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1. 发明申请

WO2006015358A3 AQUEOUS SUSPENSION OF NANOSCALE DRUG PARTICLES FROM SUPERCRITICAL FLUID PROCESSING 审中-公开
标题翻译：超临界流体工艺处理纳米级药物悬浮液的研究
公开(公告)号：WO2006015358A3
公开(公告)日：2006-12-07
申请号：PCT/US2005027508
申请日：2005-08-03
申请人： UNIV CLEMSON , SUN YA-PING
发明人： SUN YA-PING
IPC分类号： A61K9/14 , B29B9/00
CPC分类号： A61K9/5138 , A61K9/10 , A61K9/5192
摘要： The present invention is directed to an improved supercritical fluid processing technique that can be used to form particulate suspensions of biologically useful materials. The disclosed processes include variations of RESS processes. The disclosed processes do not form micelles of any stabilizing agents in the aqueous solution that receives the product materials following rapid expansion through a nozzle. In particular, stabilizing agents in the aqueous solution are either materials that will not form micelles in aqueous environments, or else they are materials that can form micelles, but are utilized at conditions that are insufficient for the formation of micelles or at least not suitable for any significant presence of micelles in the product. Through utilization of the disclosed process, particulate suspensions can be formed exclusively of very small particles, for example, particulate suspensions in which all of the particles formed are less than 100 nm in size. Moreover, the product suspension of particles can be very homogeneous, with particle size distribution standard deviations of less than about 15 nm.
摘要翻译：本发明涉及可用于形成生物有用材料的颗粒悬浮液的改进的超临界流体处理技术。所公开的过程包括RESS过程的变体。所公开的方法不会在通过喷嘴快速膨胀后接收产品材料的水溶液中形成任何稳定剂的胶束。特别地，水溶液中的稳定剂是在水环境中不会形成胶束的物质，或者它们是可以形成胶束的物质，但是在不足以形成胶束的条件下使用或者至少不适用于产品中胶束的任何显着存在。通过利用所公开的方法，颗粒悬浮液可以仅由非常小的颗粒形成，例如，其中形成的所有颗粒尺寸均小于100nm的颗粒悬浮液。此外，颗粒的产物悬浮液可以是非常均匀的，其粒度分布标准偏差小于约15nm。

2. 发明申请

WO2006015358A2 AQUEOUS SUSPENSION OF NANOSCALE DRUG PARTICLES FROM SUPERCRITICAL FLUID PROCESSING 审中-公开
标题翻译：来自超临界流体加工的纳米级药物颗粒的悬浮液
公开(公告)号：WO2006015358A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027508
申请日：2005-08-03
申请人： CLEMSON UNIVERSITY , SUN, Ya-Ping
发明人： SUN, Ya-Ping
IPC分类号： A61K9/14
CPC分类号： A61K9/5138 , A61K9/10 , A61K9/5192
摘要： The present invention is directed to an improved supercritical fluid processing technique that can be used to form particulate suspensions of biologically useful materials. The disclosed processes include variations of RESS processes. The disclosed processes do not form micelles of any stabilizing agents in the aqueous solution that receives the product materials following rapid expansion through a nozzle. In particular, stabilizing agents in the aqueous solution are either materials that will not form micelles in aqueous environments, or else they are materials that can form micelles, but are utilized at conditions that are insufficient for the formation of micelles or at least not suitable for any significant presence of micelles in the product. Through utilization of the disclosed process, particulate suspensions can be formed exclusively of very small particles, for example, particulate suspensions in which all of the particles formed are less than 100 nm in size. Moreover, the product suspension of particles can be very homogeneous, with particle size distribution standard deviations of less than about 15 nm.
摘要翻译：本发明涉及可用于形成生物有用材料的微粒悬浮液的改进的超临界流体处理技术。所公开的过程包括RESS过程的变化。所公开的方法不会在通过喷嘴快速膨胀之后接收产品材料的水溶液中的任何稳定剂的胶束。特别地，水溶液中的稳定剂是在水性环境中不会形成胶束的材料，或者它们是可以形成胶束的材料，但是在不足以形成胶束的条件下使用或至少不适合于产品中胶束的任何显着存在。通过利用所公开的方法，颗粒悬浮液可以仅由非常小的颗粒形成，例如其中形成的所有颗粒的尺寸小于100nm的颗粒悬浮液。此外，颗粒的产物悬浮液可以非常均匀，粒度分布标准偏差小于约15nm。

3. 发明申请

WO2005030126A3 ADHESIN-SPECIFIC NANOPARTICLES AND PROCESS FOR USING SAME 审中-公开
标题翻译：粘蛋白特异性纳米粒子及其使用方法
公开(公告)号：WO2005030126A3
公开(公告)日：2005-07-28
申请号：PCT/US2004030090
申请日：2004-09-13
申请人： UNIV CLEMSON , STUTZENBERGER FRED J , LATOUR JR ROBERT A , SUN YA-PING , TZENG TZUEN R
发明人： STUTZENBERGER FRED J , LATOUR JR ROBERT A , SUN YA-PING , TZENG TZUEN R
IPC分类号： A61K20060101 , A61K9/51 , A61K38/00
CPC分类号： A61K41/0009 , A61K47/549 , A61K47/62 , A61K47/6933 , B82Y5/00
摘要： The present invention is generally directed to compositions useful in preventing and/or treating disease due to infection by any of a variety of biologically active pathogenic microorganisms. The compositions include nanoparticles formed of a hydrophobic polymeric core, hydrophilic linking agents bound to the core, and biofunctional materials bound to the linking agents. The biofunctional materials are functionally identical to receptors on host cell surfaces that can be recognized and bound by adhesins on the surface of the targeted pathogenic adhesin-bearing microorganisms. In one embodiment, the binding action between the nanoparticles and the microorganisms can lead to the formation of large agglomerated complexes, which can then be easily removed from an area, including the digestive tract of an infected individual. The compositions of the present invention can also be utilized in preventing enteric infections via the ability to purge animals of enteropathogens prior to transport and processing for human consumption.
摘要翻译：本发明一般涉及可用于预防和/或治疗由于各种生物活性致病微生物中的任何一种感染引起的疾病的组合物。组合物包括由疏水性聚合物核心形成的纳米颗粒，与核心结合的亲水连接剂和与连接剂结合的生物功能材料。生物功能材料与宿主细胞表面上的受体功能上相同，其可以被靶向致病性粘附素微生物的表面上的粘附素识别和结合。在一个实施方案中，纳米颗粒和微生物之间的结合作用可导致形成大的附聚复合物，其可以容易地从包括感染个体的消化道的区域中去除。本发明的组合物还可用于通过在运输和处理人类消费之前清除肠道病原体的动物来预防肠道感染。

4. 发明申请

WO2007050984A3 FLUORESCENT CARBON NANOPARTICLES 审中-公开
标题翻译：荧光碳纳米粒子
公开(公告)号：WO2007050984A3
公开(公告)日：2007-08-02
申请号：PCT/US2006042233
申请日：2006-10-27
申请人： UNIV CLEMSON , SUN YA-PING
发明人： SUN YA-PING
IPC分类号： C09K11/65 , G01N33/551
CPC分类号： C09K11/025 , C01B32/05 , G01N33/587 , Y10S977/70 , Y10S977/702 , Y10S977/703 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.
摘要翻译：公开的是光致发光粒子。颗粒包括核心纳米尺寸的碳颗粒和结合到纳米颗粒表面的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以衍生用于特定的应用。例如，光致发光碳纳米颗粒可被衍生化以识别并结合目标材料，例如生物活性材料，污染物或组织或细胞表面上的表面受体，例如在标签或染色方案中。

5. 发明申请

WO2007050984A2 FLUORESCENT CARBON NANOPARTICLES 审中-公开
标题翻译：荧光碳纳米管
公开(公告)号：WO2007050984A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042233
申请日：2006-10-27
申请人： CLEMSON UNIVERSITY , SUN, Ya-Ping
发明人： SUN, Ya-Ping
IPC分类号： C09K9/02
CPC分类号： C09K11/025 , C01B32/05 , C09K11/65 , G01N33/587 , Y10S977/70 , Y10S977/702 , Y10S977/703 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.
摘要翻译：披露的是光致发光颗粒。颗粒包括核心纳米尺寸的碳颗粒和与纳米颗粒表面结合的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以为特定应用衍生化。例如，可以将光致发光碳纳米颗粒衍生化以识别和结合目标材料，例如组织或细胞表面上的生物活性材料，污染物或表面受体，例如标记或染色方案。

6. 发明申请

WO2009009630A1 PHOTOLUMINESCENT MATERIALS FOR MULTIPHOTON IMAGING 审中-公开
标题翻译：用于多光子成像的光致发光材料
公开(公告)号：WO2009009630A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069585
申请日：2008-07-10
申请人： CLEMSON UNIVERSITY , SUN, Ya-Ping
发明人： SUN, Ya-Ping
IPC分类号： F21V9/16 , G01J1/58 , G01T1/10 , G21H3/02
CPC分类号： G01J1/58 , B82Y15/00 , G01N21/6428 , G01N21/6458
摘要： Disclosed are nano-sized materials that can exhibit luminescence in a multi-photon imaging technique. The materials include a nano-sized particle or a carbon nanotube and a passivation agent bound to the surface of the nanoparticle or nanotube. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the luminescent materials can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol. The materials exhibit strong luminescence with multi-photon excitation in the near infrared.
摘要翻译：公开了可以在多光子成像技术中显示发光的纳米尺寸的材料。该材料包括纳米尺寸颗粒或碳纳米管以及与纳米颗粒或纳米管表面结合的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以为特定应用衍生化。例如，发光材料可以被衍生化以识别和结合靶标材料，例如组织或细胞表面上的生物活性材料，污染物或表面受体，例如标记或染色方案。该材料在近红外线中表现出强光发射与多光子激发。

7. 发明申请

WO2005069789A3 PROCESS FOR SEPARATING METALLIC FROM SEMICONDUCTING SINGLE-WALLED CARBON NANOTUBES 审中-公开
标题翻译：从半导体单壁碳纳米管分离金属的工艺
公开(公告)号：WO2005069789A3
公开(公告)日：2006-02-02
申请号：PCT/US2004042412
申请日：2004-12-16
申请人： UNIV CLEMSON , SUN YA-PING
发明人： SUN YA-PING
IPC分类号： C01B31/02 , B01D11/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/172 , C01B2202/02 , C01B2202/22 , Y10S977/751 , Y10S977/845 , Y10T436/255
摘要： A method for separating semiconducting single-walled carbon nanotubes from metallic single-walled carbon nanotubes is disclosed. The method utilizes separation agents that preferentially associate with semiconducting nanotubes due to the electrical nature of the nanotubes. The separation agents are those that have a planar orientation, p-electrons available for association with the surface of the nanotubes, and also include a soluble portion of the molecule. Following preferential association of the separation agent with the semiconducting nanotubes, the agent/nanotubes complex is soluble and can be solubilized with the solution enriched in semiconducting nanotubes while the residual solid is enriched in metallic nanotubes.
摘要翻译：公开了一种从金属单壁碳纳米管分离半导体单壁碳纳米管的方法。该方法利用由于纳米管的电性质优先与半导体纳米管缔合的分离剂。分离剂是具有平面取向的分离剂，可用于与纳米管表面缔合的p-电子，并且还包括分子的可溶部分。随着分离剂与半导体纳米管的优先结合，试剂/纳米管复合物是可溶的，并且可以用富含半导体纳米管的溶液溶解，同时残留的固体富含金属纳米管。

8. 发明申请

WO2005069789A2 PROCESS FOR SEPARATING METALLIC FROM SEMICONDUCTING SINGLE-WALLED CARBON NANOTUBES 审中-公开
标题翻译：从半导体单壁碳纳米管分离金属的工艺
公开(公告)号：WO2005069789A2
公开(公告)日：2005-08-04
申请号：PCT/US2004/042412
申请日：2004-12-16
申请人： CLEMSON UNIVERSITY , SUN, Ya-Ping
发明人： SUN, Ya-Ping
IPC分类号： C01B31/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/172 , C01B2202/02 , C01B2202/22 , Y10S977/751 , Y10S977/845 , Y10T436/255
摘要： A method for separating semiconducting single-walled carbon nanotubes from metallic single-walled carbon nanotubes is disclosed. The method utilizes separation agents that preferentially associate with semiconducting nanotubes due to the electrical nature of the nanotubes. The separation agents are those that have a planar orientation, p-electrons available for association with the surface of the nanotubes, and also include a soluble portion of the molecule. Following preferential association of the separation agent with the semiconducting nanotubes, the agent/nanotubes complex is soluble and can be solubilized with the solution enriched in semiconducting nanotubes while the residual solid is enriched in metallic nanotubes.
摘要翻译：公开了一种从金属单壁碳纳米管分离半导体单壁碳纳米管的方法。该方法利用由于纳米管的电性质优先与半导体纳米管缔合的分离剂。分离剂是具有平面取向的分离剂，可用于与纳米管表面缔合的p-电子，并且还包括分子的可溶部分。随着分离剂与半导体纳米管的优先结合，试剂/纳米管复合物是可溶的，并且可以用富含半导体纳米管的溶液溶解，同时残留的固体富含金属纳米管。

9. 发明申请

WO2005030126A2 ADHESIN-SPECIFIC NANOPARTICLES AND PROCESS FOR USING SAME 审中-公开
标题翻译：粘蛋白特异性纳米颗粒及其使用方法
公开(公告)号：WO2005030126A2
公开(公告)日：2005-04-07
申请号：PCT/US2004/030090
申请日：2004-09-13
申请人： CLEMSON UNIVERSITY , STUTZENBERGER, Fred, J. , LATOUR, JR., Robert, A. , SUN, Ya-Ping , TZENG, Tzuen, R.
发明人： STUTZENBERGER, Fred, J. , LATOUR, JR., Robert, A. , SUN, Ya-Ping , TZENG, Tzuen, R.
IPC分类号： A61K
CPC分类号： A61K41/0009 , A61K47/549 , A61K47/62 , A61K47/6933 , B82Y5/00
摘要： The present invention is generally directed to compositions useful in preventing and/or treating disease due to infection by any of a variety of biologically active pathogenic microorganisms. The compositions include nanoparticles formed of a hydrophobic polymeric core, hydrophilic linking agents bound to the core, and biofunctional materials bound to the linking agents. The biofunctional materials are functionally identical to receptors on host cell surfaces that can be recognized and bound by adhesins on the surface of the targeted pathogenic adhesin-bearing microorganisms. In one embodiment, the binding action between the nanoparticles and the microorganisms can lead to the formation of large agglomerated complexes, which can then be easily removed from an area, including the digestive tract of an infected individual. The compositions of the present invention can also be utilized in preventing enteric infections via the ability to purge animals of enteropathogens prior to transport and processing for human consumption.
摘要翻译：本发明一般涉及用于预防和/或治疗由任何各种生物活性致病微生物感染引起的疾病的组合物。该组合物包括由疏水性聚合物核形成的纳米颗粒，与核结合的亲水性连接剂和与连接剂结合的生物功能材料。生物功能材料在功能上与宿主细胞表面上的受体相同，所述受体可以被目标致病粘附素携带微生物表面上的粘附素识别和结合。在一个实施方案中，纳米颗粒和微生物之间的结合作用可以导致形成大的附聚复合物，其然后可以容易地从包括受感染个体的消化道的区域移除。本发明的组合物还可用于预防肠道感染，其通过在运输和处理人类消费之前清除肠道病原体动物的能力。

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