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    • 1. 发明申请
    • CO-CULTURE METHOD OF SKIN CELLS AND CELL THERAPY COMPOSITION USING THE SAME
    • 使用相同的皮肤细胞和细胞治疗组合物的CO培养方法
    • WO2009017321A2
    • 2009-02-05
    • PCT/KR2008/004300
    • 2008-07-23
    • MODERN CELL & TISSUE TECHNOLOGIES INC.KIM, Yun-YoungLEE, Su-Hee
    • KIM, Yun-YoungLEE, Su-Hee
    • C12N5/08
    • C12N5/0698A01N1/02A01N1/0226A01N1/0231A61K35/12C12N2500/90C12N2502/091C12N2502/094C12N2502/1323C12N2502/28
    • Provided are a skin cell co-culture method of mixing and culturing keratinocyte, melanocyte, fibroblast, and endothelial cell which are extracted from minimal donor sites and a cell therapeutic composition using the same. Since various types of skin cells extracted from one type of donor site are mixed and co-cultured, due to a paracrine effect between cells, all the cells can be well grown even in a serum-free medium. In addition, the cells can be well grown in a medium that is not a medium specified for culture of each type of cells. In addition, the cells can be well grown even in a case where the number of cells is too small to be well grown in a separate culture. In addition, unlike the separate culture where freezing storage and thawing of melanocyte is almost not available, the mixed co-cultured cells can be well grown after the freezing storage and thawing. In addition, expression of an SMA (smooth muscle actin) which is induced in an in-vitro fibroblast culture is not induced in the mixed co-culture, so that fibroblast can be cultured without induction of differentiation. A cell therapeutic including the mixed, co-cultured skin cells can show an effective wound healing capability in comparison with conventional cell therapeutics including only the keratinocyte.
    • 提供了从最小供体部位提取的角化细胞,黑素细胞,成纤维细胞和内皮细胞的混合和培养的皮肤细胞共培养方法和使用其的细胞治疗组合物。 由于从一种供体位点提取的各种类型的皮肤细胞被混合并共培养,由于细胞之间的旁分泌作用,所有细胞即使在无血清培养基中也能很好地生长。 此外,细胞可以在不是每种类型的细胞的培养物规定的培养基的培养基中良好生长。 此外,即使在细胞数量太小而不能在单独培养物中良好生长的情况下,细胞也可以良好生长。 此外,不同于几乎不可获得黑素细胞的冷冻储存和解冻的单独培养物,混合的共培养细胞可以在冷藏储存和解冻后很好地生长。 此外,在体外成纤维细胞培养中诱导的SMA(平滑肌肌动蛋白)的表达在混合共培养物中不诱导,使得成纤维细胞可以在不诱导分化的情况下进行培养。 与仅包括角质形成细胞的常规细胞治疗剂相比,包括混合的共培养皮肤细胞的细胞治疗可显示有效的伤口愈合能力。
    • 3. 发明申请
    • A COMPOSITION FOR PREVENTION OR TREATMENT OF BONE MARROW DAMAGE
    • 用于预防或治疗骨质疏松症的组合物
    • WO2008091043A1
    • 2008-07-31
    • PCT/KR2007/002762
    • 2007-06-07
    • UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITYMODERN CELL & TISSUE TECHNOLOGIES INC.KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCESSON, YoungsookHONG, HyunsookLEE, Jungsun
    • SON, YoungsookHONG, HyunsookLEE, Jungsun
    • A61K38/14A61P19/00
    • A61K38/08A61K35/28A61K2300/00
    • Disclosed herein are a composition for prevention or treatment of bone marrow damage comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of a medicament for prevention or treatment of bone marrow damage; a method for prevention or treatment of bone marrow damage comprising administering a therapeutically effective amount of Substance-P to a mammal; an anticancer supplement comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of an anticancer supplement; and a method for prevention or treatment of cancer comprising administering a therapeutically effective amount of Substance-P as an anticancer supplement to a mammal. Substance-P stimulates proliferation of mesenchymal stem cells (MSCs) within the bone marrow to thereby facilitate protection and regeneration of bone marrow cells and hematopoietic stem cells. Therefore, the composition of the present invention can be therapeutically used for treatment and/or prevention of bone marrow damage. Further, the composition of the present invention can be used as an anticancer supplement for anticancer therapy.
    • 本文公开了一种用于预防或治疗骨髓损伤的组合物,其包含物质-P作为活性成分; 使用物质-P来制备用于预防或治疗骨髓损伤的药物; 一种预防或治疗骨髓损伤的方法,包括向哺乳动物施用治疗有效量的物质-P; 一种包含物质-P作为活性成分的抗癌补充剂; 使用物质-P制备抗癌补充剂; 以及预防或治疗癌症的方法,包括向哺乳动物施用治疗有效量的作为抗癌剂的物质-P。 物质-P刺激骨髓内的间充质干细胞(MSC)的增殖,从而促进骨髓细胞和造血干细胞的保护和再生。 因此,本发明的组合物可用于治疗和/或预防骨髓损伤。 此外,本发明的组合物可以用作抗癌治疗的抗癌补充剂。