-arrays, in particular for the detection of protein interactions, is described. Said microfluidic device comprises a flow cell part (1) and a chip part (2) together forming at least two crossing, preferably perpendicular, closed channels (3, 4), said flow cell part forming open channels providing the bottom wall and at least part of the side walls, in particular three walls of said closed channels (3, 4), said closed channels (3, 4) being connected to at least three fluid providing means for generating at least three fluid flows (7) and said closed channels (3, 4) being designed and dimensioned such that the flow of at least three aqueous fluids streaming through each of said channels (3, 4) is laminar at least until after said crossing of said channels (6), said chip part (2) forming the top wall and optionally part of said side walls, in particular the fourth wall, of said closed channels (3, 4) and having a surface that is activatable by reaction with an activating molecule.
摘要翻译：描述了微流体装置及其用于生产微阵列，特别是用于检测蛋白质相互作用的用途。所述微流体装置包括流动池部分（1）和芯片部分（2），一起形成至少两个交叉的，优选垂直的闭合通道（3,4），所述流动池部分形成开放通道，提供底壁并且至少侧壁的一部分，特别是所述封闭通道（3,4）的三个壁，所述封闭通道（3,4）连接至少三个流体提供装置，用于产生至少三个流体流（7）和所述封闭通道通道（3,4）的设计和尺寸使得流过每个所述通道（3,4）的至少三种含水流体的流动至少在所述通道（6），所述芯片部分 2）形成所述封闭通道（3,4）的顶壁和任选部分所述侧壁，特别是第四壁，并具有可通过与活化分子反应而激活的表面。

9. 发明申请

WO03024186A3 METHODS AND APPARATUS FOR PATTERNING A SURFACE 审中-公开
标题翻译：用于绘制表面的方法和装置
公开(公告)号：WO03024186A3
公开(公告)日：2003-05-22
申请号：PCT/US0229562
申请日：2002-09-18
申请人： EIDGENOESS TECH HOCHSCHULE , UNIV ZUERICH , HUBBELL JEFFREY A , BEARINGER JANE P , TEXTOR MARCUS
发明人： HUBBELL JEFFREY A , BEARINGER JANE P , TEXTOR MARCUS
IPC分类号： B41M3/00 , G03F7/00 , H01L21/302 , H01L21/461 , H01L51/00 , H01L51/40 , B44C1/22
CPC分类号： B29C43/003 , B29C2043/025 , B41M3/006 , C23F1/02 , G01Q80/00 , G03F7/0002 , H01L51/0015 , H01L51/0021
摘要： The present invention provides methods and apparatus for locally patterning surfaces. In one such method, an oxidizable thioether is adsorbed onto a conductive surface 10. The surface is then contacted with a fluid medium M. A conducting stamp 12 is then brought into contact with the fluid medium above the thioether-coated surface. Next, a potential V is applied between the stamp and the surface. It is expected that the charge will be transferred through the medium to the coated surface along a shortest distance path, thereby locally oxidizing the thioether and effectively creating a negative patterned image of the conducting stamp on the surface. Remaining adsorbed thioether may then be used as a mask for standard etching or material addition procedures.
摘要翻译：本发明提供了用于局部图案化表面的方法和装置。在一种这样的方法中，可氧化的硫醚被吸附到导电表面10上。然后使该表面与流体介质M接触。然后使导电印模12与硫醚涂覆表面上方的流体介质接触。接下来，在印模和表面之间施加电位V。预期电荷将沿着最短的距离路径通过介质转移到涂覆表面，从而局部氧化硫醚，并有效地在表面上产生导电印模的负图案图像。然后可以将剩余的吸附硫醚用作标准蚀刻或材料添加程序的掩模。

10. 发明申请

WO03024897A2 METHODS AND APPARATUS FOR COATING SURFACES TO REDUCE PROTEIN ADSORPTION AND CELL ADHESION AND PRESENT LIGANDS 审中-公开
标题翻译：用于涂覆表面以减少蛋白质吸附和细胞粘附和本发明配体的方法和装置
公开(公告)号：WO03024897A2
公开(公告)日：2003-03-27
申请号：PCT/US0229569
申请日：2002-09-18
申请人： EIDGENOESS TECH HOCHSCHULE , UNIV ZUERICH , HUBBELL JEFFREY A , BEARINGER JANE P , NAPOLI ALESSANDRO , TEXTOR MARCUS , TIRELLI NICOLA
发明人： HUBBELL JEFFREY A , BEARINGER JANE P , NAPOLI ALESSANDRO , TEXTOR MARCUS , TIRELLI NICOLA
IPC分类号： A61L27/34 , C07B
CPC分类号： A61L27/34 , C08L81/02
摘要： The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spacing or length of pendant chains or hydrophilic blocks in an amphiphilic thioether. Techniques for determining spacing include adsorbing the thioether from a solution or a colloidal suspension, or controlling the degree of polymerization of the thioether. Techniques for controlling the length of the pendant chains include controlling the degree of polymerization of the pendant chains. Multiblock copolymers of poly(propylene sulfide) and poly(ethylene glycol) ("PPS-PEG") represent an exemplary family of amphiphilic thioethers. Methods for coating surfaces with amphiphilic thioethers are also provided.
摘要翻译：本发明提供了用特别设计的硫醚和两亲硫醚涂覆表面的方法和装置，其减少蛋白质吸附和/或细胞粘附。该还原可以通过例如通过控制两亲性硫醚中的侧链或亲水嵌段的间隔或长度来实现。用于确定间隔的技术包括从溶液或胶体悬浮液中吸附硫醚，或控制硫醚的聚合度。用于控制侧链长度的技术包括控制侧链的聚合度。聚（丙烯硫醚）和聚（乙二醇）（“PPS-PEG”）的多嵌段共聚物代表两亲性硫醚的典型族。还提供了用两亲硫醚涂覆表面的方法。

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