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1. 发明申请

WO2012067375A2 BIO-ADHESIVE AGENT COMPRISING SURFACE-MODIFIED HYDROXYAPATITE AND USE THEREOF 审中-公开
公开(公告)号：WO2012067375A2
公开(公告)日：2012-05-24
申请号：PCT/KR2011008529
申请日：2011-11-10
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP , SON YOUNG SOOK , LEE EUN AH , NAM SEUNG WOO
发明人： SON YOUNG SOOK , LEE EUN AH , NAM SEUNG WOO
IPC分类号： A61L27/32 , A61F2/28 , A61F2/30 , A61L27/04
CPC分类号： A61L24/00 , A61L24/02 , A61L27/32 , A61L2400/18
摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.

2. 发明申请

WO2009120043A3 USE FOR CD45+ CELLS OR A CD45+ CELL CULTURE FLUID FOR PROMOTING THE GROWTH OF MESENCHYMAL STEM CELLS 审中-公开
标题翻译：用于CD45 +细胞或CD45 +细胞培养液以促进间质干细胞的生长
公开(公告)号：WO2009120043A3
公开(公告)日：2009-12-30
申请号：PCT/KR2009001581
申请日：2009-03-27
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP , SON YOUNG SOOK , HONG HYUN SOOK , AHN WOO SUNG
发明人： SON YOUNG SOOK , HONG HYUN SOOK , AHN WOO SUNG
IPC分类号： C12N5/02 , C07K14/715 , C12N9/12
CPC分类号： C12N5/0663 , C12N5/0665 , C12N2502/1157
摘要： The present invention relates to a use for CD45+ cells or a CD45+ cell culture fluid for promoting the growth of mesenchymal stem cells; a composition for promoting the growth of mesenchymal stem cells comprising CD45+ cells or a CD45+ cell culture fluid; and a culturing method for promoting the growth of mesenchymal stem cells by adding CD45+ cells or a CD45+ cell culture fluid to mesenchymal stem cells and allowing culturing to proceed. If culturing is carried out by adding CD45+ cells or a CD45+ cell culture fluid to mesenchymal stem cells, then the colony-forming ability of the mesenchymal stem cells is increased by at least three times as compared with culturing of mesenchymal stem cells alone. Moreover, CD29+ cells which have been cultured with treatment by CD45+ cells or a CD45+ cell culture fluid maintain, unchanged, the morphological characteristics of mesenchymal stem cells, cell markers, and inherent characteristics such as pluripotency. Thus CD45+ cells or a CD45+ cell culture fluid can be used to promote the growth of mesenchymal stem cells, and a culturing method in which CD45+ cells or a CD45+ cell culture fluid is added to mesenchymal stem cells and culturing is allowed to proceed can be used to grow mesenchymal stem cells in sufficient number to allow them to be used in cell therapy.
摘要翻译：本发明涉及用于促进间充质干细胞生长的CD45 +细胞或CD45 +细胞培养液的用途; 用于促进包含CD45 +细胞或CD45 +细胞培养液的间充质干细胞生长的组合物; 以及通过将CD45 +细胞或CD45 +细胞培养液添加至间充质干细胞并允许进行培养来促进间充质干细胞生长的培养方法。如果通过将CD45 +细胞或CD45 +细胞培养液添加到间充质干细胞中进行培养，则与单独培养间充质干细胞相比，间充质干细胞的集落形成能力增加至少三倍。此外，通过CD45 +细胞或CD45 +细胞培养液处理而培养的CD29 +细胞维持间充质干细胞的形态特征，细胞标记和多能性等固有特征不变。因此可以使用CD45 +细胞或CD45 +细胞培养液来促进间充质干细胞的生长，并且可以使用将CD45 +细胞或CD45 +细胞培养液添加至间充质干细胞并允许进行培养的培养方法以充足的数量培养间充质干细胞以允许它们用于细胞治疗。

3. 发明申请

WO2007052935A1 ARTIFICIAL CARTILAGE CONTAINING CHONDROCYTES OBTAINED FROM COSTAL CARTILAGE AND PREPARATION PROCESS THEREOF 审中-公开
标题翻译：含有从成本中获得的人造丝的人造AGE AGE AGE OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2007052935A1
公开(公告)日：2007-05-10
申请号：PCT/KR2006/004479
申请日：2006-10-31
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , KOREA ATOMIC ENERGY RESEARCH INSTITUTE , UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY , SON, Young Sook , LEE, Jung Sun , LEE, Eun Kyung , LEE, Jin Yeon
发明人： SON, Young Sook , LEE, Jung Sun , LEE, Eun Kyung , LEE, Jin Yeon
IPC分类号： C12N5/08 , C12N5/00 , A61K35/00 , A61K35/12 , A61K35/32
CPC分类号： A61K35/28 , A61K35/12 , A61K35/32 , A61L27/20 , A61L27/3804 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N5/0668 , C12N2501/115 , C08L5/08
摘要： The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
摘要翻译：本发明涉及通过培养肋软骨细胞获得的含有间充质干细胞（MSC）的去分化细胞的人造软骨及其制备方法。

4. 发明申请

WO2012067375A3 BIO-ADHESIVE AGENT COMPRISING SURFACE-MODIFIED HYDROXYAPATITE AND USE THEREOF 审中-公开
标题翻译：包含表面改性的羟基磷灰石的生物粘附剂及其用途
公开(公告)号：WO2012067375A3
公开(公告)日：2012-07-12
申请号：PCT/KR2011008529
申请日：2011-11-10
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP , SON YOUNG SOOK , LEE EUN AH , NAM SEUNG WOO
发明人： SON YOUNG SOOK , LEE EUN AH , NAM SEUNG WOO
IPC分类号： A61L27/32 , A61F2/28 , A61F2/30 , A61L27/04
CPC分类号： A61L24/00 , A61L24/02 , A61L27/32 , A61L2400/18
摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.
摘要翻译：本发明涉及包含表面改性羟基磷灰石的生物粘附剂及其用途。更具体地说，本发明涉及一种用于骨与骨，骨与组织，骨与软骨或骨与肌腱之间的粘附或用于在骨或人造关节之间粘附屏蔽物的生物粘附剂，其包含表面改性的羟基磷灰石作为活性成分，其中所述表面改性的羟基磷灰石的特征在于某些接头化合物共价键合到羟基磷灰石的表面; 使用表面改性的羟基磷灰石涂覆金属假体的表面的方法; 以及用通过所述方法获得的表面改性羟基磷灰石涂覆的金属假体。

5. 发明申请

WO2011155649A1 AGENT FOR OSTEOGENESIS USING SUBSTANCE-P AND PREPARATION PROCESS THEREOF 审中-公开
标题翻译：使用物质P及其制备方法进行骨质疏松症的药剂
公开(公告)号：WO2011155649A1
公开(公告)日：2011-12-15
申请号：PCT/KR2010/003784
申请日：2010-06-11
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY , SON, Young Sook , LEE, Eun Ah , HONG, Hyun Sook
发明人： SON, Young Sook , LEE, Eun Ah , HONG, Hyun Sook
IPC分类号： A61K36/00 , A61K35/28 , A61K35/14 , A61P19/10 , A61P19/00
CPC分类号： A61K35/28
摘要： The present invention relates to an agent for osteogenesis containing as an active ingredient mesenchymal stem cells (MSCs) that have been mobilized from bone marrow into blood by administration of Substance-P; and a process of preparing the agent.
摘要翻译：本发明涉及含有作为活性成分的间质干细胞（MSC）的成骨剂，其通过给予物质-P从骨髓移入血液; 以及制备该试剂的方法。

6. 发明申请

WO2011019221A2 AGENT FOR STIMULATING MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS 审中-公开
标题翻译：促进内皮祖细胞移植的促进剂
公开(公告)号：WO2011019221A2
公开(公告)日：2011-02-17
申请号：PCT/KR2010/005307
申请日：2010-08-12
申请人： CELL & BIO CO., LTD. , SON, Young Sook , HONG, Hyun Sook
发明人： SON, Young Sook , HONG, Hyun Sook
IPC分类号： A61K38/08 , A61P9/10
CPC分类号： A61K38/046
摘要： The present invention provides a composition for stimulating the mobilization of endothelial precursor cells, which comprises subs tance-P (SP). Substance-P accordingto the invention exhibits an activity of stimulating the mobilization of endothelial precursor cells from the bone marrow, thereby stimulating vasculogenesis. Thus, substance-P exhibits excellent effects on the prevention or treatment of diseases, including myocardial infarction, angina, ischemic stroke, cerebrovascular dementia, cerebral infarction, sequelae of cerebral injury, spinal cord injury, sequelae of spinal nerve injury, degenerative diseases, sequelae of cerebral infarction, peripheral nerve disorders, presbyopia, degenerative hearing loss, sequelae of brain surgery, and diabetic ulcer, which are accompanied by ischemic vascular injury or traumatic vascular injury.
摘要翻译：本发明提供了用于刺激内皮前体细胞动员的组合物，其包含基础-P（SP）。根据本发明的物质-P表现出刺激来自骨髓的内皮前体细胞的动员，从而刺激血管发生的活性。因此，P物质在预防或治疗疾病包括心肌梗塞，心绞痛，缺血性中风，脑血管性痴呆，脑梗塞，脑损伤后遗症，脊髓损伤，脊髓神经损伤后遗症，退行性疾病，后遗症伴有缺血性血管损伤或创伤性血管损伤的脑梗塞，周围神经障碍，老花，退行性听力丧失，脑外科手术后遗症和糖尿病性溃疡。

7. 发明申请

WO2002062971A1 METHOD OF ISOLATING EPITHELIAL CELLS, METHOD OF PRECONDITIONING CELLS, AND METHODS OF PREPARING BIOARTIFICIAL SKIN AND DERMIS WITH THE EPITHELIAL CELLS OR THE PRECONDITIONED CELLS 审中-公开
标题翻译：分离上皮细胞的方法，预处理细胞的方法以及用上皮细胞或预先给予的细胞制备生物皮肤和细胞的方法
公开(公告)号：WO2002062971A1
公开(公告)日：2002-08-15
申请号：PCT/KR2001/001873
申请日：2001-11-06
申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE , SON, Young-Sook , PARK, Hyun-Sook , KIM, Chun-Ho , KANG, Hyun-Ju , KIM, Chang-Hwan , KIM, Youn-Young , CHOI, Young-Ju , LEE, Su-Hyun , GIN, Yong-Jae
发明人： SON, Young-Sook , PARK, Hyun-Sook , KIM, Chun-Ho , KANG, Hyun-Ju , KIM, Chang-Hwan , KIM, Youn-Young , CHOI, Young-Ju , LEE, Su-Hyun , GIN, Yong-Jae
IPC分类号： C12N5/08
CPC分类号： C12N5/0698 , A61K35/12 , C12N5/0629 , C12N2502/094 , C12N2502/1323 , C12N2502/28 , C12N2509/00 , C12N2509/10
摘要： A method of isolating epithelial cells from a human skin tissue or internal organ tissue using trypsin and ethylenediamine tetraacetic acid (EDTA) simultaneously with the application of magnetic stirring, a method of preconditioning isolated biological cells by the application of physical stimulus, i.e., strain, are provided. Epithelial cells can be isolated by the method with increased yield, colony forming efficiency (CFE), and colony size. Also, the increased percentage of stem cells in isolated cells is advantageous in therapeutic tissue implantation by autologous or allogeneic transplantation. In skin cells preconditioned by the application of strain, cell division is facilitated, and the secretion of extracellular matrix components and growth factors and the activity of matrix metalloproteinases (MMPs) are improved. When preconditioned cells are implanted by autologous or allogeneic transplantation to heal a damaged tissue, the improved cell adhesion, mobility, and viability provides a biological adjustment effect against a variety of stresses or physical stimuli which the cells would undergo after implantation, with improved capability of integration into host tissue, thereby markedly improving the probability of success in skin grafting.
摘要翻译：一种利用磁力搅拌同时使用胰蛋白酶和乙二胺四乙酸（EDTA）从人皮肤组织或内部器官组织分离上皮细胞的方法，一种通过应用物理刺激预处理分离的生物细胞的方法，即应变，被提供。可以通过增加产量，菌落形成效率（CFE）和菌落大小的方法分离上皮细胞。此外，分离的细胞中干细胞的增加百分比在通过自体或同种异体移植治疗组织植入方面是有利的。在通过应用菌株预处理的皮肤细胞中，促进细胞分裂，细胞外基质成分和生长因子的分泌以及基质金属蛋白酶（MMPs）的活性得到改善。当通过自体或同种异体移植植入预处理细胞以愈合损伤的组织时，改善的细胞粘附性，迁移性和活力提供了针对细胞在植入后将经历的各种应力或物理刺激的生物调节作用，具有改善的整合到宿主组织中，从而显着提高皮肤移植成功的可能性。

8. 发明申请

WO2011019221A3 AGENT FOR STIMULATING MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS 审中-公开
标题翻译：刺激内源性原核细胞动员的药剂
公开(公告)号：WO2011019221A3
公开(公告)日：2011-05-26
申请号：PCT/KR2010005307
申请日：2010-08-12
申请人： CELL & BIO CO LTD , SON YOUNG SOOK , HONG HYUN SOOK
发明人： SON YOUNG SOOK , HONG HYUN SOOK
IPC分类号： A61K38/08 , A61P9/10
CPC分类号： A61K38/046
摘要： The present invention provides a composition for stimulating the mobilization of endothelial precursor cells, which comprises subs tance-P (SP). Substance-P accordingto the invention exhibits an activity of stimulating the mobilization of endothelial precursor cells from the bone marrow, thereby stimulating vasculogenesis. Thus, substance-P exhibits excellent effects on the prevention or treatment of diseases, including myocardial infarction, angina, ischemic stroke, cerebrovascular dementia, cerebral infarction, sequelae of cerebral injury, spinal cord injury, sequelae of spinal nerve injury, degenerative diseases, sequelae of cerebral infarction, peripheral nerve disorders, presbyopia, degenerative hearing loss, sequelae of brain surgery, and diabetic ulcer, which are accompanied by ischemic vascular injury or traumatic vascular injury.
摘要翻译：本发明提供了一种用于刺激内皮前体细胞动员的组合物，其包括临界-P（SP）。根据本发明的物质-P表现出刺激内皮前体细胞从骨髓的动员，从而刺激血管发生的活性。因此，物质-P对预防或治疗包括心肌梗死，心绞痛，缺血性中风，脑血管性痴呆，脑梗塞，脑损伤后遗症，脊髓损伤，脊髓神经损伤后遗症，退行性疾病，后遗症等疾病的预防或治疗具有优异的效果的脑梗塞，周围神经障碍，老花眼，退行性听力损失，脑外科后遗症和糖尿病性溃疡，伴有缺血性血管损伤或创伤性血管损伤。

9. 发明申请

WO2007091790A1 A COMPOSITION FOR TREATING DAMAGE OF CENTRAL OR PERIPHERAL NERVE SYSTEM 审中-公开
标题翻译：用于治疗中央或外周神经系统损伤的组合物
公开(公告)号：WO2007091790A1
公开(公告)日：2007-08-16
申请号：PCT/KR2007/000316
申请日：2007-01-19
申请人： KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES , UNIVERSITY-INDUSTRY COOPERATION GROUPE OF KYUNGHEE UNIVERSITY , SON, Young-Sook , CHI, Guang-Fan , KIM, Mi-Ra
发明人： SON, Young-Sook , CHI, Guang-Fan , KIM, Mi-Ra
IPC分类号： A61K35/30 , C12N5/06
CPC分类号： C12N5/0622 , A61K35/30 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/385
摘要： The present invention provides a composition for treating damage of central or peripheral nerve system comprising neural precursor cell derived from subcutaneous tissue; neuron obtained by differentiating the neural precursor cell; or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell; a use of neural precursor cell derived from subcutaneous tissue, neuron obtained by differentiating the neural precursor cell, or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell, for the manufacture of an agent for treating damage of central or peripheral nerve system; a method for treating damage of central or peripheral nerve system which comprises administrating to a mammal a therapeutically effective amount of neural precursor cell derived from subcutaneous tissue, neurons obtained by differentiating the neural precursor cell, or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell. Further, the present invention provides a method of preparing the neural precursor cell, neurons, oligodendrocyte or Schwann cell of the present invention.
摘要翻译：本发明提供一种用于治疗包含来自皮下组织的神经前体细胞的中枢或周围神经系统的损伤的组合物; 通过分化神经前体细胞获得的神经元; 或通过分化神经前体细胞获得的少突胶质细胞或雪旺氏细胞; 使用衍生自皮下组织的神经前体细胞，通过分化神经前体细胞获得的神经元，或通过分化神经前体细胞获得的少突胶质细胞或施旺细胞，用于制造用于治疗中枢或周围神经系统损伤的药剂; 用于治疗中枢或周围神经系统的损伤的方法，其包括向哺乳动物施用治疗有效量的来自皮下组织的神经前体细胞，通过分化神经前体细胞获得的神经元，或通过分化神经前体获得的少突胶质细胞或施万细胞细胞。此外，本发明提供了制备本发明的神经前体细胞，神经元，少突胶质细胞或雪旺氏细胞的方法。

10. 发明申请

WO2012067375A9 BIO-ADHESIVE AGENT COMPRISING SURFACE-MODIFIED HYDROXYAPATITE AND USE THEREOF 审中-公开
公开(公告)号：WO2012067375A9
公开(公告)日：2012-05-24
申请号：PCT/KR2011/008529
申请日：2011-11-10
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY , SON, Young Sook , LEE, Eun Ah , NAM, Seung Woo
发明人： SON, Young Sook , LEE, Eun Ah , NAM, Seung Woo
IPC分类号： A61L27/32 , A61L27/04 , A61F2/28 , A61F2/30
摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.

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