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    • 2. 发明申请
    • NOVEL EP4 RECEPTOR AGONIST COMPOUNDS
    • 新EP4受体激动剂化合物
    • WO2009147165A1
    • 2009-12-10
    • PCT/EP2009/056789
    • 2009-06-03
    • GLAXO GROUP LIMITEDGAIBA, AlessandraHEALY, Mark, PatrickPRICE, Helen, SusanneSTANWAY, Steven, JamesSWARBRICK, Martin, Edward
    • GAIBA, AlessandraHEALY, Mark, PatrickPRICE, Helen, SusanneSTANWAY, Steven, JamesSWARBRICK, Martin, Edward
    • C07C235/64C07C237/40A61K31/192A61K31/196A61P19/08
    • C07C235/64C07C237/40
    • A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    • 选自:(3-氯-4 - {[(5-氯-2 - {[(2-氯苯基)甲基]氧基}苯基)羰基]氨基}苯基)乙酸的化合物。 {4 - [({5-氯-2 - [(苯基甲基)氧基]苯基}羰基)氨基]苯基}乙酸; {3-氯-4 - [({5-氯-2 - [(苯基甲基)氧基]苯基}羰基)氨基]苯基}乙酸; (3-氯-4 - {[(5-氯-2 - {[(3-氯苯基)甲基]氧基}苯基)羰基]氨基}苯基)乙酸; {4 - [({2 - [(苯基甲基)氧基]苯基}羰基)氨基]苯基}乙酸; (4 - {[(5-氯-2 - {[(3-氯苯基)甲基]氧基}苯基)羰基]氨基} -2-氟苯基)乙酸; {3-氯-4 - [({2 - [(苯基甲基)氧基]苯基}羰基)氨基]苯基}乙酸; (3-氯-4 - {[(2 - {[(3-氯苯基)甲基]氧基}苯基)羰基]氨基}苯基)乙酸 {4 - [({2-氯-6 - [(苯基甲基)氧基]苯基}羰基)氨基]苯基}乙酸; (4 - {[(2-氯-6 - {[(3-氯苯基)甲基]氧基}苯基)羰基]氨基}苯基)乙酸; {4 - [({5-氯-2 - [(苯基甲基)氨基]苯基}羰基)氨基]苯基}乙酸; (4 - {[(5-氯-2 - {[(3-氯苯基)甲基]氨基}苯基)羰基]氨基}苯基)乙酸; 和(4 - {[(5-氯-2 - {[(2-氯苯基)甲基]氨基}苯基)羰基]氨基}苯基)乙酸或其药学上可接受的盐,包含这些化合物的药物组合物和 药物中的这种化合物。