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1. 发明申请

WO2006012192A8 TWO-STAGE STENT-GRAFT AND METHOD OF DELIVERING SAME 审中-公开
标题翻译：两级钢丝绳及其交付方法
公开(公告)号：WO2006012192A8
公开(公告)日：2006-03-02
申请号：PCT/US2005022222
申请日：2005-06-22
申请人： SCIMED LIFE SYSTEMS INC , SOWINSKI KRZYSZTOF , RAKOS RONALD , KUJAWSKI DENNIS , NAZZARO PATRICE K
发明人： SOWINSKI KRZYSZTOF , RAKOS RONALD , KUJAWSKI DENNIS , NAZZARO PATRICE K
IPC分类号： A61F2/06 , A61F2/84
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/9505 , A61F2002/9511 , A61F2230/0054
摘要： A stent-graft (26) is provided for defining a prosthetic fluid passage within a body lumen (L). The stent-graft includes a graft (12) having a forward section (14), and a pilot stent (16) located within the forward section of the graft. The pilot stent has an expanded diameter less than that of a lumen in which it is to be deployed to permit fluid flow within the lumen during deployment of the stent-graft. Means are provided for subsequently expanding the pilot stent and the graft to the full diameter of the lumen.
摘要翻译：提供了一种用于限定体腔（L）内的假体流体通道的支架移植物（26）。支架移植物包括具有前部（14）的移植物（12）和位于移植物的前部中的先导支架（16）。导管支架的扩张直径小于内窥镜的扩张直径，其中其将被部署以在展开支架移植物期间允许流体在腔内流动。提供了用于随后将导管支架和移植物扩大到管腔的整个直径的装置。

2. 发明申请

WO2006012192A1 TWO-STAGE STENT-GRAFT AND METHOD OF DELIVERING SAME 审中-公开
标题翻译：两阶段钢丝绳及其交付方法
公开(公告)号：WO2006012192A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/022222
申请日：2005-06-22
申请人： SCIMED LIFE SYSTEMS, INC , SOWINSKI, Krzysztof , RAKOS, Ronald , KUJAWSKI, Dennis , NAZZARO, Patrice, K.
发明人： SOWINSKI, Krzysztof , RAKOS, Ronald , KUJAWSKI, Dennis , NAZZARO, Patrice, K.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/9505 , A61F2002/9511 , A61F2230/0054
摘要： A stent-graft is provided for defining a prosthetic fluid passage within a body lumen. The stint-graft includes a graft having a forward section (14), and a pilot stent (16) located within the forward section of the graft. The pilot stent has an expanded diameter less than that of a lumen in which it is to be deployed to permit fluid flow within the lumen during deployment of the stent-graft. Means are provided for subsequently expanding the pilot stent and the graft to the full diameter of the lumen.
摘要翻译：提供了一种用于在体腔内限定假体流体通道的支架移植物。胫骨移植物包括具有前部（14）的移植物和位于移植物的前部内的先导支架（16）。导管支架的扩张直径小于其部署以在展开支架移植物期间允许流体在腔内流动的内腔的直径。提供了用于随后将导管支架和移植物扩大到管腔的整个直径的装置。

3. 发明申请

WO2006031660A1 HIGH STRETCH, LOW DILATION KNIT PROSTHETIC DEVICE AND METHOD FOR MAKING THE SAME 审中-公开
标题翻译：高拉伸，低伸缩编织前置装置及其制造方法
公开(公告)号：WO2006031660A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032248
申请日：2005-09-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , DONG, Jerry, Q. , SPIRIDIGLIOZZI, John , RAKOS, Ronald , SOWINSKI, Krzysztof , QUINN, William
发明人： DONG, Jerry, Q. , SPIRIDIGLIOZZI, John , RAKOS, Ronald , SOWINSKI, Krzysztof , QUINN, William
IPC分类号： A61F2/06 , D04B21/00
CPC分类号： A61F2/06 , A61F2/07 , A61F2002/065 , D04B21/205 , D04C1/06 , D10B2403/0333 , D10B2509/06
摘要： A method for providing dilation resistance to an implantable tubular graft includes the steps of (a) providing a graft having opposed open ends and a textile wall extending in a lengthwise direction therebetween defining a graft diameter, wherein the textile wall has radially extending yarns having a radial extent which inter-engage longitudinally extending yarns having a longitudinal extent to define a textile pattern and further wherein the radially extending yarns are obliquely oriented to the lengthwise direction of the graft, thereby defining a first acute angle from the lengthwise direction of the graft; (b) providing an elongate tubular mandrel having a diameter which differs from the graft diameter by a factor of at least 1.5; (c) positioning the graft over the mandrel to radially distend the graft, thereby reorienting the radially extending yarns to reduce the radial extent and to shift the radially extending yarns to a second acute angle from the lengthwise direction of the graft to define an reoriented textile pattern, wherein the second acute angle is greater than the first acute angle; and (d) heat setting the graft at a first temperature to set the inter-engaging yarns in the reoriented textile pattern to provide a graft with improved dilation resistance.
摘要翻译：提供对可植入管状移植物的抗扩张性的方法包括以下步骤：（a）提供具有相对的开放端的移植物和沿其长度方向延伸的织物壁，限定移植物直径，其中织物壁具有径向延伸的纱线，其具有相互接合的纵向延伸的纱线具有纵向延伸以限定纺织品图案，并且其中所述径向延伸的纱线沿着所述移植物的长度方向倾斜地定向，从而从所述移植物的长度方向限定第一锐角; （b）提供具有与移植物直径不同至少1.5倍的直径的细长管状心轴; （c）将移植物定位在心轴上以使移植物径向膨胀，从而使径向延伸的纱线重新定向以减小径向范围并将径向延伸的纱线从移植物的长度方向移动到第二锐角，以限定重新定向的纺织品图案，其中所述第二锐角大于所述第一锐角; 和（d）将移植物热定形在第一温度以将相互接合的纱线设置在重新定向的织物图案中，以提供具有改善的耐扩张性的移植物。

4. 发明申请

WO2006002386A1 IMPLANTABLE PROSTHESIS HAVING REINFORCED ATTACHMENT SITES 审中-公开
标题翻译：具有加固附件站点的可伸缩假设
公开(公告)号：WO2006002386A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/022527
申请日：2005-06-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAKOS, Ronald , SOWINSKI, Krzysztof , KUJAWSKI, Dennis , DONG, Jerry, Q.
发明人： RAKOS, Ronald , SOWINSKI, Krzysztof , KUJAWSKI, Dennis , DONG, Jerry, Q.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2002/072 , A61F2002/075 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0075
摘要： The present invention provides an implantable graft that includes an elongate graft tube (12) having opposing ends defining an attachment site for attaching the graft to a stent (42). The graft further includes a reinforcement member (18) attached adjacent to at least one of the ends of the graft for establishing a reinforced attachment site for the graft, thereby preventing elongation of a suture hole in the material. Furthermore, the present invention provides a graft wherein at least one end of the graft is folded over itself and glued or sutured to itself and/or the stent, thereby forming a reinforcement thereto.
摘要翻译：本发明提供了一种可植入移植物，其包括细长的移植管（12），其具有限定用于将移植物附接到支架（42）的附接位置的相对端。移植物还包括附着在移植物的至少一个端部附近的加强构件（18），用于建立用于移植物的增强的附着部位，从而防止材料中缝合孔的伸长。此外，本发明提供了一种移植物，其中移植物的至少一端自身折叠并且胶合或缝合到自身和/或支架上，从而形成加强物。

5. 发明申请

WO2007041010A1 VARIABLE LAMINATION OF VASCULAR GRAFT 审中-公开
标题翻译：血管碎片的可变层压
公开(公告)号：WO2007041010A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/036841
申请日：2006-09-21
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SOWINSKI, Krzysztof , HENDERSON, Jamie
发明人： SOWINSKI, Krzysztof , HENDERSON, Jamie
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/06 , A61F2250/0018 , A61F2250/0036
摘要： The vascular graft (20) includes a conduit structure (22) having outer and inner wall surfaces . The conduit structure includes a longitudinal central portion having a flexibility. The conduit structure further includes a pair of longitudinal intermediate portions (28) each of which are integral with the central portion (26) and located longitudinally such that the central portion is between the intermediate portions. The intermediate portions each have a flexibility which is less than the flexibility of the central portion.
摘要翻译：血管移植物（20）包括具有外壁和内壁表面的导管结构（22）。导管结构包括具有柔性的纵向中心部分。导管结构还包括一对纵向中间部分（28），每个纵向中间部分（28）与中心部分（26）成一体并且纵向定位，使得中心部分位于中间部分之间。中间部分各自具有小于中心部分的柔性的柔性。

6. 发明申请

WO2006074002A1 METHOD FOR MAKING EPTFE AND STRUCTURE CONTAINING SUCH EPTFE, SUCH AS A VASCULAR GRAFT 审中-公开
标题翻译：用于制造EPTFE和包含这种EPTFE的结构的方法，例如血管片
公开(公告)号：WO2006074002A1
公开(公告)日：2006-07-13
申请号：PCT/US2005/047253
申请日：2005-12-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , DURAN, Julio , SOWINSKI, Krzysztof
发明人： DURAN, Julio , SOWINSKI, Krzysztof
IPC分类号： A61L27/16 , B29C55/26 , A61F2/06
CPC分类号： A61L27/16 , A61F2/07 , A61F2002/075 , B29C55/26 , B29K2027/18 , B29L2031/7534 , Y10T428/1352 , Y10T428/139 , C08L27/18
摘要： A method for making a vascular graft includes providing a PTFE green tube extrudate (12) which is un-sintered, and then initially expanding the un-sintered extrudate (17) to produce an initial node and fibril micro-structure therein. This is followed by heating the extrudate to raise the temperature thereof for a time period of sufficient duration such that the extrudate is partially sintered. The partially sintered extrudate is subsequently expanded (25) to make the vascular graft. The subsequent expansion produces a subsequent node and fibril microstructure in the vascular graft. An alternative method for making a vascular graft includes providing a PTFE green tube extrudate which is un-sintered, longitudinally expanding the unsintered extrudate to form an ePTFE tube structure, and radially expanding the un-sintered ePTFE tube structure. ePTFE made according to the method is fabricated into various structures, such as tube structures, filament structures, and sheet structures.
摘要翻译：制造血管移植物的方法包括提供未烧结的PTFE绿色管挤出物（12），然后最初膨胀未烧结的挤出物（17）以在其中产生初始节点和原纤维微结构。然后加热挤出物以使其温度持续足够的时间以使挤出物部分烧结。随后将部分烧结的挤出物膨胀（25）以制备血管移植物。随后的扩张在血管移植物中产生后续的节点和原纤维微结构。制备血管移植物的替代方法包括提供未烧结的PTFE绿色管挤出物，纵向膨胀未烧结的挤出物以形成ePTFE管结构，以及径向膨胀未烧结的ePTFE管结构。根据该方法制成的ePTFE被制成各种结构，例如管结构，细丝结构和片状结构。

7. 发明申请

WO2006071909A1 LOW PROFILE, DURABLE, REINFORCED ePTFE COMPOSITE GRAFT 审中-公开
标题翻译：低配置，耐用，增强的ePTFE复合材料
公开(公告)号：WO2006071909A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/047168
申请日：2005-12-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SOWINSKI, Krzysztof , DONG, Jerry
发明人： SOWINSKI, Krzysztof , DONG, Jerry
IPC分类号： A61F2/06
CPC分类号： A61F2/06
摘要： A composite graft (10) having a first seamless tubular layer (22) including biocompatible first polymeric material and having a luminal surface and an exterior surface; a biocompatible reinforcing member (24) arranged in a pattern to define a second tubular layer (20), the second tubular layer (20) being disposed over the exterior surface of the first tubular layer (22); and a third seamless tubular layer (18) including biocompatible second polymeric material and having a luminal surface and an exterior surface. The luminal surface of the third tubular layer (18) is securably disposed over the second tubular layer (20) and over the first tubular layer (22). The tubular layers (18, 20, 22) define a wall of the graft (10) having a wall thickness of less than 0.1 mm. Desirably, the graft wall thickness is less than 0.05 mm.
摘要翻译：一种复合移植物（10），其具有包括生物相容的第一聚合物材料并具有管腔表面和外表面的第一无缝管状层（22）布置成图案以限定第二管状层（20）的生物相容性加强构件（24），所述第二管状层（20）设置在所述第一管状层（22）的外表面上方。以及包括生物相容的第二聚合物材料并具有腔表面和外表面的第三无缝管状层（18）。第三管状层（18）的管腔表面牢固地设置在第二管状层（20）上并且在第一管状层（22）上方。管状层（18,20,22）限定了壁厚小于0.1mm的移植物（10）的壁。理想地，接枝壁厚度小于0.05mm。

8. 发明申请

WO2005060875A1 PRESSURE LAMINATION METHOD FOR FORMING COMPOSITE ePTFE/TEXTILE AND ePTFE/STENT/TEXTILE PROSTHESES 审中-公开
标题翻译：用于形成复合ePTFE /纺织品和ePTFE / STENT /纺织品的压力层压方法
公开(公告)号：WO2005060875A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/042008
申请日：2004-12-15
申请人： SCIMED LIFE SYSTEMS, INC , RAKOS, Ronald , SOWINSKI, Krzysztof
发明人： RAKOS, Ronald , SOWINSKI, Krzysztof
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61F2/06 , A61F2/07 , A61F2/89 , A61F2002/072 , A61L27/16 , A61L27/48 , A61L31/048 , A61L31/129 , C08L27/18
摘要： A method of forming a composite textile and ePTFE implantable device includes the steps of providing an ePTFE layer; providing a textile layer; applying a coating of an elastomeric bonding agent to one of the surfaces of the ePTFE layer or the textile layer; providing a hollow member having an open end and an opposed closed end defining a fluid passageway therebetween and having a wall portion with at least one hole extending therethrough, the hole being in fluid communication with the fluid passageway; concentrically placing the ePTFE layer and the textile layer onto the hollow member and over the at least one hole of the hollow member, thereby defining a composite assembly; placing the hollow member with the composite assembly within a pressure chamber; applying a pressure differential so that the pressure within the chamber is greater than a pressure within the fluid passageway of the hollow member; and applying heat to the bonding agent to adhesively bond the textile layer and the ePTFE layer to provide a laminated composite assembly.
摘要翻译：一种形成复合织物和ePTFE可植入装置的方法包括提供ePTFE层的步骤; 提供纺织层; 在ePTFE层或织物层的一个表面上施加弹性粘合剂的涂层; 提供具有开口端的中空构件和相对的封闭端，在其间限定流体通道，并且具有壁部分，其中至少有一个孔延伸穿过其中，所述孔与流体通道流体连通; 同心地将ePTFE层和织物层放置在中空构件上并且在中空构件的至少一个孔上方，从而限定复合组件; 将所述中空构件与所述复合组件放置在压力室内; 施加压差使得室内的压力大于中空构件的流体通道内的压力; 并向结合剂施加热量以使织物层和ePTFE层粘合以提供层压复合组件。

9. 发明申请

WO2005115272A3 COMPOSITE MEDICAL TEXTILE MATERIAL AND IMPLANTABLE DEVICES MADE THEREFROM 审中-公开
标题翻译：复合医疗纺织材料和可植入的器械
公开(公告)号：WO2005115272A3
公开(公告)日：2006-01-26
申请号：PCT/US2005013057
申请日：2005-04-18
申请人： BOSTON SCIENT SCIMED INC , RAKOS RONALD , SOWINSKI KRZYSZTOF
发明人： RAKOS RONALD , SOWINSKI KRZYSZTOF
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61F2/90 , A61F2/0063 , A61F2/06 , A61F2/07 , A61F2/88 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2250/0028 , A61F2250/0039 , D04B21/20 , D10B2403/0333 , D10B2509/06
摘要： An implantable composite medical device (10) having a longitudinal length a woven textile portion (26a, b) having yarns interlaced in a woven pattern, a knitted textile portion (24) having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful. A knitted portion with a resiliently longitudinal stretchability from about 5 to about 200 linear percent over its quiescent longitudinal dimension is also useful.
摘要翻译：一种具有纵向长度的可植入复合医疗装置（10），编织织物部分（26a，b）具有以编织图案交织的纱线，编织织物部分（24）具有以编织图案互相连接的纱线。织造和针织部分牢固地附接到一个并且沿着装置的纵向长度提供复合编织和针织织物表面。此外，具有弹性纵向拉伸性的卷曲编织部分在其静态纵向尺寸上为大约10至大约100线性百分比，或者在其静态纵向尺寸上具有小于约10线性百分比的弹性纵向拉伸性的未卷边的编织部分是有用的。在其静态纵向尺寸上具有约5至约200线性百分比的弹性纵向拉伸性的针织部分也是有用的。

10. 发明申请

WO2005115272A2 COMPOSITE MEDICAL TEXTILE MATERIAL AND IMPLANTABLE DEVICES MADE THEREFROM 审中-公开
标题翻译：复合医疗纺织材料和可植入的器械
公开(公告)号：WO2005115272A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/013057
申请日：2005-04-18
申请人： BOSTON SCIENTIFIC SCIMED, INC , RAKOS, Ronald , SOWINSKI, Krzysztof
发明人： RAKOS, Ronald , SOWINSKI, Krzysztof
IPC分类号： A61F2/00
CPC分类号： A61F2/90 , A61F2/0063 , A61F2/06 , A61F2/07 , A61F2/88 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2250/0028 , A61F2250/0039 , D04B21/20 , D10B2403/0333 , D10B2509/06
摘要： An implantable composite medical device having a longitudinal length a woven textile portion having yarns interlaced in a woven pattern, a knitted textile portion having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. The woven portion may have a permeability from about 30 to about 500 m1/min/cm 2 , and the knitted portion may have a permeability from about 30 to about 15,000 m1/min/cm 2 . Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful. A knitted portion with a resiliently longitudinal stretchability from about 5 to about 200 linear percent over its quiescent longitudinal dimension is also useful.
摘要翻译：一种具有纵向长度的可植入复合医疗装置（10），编织织物部分（26a，b）具有以编织图案交织的纱线，编织织物部分（24）具有以编织图案互相连接的纱线。织造和针织部分牢固地附接到一个并且沿着装置的纵向长度提供复合编织和针织织物表面。此外，具有弹性纵向拉伸性的卷曲编织部分在其静态纵向尺寸上为大约10至大约100线性百分比，或者在其静态纵向尺寸上具有小于约10线性百分比的弹性纵向拉伸性的未卷曲的编织部分是有用的。在其静态纵向尺寸上具有约5至约200线性百分比的弹性纵向拉伸性的针织部分也是有用的。

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