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1. 发明申请

WO2003072156A1 BIOMEDICAL IMPLANT SURFACES WITH OSTEOGENIC PROPERTIES 审中-公开
标题翻译：生物医学植物表面与生物特性
公开(公告)号：WO2003072156A1
公开(公告)日：2003-09-04
申请号：PCT/CH2002/000125
申请日：2002-02-28
申请人： EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH OBERFLÄCHENTECHNIK , SIMPSON, James, P. , DENZER, Alain, J. , BOYAN, Barbara, D. , SCHWARTZ, Zvi, D. , TOSATTI, Samuele , SPENCER, Nicholas, D. , TEXTOR, Marcus
发明人： SIMPSON, James, P. , DENZER, Alain, J. , BOYAN, Barbara, D. , SCHWARTZ, Zvi, D. , TOSATTI, Samuele , SPENCER, Nicholas, D. , TEXTOR, Marcus
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , C08L101/02
摘要： The invention relates to a device with a surface covered by a thin film or monolayer of a poly (ethylene glycol)-grafted copolymer exhibiting osteogenic properties, defined in an osteoblastic cell culture test as a surface that increases the expression of growth factor TFG-β1, the expression of hormone PGE 2 and/or the expression of mineralization marker osteocalcin by at least a factor of 2 in comparison to the corresponding control surface consisting of either unmodified substrate surface or of tissue-culture polystyrene (TCPS).
摘要翻译：本发明涉及一种具有表面覆盖的表面的器件，其表现出成骨细胞培养试验中定义的表现成骨形成特性的聚（乙二醇）移植共聚物的薄膜或单层，作为增加生长因子TFG-β1的表达的表面，与由未修饰的底物表面或组织培养聚苯乙烯（TCPS）组成的相应的对照表面相比，激素PGE2的表达和/或矿化标记骨钙素的表达至少为2倍。

2. 发明申请

WO2003089551A3 ENVIRONMENTALLY COMPATIBLE ADDITIVES FOR AQUEOUS LUBRICANTS 审中-公开
公开(公告)号：WO2003089551A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011868
申请日：2003-04-15
申请人： EIDGENOSSISCH TECHNISCHE HOCHSCHULE ZURICH , SPENCER, Nicholas, D. , LEE, Seunghwan
发明人： SPENCER, Nicholas, D. , LEE, Seunghwan
IPC分类号： B05D1/00
摘要： Lubricating compositions, containing non-modified and modified multifunctional, polyionic copolymers and an aqueous lubricating medium, and methods for making and using such compositions are described herein. The lubricating compositions are applied to metal oxide surfaces, which are in contact with each other. The copolymers can serve as a surface protective boundary layer for the sliding surfaces, or they can also be used for the immobilization of further molecules, which can modify the tribological properties of the surfaces.

3. 发明申请

WO2012152512A1 LUBRICATION WITH OIL-COMPATIBLE POLYMER BRUSHES 审中-公开
标题翻译：润滑与油相容的聚合物刷
公开(公告)号：WO2012152512A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/056070
申请日：2012-04-03
申请人： THE SWATCH GROUP RESEARCH AND DEVELOPMENT LTD , BIELECKI, Robert, M. , BENETTI, Edmondo, M. , SPENCER, Nicholas, D.
发明人： BIELECKI, Robert, M. , BENETTI, Edmondo, M. , SPENCER, Nicholas, D.
IPC分类号： C10M107/28 , C10M177/00 , C09D133/08 , C09D133/10 , C08J7/04 , C10N50/00 , C10N70/00
CPC分类号： C10M107/28 , C09D133/08 , C10M177/00 , C10M2203/0206 , C10M2203/065 , C10M2207/0406 , C10M2207/2805 , C10M2207/401 , C10M2209/0845 , C10N2250/121 , C10N2270/00
摘要： A polymer-brush-based, surface-modification strategy for friction and wear réduction in hard contact under boundary-lubrication conditions is proposed, specifically for a non-aqueous environment. Surface-initiated Atom Transfer Radical Polymérisation (SI-ATRP) was employed for the synthesis of three différent oil-compatible, hydrophobic polymer brushes based on alkyl methacrylates. This study présents polymérisation kinetics, chemical characterization by means of Fourier transform infrared spectroscopy (FTIR) and surface morphologies observed in atomic force microscopy (AFM). The lubrication properties of the anchored polymers were evaluated macroscopically by means of ball-on-disk methods and on the nanonewton scale by latéral force microscopy (AFM/LFM) and showed significant réduction in friction up to contact pressures as high as 460 MPa. The frictional response of surface-grafted polymers is shown to dépend strongly on the compatibility of the polymer with the chosen lubricating fluid. Their good tribological performances have also been proven with watchmaking lubricants. Thèse results do make the prevent invention a suitable candidate for a watchmaking application (such as at the balance pivot or the escapement) in order to increase the efficiency and reliability of the movements.
摘要翻译：提出了一种基于聚合物刷的表面改性策略，用于在边界润滑条件下硬接触的摩擦和磨损磨损，特别是针对非水环境。表面引发的原子转移自由基聚合（SI-ATRP）用于合成基于甲基丙烯酸烷基酯的三种不同油相容的疏水性聚合物刷。本研究通过傅里叶变换红外光谱（FTIR）和原子力显微镜（AFM）中观察到的表面形态进行聚合动力学，化学表征。锚固聚合物的润滑性能通过球盘式方法和纳米级尺度通过拉力显微镜（AFM / LFM）进行宏观评估，并显示高达460MPa的接触压力下摩擦力的显着变化。显示表面接枝聚合物的摩擦响应强烈地反映了聚合物与所选择的润滑流体的相容性。他们的良好的摩擦学性能也被制表润滑剂证明。 Thèse的结果使得防止发明成为制表应用（例如平衡枢轴或擒纵机构）的合适候选者，以便提高运动的效率和可靠性。

4. 发明申请

WO2005002743A1 CONTROLLED SURFACE-CHEMICAL GRADIENTS 审中-公开
标题翻译：控制表面化学级
公开(公告)号：WO2005002743A1
公开(公告)日：2005-01-13
申请号：PCT/US2004/009949
申请日：2004-03-31
申请人： EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH , SPENCER, Nicholas, D. , MORGENTHALER, Sara, Maria , LEE, Seunghwan
发明人： SPENCER, Nicholas, D. , MORGENTHALER, Sara, Maria , LEE, Seunghwan
IPC分类号： B05D1/18
CPC分类号： B82Y30/00 , B01L3/5088 , B05D1/283 , B05D5/00 , B82Y40/00 , G01N13/02 , G01N33/5005 , G01N33/5029 , G01N33/52 , G01N2610/00
摘要： A simple and reproducible preparative method for the fabrication of surface-chemical gradients is described herein. Surface-chemical gradient films are prepared by using a liquid front in relative motion to the substrate (e.g. immersion by a linear-motion drive or the use of a spreading droplet) to gradually expose substrate samples to very dilute solutions of adsorbates. As demonstrated by XPS, the self: assembled monolayer gradients produced in this way display a high packing density. This method can be used in the preparation of other gradients of various chemical or biochemical functionalities in one or two dimensions. Such gradients can be used in a wide variety of applications in such diverse areas as cell motility studies, nanotribology research, and high-throughput screening.
摘要翻译：本文描述了用于制造表面化学梯度的简单且可重现的制备方法。通过使用与基底相对运动的液体前沿（例如通过线性运动驱动的浸入或使用扩散液滴）来制备表面化学梯度膜，以逐渐将底物样品暴露于非常稀的吸附物溶液。如XPS所证明的，以这种方式生产的自组装单层梯度显示出高的堆积密度。该方法可用于制备一维或二维各种化学或生物化学功能的其他梯度。这种梯度可以用于各种领域，例如细胞运动性研究，纳米技术研究和高通量筛选。

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