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1. 发明申请

WO2009056582A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2009056582A1
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064700
申请日：2008-10-30
申请人： GLAXO GROUP LIMITED , GAIBA, Alessandra , ROOMANS, Susan , SWARBRICK, Martin, Edward
发明人： GAIBA, Alessandra , ROOMANS, Susan , SWARBRICK, Martin, Edward
IPC分类号： C07C235/46 , C07D213/80 , C07D257/04 , A61K31/166 , A61K31/41 , A61K31/44 , A61K31/455 , A61P29/00 , A61P19/08 , A61P25/28 , A61P13/12 , A61P37/00 , C07C235/52
CPC分类号： C07C235/52 , C07D213/30 , C07D213/80 , C07D257/04
摘要： A compound of formula (I) or salts thereof, wherein R 1 , R 2 , R 3 , R 4 , n and X are as defined in the specification; a process for preparing such compounds, a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其盐，其中R1，R2，R3，R4，n和X如说明书中所定义; 制备这些化合物的方法，包含这些化合物的药物组合物; 并在药物中使用这些化合物。

2. 发明申请

WO2009147165A1 NOVEL EP4 RECEPTOR AGONIST COMPOUNDS 审中-公开
标题翻译：新EP4受体激动剂化合物
公开(公告)号：WO2009147165A1
公开(公告)日：2009-12-10
申请号：PCT/EP2009/056789
申请日：2009-06-03
申请人： GLAXO GROUP LIMITED , GAIBA, Alessandra , HEALY, Mark, Patrick , PRICE, Helen, Susanne , STANWAY, Steven, James , SWARBRICK, Martin, Edward
发明人： GAIBA, Alessandra , HEALY, Mark, Patrick , PRICE, Helen, Susanne , STANWAY, Steven, James , SWARBRICK, Martin, Edward
IPC分类号： C07C235/64 , C07C237/40 , A61K31/192 , A61K31/196 , A61P19/08
CPC分类号： C07C235/64 , C07C237/40
摘要： A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：选自：（3-氯-4 - {[（5-氯-2 - {[（2-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸的化合物。 {4 - [（{5-氯-2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; {3-氯-4 - [（{5-氯-2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （3-氯-4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸; {4 - [（{2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基} -2-氟苯基）乙酸; {3-氯-4 - [（{2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （3-氯-4 - {[（2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸 {4 - [（{2-氯-6 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（2-氯-6 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸; {4 - [（{5-氯-2 - [（苯基甲基）氨基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氨基}苯基）羰基]氨基}苯基）乙酸; 和（4 - {[（5-氯-2 - {[（2-氯苯基）甲基]氨基}苯基）羰基]氨基}苯基）乙酸或其药学上可接受的盐，包含这些化合物的药物组合物和药物中的这种化合物。

3. 发明申请

WO2008071736A1 BENZAMIDE DERIVATIVES AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译：苯扎林衍生物作为EP4受体激动剂
公开(公告)号：WO2008071736A1
公开(公告)日：2008-06-19
申请号：PCT/EP2007/063796
申请日：2007-12-12
申请人： GLAXO GROUP LIMITED , GAIBA, Alessandra , HEALY, Mark, Patrick , JOHNSON, Christopher, Norbert , ROOMANS, Susan , STANWAY, Steven, James , SWARBRICK, Martin, Edward
发明人： GAIBA, Alessandra , HEALY, Mark, Patrick , JOHNSON, Christopher, Norbert , ROOMANS, Susan , STANWAY, Steven, James , SWARBRICK, Martin, Edward
IPC分类号： A61K31/167 , C07C235/56 , A61P19/00 , A61P25/00
CPC分类号： C07C235/56
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 , R 2 , R 3 , R 4 , R 5 , m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，R 3， 4，R 5，m，n和X如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

4. 发明申请

WO2008020055A1 NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译：新的ISOINDOL衍生物作为EP4受体激动剂
公开(公告)号：WO2008020055A1
公开(公告)日：2008-02-21
申请号：PCT/EP2007/058514
申请日：2007-08-16
申请人： GLAXO GROUP LIMITED , GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , LIVERMORE, David George , PRICE, Helen Susanne , SWARBRICK, Martin Edward
发明人： GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , LIVERMORE, David George , PRICE, Helen Susanne , SWARBRICK, Martin Edward
IPC分类号： C07D209/46 , C07D209/48 , A61K31/4035 , A61P25/00
CPC分类号： C07D209/46 , C07D209/48
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 , R 2 , R 3 , R 4 and R 5 , X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，R 3， 4和R 5，X和Y如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

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