会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明申请
    • BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR
    • BENZO'F!具有对EP4受体的亲和力的ISOINDOLE衍生物
    • WO2002064564A1
    • 2002-08-22
    • PCT/GB2002/000522
    • 2002-02-07
    • GLAXO GROUP LIMITEDCONGREVE, Miles, StuartGIBLIN, Gerard, Martin, PaulMASON, Andrew, McMurtrieMILLER, Neil, DerekROOMANS, SusanWALKER, Ann, Louise
    • CONGREVE, Miles, StuartGIBLIN, Gerard, Martin, PaulMASON, Andrew, McMurtrieMILLER, Neil, DerekROOMANS, SusanWALKER, Ann, Louise
    • C07D209/64
    • C07D209/66C07D209/64
    • A compound of formula (I) wherein R 1 and R 3 are the same or different and represent =O, hydrogen, C 1-6 alkyl, C 1-6 dialkyl, =CHC 1 -C 5 alkyl, =S, or a 5- or 6-membered anyl; R 4 to R 9 are the same or different and represent hydrogen, C 1-6 alkoxy, OCF 3 , OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, C 1 -C 6 alkyl, S-alkyl, NR 2 10¿ where R 10 is hydrogen or C 1-6 alkyl, halogen, NO 2 , OH, CH 2 OC 1 -C 6 alkly, CH 2 OH, or CF 3 ; Q 1 is hydrogen, C 1-6 alkyl, C 1-6 dialkyl, C 1-6 alkoxy, NHAc, NR 2 10¿ where R 10 is hydrogen is hydrogen or C 1-6 alkyl, difluoro, fluoro, =O, or OH; Q 2 , Q 3 , Q 4 and Q 5 are the same or different and represent hydrogen, C 1-6 alkoxy, OCF 3 , OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, C 1 -C 6 alkyl, S-alkyl, NR 2 10¿ where R 10 is hydrogen or C 1-6 alkyl, halogen, NO 2 , OH, CH 2 OC 1 -C 6 alkyl, CH 2 OH, or a 5-or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof.
    • 式(I)化合物,其中R 1和R 3相同或不同,表示= O,氢,C 1-6烷基,C 1-6二烷基,= CHCl-C 5烷基,= S或5-或 6元芳基; R 4至R 9相同或不同,表示氢,C 1-6烷氧基,OCF 3,OCH 2 CF 3,O-环丙基,OCH 2 - 环丙基,C 1 -C 6烷基,S-烷基,NR 2 10,其中R 10为氢或C1- 6烷基,卤素,NO 2,OH,CH 2 OC 1 -C 6烷基,CH 2 OH或CF 3; Q 1是氢,C 1-6烷基,C 1-6二烷基,C 1-6烷氧基,NHAc,NR 2 10,其中R 10是氢或C 1-6烷基,二氟,氟,= O或OH; Q 2,Q 3,Q 4和Q 5相同或不同,表示氢,C 1-6烷氧基,OCF 3,OCH 2 CF 3,O-环丙基,OCH 2 - 环丙基,C 1 -C 6烷基, 烷基,NR210,其中R10是氢或C1-6烷基,卤素,NO2,OH,CH2OC1-C6烷基,CH2OH或5-或6-元芳基; 条件是化合物[4-(1-氧代-1,3-二氢-2H-苯并[f]异吲哚-2-基)苯基] -2-丙酸钠盐和[4-(4,9 - 二乙氧基-1-氧代-1,3-二氢-2H-苯并[f]异吲哚-2-基)苯基]乙酸; 及其药学上可接受的衍生物。