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1. 发明申请

WO1998006855A1 COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS TO HEPATOCYTES 审中-公开
标题翻译：用于向细胞核递送核酸的组合物和方法
公开(公告)号：WO1998006855A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014504
申请日：1997-08-15
申请人： THE TEXAS A & M UNIVERSITY SYSTEM , SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , JARVIS, Donald, L. , LANFORD, Robert
发明人： THE TEXAS A & M UNIVERSITY SYSTEM , SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
IPC分类号： C12N15/54
CPC分类号： C07H19/10 , A61K31/7048 , C07H19/20 , C12N9/1051 , C12N15/86 , C12N2710/14143 , Y02A50/387 , Y02A50/401 , Y02A50/463 , Y10S514/81 , Y10S514/811
摘要： Disclosed are recombinant baculoviruses that are used to deliver hepatocyte expressable nucleic acid constructs specifically to hepatocytes. Also provided are a variety of recombinant baculovirus vectors which comprise at least one oligosaccharide processing enzyme gene and a hepatocyte expressible nucleic acid segment. The invention also provides methods of using the expression systems and recombinant baculoviruses, particularly in the treatment of liver diseases and/or infections.
摘要翻译：公开了用于将肝细胞可表达的核酸构建体特异性递送至肝细胞的重组杆状病毒。还提供了包含至少一种寡糖加工酶基因和肝细胞可表达的核酸片段的各种重组杆状病毒载体。本发明还提供使用表达系统和重组杆状病毒的方法，特别是用于治疗肝脏疾病和/或感染。

2. 发明申请

WO1991015574A1 PURIFIED HCV AND HCV PROTEINS AND PEPTIDES 审中-公开
标题翻译：纯化的HCV和HCV蛋白质和肽
公开(公告)号：WO1991015574A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002298
申请日：1991-04-02
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , BURK, Kenneth, H. , JACOB, James, R. , LANFORD, Robert, E.
IPC分类号： C12N07/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5252 , C12N7/00 , C12N2770/24222 , C12N2770/24234 , C12N2770/24251
摘要： Intact hepatitis C virus (HCV) particles, purified HCV proteins, and glycopeptide antigens specific to HCV particles are disclosed. The virus particles, in inactivated or attenuated form, are useful in a vaccine. The purified proteins, and glycopeptide antigens are useful in a diagnostic system, for detection of human HCV antisera, and in vaccine compositions. Also disclosed are antibodies specific against the glycopeptide antigens.
摘要翻译：公开了完整丙型肝炎病毒（HCV）颗粒，纯化的HCV蛋白质和HCV颗粒特异性的糖肽抗原。灭活或减毒形式的病毒颗粒可用于疫苗。纯化的蛋白质和糖肽抗原可用于诊断系统，用于检测人类HCV抗血清和疫苗组合物。还公开了针对糖肽抗原的抗体。

3. 发明申请

WO1987002775A1 SYNTHETIC PEPTIDES AND USE FOR DIAGNOSIS AND VACCINATION FOR AIDS AND ARC 审中-公开
标题翻译：合成肽及其用于艾滋病和ARC的诊断和疫苗接种
公开(公告)号：WO1987002775A1
公开(公告)日：1987-05-07
申请号：PCT/US1986002234
申请日：1986-10-22
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , KENNEDY, Ronald, C. , DREESMAN, Gordon, R. , ESSEX, Myron
IPC分类号： G01N33/53
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , G01N33/56988
摘要： Composition and method for detection of and vaccination against the viral causative agents of AIDS and ARC. The composition is a synthetic peptide, the amino acid sequence of which is sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV-III, LAV or ARC to produce an immunogenic response in a patient and which has a hydrophilic region therein. The composition may be conjugated to an appropriate carrier for use as a vaccine against AIDS and ARC or bound to the ligand of a specific binding pair, contacted with a sample of biological fluid from a patient suspected of having contracted AIDS or ARC and thereafter contacted with the anti-ligand of the specific binding pair for detection of any antibodies against the viral causative agents of AIDS or ARC which may be present in the sample.
摘要翻译：用于检测和接种艾滋病和ARC病毒致病因子的组合物和方法。该组合物是合成肽，其氨基酸序列与HTLV-III，LAV或ARC的gp160包膜糖蛋白的gp41和gp120亚基的氨基酸序列充分同源，以产生免疫原性应答并且其中具有亲水区域。组合物可以与适当的载体结合，用作针对AIDS和ARC的疫苗或与特异性结合对的配体结合，与来自怀疑患有感染AIDS或ARC的患者的生物液体样品接触，然后与特异性结合对的抗配体用于检测可能存在于样品中的针对AIDS或ARC病毒致病因子的任何抗体。

4. 发明申请

WO2004078709A2 METHOD FOR PREPARING 17 α-ACETOXY-11β-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES THEREOF, AND METHODS FOR THE PREPARATION OF SUCH INTERMEDIATES 审中-公开
标题翻译：制备17α-乙酰氧基-11β-（4-N，N-二甲基氨基苯基）-19-壬基-4,9-二烯-3,20-二酮的方法，其中间体及其制备这种中间体的方法
公开(公告)号：WO2004078709A2
公开(公告)日：2004-09-16
申请号：PCT/US2004/004246
申请日：2004-02-13
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , KIM, Hyun, K. , RAO, Pemmaraju, N. , SIMMONS, Anne-Marie
发明人： KIM, Hyun, K. , RAO, Pemmaraju, N. , SIMMONS, Anne-Marie
IPC分类号： C07D
CPC分类号： C07J7/00 , C07J5/00 , C07J21/00
摘要： Methods for the preparation of the 19-norprogesterone of formula I and its intermediates, in crystalline and amorphous forms.
摘要翻译：用于制备结晶和无定形形式的式I及其中间体的19-去甲孕酮的方法。

5. 发明申请

WO1993011782A1 CETP INHIBITOR POLYPEPTIDE, ANTIBODIES AGAINST THE SYNTHETIC POLYPEPTIDE AND PROPHYLACTIC AND THERAPEUTIC ANTI-ATHEROSCLEROSIS TREATMENTS 审中-公开
标题翻译： CETP抑制剂多肽，抗体合成多肽和丙酰胆碱酯酶和治疗药物治疗的抗体
公开(公告)号：WO1993011782A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010846
申请日：1992-12-15
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , KUSHWAHA, Rampratap , BORN, Kathleen , MCGILL, Henry, C., Jr. , KANDA, Patrick , DUNHAM, Raymond, G.
IPC分类号： A61K37/00
CPC分类号： C07K14/775 , A61K38/00 , C07K14/4703 , C07K16/18
摘要： A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically-acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW:31kD) or modified apo E (MW:41kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.
摘要翻译：多肽及其类似物抑制胆固醇酯转移蛋白（CETP）。抗动脉粥样硬化组合物包含抗动脉粥样硬化有效量的多肽和药学上可接受的载体。抗动脉粥样硬化试剂盒在分开的无菌容器中包含含有多肽的组合物的至少一个单位，一个注射器和一个针头。抗体对本发明的多肽，狒狒CETP 4kD多肽抑制剂，载脂蛋白C-1的1-36氨基酸N-末端片段，修饰的载脂蛋白A-I（MW：31kD）或修饰的载脂蛋白E（MW：41kD）具有特异性。预防哺乳动物易于发生该病症的动脉粥样硬化的方法包括向哺乳动物施用预防有效量的本发明多肽，以及治疗患有动脉粥样硬化的哺乳动物的方法包括施用治疗有效量的多肽这里公开。

6. 发明申请

WO1987006594A1 POLYAMIDE RESIN AND METHOD FOR PREPARATION OF REAGENTS FOR IMMUNODIAGNOSTIC USE 审中-公开
标题翻译：聚酰胺树脂和制备免疫缺陷病毒试剂的方法
公开(公告)号：WO1987006594A1
公开(公告)日：1987-11-05
申请号：PCT/US1987000971
申请日：1987-04-29
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , BAYLOR COLLEGE OF MEDICINE
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , BAYLOR COLLEGE OF MEDICINE , KANDA, Patrick , KENNEDY, Ronald, C. , SPARROW, James, T.
IPC分类号： C08F20/56
CPC分类号： G01N33/54313 , A61K47/58 , C08F220/56
摘要： A polyamide resin for use in peptide and protein synthesis, and a method of preparing and using same. The polyamide resin is prepared by cross-linking a dimethylacrylamide monomer by co-polymerization with a functional monomer in an aqueous solution, emulsifying the aqueous solution in an organic solvent and isolating the polyamide resin beads formed by adding an initiator and a promotor. The beads are used as a solid phase for peptide and protein synthesis according to methods known in the art. The conjugate of the polymide resin and the synthesized peptide or protein is used directly for immunoassays or immunization without the need for separation of the peptide or protein from the resin and subsequent purification.
摘要翻译：用于肽和蛋白质合成的聚酰胺树脂及其制备和使用方法。聚酰胺树脂是通过在水溶液中与官能单体共聚合使二甲基丙烯酰胺单体交联而制得的，将有机溶剂中的水溶液乳化，并分离通过加入引发剂和促进剂形成的聚酰胺树脂珠。根据本领域已知的方法，将珠子用作肽和蛋白质合成的固相。聚酰亚胺树脂和合成的肽或蛋白质的缀合物直接用于免疫测定或免疫，而不需要将肽或蛋白质与树脂分离并随后纯化。

7. 发明申请

WO1995004755A1 CETP INHIBITOR POLYPEPTIDE, ANTIBODIES AGAINST THE SYNTHETIC POLYPEPTIDE AND PROPHYLACTIC AND THERAPEUTIC ANTI-ATHEROSCLEROSIS TREATMENTS 审中-公开
标题翻译： CETP抑制剂多肽，抗体合成多肽和丙酰胆碱酯酶和治疗药物治疗的抗体
公开(公告)号：WO1995004755A1
公开(公告)日：1995-02-16
申请号：PCT/US1994008624
申请日：1994-08-02
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , KUSHWAHA, Rampratap, S. , MCGILL, Henry, C., Jr. , KANDA, Patrick
IPC分类号： C07K14/435
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4703
摘要： A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW:31kD) or modified apo E (MW:41kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.
摘要翻译：多肽及其类似物抑制胆固醇酯转移蛋白（CETP）。抗动脉粥样硬化组合物包含抗动脉粥样硬化有效量的多肽和药学上可接受的载体。抗动脉粥样硬化试剂盒在分开的无菌容器中包含含有多肽的组合物的至少一个单位，一个注射器和一个针头。抗体对本发明的多肽，狒狒CETP 4kD多肽抑制剂，载脂蛋白C-1的1-36氨基酸N-末端片段，修饰的载脂蛋白A-I（MW：31kD）或修饰的载脂蛋白E（MW：41kD）具有特异性。预防哺乳动物易于发生该病症的动脉粥样硬化的方法包括向哺乳动物施用预防有效量的本发明多肽，以及治疗患有动脉粥样硬化的哺乳动物的方法包括施用治疗有效量的多肽这里公开。

8. 发明申请

WO1988000471A1 COMPOSITION OF MATTER AND METHOD OF IMMUNIZING AGAINST VIRAL CAUSATIVE AGENTS OF AIDS AND ARC 审中-公开
标题翻译：艾滋病和弧病毒的病原体的免疫组织和免疫方法
公开(公告)号：WO1988000471A1
公开(公告)日：1988-01-28
申请号：PCT/US1987001733
申请日：1987-07-20
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , KANDA, Patrick , KENNEDY, Ronald, C.
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K47/58 , A61K2039/6093 , C12N2740/16122 , C12N2740/16134
摘要： Composition and method for induction of a neutralizing antibody against the viral causative agents of AIDS and ARC. The composition is a conjugate of a polyamide resin and a synthetic peptide, the amino acid sequence of the synthetic peptide being sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV-III, LAV or ARV to produce an immunogenic response in an experimental animal and having a hydrophilic region therein. The composition is given with or without an adjuvant in an amount effective to induce an immunogenic response, thereby protecting the experimental animal from exposure to the HTLV-III, LAV and/or ARV causative agents of AIDS and/or ARC.
摘要翻译：用于诱导针对AIDS和ARC的病毒致病因子的中和抗体的组合物和方法。该组合物是聚酰胺树脂和合成肽的共轭物，合成肽的氨基酸序列与HTLV-III，LAV的gp160包膜糖蛋白的gp41和gp120亚基的氨基酸序列充分同源或ARV以在实验动物中产生免疫原性应答并且其中具有亲水区域。所述组合物以有效诱导免疫原性应答的量给予有或没有佐剂，从而保护实验动物不暴露于AIDS和/或ARC的HTLV-III，LAV和/或ARV致病因子。

9. 发明申请

WO1996010649A1 ISOLATED HUMAN HEPATITIS B VIRUS POLYMERASE AND USES THEREOF 审中-公开
标题翻译：分离的人类HEPATITIS B病毒聚合酶及其用途
公开(公告)号：WO1996010649A1
公开(公告)日：1996-04-11
申请号：PCT/US1995012960
申请日：1995-09-29
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , LANFORD, Robert, E. , NOVTALL, Lena, M. , BEAMES, Burton, D.
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
IPC分类号： C12Q01/70
CPC分类号： C07K14/005 , C12N9/1252 , C12N9/1276 , C12N2730/10122
摘要： The invention is directed to an isolated active recombinant human HBV pol complex. The complex may comprise a human HBV pol fusion protein or an epitope useful for purification. The invention is also directed to an isolated nucleic acid encoding a protein component of an active recombinant human HBV pol complex. The nucleic acid may encode an HBV pol fusion protein. The invention is also directed to a replicable vector comprising the nucleic acids above. The invention is also directed to host cells containing the proteins or nucleic acids above. Methods are also described. In one embodiment the invention is a method of expressing and isolating active human HBV pol. In another embodiment the invention is a method of screening a compound as an inhibitor or stimulator of a recombinant human HBV pol activity. The invention is also directed to a kit useful for screening a compound for activity as an inhibitor or stimulator of a human HBV pol.
摘要翻译：本发明涉及分离的活性重组人HBV pol复合物。复合物可以包含人HBV pol融合蛋白或可用于纯化的表位。本发明还涉及编码活性重组人HBV pol复合物的蛋白质组分的分离的核酸。核酸可编码HBV pol融合蛋白。本发明还涉及包含上述核酸的可复制载体。本发明还涉及含有上述蛋白质或核酸的宿主细胞。还描述了方法。在一个实施方案中，本发明是表达和分离活性人HBV pol的方法。在另一个实施方案中，本发明是筛选化合物作为重组人HBV pol活性的抑制剂或刺激剂的方法。本发明还涉及可用于筛选化合物作为人HBV pol的抑制剂或刺激剂的活性的试剂盒。

10. 发明申请

WO1991015573A1 AN IMMORTALIZED PRIMATE HEPATOCYTE CELL LINE 审中-公开
标题翻译：完全免疫原性细胞细胞系
公开(公告)号：WO1991015573A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002296
申请日：1991-04-02
申请人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH
发明人： SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH , BURK, Kenneth, H. , JACOB, James, R. , LANFORD, Robert, E.
IPC分类号： C12N05/10
CPC分类号： C07K14/005 , C07K14/75 , C12N5/067 , C12N9/6435 , C12N2500/25 , C12N2500/36 , C12N2501/01 , C12N2501/18 , C12N2501/305 , C12N2501/315 , C12N2501/375 , C12N2501/39 , C12N2501/395 , C12N2770/24222 , C12Y304/21007 , G01N33/5008 , G01N2333/18
摘要： An immortalized primate hepatocyte cell line which produces normal liver secretory proteins, and which is able to support replication by human hepatotropic viruses is disclosed. The cell line is useful in producing hepatotropic viruses, such as hepatitis C virus, and for screening drug compounds for ability to inhibit the growth of such viruses. The cell line is also useful as a source of liver-specific protein products.
摘要翻译：公开了产生正常肝脏分泌蛋白，能够支持人类嗜肝病毒复制的永生化的灵长类动物肝细胞系。细胞系可用于产生嗜肝病毒如丙型肝炎病毒，并且用于筛选药物化合物以抑制这种病毒生长的能力。细胞系也可用作肝特异性蛋白质产物的来源。

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