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1. 发明申请

WO2009017321A2 CO-CULTURE METHOD OF SKIN CELLS AND CELL THERAPY COMPOSITION USING THE SAME 审中-公开
标题翻译：使用相同的皮肤细胞和细胞治疗组合物的CO培养方法
公开(公告)号：WO2009017321A2
公开(公告)日：2009-02-05
申请号：PCT/KR2008/004300
申请日：2008-07-23
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , KIM, Yun-Young , LEE, Su-Hee
发明人： KIM, Yun-Young , LEE, Su-Hee
IPC分类号： C12N5/08
CPC分类号： C12N5/0698 , A01N1/02 , A01N1/0226 , A01N1/0231 , A61K35/12 , C12N2500/90 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2502/28
摘要： Provided are a skin cell co-culture method of mixing and culturing keratinocyte, melanocyte, fibroblast, and endothelial cell which are extracted from minimal donor sites and a cell therapeutic composition using the same. Since various types of skin cells extracted from one type of donor site are mixed and co-cultured, due to a paracrine effect between cells, all the cells can be well grown even in a serum-free medium. In addition, the cells can be well grown in a medium that is not a medium specified for culture of each type of cells. In addition, the cells can be well grown even in a case where the number of cells is too small to be well grown in a separate culture. In addition, unlike the separate culture where freezing storage and thawing of melanocyte is almost not available, the mixed co-cultured cells can be well grown after the freezing storage and thawing. In addition, expression of an SMA (smooth muscle actin) which is induced in an in-vitro fibroblast culture is not induced in the mixed co-culture, so that fibroblast can be cultured without induction of differentiation. A cell therapeutic including the mixed, co-cultured skin cells can show an effective wound healing capability in comparison with conventional cell therapeutics including only the keratinocyte.
摘要翻译：提供了从最小供体部位提取的角化细胞，黑素细胞，成纤维细胞和内皮细胞的混合和培养的皮肤细胞共培养方法和使用其的细胞治疗组合物。由于从一种供体位点提取的各种类型的皮肤细胞被混合并共培养，由于细胞之间的旁分泌作用，所有细胞即使在无血清培养基中也能很好地生长。此外，细胞可以在不是每种类型的细胞的培养物规定的培养基的培养基中良好生长。此外，即使在细胞数量太小而不能在单独培养物中良好生长的情况下，细胞也可以良好生长。此外，不同于几乎不可获得黑素细胞的冷冻储存和解冻的单独培养物，混合的共培养细胞可以在冷藏储存和解冻后很好地生长。此外，在体外成纤维细胞培养中诱导的SMA（平滑肌肌动蛋白）的表达在混合共培养物中不诱导，使得成纤维细胞可以在不诱导分化的情况下进行培养。与仅包括角质形成细胞的常规细胞治疗剂相比，包括混合的共培养皮肤细胞的细胞治疗可显示有效的伤口愈合能力。

2. 发明申请

WO2009110647A1 TISSUE SHEET OF CORNEA OR CONJUNCTIVA USING NASAL MUCOSA EPITHELIUM 审中-公开
标题翻译：使用玄武岩上皮的CORNEA或CONJUNCTIVA组织表
公开(公告)号：WO2009110647A1
公开(公告)日：2009-09-11
申请号：PCT/KR2008/001219
申请日：2008-03-03
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , KIM, Jae-Chan , LEE, Su-Hyon , JUNG, Haeng-Sun
发明人： KIM, Jae-Chan , LEE, Su-Hyon , JUNG, Haeng-Sun
IPC分类号： A61L27/38
CPC分类号： A61L27/3839 , A61L27/3604 , A61L27/3813 , A61L2430/16
摘要： Disclosed is a corneal or conjunctival tissue sheet including amnion and nasal mucosa epithelial cells grown on the amnion, more particularly a corneal or conjunctival tissue sheet derived from nasal mucosa epithelial cells prepared by seeding nasal mucosa epithelial cells on the amnion and growing them in the presence of feeder cells to form multiple layers. The disclosed nasal mucosa epithelial sheet exhibits expression patterns similar to that of human normal cornea or conjunctiva, contributes to the stabilization of ocular surface with abundant mucin-secreting cells, and may be employed for permanent corneal or conjunctival implantation with superior engraftment and consistency.
摘要翻译：公开了包括在羊膜上生长的羊膜和鼻粘膜上皮细胞的角膜或结膜组织片，更具体地，衍生自通过在羊膜上接种鼻粘膜上皮细胞制备的鼻粘膜上皮细胞的角膜或结膜组织片，并在存在下生长它们的饲养细胞形成多层。所公开的鼻粘膜上皮细胞表现出类似于人正常角膜或结膜的表现模式，有助于用大量粘液分泌细胞稳定眼表，并可用于永久性角膜或结膜植入，具有优异的移植和一致性。

3. 发明申请

WO2008091043A1 A COMPOSITION FOR PREVENTION OR TREATMENT OF BONE MARROW DAMAGE 审中-公开
标题翻译：用于预防或治疗骨质疏松症的组合物
公开(公告)号：WO2008091043A1
公开(公告)日：2008-07-31
申请号：PCT/KR2007/002762
申请日：2007-06-07
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY , MODERN CELL & TISSUE TECHNOLOGIES INC. , KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES , SON, Youngsook , HONG, Hyunsook , LEE, Jungsun
发明人： SON, Youngsook , HONG, Hyunsook , LEE, Jungsun
IPC分类号： A61K38/14 , A61P19/00
CPC分类号： A61K38/08 , A61K35/28 , A61K2300/00
摘要： Disclosed herein are a composition for prevention or treatment of bone marrow damage comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of a medicament for prevention or treatment of bone marrow damage; a method for prevention or treatment of bone marrow damage comprising administering a therapeutically effective amount of Substance-P to a mammal; an anticancer supplement comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of an anticancer supplement; and a method for prevention or treatment of cancer comprising administering a therapeutically effective amount of Substance-P as an anticancer supplement to a mammal. Substance-P stimulates proliferation of mesenchymal stem cells (MSCs) within the bone marrow to thereby facilitate protection and regeneration of bone marrow cells and hematopoietic stem cells. Therefore, the composition of the present invention can be therapeutically used for treatment and/or prevention of bone marrow damage. Further, the composition of the present invention can be used as an anticancer supplement for anticancer therapy.
摘要翻译：本文公开了一种用于预防或治疗骨髓损伤的组合物，其包含物质-P作为活性成分; 使用物质-P来制备用于预防或治疗骨髓损伤的药物; 一种预防或治疗骨髓损伤的方法，包括向哺乳动物施用治疗有效量的物质-P; 一种包含物质-P作为活性成分的抗癌补充剂; 使用物质-P制备抗癌补充剂; 以及预防或治疗癌症的方法，包括向哺乳动物施用治疗有效量的作为抗癌剂的物质-P。物质-P刺激骨髓内的间充质干细胞（MSC）的增殖，从而促进骨髓细胞和造血干细胞的保护和再生。因此，本发明的组合物可用于治疗和/或预防骨髓损伤。此外，本发明的组合物可以用作抗癌治疗的抗癌补充剂。

4. 发明申请

WO2007069813A1 METHODS FOR CULTURING MESENCHYMAL STEM CELL AND COMPOSITIONS COMPRISING MESENCHYMAL STEM CELL FOR REPARING SKIN DEFECTS 审中-公开
标题翻译：用于培养骨髓干细胞的培养方法和包含用于复原皮肤缺陷的中枢神经干细胞的组合物
公开(公告)号：WO2007069813A1
公开(公告)日：2007-06-21
申请号：PCT/KR2006/002889
申请日：2006-07-21
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , KIM, Yun Young , PARK, Chan Woong
发明人： KIM, Yun Young , PARK, Chan Woong
IPC分类号： C12N5/08
CPC分类号： C12N5/0667 , A61K35/12 , C12N2500/90
摘要： The present invention relates to a method for culturing a mesenchymal stem cell highly expressing collagen, which comprises the steps of: (a) culturing a mesenchymal stem cell isolated from an adipose tissue in a serum-containing medium; and (b) culturing the mesenchymal stem cell in a serum-free medium, wherein the expression level of type I pro-collagen of the mesenchymal stem cell cultured in the step (b) is higher than that of fibroblast and the expression level of pro-MMP-1 (pro-matrix metalloprotease-1) of the mesenchymal stem cell cultured in the step (b) is lower than that of fibroblast. In addition, the present invention relates to a pharmaceutical composition for repairing a skin defect comprising mesenchymal stem cells as active ingredients.
摘要翻译：本发明涉及培养高表达胶原的间充质干细胞的方法，其包括以下步骤：（a）培养从含有血清的培养基中的脂肪组织分离的间充质干细胞; （b）在无血清培养基中培养间充质干细胞，其中在步骤（b）中培养的间充质干细胞的I型前胶原的表达水平高于成纤维细胞的表达水平，在步骤（b）中培养的间充质干细胞的-MMP-1（前体基质金属蛋白酶-1）低于成纤维细胞。此外，本发明涉及用于修复皮肤缺损的药物组合物，其包含间充质干细胞作为活性成分。

5. 发明申请

WO2007061168A1 PHARMACEUTICAL COMPOSITIONS FOR CELL THERAPY OF PIGMENTATION DISORDERS 审中-公开
标题翻译：用于细胞治疗的药物组合物
公开(公告)号：WO2007061168A1
公开(公告)日：2007-05-31
申请号：PCT/KR2006/002366
申请日：2006-06-20
申请人： Modern Cell & Tissue Technologies Inc. , PARK, Ki Sook , LEE, Su Hyon , HWANG, Ji Hoon , PARK, Chan Woong
发明人： PARK, Ki Sook , LEE, Su Hyon , HWANG, Ji Hoon , PARK, Chan Woong
IPC分类号： A61K38/17
CPC分类号： A61K35/36 , A61K35/12 , C12N5/0698 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2533/52 , C12N2533/54
摘要： The present invention relates to a pharmaceutical composition for cell therapy of pigmentation disorders, which comprises as an active ingredient (a) melanocytes and keratinocytes, or (b) melanocytes and fibroblasts. The cell therapy composition of this invention allows for the first time to treat pigmentation disorders through cell therapy regimen. The present composition comprises as active ingredients a mixed cell preparation of melanocytes and keratinocytes or a mixed cell preparation of melanocytes and fibroblasts such that it induces very effectively pigmentation to treat diseases associated with hypopig mentation such as vitiligo.
摘要翻译：本发明涉及色素沉着病的细胞治疗药物组合物，其包含作为活性成分（a）黑素细胞和角质形成细胞，或（b）黑素细胞和成纤维细胞。本发明的细胞治疗组合物可以首次通过细胞治疗方案治疗色素沉着病。本发明的组合物包含黑素细胞和角质形成细胞的混合细胞制剂或黑素细胞和成纤维细胞的混合细胞制剂作为活性成分，使得它非常有效地诱导色素沉着以治疗与hypopigmentation相关的疾病如白癜风。

6. 发明申请

WO2007052935A1 ARTIFICIAL CARTILAGE CONTAINING CHONDROCYTES OBTAINED FROM COSTAL CARTILAGE AND PREPARATION PROCESS THEREOF 审中-公开
标题翻译：含有从成本中获得的人造丝的人造AGE AGE AGE OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2007052935A1
公开(公告)日：2007-05-10
申请号：PCT/KR2006/004479
申请日：2006-10-31
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , KOREA ATOMIC ENERGY RESEARCH INSTITUTE , UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY , SON, Young Sook , LEE, Jung Sun , LEE, Eun Kyung , LEE, Jin Yeon
发明人： SON, Young Sook , LEE, Jung Sun , LEE, Eun Kyung , LEE, Jin Yeon
IPC分类号： C12N5/08 , C12N5/00 , A61K35/00 , A61K35/12 , A61K35/32
CPC分类号： A61K35/28 , A61K35/12 , A61K35/32 , A61L27/20 , A61L27/3804 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N5/0668 , C12N2501/115 , C08L5/08
摘要： The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
摘要翻译：本发明涉及通过培养肋软骨细胞获得的含有间充质干细胞（MSC）的去分化细胞的人造软骨及其制备方法。

7. 发明申请

WO2008130068A1 METHOD FOR PREPARING A POROUS POLYMER SCAFFOLD USING DRY ICE 审中-公开
标题翻译：使用干冰制备多孔聚合物切片的方法
公开(公告)号：WO2008130068A1
公开(公告)日：2008-10-30
申请号：PCT/KR2007/001972
申请日：2007-04-23
申请人： MODERN CELL & TISSUE TECHNOLOGIES INC. , YUN, So Hee , PARK, Hyun Sook , CHANG, Song Sun
发明人： YUN, So Hee , PARK, Hyun Sook , CHANG, Song Sun
IPC分类号： A61L27/56
CPC分类号： A61L27/56 , A61L15/425
摘要： Disclosed is a method of preparing a porous polymer scaffold, which enables the size and shape of pores, which are formed in the preparation of the porous scaffold using a freeze drying method, to be uniform throughout the three-dimensional structure of the porous scaffold. More specifically, disclosed is a method for preparing a porous polymer scaffold which can be used as a scaffold for three-dimensional cell culture, a tissue engineering scaffold or a wound dressing, the method being characterized in that it comprises, in addition to the steps of the prior freeze-drying method, a step of mixing a polymer solution with dry ice to form a slush-like material.
摘要翻译：公开了一种制备多孔聚合物支架的方法，其使得能够使用冷冻干燥方法在多孔支架的制备中形成的孔的尺寸和形状在多孔支架的整个三维结构中是均匀的。更具体地，公开了一种制备可用作三维细胞培养的支架，组织工程支架或伤口敷料的多孔聚合物支架的方法，其特征在于，除了步骤的现有冷冻干燥方法，将聚合物溶液与干冰混合以形成浆状材料的步骤。

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